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Spectroscopys mission is to enhance productivity, efciency, and the overall value of spectroscopy as a practical analytical technology across a variety of elds. Scientists, technicians, and laboratory managers gain prociency and competitive advantage for the real-world issues they face through unbiased, peer-reviewed technical articles, trusted troubleshooting advice, and best-practices application solutions.

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At Spectroscopy, service to our audience starts with our print products: our regular monthly issues containing peer-reviewed technical articles and installments from our renowned columnists that provide advice on core and emerging methods, troubleshooting, and the latest equipmentalong with special issues on techniques such as Raman, FT-IR, and ICP/ICP-MS; application notebooks; and our quarterly supplement series, Current Trends in Mass Spectrometry. We then carry our missionand our passion for excellenceonline, with our digital edition that enables readers around the globe to access the articles of our print issues; a weekly electronic newsletter (The Wavelength); educational web seminars, and podcasts. We also connect with our readers through social media, providing a forum for conversation and advice through our LinkedIn group. As the web transforms the way we interact and offers us new opportunities, Spectroscopy continues to provide the scientic leadership our readers have come to expect from us. Regardless of the format, we know that separation scientists rely on Spectroscopy to provide unbiased, nuts-and bolts technical and applicationsoriented information that they can trust.

www.spectros copyonline.com 27 Number July 2012 Volume 7

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July 2012

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LCGC Europe

Spectroscopy

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ic Barley Measuring Transgen LCMS n with Protein Expressio the LCMS Proling of Yeast Metabolome e Oils with Characterizing Crud ProbeMS Direct Insertion ing Quantitative Imag Mass Spectrometry

TECHNOLOGY
pists Spectrosco for Todays

RAMAN

76.3% of subscribers rated Spectroscopy the top publication for offering in-depth coverage of spectroscopic instrumentation and applications*

Monthly Features
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Mass Spectrometry Forum

Those Ions Know What They Are Doing, Part I

The phrase the ions know what they are doing emphasizes that ions, once formed, react according to known rules and logical patterns. We can change their environment in different experiments and observe their behavior with different instruments, but they follow the rules. We depend on this underlying rationality so that, for example, a pattern of unimolecular dissociation reactions in electron ionization can be interpreted to discern ion structure, and by analogy, molecular structure. An integral part of all mass spectral interpretation, using the variety of ionization methods available, is to examine the mass spectra, deduce the rules, and discover those patterns. Accomplishing this requires an understanding of the environment in which the ions are formed, the environments in which they dissociate, and the time they reside within each. Because ions move through a beam instrument or reside for extended periods in others, the range of environments becomes broad, and the experimental options numerous.
Kenneth L. Busch
elcome to analysis by modern mass spectrometry (MS). Would you like ions from your sample created by electron ionization (EI), chemical ionization (CI), electrospray ionization (ESI), or matrix-assisted laser desorptionionization (MALDI)? Perhaps you may be interested in another variant in ionization methods accessible to the modern analyst. If you have been following this column over the years, you realize that some of these ionization methods may create protonated ions from the molecule, while others may create odd-electron molecular ions. Some of the ionization methods are considered hard (creating ions with a great deal of internal energy), and others are soft (creating ions that contain less internal energy). Intuitively, we surmise that ions with more internal energy are likely to dissociate to a greater degree, at faster rates, or follow different dissociation pathways than a cool ion does. We are not surprised that the recorded mass spectra change when using different ionization methods or recording the mass spectra under different experimental conditions. Invariably, if we observe a difference,

Spectrometers for Elemental Spectrochemical Analysis, Part III: Arc/Spark Optical Emission Spectrometers
The author discusses arc/spark optical emission spectrometers. The basic modules of spectrometer systems have already been discussed in Part I of this series (1).
Volker Thomsen
f the arc/spark optical emission spectrometers in service today, 99% are used for the routine spectrochemical analysis of metals. Alloys of iron, aluminum, and copper together make up about 80% of this total. The remaining applications concern alloys of nickel, cobalt, zinc, titanium, magnesium, and the lead/tin/solder group. Refractories, precious metals, steel-making slags and geological materials, and other exotic materials account for the remaining 1% (2,3).

