Beruflich Dokumente
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RESEARCH BULLETIN
Dawn DeCosta
Jan Reiss
Bjorn R. Olsen, MD, PhD, Receives Award from Rhode Island Hospital
Roland Baron, chair and professor in the department of the department of oral medicine, infection, and immunity, received an R01 from NIH-NIAMS for his project Mechanisms and function of the microtubule podosome connection in osteoclasts. Increased osteoclastic resorption is responsible for multiple bone diseases, whether systemic (osteoporosis, Pagets disease, or hyper-parathyroidism, for instance) or local (rheumatoid arthritis, periodontal disease, multiple myeloma, tumor osteolysis, etc.). Despite the existence of several antiresorptive drugs, evidence of unwanted effects is emerging. It therefore remains of the utmost clinical importance to better understand the biology of the osteoclast (OC) and of bone resorption. The Baron Laboratory has been heavily invested in the detailed molecular understanding of OC biology and bone resorption. One of the most salient features of this work, supported by many other laboratories, is the demonstration of the critical importance of the attachment of the OC to bone, mediated by a specialized adhesion structure, the actin-containing podosome, which in OCs is specifically organized in a peripheral belt (the actin ring) and ultimately in a sealing zone when OCs are on bone and actively resorbing. The formation of a podosome belt is an OC-specific feature. The primary goal of this project is to further elucidate the molecular mechanisms by which microtubules are connected to and regulate the podosomes, and in particular the transition from clusters to a peripheral belt, and bone resorption. The studies may open new therapeutic avenues to regulate bone resorption, with potential impact on the treatment of osteoporosis, osteolytic diseases, and cancer, given the similarities between podosomes and invadopodia.
Bjorn R. Olsen, dean for research and professor in the department of developmental biology, received an award from the Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair at Rhode Island Hospital. Olsen will serve as a mentor to Anthoy Reginato, PhD, MD, one of Olsens former postdoctoral fellows and a faculty member in rheumatology at Roger Williams Medical Center. COBRE enables clinicians, basic scientists, engineers, and biologists to work on multidisciplinary research aimed at better understanding cartilage and joint health mechanisms and the strategy for the prevention and treatment of skeletal joint diseases.
Tracy Keller, PhD, and Malcolm Whitman, PhD, Featured in National Geographic Magazine
Tracy Keller, instructor, and Malcolm Whitman, professor of developmental biology, were featured in the October 2012 National Geographic magazine for their research on deciphering how the molecule halofuginone works, which may lead to new therapeutic approaches for diseases involving autoimmunity, metabolic signaling, and inflammation. The results of this research were published in Nature Chemical Biology and heralded in dozens of news outlets in many languages around the world.
Jan Reiss
While obtaining her BA in chemistry and conducting research during her undergraduate years at Barnard College, Erica Shapiro was trying to decide whether she should continue her chemistry studies in a doctoral program or pursue her interest in dentistry. After graduating summa cum laude as a Centennial Scholar, Shapiro matriculated in the DMD program at HSDM. She decided that she didnt have to choose combining her two passions would be the perfect answer, and the PhD Biological Sciences in Dental Medicine (BSDM) program would allow her to do that. Upon acceptance to the BSDM program, Shapiro took a leave after the second year of the DMD program. BSDM provides Shapiro with the flexibility to tailor her PhD studies and research exactly to her interests and provides an abundance of world-class research opportunities. Shapiros ultimate goal is to conduct applied dental research that allows her to move between the scientific and clinical aspects of dentistry, pinpointing limiting factors in dental practice and developing solutions in the laboratory.
Shirin Khoynezhad
Jovana Kaludjerovic, originally from Serbia, earned her BSc in biochemistry from McMaster University in Ontario and her MSc from the University of Toronto, where she also earned her PhD in nutritional sciences. She worked with Dr. Wendy Ward and completed a dissertation entitled Programming of bone and reproductive health by early life exposure to soy isoflavones and/or folic acid in CD-1 mice. In the Lanske Lab, her primary focus, for which she received a fellowship from the Canadian Institute of Health Research, is to investigate whether FGF23 and 17-estradiol work in combination to promote chondrocyte differentiation and longitudinal bone growth.
Junhyck Kim (MMSc 2013, Prosthodontics), placed second for his presentation entitled The effect of different surface treatments on shear bond strength of interim restorative resins at the New England Section of the American College of Prosthodontics. Kim went on to compete nationally at the American College of Prosthodontics meeting in Baltimore, MD.
