2013 vaccine schedules for South Africa

Compiled by Amayeza Info Services Vaccine Helpline: 0860 160 160

Age of child At birth

EPI schedule OPV (0) BCG OPV (1) RV (1) DTaP-IPV//Hib (1) HBV (1) PCV (1) DTaP-IPV//Hib (2) HBV (2)

Age of child At birth

Private practice: Option 1 OPV (0) BCG OPV (1) RV (1) DTaP-IPV//Hib (1) HBV (1) PCV (1) RV (2)2 DTaP-IPV//Hib (2) HBV (2) PCV (2) RV (2 or 3)2 DTaP-IPV//Hib (3) HBV (3) PCV (3) Measles vaccine PCV (4)3 Chickenpox (varicella) vaccine (1)4 MMR (1) or MMRV5 Hepatitis A vaccine (repeat 6 months later) DTaP-IPV//Hib (4)

Private practice: Option 2 OPV (0) BCG HBV1 OPV (1) RV (1) DTaP-IPV//Hib/HBV (1) PCV (1) RV (2)2 DTaP-IPV//Hib/HBV (2) PCV (2) RV (2 or 3)2 DTaP-IPV//Hib/HBV (3) PCV (3) Measles vaccine

Age of child At birth

Private practice: Option 3 OPV (0) BCG OPV (1) RV (1) DTaP-IPV//Hib/HBV (1) PCV (1) RV (2)2 DTaP-IPV//Hib/HBV (2) PCV (2) RV (2 or 3)2 DTaP-IPV//Hib/HBV (3) PCV (3) Measles vaccine PCV (4)3 Chickenpox (varicella) vaccine (1)4 MMR (1) or MMRV5 Hepatitis A vaccine (repeat 6 months later) DTaP-IPV//Hib or DTaP-IPV//Hib/ HBV(4)6 MMR (2) or MMRV5 Chickenpox (varicella) vaccine (2) DTaP or TdaP-IPV HPV (from 9 years)7 TdaP-IPV

6 weeks

6 weeks

2 months

10 weeks

10 weeks

3 or 4 months

14 weeks

RV (2) DTaP-IPV//Hib (3) HBV (3) PCV (2) Measles vaccine (1) PCV (3) DTaP-IPV//Hib (4) Measles vaccine (2)

14 weeks

4 or 6 months

9 months 18 months

9 months 12-15 months

9 months

PCV (4)3 12-15 months Chickenpox (varicella) vaccine (1)4 MMR (1) or MMRV5 Hepatitis A vaccine (repeat 6 months later) DTaP-IPV//Hib or DTaP-IPV//Hib/HBV (4)6 18 months

18 months

6 years

Td vaccine

5-6 years

MMR (2) or MMRV5 Chickenpox (varicella) vaccine (2) DTaP or TdaP-IPV HPV (from 9 years)7 TdaP-IPV

MMR (2) or MMRV5 5-6 years Chickenpox (varicella) vaccine (2) DTaP or TdaP-IPV HPV (from 9 years)7 TdaP-IPV 9 years 12 years

9 years 12 years Td vaccine 12 years

Sources for vaccines schedules Expanded Programme of Immunisation (EPI) (April 2009). Package inserts: Adacel Quadra, Boostrix Tetra, Cervarix, Gardasil, Infanrix-Hexa, Pentaxim, Prevenar, Priorix, Priorix Tetra, Synflorix, Trimovax, Varilrix. Personal communication with GSK (Upper age limit of Infanrix-Hexa). Centers for Disease Control pink book: http://www.cdc.gov/vaccines/Pubs/pinkbook/pink-chapters.htm.

Abbreviations
(0) : Birth dose, which doesnt count as part of primary series (1) : First dose in a series (2) : Second dose in a series (3) : Third dose in a series (4) : Fourth dose (booster) BCG : Bacille Calmette-Gurin (tuberculosis vaccine) DTaP-IPV//Hib/HBV (hexavalent) : Diphtheria, tetanus, acellular pertussis/inactivated polio vaccine/ Haemophilus influenzae type b and hepatitis B vaccine DTaP-IPV//Hib (pentavalent) : Diphtheria, tetanus, acellular pertussis/inactivated polio vaccine and Haemophilus influenzae type b vaccine EPI : Expanded Programme of Immunisation HBV : Hepatitis B vaccine HPV : Human papillomavirus vaccine MMR : Measles, mumps and rubella vaccine MMRV : Measles, mumps, rubella and varicella vaccine OPV : Oral polio vaccine PCV : Pneumococcal conjugated vaccine RV : Rotavirus vaccine Tdap-IPV (quadrivalent) : Tetanus and reduced amount of diphtheria vaccine with acellular pertussis and inactivated polio vaccine. Td vaccine : Tetanus and reduced amount of diphtheria vaccine

Notes (superscripted numbers)

1. If the hexavalent vaccine (Infanrix-Hexa) is given according to the EPI schedule (6, 10 and 14 weeks), a birth dose of HBV (not routinely given in South Africa) is required. 2. If pentavalent RV is given, three doses are required, at 6, 10 and 14 weeks. If monovalent vaccine is given, only two doses are required, at 6 and 14 weeks. 3. When Synflorix is given, the fourth dose can be given from 9.5 months, provided it has been six months since the last dose. 4. Chickenpox (varicella) vaccine can be given at any time from 9 months of age, but is probably most effective if given after the age of 12 months. If not given on the same day as measles vaccines, the vaccines must be separated by at least one month. Varicella vaccine can now be given in combination with MMR as MMRV. 5. MMRV is an option if varicella vaccine has not been given yet. MMRV can be given in place of MMR and varicella vaccines. 6. A booster of HBV is not routinely recommended in South Africa. 7. HPV quadrivalent vaccine can be given to boys and girls; the course consists of three doses, at 0, 2 and 6 months. HPV bivalent vaccine can be given to girls only; the course consists of three doses, at 0, 1 and 6 months.

Vaccine trade names

Vaccine BCG Chickenpox DTaP-IPV//Hib/ HBV DTaP-IPV/Hib Hepatitis A Hepatitis B (HBV) Trade name BCG Varilrix Infanrix-Hexa Pentaxim Avaxim 80 Havrix Junior Heberbiovac HB Euvax Engerix-B Gardasil (quadrivalent) Cervarix (bivalent) Rouvax Trimovax Priorix Priorix Tetra OPV-Merieux Polioral Age group Usually at birth only In certain cases, up to 1 year 9 months and older 8 weeks to 2 years 6 weeks to 2 years 115 years Birth to adulthood Dose according to age 9-26 years 9 years and older 9 months and older 1 year to adulthood 9 months to 12 years Birth to adulthood Not generally recommended in adulthood, because of vaccine-associated paralytic polio (VAPP) 6 weeks to 5 years 6 weeks to 2 years First dose from 6 weeks, second dose before 24 weeks First dose from 6 weeks, last dose before 32 weeks From 3 years From 4 years 6 years and older

HPV

Measles MMR MMRV OPV

PCV

Paediatric vaccines available for other situations

Hiberix [Hib (Haemophilus influenzae type b)]: Up to 5 years of age. Infanrix [DTaP (diphtheria, tetanus, acellular pertussis)]: Up to 7 years of age. Twinrix (hepatitis A and B). RV

Prevenar-13 Synflorix Rotarix Rotateq

TdaP-IPV Td

Adacel Quadra Boostrix Tetra Diftavax