XPS Surface Characterization of Disposable Laboratory Gloves and the Transfer of Glove Components to Other Surfaces
Surface contamination on analytical samples or other handled materials can come from sources such as human hands, inappropriate packaging materials, airborne dust fallout, contaminated sample handling tools, or contaminated sample holders. An often overlooked source of contamination is disposable laboratory gloves, which are frequently worn for the purpose of protecting handled materials from fingerprints and other contaminants present on bare fingers. However, the gloves themselves may be a source of potential contamination transfer equal to or even greater than bare fingers. This study shows how X-ray photoelectron spectroscopy (XPS) can be used to determine the contaminants present on laboratory gloves and also evaluate the type and amount of contamination transfer from gloves to other surfaces.
Brian R. Strohmeier, John D. Piasecki, and Alexander Plasencia

Arc/Spark Excitation
we then seek to explain it. Ions created by EI and CI have been examined for decades, and our understanding is advanced, underpinning the discussion in this column. For ESI and MALDI, despite the broad applicability of the methods, our understanding of the ionic environments in those sources has not yet advanced to an analogous level of detail.
Electrical discharge excitation sources were developed in the latter part of the 19th entury. The first two decades of the 20th century saw considerable development in direct current, alternating current, and high voltage excitation sources. In the arc/spark spectrometer, the excitation is produced by the energy of the electrical discharge between the sample and the electrode. The resulting plasma temperatures effectively remove sample material (called ablation) and excite the constituent atoms. Today, this electrical discharge typically is carried out in an argon atmosphere, although all early instruments were run in air. For this type of spectrometer using electrical excitation, the sample must be electrically conductive. Therefore, this instrumentation is very popular in the metals industry. The Spark Stand and Arc/Spark Source: A diagram of a typical spark stand (electrode and sample geometry) is shown in Figure 1. It illustrates the conventional point-to-plane configuration (electrode to sample). The electrode typically is made of tungsten, although graphite electrodes have been used in the past with nonferrous materials.

The Fundamentals
An elementary fact about chemical reactions is that their rate depends on the temperature of the system. For many reactions, the reaction rate increases with an increase in temperature, and that dependence is shown by the classical Arrhenius rate equation. In short, the Arrhenius rate equation expresses the rate constant k of a reaction on the temperature T: k = Ae-E(act)/RT [1]

In this equation, A is the pre-exponential factor, R is the universal gas constant, and E(act) is the activation energy for the

The spark stand in modern instrumentation is flushed with argon to prevent oxidation effects and allow transmission of UV wavelengths absorbed by oxygen. A very basic electrical circuit diagram used to provide the discharge is shown in Figure 2, where V is a voltage source, S is a switch, C a capacitor, L an inductor, and R is a resistor. When the switch is closed the capacitor is charged to the voltage V. When the switch is opened, the electrical energy stored in the capacitor is released through the inductor and resistor, producing a discharge across the spark gap. Several comments must be made concerning the basic electrical circuit of Figure 2: The voltage in the circuit is generally between about 400 and 1000 V. This is not enough to cross (breakdown) the 34 mm spark gap. A much higher voltage, on the order of 10,000 V, is required. This is provided by an ignitor circuit (similar to the ignition coil of an automobile), whose sole function is to bridge the gap. Once this short path has been ionized, the lower voltage is sufficient for a continued discharge. In modern spark excitation sources, the discharge is unidirectional, from the electrode to the sample. To prevent an oscillating discharge as would occur normally in the circuit of Figure 2, a diode D is included across the capacitor. (A diode is an electrical circuit component that only permits a current to flow in only one direction.) The switch S is opened and closed electronically many times per second. This is referred to as the frequency of the discharge. The spark gap generally is referred to as the analytical gap in arc/spark spectrometry. The 500015,000 K plasma temperatures generated in this region is where the analytical

isposable elastic gloves are ubiquitous in scientific laboratories and are also widely used in many industries while handling critical surfaces. Disposable gloves are typically made from nitrile or latex rubber and offer their users protection from various aqueous acids and bases, biological and medical fluids, organic solvents, and other potentially harmful substances. A second major use of disposable gloves is to protect manufactured products and analytical samples from contamination caused by the transfer of skin cells, oils, salts, cosmetics, hand lotions, or other residues resulting from contact with bare hands. However, disposable gloves can also be an overlooked potential source of contamination on handled surfaces. In addition to the primary polymer structure, many types of common laboratory gloves also contain a variety of inorganic salt additives in the glove formulation. For example, zinc oxide is often added as an accelerator and calcium nitrate is used as a coagulant (1). Post-forming processes such as chlorination are often used to oxidize the outer glove surface to reduce surface tackiness (2). Silicone-containing mold-release agents that allow powder-free gloves to be

easily stripped from the glove formers during fabrication may be present on glove surfaces. Silicones are leachable and can be easily transferred to any object they contact (2). Furthermore, the inner surfaces of disposable gloves may have various polymeric surface coatings for improved donning properties or other specialized uses (2). These inner coatings or bulk glove components may permeate the glove material and segregate to the outer glove surface after exposure to certain solvents. Contact with solvents during rinsing of items being held may also transfer glove components to the surfaces of those items. Contamination resulting from surface residues on gloves can adversely affect materials used in industries in which surface cleanliness is essential for optimum product performance and can also interfere with sample analyses depending on the specificity and sensitivity of the analytical technique being used. Therefore, it is important to know if the various components within a particular glove material are leached out by certain solvents or if manufacturing residues present on the surfaces of gloves are easily transferred to other materials.

