Tranexamic acid Cyklokapron CLASSIFICATION(S) Therapeutic: hemostatic agents; Pharmacologic: antifibrinolytics , plasminogen inactivators INDICATIONS Prevention or reduction of hemorrhage

following dental surgery in hemophiliacs ACTION Inhibits activation of plasminogen, thereby preventing the conversion of plasminogen to plasmin Therapeutic Effects: Decreased bleeding following dental surgery in hemophiliacs Reduced need for replacement therapy CONTRAINDICATIONS/PRECAUTIONS Hypersensitivity Active intravascular clotting Acquired defective color vision Subarachnoid hemorrhage ADVERSE REACTIONS/SIDE EFFECTS* CNS: dizziness; EENT: visual abnormalities,CV: hypotension, thromboembolism, thrombosis, GI: diarrhea, nausea, vomiting,

AVAILABILITY Tablets: 500 mg Solution for injection: 100 mg/ml in 5-ml ampules, 100 mg/ml in 10-ml ampules NURSING IMPLICATIONS Instruct patient to take tranexamic acid as directed. Do not take more or less than directed. If a dose is missed, take as soon as possible unless almost time for next dose; do not double doses Advise patient to inform health care professional of any changes in vision. Inform patients on prolonged therapy of the importance of regular ophthalmologic follow-up Caution patient to avoid products containing aspirin or NSAIDs without consulting health care professional Instruct patient to notify health care professional if signs and symptoms of thrombosis (severe, sudden headache; pains in chest, groin, or legs, especially calves; sudden loss of coordination; sudden and unexplained shortness of breath; slurred speech; visual changes; weakness or numbness in arm or leg) occur