Turban PUVASOL: An Effective Treatment in Alopecia Totalis

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Turban PUVASOL: An Effective Treatment in Alopecia Totalis

L Sornakumar, C Shanmuga Sekar, and CR Srinivas

Abstract
Alopecia areata is characterized by patchy hair loss involving the scalp, eyelashes, and beard. The disease may at times lead to complete baldness of the scalp (alopecia totalis) or of the entire body (alopecia universalis). Alopecia totalis is usually resistant to therapy. We report two cases of alopecia totalis treated with turban psoralen with sunlight exposure (PUVASOL).
Keywords: Alopecia totalis, PUVASOL, Turban

INTRODUCTION
Alopecia totalis is a distressing problem which is usually resistant to various therapeutic modalities. PUVA therapy is an effective therapeutic option but is associated with side effects such as nausea, requires eye protection, and cannot be used in children. Through use of turban PUVASOL, it is now possible to administer a dilute bathwater solution containing 8methoxypsoralen (8-MOP) to the scalp. We report two cases of alopecia totalis which responded to turban PUVASOL (psoralen with sunlight exposure).

CASE REPORTS
Case 1
A 41-year-old woman presented with complete loss of scalp hair since 12 months [Figure 1]. The diagnosis was confirmed by biopsy. She was treated with minoxidil 10% twice daily and 4 mg of betamethasone twice weekly for 6 months with no significant response. She was further treated with turban PUVASOL therapy as described below. After 2 months, vellus hair started growing and by 4 months, she had significant hair growth [Figure 2].
Figure 1 Complete loss of scalp hair

Figure 2 Regrowth of scalp hair after 6 months

In the turban PUVASOL therapy, 1 ml of 8-methoxypsoralen (8-MOP) 1% was diluted in 2 l of water. A clean absorbent cotton cloth was soaked into the solution for 30 seconds and wrapped around the scalp in a turban-like fashion for 5 minutes. The process was repeated four times. The patients were further exposed to sunlight for 5 minutes and the time was gradually increased up to 15 minutes. The treatment was carried out thrice a week. The time of exposure was between 10:00 and 10:15 AM when the ultraviolet (UV)A : UVB ratio is maximum. The patient was advised to avoid sun exposure for few hours after treatment.

Case 2
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Turban PUVASOL: An Effective Treatment in Alopecia Totalis

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Case 2
An 8-year-old boy presented with complete loss of hair over the scalp since 20 months. The diagnosis was confirmed by histopathology. He was treated for 1 year with 2 mg of betamethasone twice weekly and minoxidil 5% twice daily with no significant response. We decided to treat the patient with turban PUVASOL therapy similar to previous case. The patient started having vellus hair growth after 2 months and by 6 months there was almost complete regrowth of scalp.

DISCUSSION
Alopecia areata (AA) is an autoimmune disease characterized by patchy, nonscarring hair loss. Although it most commonly affects the scalp, it can involve any hair-bearing area on the body. Alopecia totalis refers to complete loss of scalp hair. AA can lead to severe emotional distress. Various therapeutic modalities such as systemic steroids, contact immunotherapy, and phototherapy have been tried with partial success. In 1974, Rollier and Warcewski[1] induced hair regrowth in a patient with AA using 8-MOP and natural sunlight. The first report of PUVA treatment with artificial UVA light for AA was published in 1978 by Weissman et al.[2] who obtained encouraging results in five patients. The turban PUVA can be considered a variation of the so called bath suit PUVA method as described by Pai and Srinivas.[3] It has the advantage of delivering the desired photosensitizing effect in a localized area without systemic side effects. Behrens-Williams et al.[4] reported hair regrowth in six of nine patients after 10 weeks of treatment. Broniarczyk-Dyla et al. [5] observed that turban PUVA was significantly more effective in AA vulgaris than in AA totalis or universalis and proved to be a safe, well-tolerated method without the systemic side effects of PUVA. Our patients were not able to come regularly for turban PUVA treatment and hence we decided to modify it as turban PUVASOL. The mechanism of action of PUVA in AA is not clearly understood. There is circumstantial and indirect evidence that AA is a T cell-mediated autoimmune disease of the hair follicle. Immunohistochemical studies in human beings and animal models have demonstrated a perifollicular accumulation of dendritic cells plus CD4+ and CD8+ T lymphocytes and isolated polymorphonuclear cells.[6] Because dendritic cells are thought to play an important role in the initiation of AA by antigen presentation and costimulation, PUVA treatment might exert an inhibitory effect on the development of AA. Suppression of IL-2 and IL-1 production might suppress an already present lymphocytic infiltrate in AA and induce hair growth. The time chosen for phototherapy was between 10:00 and 10:15 AM. Balasaraswathy et al.[7] in a study proved that the ideal time for PUVASOL is between 9:15 and 11:15 AM, which will minimize unwanted exposure to UVB and infrared radiation and hence we regularly advise this particular time in our institute. Both our patients had significant improvement after therapy. We report this case as the effectiveness of turban PUVASOL in AA has never been reported.

Footnotes
Source of Support: Nil Conflict of Interest: None declared

Article information
Int J Trichology. 2010 Jul-Dec; 2(2): 106107. doi: 10.4103/0974-7753.77520 PMCID: PMC3107953 L Sornakumar, C Shanmuga Sekar, and CR Srinivas Department of Dermatology, PSG Hospitals, Coimbatore, Tamil Nadu, India Address for correspondence: Dr. C. Shanmuga Sekar, Department of Dermatology, PSG Hospitals, Peelamedu, Coimbatore - 641 004, Tamil Nadu, India. Email: drshannfun/at/sify.com
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Turban PUVASOL: An Effective Treatment in Alopecia Totalis

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Copyright International Journal of Trichology This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Articles from International Journal of Trichology are provided here courtesy of Medknow Publications

REFERENCES
1. Rollier R, Warcewski Z. Le traitement de la pelade par la meladinine. Bull Soc Fr Dermatol Syph. 1974;81:97. 2. Weissman I, Hofmann C, Wagner G. PUVA therapy for alopecia areata: An investigative study. Arch Dermatol Res. 1978;262:3336. [PubMed] 3. Pai S, Srinivas CR. Bathing suit delivery of 8 - methoxypsoralen for psoriasis: A double-blind, placebo-controlled study. Int J Dermatol. 1994;33:5768. [PubMed] 4. Behrens-Williams SC, Leiter U, Schiener R, Weidmann M, Peter RU, Kerscher M. The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata. J Am Acad Dermatol. 2001;44:24852. [PubMed] 5. Broniarczyk-Dyla G, Wawrzycka-Kaflik A, Dubla-Berner M, Prusinska-Bratos M. Effects of psoralen-UV-A-Turban in alopecia areata. Skinmed. 2006;5:648. [PubMed] 6. McElwee KJ, Tobin DJ, Bystryn JC, King LE, Jr, Sundberg JP. Alopecia areata: An autoimmune disease? Exp Dermatol. 1999;8:371 9. [PubMed] 7. Balasaraswathy P, Kumar U, Srinivas CR, Nair S. UVA and UVB in sunlight: Optimal utilization of UV rays in sunlight for phototherapy. Indian J Dermatol Venereol Leprol. 2002;68:198201. [PubMed]

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