> Columns are discussions of

popular topics in the eld of spectroscopy, brought to you by our team of veteran industry experts.

> Technical Tutorials are brief,

peer-reviewed instructional articles aimed at delivering basic or refresher information on a particular spectroscopic technique or application area.

> Technical Articles are peer-reviewed scientic papers that focus on novel uses of spectroscopic techniques and instrumentation to solve real-world problems.

The latest research, news, training courses, vendor announcements, and more. A comprehensive look at instruments, consumables, software, components, and more. A month-by-month roundup of conferences, exhibitions, and courses on spectroscopy, analytical chemistry, and related elds.

> News Spectrum

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PRODUC T R E SOURCE S
Long-path gas cells
PIKEs long-path IR gas cells are designed for analysis of air contaminants, pure gases, and gas mixtures. According to the company, the fixedpath cells range from 2.4 m to 20 m, and the variable model can be adjusted from 1 m to 16 m. All of the cells reportedly mount rigidly to the baseplate of an FT-IR spectrometer.

News Spectrum
Jens Frisvad Receives Thought Leader Award
Agilent Technologies (Santa Clara, California) has announced the recipient of its latest Thought Leader award: Dr. Jens Frisvad from the Center for Microbial Biotechnology in the department of systems biology at the Technical University of Denmark (Lyngby, Denmark). The center is working to create a targeted metabolomics approach for thousands of compounds produced by Aspergillus, Penicillium, and Fusarium fungi. Scientists will use mutable internal standards to calibrate changes in both chromatographic retention and mass spectrometry (MS) sensitivity to compare extracts over many years. The award will provide the laboratory with use of a liquid chromatographyquadrupole time-of-flight (LCQTOF) MS system for discovery metabolomics, as well as an LCtriple-quadrupole (QQQ) MS system for target screening. Agilent will be supporting research in food safety, specifically the metabolomics of mycotoxins (toxins made by mold). Frisvad commented, Our research is aimed at showing the impact that analysis of LCQTOF and LC QQQ data can have on understanding the metabolomics of mycotoxins. We are extremely pleased that Agilent is helping us continue this important food-safety research. Mike McMullen, president of Agilents chemical analysis group, said, Our support of the work being done at the center for microbial biotechnology closely aligns with a major initiative at Agilent: providing tools and methods that help test the global food supply. By providing instruments to Dr. Frisvad and his team, we continue Agilents long history of helping create innovative ways to improve food safety.

Detector array sensor

Andors iDus InGaAs detector array series is designed for spectroscopy applications at wavelengths up to 2.2 m. According to the company, the instrument is capable of cooling to -90 C without liquid nitrogen, and providing wavelength coverage from 600 nm to 17 m and 800 nm to 2.2 m.

PIKE Technologies,
Madison, WI; www.piketech.com

Waters and Fera Focus on Food Safety

Waters (Milford, Massachusetts) and the Food and Environment Research Agency (Fera) (York, UK) have announced that they will open a new laboratory-based training facility that will combine their respective regulatory, scientific, and industry expertise to help solve the global food safety challenge. The Fera International Food Safety Training Laboratory (Fera IFSTL) will teach the best available techniques for testing for food contamination and educating on the different food safety regulatory standards around the world. The training facility, based near York, will primarily train those concerned with exporting foods to Europe. As part of the collaboration with Fera, Waters will help establish the laboratorys construction, provide analytical systems, and assist Fera in designing training programs.

Andor Technology,
South Windsor, CT; www.andor.com

> Product Resources

Coated filters

Coated filters from Optometrics are designed with ion-assisted deposition of refractory oxides and soft-coated filter capabilities. According to the company, the coatings remain stable and survive 300 C for long periods of time. Applications reportedly include fluorescence, analytical instrumentation, laser techniques, environmental monitoring, and imaging systems. Optometrics, Ayer, MA; www.optometrics.com

Raman analyzers

The ProRaman-L series Raman spectrometers from Enwave Optronics are designed to provide measurement capability down to low parts-per-million levels. According to the company, the instruments are suitable for process analytical method developments and other measurements requiring high sensitivity and high speed analysis. Enwave Optronics, Inc., Irvine, CA; www.enwaveopt.com

> Calendar

Miniature spectrometer

B&W Teks Exemplar miniature spectrometer features on-board data processing that includes averaging, smoothing, and automatic dark subtraction. According to the company, the instrument provides data transfer of 900 spectra/s, trigger delay of 14 ns, and gate jitter of 1 ns. B&W Tek, Newark, DE; www.bwtek.com/product/spectrometer/exemplar.html

