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F.S. M.

PHARM-I
PHR 511 F.S. M.PHARM. (ALL DISCIPLINES) METHODS IN PHARMACEUTICAL RESEARCH Theory: 4 hrs !ee" M#$. M#r"s Theory: 1%% Pr#&'(&#)s: * hrs !ee" M#$. M#r"s Pr#&'(&#)s: 1%% 1. Basic theoretical background of NMR spectroscopy, interpretation of PMR spectra of common organic compounds, Basics of FT-NMR, !" NMR, #pplications of $%-NMR. +. Basic fundamentals of mass spectroscopy, &arious ion sources, analyses. 'nterpretation of mass spectra of simple compounds. ,. 'nterpretation of 'R spectra of compounds, Basics of FT-'R, #d&antages of FT-'R o&er disperse 'R. 4. hromatography - Basic concepts, recent trends in the techni(ues and pharmaceutical applications of the follo)ing* +P, , and its &arious modes like adsorption, partition, re&ersed-phase, chemically bonded phase, ion-e-change, ionic, ion-pair, affinity, si.ee-clusion, and hiral separations. +PT, and / . 5. Thermal Methods - 'ntroduction of &arious thermal methods. T/#, %T# and %0 theory, instrumentation of thermographs and applications. *. 1ptical Rotatory %ispersion and ircular %ichroism * /eneral principle, instrumentation and applications. -. 2lectron Microscopy, 2lectron %iffraction, 3-ray diffraction methods. .. Principles and applications of R'#. /. Bio-statistics and its applications in Pharmaceutical Research. 1%.To-icology in Pharmaceutical Research * #cute, 0ub-acute and chronic to-icity studies * Teretogenicity, mutogenicity and carcinogenic studies. Pr#&'(&#)s: Practical e-ercises based on the topics mentioned in the theory syllabus. PHR 51+ (#) F.S.M.PHARM. (PT) PHARMACO0INETICS AND FORMULATION DESI1N Theory : 4 hrs !ee" M#$. M#r"s : 1%% 1. No2)(2e#r Ph#r3#&o"(2e'(&s : Michaelis-Menten 4inetics, 2stimation of 4m and 5m, learance, half life and &olume of distribution, steady state, Bioa&ailability etc., 6rinary e-cretion process and other nonlinear elimination process, some problems in (uantifying nonlinear pharmacaokinetics. +. Phys(o)o4(&#) Ph#r3#&o"(2e'(& Mo5e)s : Blood flo) rate - limited models - blood

clearance, lung clearance, apparent &olume of distribution, nonlinear dispositions, Membrane limited models. ,. No2&o36#r'3e2' A2#)ys(s : Based on statistical moment theory * statistical moments, Bioa&ailability, clearance, +alflife, #bsorption kinetics, apparent &olume of distribution etc., 0teady state. 4. Co367'er 3o5e)(24 o8 6h#r3#&o"(2e'(& 5#'#. 5. Pre8or37)#'(o2 s'75(es - Pers6e&'(9e #25 &o2&e6's : %etailed study of parameters like solubility, partition coefficient, dissolution, crystal morphology, crystal optics, polymorphism and purity studies * drug e-cipient compatibility study. *. S'#:()('y s'75(es : 0olid state drug stability, kinetics, stability study programs for formulations. -. Po)y3ers - lassification, /eneral methods of synthesis, properties, characteri.ation and e&aluation * Biodegradable polymers - lassification - Mechanism of biodegradation in the body * Polymer processing )ith respect to no&el formulation design * #pplications of polymers in no&el drug deli&ery systems, Medical prosthetics and packaging. ;oo"s Re&o33e25e5 : !. Milo /ibaldi and %onald Perrier, <Ph#r3#&o"(2e'(&s=, %rugs and Pharm. 0ci. 0eries, 5ol. !7, Marcel %ekker 'nc., N.8. $. 9. .:agner, <F725#3e2'#)s o8 C)(2(&#) Ph#r3#&o"(2e'(&s=, %rug 'ntelligence Publications, +amilton, !;<7. ". Bert N. ,a%u, <F725#3e2'#)s o8 Dr74 Me'#:o)(s3 > D(s6os('(o2=, :a&erley Press 'nc., Baltimore, !;<$. =. T.>.,saky, <I2'es'(2#) A:sor6'(o2 > M#)#:sor6'(o2=, Ra&en Press, N.8., !;<7. 7. 9.T. arstensen, <Theory o8 Ph#r3.Sys'e3s=, 5ols. !-", #cademic Press, N.8. ?. +.0. Beans, #.+.Beckett and 9.2. araless, <A59#2&es (2 Ph#r3.S&(.=, 5ol. ! to =. <. 9.T. arstensen, <Dr74 S'#:()('y : Pr(2&(6)es #25 Pr#&'(&es=, %rugs and Pharm. 0ci. 0eries, 5ol. =", Marcel %ekker 'nc., N.8. PHR 51+ (:) F.S.M.PHARM. (HDT P?Co) DDD) METHODS IN DRU1 E@ALUATION Theory: 4 hrs !ee" M#$. M#r"s: 1%% Pharmacological approach of modern medicine Ne) approach in drug disco&ery @+T0A 2&aluation of drugs for cardio&ascular, respiratory, psychotropic and neurotropic, analgesic, anti-inflammatory, antipyretic, immuno-modulatory, anti-diabetic and anti obesity, anti artherosclerotic acti&ities. /uidelines for the use and care of laboratory animals. Techni(ues in the estimation of en.yme and the endogenous substances in the

