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PHACTR3 - Wikipedia, the free encyclopedia

PHACTR3
From Wikipedia, the free encyclopedia

tin regulator 3

oloGene: 14482 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

org/cgi-bin/carddisp.pl?id_type=entrezgene&id=116154)

ms&depth=0&query=GO:0003779)

&search_constraint=terms&depth=0&query=GO:0004864)

rms&depth=0&query=GO:0016363)

KB:Q96KR7) / QuickGO (http://www.ebi.ac.uk/QuickGO/GProtein?ac=Q96KR7)

(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=74189&rn=1)

ENSMUSG00000027525 (http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000027525;db=core)

Q8BYK5 (http://www.uniprot.org/uniprot/Q8BYK5)

NM_001007154 (http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001007154)

NP_001007155 (http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001007155)

178.12 178.34 Mb (http://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm9&position=chr2:178118975-178338492) (http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=74189)

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.[1][2] The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[2]

Interactions
PHACTR3 has been shown to interact with PPP1CA.[3]
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PHACTR3 - Wikipedia, the free encyclopedia

References
1. ^ Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins" (//www.ncbi.nlm.nih.gov/pmc/articles/PMC406487). Proc Natl Acad Sci U S A 101 (18): 718792. doi:10.1073/pnas.0401673101 (http://dx.doi.org/10.1073%2Fpnas.0401673101). PMC 406487 (//www.ncbi.nlm.nih.gov/pmc/articles/PMC406487). PMID 15107502 (//www.ncbi.nlm.nih.gov/pubmed/15107502). 2. ^ a b "Entrez Gene: PHACTR3 phosphatase and actin regulator 3" (http://www.ncbi.nlm.nih.gov/sites/entrez? Db=gene&Cmd=ShowDetailView&TermToSearch=116154). 3. ^ Sagara, Junji; Higuchi Tsukasa, Hattori Yukiko, Moriya Mie, Sarvotham Haritha, Shima Hiroshi, Shirato Haruki, Kikuchi Kunimi, Taniguchi Shunichiro (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. (United States) 278 (46): 456119. doi:10.1074/jbc.M305227200 (http://dx.doi.org/10.1074%2Fjbc.M305227200). ISSN 0021-9258 (//www.worldcat.org/issn/0021-9258). PMID 12925532 (//www.ncbi.nlm.nih.gov/pubmed/12925532).

Further reading
Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human.". Cytogenet. Genome Res. 115 (1): 239. doi:10.1159/000094797 (http://dx.doi.org/10.1159%2F000094797). PMID 16974080 (//www.ncbi.nlm.nih.gov/pubmed/16974080). Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." (//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). Genome Res. 14 (10B): 21217. doi:10.1101/gr.2596504 (http://dx.doi.org/10.1101%2Fgr.2596504). PMC 528928 (//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928). PMID 15489334 (//www.ncbi.nlm.nih.gov/pubmed/15489334). Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway." (//www.ncbi.nlm.nih.gov/pmc/articles/PMC442148). Genome Res. 14 (7): 132432. doi:10.1101/gr.2334104 (http://dx.doi.org/10.1101%2Fgr.2334104). PMC 442148 (//www.ncbi.nlm.nih.gov/pmc/articles/PMC442148). PMID 15231748 (//www.ncbi.nlm.nih.gov/pubmed/15231748). Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 405. doi:10.1038/ng1285 (http://dx.doi.org/10.1038%2Fng1285). PMID 14702039 (//www.ncbi.nlm.nih.gov/pubmed/14702039). Sagara J, Higuchi T, Hattori Y, et al. (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure.". J. Biol. Chem. 278 (46): 456119. doi:10.1074/jbc.M305227200 (http://dx.doi.org/10.1074%2Fjbc.M305227200). PMID 12925532 (//www.ncbi.nlm.nih.gov/pubmed/12925532). Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 fulllength human and mouse cDNA sequences." (//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899903. doi:10.1073/pnas.242603899 (http://dx.doi.org/10.1073%2Fpnas.242603899). PMC 139241 (//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241). PMID 12477932 (//www.ncbi.nlm.nih.gov/pubmed/12477932). Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 86571. doi:10.1038/414865a (http://dx.doi.org/10.1038%2F414865a). PMID 11780052 (//www.ncbi.nlm.nih.gov/pubmed/11780052).

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