Potassium bromide windows

Edmund Optics potassium bromide windows are designed for FT-IR spectroscopy. The windows reportedly provide transmission from 250 nm to 26 m with an index of refraction of 1.461.59 over that range. According to the company, the windows can be cleaved and used at temperatures up to 300 C. Edmund Optics, Barrington, NJ; www.edmundoptics.com

Market Profile: UVvisNIR microscopy

As with other molecular spectroscopy techniques, demand Jasco is the market leader, having introduced its MSV-300 series in 2007, and following it up with the for microscopy-enabled UVvisnear infrared (NIR) spectroscopy is a developing segment of the market. introduction of the MSV-5000 series this year. CRAIC Demand from the semiconductor and electronics industry Technologies is a small California-based company that was one of the first vendors to develop a commercially is the primary driver, although there is considerable potential for other applications as well. So far none of the available UVvisNIR microscopy system. A third major UVvisNIR vendors compete in this niche market, competitor of note is J&M Analytik, which is a but that could soon change. small German company that The strongest demand for is focused on UVvisNIR Semiconductor, electronics, 9% and nanotechnology - 35% spectroscopy. None of the four conventional UVvisNIR 35% 11% Academia - 24% largest suppliers of UVvis spectrophotometers comes from Forensics (government) - 21% 21% the semiconductor, electronics, NIR spectrophotometers as yet 24% Other - 11% and nanotechnology industries, so offers either integrated UV Pharmaceuticals - 9% visNIR microscopy systems or it should come as no surprise that the same is true for UVvisNIR microscopy accessories. UVvisNIR microscopy demand by industry. microscopes. The wide spectral The foregoing data were extracted Figure caption Figure caption Figure caption range provides considerable from SDis market analysis and analytical flexibility, and the incorporation of microscopy perspectives report entitled The Global Assessment Report, 11th Edition: The Laboratory Life Science and Analytical adds imaging and mapping capabilities. UVvisNIR microscopy also finds significant demand from forensics Instrument Industry, October 2010. For more information, applications, where the wide spectrum potentially can help contact Stuart Press, Vice President, Strategic Directions International, Inc., 6242 Westchester Parkway, Suite 100, to identify much more information. As a relatively new Los Angeles, CA 90045, (310) 641-4982, fax: (310) 641-8851, niche technique, academia naturally accounts for a major percentage of demand as well. www.strategic-directions.com.

XRD and XRF sample preparation

The McCrone Micronising mill from Glen Creston is designed to reduce solid samples to micrometer sizes suitable for X-ray diffraction, X-ray fluorescence, infrared spectroscopy, and atomic absorption analysis. According to the company, the mills cylinder-grinding action produces linear contact blows and planar shearing, resulting in a short grinding time with little sample loss, even particle size distribution, and minimal crystal lattice disturbance. McCrone, London, England; www.mccrone.co.uk.

ICP sample uptake monitor

The TruFlo sample uptake monitor from Glass Expansion is designed to measure and digitally display the sample flow rate to an ICP-OES or ICP-MS nebulizer. According to the company, the monitor can be programmed to sound an alarm when deviation from specified flow rates occurs.

Glass Expansion,
Pocasset, MA; www.geicp.com

July 2012 Readership Study Conducted by Advanstar Research Services

Columnists
Leading Industry Experts
Our columns, written by our industry-leading editors, provide unique sources of practical information on the techniques and principles of spectroscopy. Molecular Spectroscopy Workbench By Fran Adar and David Tuschel, Horiba Jobin Yvon Now in her fth year as a Spectroscopy columnist, renowned expert Fran Adar surveys the state-of-the-art in Raman, FT-IR, NIR, optical molecular spectroscopy, and more. Mass Spectrometry Forum By Kenneth L. Busch, National Science Foundation Veteran Spectroscopy columnist Ken Busch brings readers the basics of MS theory and instrumentation explained for all skill levels. The Baseline By David W. Ball, Cleveland State University Well-known theoretical expert David Ball brings readers his popular series of back-to-basics articles on key spectroscopic principles and instrumentation. Focus on Quality By R.D. McDowall, McDowall Consulting Bob McDowall, one of the foremost authorities on data, software, and validation provides unique commentary on a range of topics dealing with obtaining, handling, and reporting quality laboratory data. A must-read for spectroscopists in pharmaceutical, environmental, or other regulated laboratories. Chemometrics in Spectroscopy By Howard Mark and Jerome Workman Jr. Howard Mark, Spectroscopy veteran of over 21 years, and industry leader Jerome Workman discuss the principles of, and important topics in, applied chemometrics. Atomic Perspectives With each installment written by an industry expert, this invaluable column covers techniques such as ICP-MS, ICP-OES, and XRF. Laser and Optics Interface Covers innovations in the eld of lasers and optics technology as well as core information about choosing and controlling laser power when working with different types of applications.

