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Major Research Studies and Findings
Our work over the past thirty-four years has shown consistent, reliable, and reproducible demonstrations of major and clinically relevant reductions in medical and psychological symptoms across a wide range of medical diagnoses, including many different chronic pain conditions [Kabat-Zinn, 1982; Kabat-Zinn, Lipworth and Burney, 1985; Kabat-Zinn et al, 1986], other medical diagnoses [Kabat-Zinn and Chapman-Waldrop, 1988]; and in medical patients with a secondary diagnosis of anxiety and/or panic [Kabat-Zinn et al, 1992; Miller et al, 1995], over the eight weeks of the MBSR intervention, and maintenance of these changes in some cases for up to four years of follow-up. We have also seen consistent, reliable, and reproducible demonstrations of significant and clinically relevant increases in trait measures which are usually stable in adulthood, indicative of enhanced psychological hardiness (Kobasa) and greater sense of coherence (Antonovsky) over the course of the eight week intervention, and maintenance of these gains for up to three years of follow-up. The latter measures indicate a heightened sense of self and self-in-relationship, and a greater ability to find coherence and act effectively under high degrees of stress. These changes enhance the experience of self-efficacy in patients and their view of the value of engaging in their own on-going health and well-being through meditation, yoga, and above all, the systematic cultivation of awareness [Kabat-Zinn, Skillings, and Salmon, manuscript submitted].
Major research findings - CFM - UMass Medical School - Worcester practicing mindfulness, while receiving phototherapy. 2003 , with Richard Davidson, PhD, Jon Kabat-Zinn and colleagues published a study in Psychosomatic Medicine showing positive changes in brain activity, emotional processing under stress, and immune function in people taking an MBSR course in a corporate work setting in a randomized clinical trial. 2003 , the Center received the first federally funded DOD grant to study stress reduction and prostate cancer; James Carmody, PhD, principal investigator. 2006 , the Centers clinical research infrastructure supported two NIH-funded studies of MBSR for hot flashes and asthma in adult populations. James Carmody, PhD, and Lori Pbert, PhD, principal investigators. Pilot data from the hot flash study suggested preliminary positive evidence of the feasibility and efficacy of MBSR in supporting women who are experiencing severe hot flashes. Data from the asthma study suggested MBSR produced lasting and clinically significant improvements in asthma-related quality of life and stress in patients with persistent asthma, without improvements in lung function. 2008 , Drs. David Ludwig and Jon Kabat-Zinn published the Mindfulness in Medicine article in the Journal of the American Medical Association exploring clinical applications, research challenges, and possible mechanisms of action. 2011 , Drs. Britta Hlzel, James Carmody, et al, published Mindfulness practice leads to increases in regional brain gray matter density in Psychiatry Research. Anatomical magnetic resonance (MR) images from 16 healthy, meditation-nave participants were obtained before and after they underwent the 8-week program. The results suggested that participation in MBSR is associated with changes in gray matter concentration in brain regions involved in learning and memory processes, emotion regulation, self-referential processing, and perspective taking. back to main Research page Email this page
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