Jan Reiss
Xuchen Aimee Duan is from Beijing, China, where she received her BSc in biological sciences at Liaoning University in 2006. In 2008, she completed an MSc in pharmaceutical sciences at Utrecht University in the Netherlands. Duan pursued a DPhil at University of Oxford with Drs. James Triffitt and Graham Russell, working on bisphosphonates, and received her doctorate in orthopaedic surgery in 2011 with a dissertation entitled Biological and physiological mechanisms of bisphosphonate action. After a one-year postdoctoral fellowship at Oxford, she recently joined the Olsen Lab for a postdoctoral fellowship, during which she will focus on the biochemical and genetic studies of an engineered endostatin-containing trimeric NC1 fragment of collagen XVIII.
Forsyth Institute News Martin Taubman, PhD, DDS, Receives Slavkin Award
Martin Taubman, professor of developmental biology at HSDM and head of the Department of Immunology and Infectious Disease at the Forsyth Institute, was honored by the Friends of the National Institute of Dental and Craniofacial Research (NIDCR) with the 2012 DENTSPLY/ Harold Slavkin Oral Health Science Education Award. The DENTSPLY/Harold Slavkin Oral Health Science Education Award was presented to Taubman at the Friends of the NIDCR annual dinner in Washington, D.C., on December 6. This award is presented annually to an individual who has demonstrated creative and innovative use of science curricula to teach oral health, which imparts excitement about oral health and oral health research. Taubman, who joined Forsyth in 1970, is a noted immunologist with a passion for research and science education. In addition to teaching at HSDM since 1975, he has led Forsyths efforts to engage the next generation of scientists. Twenty years ago, Taubman developed Forsyths Educational Outreach Program to expose high school students to scientific research. Created in response to concerns regarding diminished opportunities for young people to experience the research process, the program is intended to promote and encourage scientific careers and success in scientific research by young people. It provides opportunities for high school students to work side-by-side in the laboratory with scientists engaged in cutting-edge research. More than 140 students have participated in the program since its inception.
Jan Reiss
Dr. Jonatas Esteves joins HSDM from Brazil. In 2005 he earned a DDS in Dentistry from the Araatuba School of Dentistry UNESP in Brazil. In 2010 he obtained an MS in Oral and Maxillofacial Surgery from the same dental school and currently he is a graduate student in the PhD program in Implantology at the Araraquara School of Dentistry UNESP, Brazil. His PhD studies aim at understanding the bone healing process around dental implants placed in surgical alveolus prepared using various methods, such as conventional drilling, piezosurgery and Er,Cr:YSGG laser. He joins the Intini Lab to complete his graduate studies as part of a research agreement between his dental school and Dr. Intini.
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Research Bulletin NovemberDecember 2012 Harvard School of Dental Medicine
HSDM Publications
DEVELOPMENTAL BIOLOGY
Adams A, McBratney-Owen B, Newby B, Bowen ME, Olsen BR, Warman ML. Presphenoidal synchondrosis fusion in DBA/2J mice. Mammalian Genome 2012; Nov 21. Giddon DB. Oral physicians. British Dental Journal 2012;213(10):497-498. Jafari M, Primo V, Smejkal GB, Moskovets EV, Kuo WP, Ivanov AR. Comparison of in-gel protein separation techniques commonly used for fractionation in mass spectrometry-based proteomic profiling. Electrophoresis 2012;33(16):2516-2526. Jumlongras D, Lachke SA, OConnell DJ, Aboukhalil A, Li X, Choe SE, Ho JW, Turbe-Doan A, Robertson EA, Olsen BR, Bulyk ML, Amendt BA, Maas RL. An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud. PLoS One 2012;7(6):e38568. Momen-Heravi F, Balaj L, Alian S, Tigges J, Toxavidis V, Ericsson M, Distel RJ, Ivanov AR, Skog J, Kuo WP. Alternative methods for characterization of extracellular vesicles. Frontiers in Physiology 2012;3:354. Ng MW, Chase I. Early childhood caries: risk-based disease prevention and management. Dental Clinics of North America 2013;57(1):1-16. Yamano S, Kuo WP, Sukotjo C. Downregulated gene expression of TGF-s in diabetic oral wound healing. Journal of Craniomaxillofacial Surgery 2012; Sep 7.