Circulation
Advertising in a BPA-audited publication ensures your message is reaching a qualied, quantiable group of subscribers. With our audience of 27,822 BPA-qualied subscribers, you can be sure your message is being seen by subscribers in the industries and functions integral to the eld of spectroscopy.

Spectroscopy reaches top professionals in the industrys primary businesses

Universities, Colleges 17.4% Government 10.2% Research Labs, Institutes, Foundations 4.9% Independent Analytical Labs 3.5% Hospitals, Medical Centers 3.7% Energy 1.0%

Private Industry 59.3%

Spectroscopy connects with subscribers who serve a variety of job functions

Quality Control, Assurance Validation 9.3% Corporate Management 8.8% Lab Management 7.7% Teaching 6.5% Process Control, Manufacturing 6.3% Technical Services 5.2% Analysis 5.0% Marketing, Sales 3.8% Engineering Design 2.9% Regulatory 1.7%

Research and Development 42.8%

BPA June 2012. BPA Worldwide audits Spectroscopys circulation. Go to BPAs free searchable website at www.bpaww.com.

Circulation
88.7% of Spectroscopy readers recommend, inuence, or authorize the purchasing of spectroscopic instruments* Spectroscopy readers represent the following top 3 job titles*
Senior/Chief Chemist/Scientist 27.9% Laboratory/R&D Manager/Supervisor 21.0% Research/Bench Chemist/Scientist 9.7% 0 10 20 30 40 50 60 70

Spectroscopy is essential to our audience in their eld of work^

Pharmaceuticals/Life Sciences1 36.9% Analytical Chemistry 19.6% Environmental 10.8% Applied Materials Research2 10.2% Instrumentation Design/Development 7.5% Organic/Inorganic Chemicals 5.7% Agriculture/Food 5.5% Energy/Petroleum 3.7% 0 10 20 30 40 50 60 70

Spectroscopy readers use the following techniques^

UV/VIS 61.1% Infrared (FT-IR, NIR) 53.6% MS-MS, MALDI-TOF 41.5% Fluorescence 35.0% Atomic (absorption, emission, plasma) 26.8% ICP, ICP-MS 24.0% X-Ray (ESCA) 22.5% NMR, MRI, EPR 20.3% Raman 19.5% Laser Techniques 13.8% 0 10 20 30 40 50 60 70

*July 2012 Readership Study Conducted by Advanstar Research Services ^Publishers Own Data, May 2012
1 2

Includes biotechnology, forensics/narcotics, medical/biological, and pharmaceuticals Includes electronics/semiconductors, plastics/polymers/rubber, metallurgy, and ceramics

Reader Trends
Readers still choose print publications most frequently when looking for information sources to keep up-to-date in their industry*
Trade magazines/print publications 65.8% Conferences 62.9% Search engines 55.0% E-newsletters 49.0% Web seminars 48.5% Digital magazines 44.6% Supplier websites 42.6% Trade shows 33.7% Publication websites 33.7% Industry websites 33.2% Social networking online 19.8% Online/training videos 16.3% Blogs 10.9% Podcasts 8.4% 0 10 20 30 40 50 60 70 80 90 100

Readers take action as a result of seeing your advertisement in Spectroscopy*

Visited a companys website 88.6% Recommended/discussed product/service with others 27.3% Sent an email to the company 19.9% Requested information from a salesperson 19.3% Filed advertisement for future reference 17.6% Purchased product or service 11.9% Contacted an advertiser by phone 11.9% Scanned QR codes 4.0% 0 10 20 30 40 50 60 70 80 90 100

*July 2012 Readership Study Conducted by Advanstar Research Services

Reader Trends
42.0% of readers share their copy of Spectroscopy with at least one additional colleague, increasing your visibility each month*
Over the past ve years, 87.1% of readers have increased or stayed consistent in their readership of Spectroscopy*

Reading habits increased 36.1% Reading habits haven't changed 51.0%

Reading habits decreased 12.9%

72.6% of readers have read or looked through at least 3 of 4 of the last 4 issues of Spectroscopy*
Read 3 of 4 of the last 4 issues of Spectroscopy 19.9%

Read 4 of 4 of the last 4 issues of Spectroscopy 52.7%

Read 2 of 4 of the last 4 issues of Spectroscopy 18.9%

Read 1 of 4 of the last 4 issues of Spectroscopy 5.0%

Readers spend an average of 66 minutes reading or looking through a typical issue of Spectroscopy*
45 minutes 16.9% 1 to 2 hours 31.8% 30 minutes 28.9% 2 to 3 hours 11.9% More than 3 hours 3.0% 15 minutes or less 7.5%

*July 2012 Readership Study Conducted by Advanstar Research Services

Electronic Product Usage

Through an array of electronic products, Spectroscopy delivers practical, nuts-andbolts information to help our audience of scientists and lab managers become more procient in the use of spectroscopic techniques and instrumentation.

When searching for information on spectroscopic products or services, the website our readers nd the most trustworthy is www.spectroscopyonline.com*
www.spectroscopyonline.com.......................................................................................40.4% www.acs.org. ....................................................................................................... 12.3% www.spectroscopynow.com..................................................................................... 8.8% www.sciencedirect.com......................................................................................... 14.0% www.appliedspectroscopy.com. ................................................................................ 7.6% www.laboratoryequipment.com................................................................................ 2.9% www.s-a-s.org. ........................................................................................................ 1.8% www.labmanager.com............................................................................................ 4.1% www.globalspec.com.............................................................................................. 4.1% www.americanpharmaceuticalreview.com. ................................................................. 0.0% www.iscpubs.com................................................................................................... 0.0% www.labcompare.com. ............................................................................................ 0.6% www.americanlaboratory.com. ................................................................................. 3.5% www.biocompare.com............................................................................................ 4.2%

Readers receive Spectroscopys e-newsletters more than any others*

Spectroscopys The Wavelength e-newsletter. .................................................................62.8% Spectroscopys E-Application Note Alert........................................................................40.0% Spectroscopy Now. ............................................................................................... 46.2% American Lab....................................................................................................... 15.9% Lab Manager....................................................................................................... 14.5% GlobalSpec. ......................................................................................................... 10.3% Select Science........................................................................................................ 6.9% American Pharmaceutical Review. ............................................................................. 9.7%

Readers consider Spectroscopys e-newsletters alerts more valuable than any others*
Spectroscopys The Wavelength e-newsletter. .................................................................44.5% Spectroscopys E-Application Note Alert........................................................................17.5% Spectroscopy Now. ............................................................................................... 21.2% Lab Manager......................................................................................................... 3.6% American Lab......................................................................................................... 4.4% GlobalSpec. ........................................................................................................... 2.9% Select Science........................................................................................................ 3.6% LabCompare.......................................................................................................... 0.0% American Pharmaceutical Review. ............................................................................. 2.2%

*July 2012 Readership Study Conducted by Advanstar Research Services

2013 Editorial Calendar

DELIVERING CUTTING-EdGE INFORMATION TO THE SPECTROSCOPIC COMMUNITY FOR OVER 28 YEARS

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2013 EDITORIAL CALENDAR

EDITORIAL FOCUS
ICP/ICP-MS Lasers and Optics Pre-Pittcon Issue

ColuMNs
MS Forum The Baseline Laser and Optics Interface

SPecial SuPPleMeNts

BoNus DistributioN
SPIE Photonics West Winter Conference on Plasma Spectrochemistry

Value-Added OPPortuNities
ICP e-Product Showcase* Pittcon Package (call your rep for details) Results from e-Media Survey 4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

SPONSORSHIP OPPortuNities
Photonics West e-Show Daily Educational Webcast ICP/ICP-MS

JANUARY

Space Close: December 3

Pittcon Latest Spectroscopic Techniques

Molecular Spectroscopy Workbench Chemometrics in Spectroscopy

Application Notebook

Pittcon

Pittcon e-Product Alert* 4-Color Product/Literature Release in print and online Results from Spectroscopy Buyer Intention Survey Advertisement in the Global Digital Edition

FEBRUARY

Space Close: January 7

Salary Survey New Instrumentation Trends Raman

MS Forum Molecular Spectroscopy Workbench Atomic Perspectives

Current Trends in Mass Spectrometry 30,000 Global Distribution

MRS Spring

4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

Pittcon e-Show Daily Pittcon Live Theater Educational Webcast Series: Raman New Current Trends in Mass Spec global e-newsletter

MARCH

Space Close: February 4

Pharmaceutical Applications Food/Beverage Applications

The Baseline Focus on Quality

SPIE Photonics Europe Interphex

Ad Performance Study 4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

Laser and Optics Interface

APRIL

Ad Performance Study Space Close: March 4

SPIE Defense, Security + Sensing Laser World of Photonics

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2013 EDITORIAL CALENDAR

EDITORIAL FOCUS
Pittcon Product Review Space Close: April 1 Atomic Perspectives

ColuMNs
Chemometrics in Spectroscopy

SPecial SuPPleMeNts
Current Trends in Mass Spectrometry 30,000 Global Distribution

BoNus DistributioN
ASMS CLEO

Value-Added OPPortuNities
Survey Results from Mass Spectroscopy Survey 4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

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ASMS e-Show Daily New Current Trends in Mass Spec global e-newsletter

MAY

Pittcon Product Review

Environmental FT-IR/NIR Space Close: May 1

Molecular Spectroscopy Workbench The Baseline Chemometrics in Spectroscopy

Raman Technology for Todays Spectroscopists

HPLC

Results from Raman User Survey 4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

Educational Webcast: Raman

JUNE
X-Ray Analysis Microscopy Optics & Lasers

Mass Spec Forum Atomic Perspectives Laser and Optics Interface

Current Trends in Mass Spectrometry 30,000 Global Distribution

Microscopy & Microanalysis Denver X-Ray

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JULY

Space Close: June 3

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FT-IR Technology

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AUGUST
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FACSS/SCIX Show Issue Pharmaceutical Applications

ColuMNs
Molecular Spectroscopy Workbench Mass Spec Forum The Baseline Focus on Quality

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Application Notebook

BoNus DistributioN
FACSS/SCIX

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4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

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FACSS/SCIX e-Show Daily

SEPTEMBER

Optics & Lasers Space Close: August 1

Raman/FT-IR Biofuels Space Close: September 3

Chemometrics in Spectroscopy Molecular Spectroscopy Workbench

Current Trends in Mass Spectrometry 30,000 Global Distribution

AAPS

4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

Educational Webcast: FT-IR

OCTOBER
Environmental Applications Surface Analysis Applications

Mass Spec Forum Focus on Quality Atomic Perspectives

Applications of ICP & ICP-MS Techniques for Todays Spectroscopist

AVS EAS MRS Fall

4-Color Product/Literature Release in print and online Advertisement in the Global Digital Edition

EAS e-Show Daily Educational Webcast: ICP/ICP-MS

NOVEMBER

Space Close: October 1

Annual Corporate Capabilities & Application Notebook Space Close: November 4

The Baseline Focus on Quality

Distributed at all shows attended by Spectroscopy in 2014

4-Color Full Page Advertorial Advertisement and Proles in Global Digital Edition

New Current Trends in Mass Spec global e-newsletter

DECEMBER
*Discounted rate for issue advertisers; contact your sales representative for pricing

EDITORIAL OVERVIEW

For more than 28 years, Spectroscopy has been the only publication dedicated to the spectroscopic sciences. The in-depth coverage of this science provided by Spectroscopy continues to connect industry professionals with the critical information, research, and instrumentation they require. Every issue reaches 27,882 spectroscopists, leading the way in all areas of spectroscopy, with peer-reviewed research articles and technical reports on innovative applications and instruments, tutorials on key techniques, productivity-boosting columns, and comprehensive news coverage of products and industry events.

SPECIAL SUPPLEMENTS
The Application Notebook Published in February, September, and December Spectroscopys Application Notebook provides manufacturers with an opportunity to publish valuable information about the performance of their products under specic laboratory conditions. These application notes help chemists determine the usability and efciency of these products for their own work. The Application Notebook is a valuable resource, connecting Spectroscopy subscribers and manufacturers working in Molecular, Atomic, and Mass Spectrometry. Current Trends in Mass Spectrometry Global Circulation: 30,000* Published in March, May, July, and October
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Spectroscopy

The explosion of interest in mass spectrometry means chemists from a variety of backgrounds and specialties want to know more about this powerful technique. Current Trends in Mass Spectrometry offers practical, technical, and tutorial information about mass spectrometry and its ability to solve complex analytical problems in diverse areas such as drug discovery, anti-terrorism, and environmental applications. Spectroscopy Primer Series: Raman, FT-IR, and ICP-MS Published in June, August, and November An invaluable resource for readers and advertisers alike, Spectroscopys Primer Series will be published for the eighth straight year. Each primer will explore the latest technical information in a targeted discipline, with this years topics centering around Raman, FT-IR, and ICP-MS. This is just one more way Spectroscopy provides its readers with the kind of cutting-edge information required in todays laboratory.
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BPA June 2012. BPA Worldwide audits Spectroscopys circulation. Go to BPAs free searchable website at www.bpaww.com. *Publishers Sworn Statement

2013 HIGHLIGHTS

Annual Resources
Annual Salary Survey Published in March Spectroscopys annual survey of spectroscopists salaries and employment issues measures the changes in compensation packages for spectroscopists. This popular annual series documents how the industrys bottom line affects the paychecks of spectroscopists, and provides a general outlook on employment conditions for the next year. Buyers Guide and Industry Trends 2013-2014 Published in August The annual Buyers Guide and Industry Trends issue is the most comprehensive resource for any spectroscopist looking for the latest spectroscopy related suppliers, products or services, organized in categories specic to their needs. This issue also features cutting-edge market research and analysis from a leading independent consulting rm, exploring each technology area of this dynamic market. The Buyers Guide and Industry Trends issue continues to be a trusted and valued resource among the most inuential buyers in the industry. Corporate Capabilities 2013 Published in December This unique advertorial and application notebook publication presents you with an excellent opportunity to provide more than 26,000 of your best prospects with detailed information about your company and products.

March 2012 Volume 27 Number 3 www.spectroscopyonline.com

2012 Salary Survey

Spectroscopy Market Continues to Grow The Theory and Practice of Raman Crystallography

SP TR ECIAINS EN L ID DS IN E: FE DUS AT TR U RE Y

Volume 26 Number 8

August 2011 Volume 26 Number 8

www.spectroscopyonline.com

2011-2012

SPECTROSCOPY 20112012 BUYERS GUIDE August 2011

Volume 26 Number 12 SPECTROSCOPY CORPORATE CAPABILITIES ISSUE December 2011

BUYERS GUIDE
& Industry Trends

Optics, Electro-Optics, Optronics, Fiberoptics, and Related Components Spectroscopy Software/Computer Hardware/ Automation Products Spectroscopic Instrumentation: Spectrometer Systems General Scientic Equipment and Accessories Process Analytical Instrumentation Sampling/Sample Handling Bioanalysis Instruments Spectroscopy Services

December 2011 Volume 26 Number 12

www.spectroscopyonline.com

2012 Corporate Capabilities

Online FT-IR Spectroscopy for Characterizing Chemical Process Streams 2011 Editorial Index
Application Notes See page 93

Ad Performance Study

Spectroscopy has partnered with Readex Research to obtain subscriber feedback about your advertising presentation and message. Advertisers who run full-page, spread, half-page, or fractional-page ad units in the April issue of Spectroscopy will receive a bound report that provides an in-depth analysis on what our readers think about your advertisement and its effectiveness.

Results include:
Ad recall Message awareness Message impact Verbatim assessments Comparative scoring of your ad against other ads featured in the issue

2013 Rates

FOUR COLOR RATES - US DOLLARS

1x Full Page 10,350 2/3 Page 9,340 1/2 Page Island 8,675 1/2 Page 8,405 1/3 Page 6,685 1/4 Page 5,685 Cover 2 1,775 Cover 3 1,775 Cover 4 3,340 Preferred Pos. 1,410
Ad DIMeNsIoNs WIdtH x DePtH PuBlIcatIoN DIMeNsIoNs WIdtH
1

3x 10,205 9,205 8,550 8,290 6,590 5,595

6x 10,110 9,110 8,460 8,260 6,500 5,525

12x 10,030 9,055 8,405 8,145 6,455 5,470

18x 9,280 8,380 7,785 7,545 5,995 5,110

24X 9,050 8,155 7,580 7,340 5,855 4,965

36X 9,035 8,150 7,570 7,330 5,835 4,935

DePtH

PrIMers

WIdtH

DePtH

Full Page Trim Size Full Page Bleed Full Page Live Area Full Page Non-Bleed 2/3 Page 1/2 Page Island 1/2 Page Horizontal 1/2 Page Vertical 1/3 Page Square 1/3 Page Vertical 1/4 Page

7 4
3

x x x x x x x x x x x

10 2
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Spread Size Bleed (Spread)

14 2 x 1534 x

9 2
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Trim Bleed Live Area Spread Bleed (Spread)

5 4
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x x x x x

838 858 738 838 858

8 7 634 4 2
1

1034 934 9 9 2
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1034

512 414 1012 11

412 6 4
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7 458 912 458 912 458

338 412 2 338

Digital Ad Requirements 1. D  igital data is required for all ad submissions. Preferred format is PDF/X-1a. Note that a standard PDF is not a preferred format, les should be a PDF/X-1a which is a PDF subset specic to printing. Publisher shall have no obligation or liability to Advertiser of any kind (including, without limitation, the obligation to offer Advertiser makegoods or any other form of compensation) if an ad is supplied to Publisher by Advertiser in any format other than our preferred formats. Non-preferred or non-acceptable formats will be charged a $150 processing fee. All les should be built to exact ad space dimensions purchased. For detailed instructions on preparing PDF/X-1a les and submitting ad les to the correct size, go to www.AdsAtAdvanstar.com or contact the production manager. 2. P  ublisher will not supply a faxed or soft proof for Advertiser-supplied les. Advertiser is solely responsible for preighting and proong all advertisements prior to submission to Publisher. If Publisher detects an error before going to press, Publisher will make a reasonable effort to contact Advertiser to give Advertiser an opportunity to correct and resubmit Advertisers le before publication. 3. A  ccepted Method of Delivery: The preferred method of delivering ad les to Advanstar is via a web based ad uploader, www.AdsAtAdvanstar. com. Files can also be submitted on CD-R or DVD-R disc format. Ad Proofs: To insure that Advertisers ad is reproduced correctly, a SWOP-certied color proof that has been made from the same le that 4.  Advertiser supplies to Publisher must be provided. Publisher cannot provide Advertiser any assurances regarding the accuracy of reproduction of any ad submitted without a SWOP proof. Publisher shall have no obligation or liability to Advertiser of any kind (including, without limitation, the obligation to offer Advertiser makegoods or any other form of compensation) for any ad supplied to Publisher by Advertiser without a SWOP proof.