body fluids in the physiological and pathological condition. Bioassay of &arious drugs and hormones. linical trials and to-icological e&aluation of &arious drugs. /uidelines for 'n&estigational Ne) %rug #pplication @'N%A. PHR 51+ (&) F.S.M.PHARM. (PAA) ADVANCES IN DRUG EVALUATION Theory : 4 hrs !ee" M#$. 3#r"s : 1%% 1. # critical re&ie) of pharmacopoeia and other ad&anced methods used for (ualitati&e and (uantitati&e estimation of drugs and their formulations. +. #n approach to the de&elopment of analytical methods for drugs in bulk and in their formulations, reco&ery studies, stability indicating analytical methods. ,. Methods of analysis of common e-cipientsBadditi&ses in formulations. %etermination of acti&e constituents in presence of these e-cipients. 4. #nalysis of drugsBmetabolites in biological fluids like urine, blood and tissues, en.ymatic analysis. 5. Biochemical analysis of drugs, estimation of en.ymes and other endogenous materials. *. Microbiological essay of antibiotic and &itamins. PHR 51, (#) F.S. M. PHARM. I( PTB PAA) PROCESS @ALIDATION AND C1MP Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. Basic concepts of (uality assurance, Re(uirements of /MPB/,P, '01 ;CCC series, Duality audits etc.. +. Precision, accuracy and biases, sampling and operating characteristic cur&es, sampling plans, statistical inference in estimation of hypothesis testing, statistical procedures in assay de&elopment. ,. %e&elopment of ne) analytical method and its &alidation. 4. 'n-process (uality control tests for &arious dosage forms including packaging and labeling operations. 5. Preparation of documents for ne) drug application and e-port registration. * . oncepts in &alidation, &alidation of manufacturing and analytical e(uipments. Process &alidation in production of pharmaceuticals. ;oo"s Re&o33e25e5 : 1. 0. +. :illig, M.M.Tuckerman and :.0.+itchings, <1oo5 M#278#&'7r(24 Pr#&'(&es 8or Ph#r3#&e7'(&#)s=, %rugs and Pharm. 0ci. 0eries, 5ol. !?, Marcel %ekker 'nc., N.8. +. B.T.,oftus E R.#.Nash, <Ph#r3#&e7'(&#) Pro&ess @#)(5#'(o2=, %rugs and Pharm

0ci. 0eries, 5ol. $", Maarcel %ekker 'nc., N.8. ,. 0. Bolton, <Ph#r#3#&e7'(&#) S'#'(s'(&s : Pr#&'(&#) > C)(2(&#) A66)(&#'(o2s=, %rugs and Pharm. 0ci. 0eries, 5ol. $7, Marcel %ekker 'nc., N.8. 4. /.0.Banker E .T.Rhodes, <Mo5er2 Ph#r3#&e7'(&s=, %rugs and Pharm. 0ci. 0eries, 5ol. <, Maracel %ekker 'nc., N.8. PHR 51, (:) F.S.M.PHARAM. (HDT) HER;AL DRU1 TECHNOLO1C-I Theory: 4 ho7rs !ee". M#$. M#r"s : 1%% 1. Factors influencing culti&ation and utili.ation of &arious methods applied in culti&ation of some commercially important medicinal plants. 'nsecticides E pesticides of herbal origin and their suitable utili.ation. +. Microscopic Techni(ues as applied in e&aluation of Plant drugs. 6se of micro tome, camera ,ucida, etc. %etermination of 5arious diagnostic features of identification different organs as per different herbal pharmacopoeias. ,. Basic metabolic path)ays. 6se of radiotracers, en.ymes, cofactors etc. Biosynthetic schemes of some important Phyto-constituents. 4. #pplication of &arious chromatographic methods in separation and identification of Phytopharmaceuticals. Fingerprint techni(ue and its importance. 5. ommercial sources, methods of isolation, and separation, properties and therapeutic uses of some medicinally important class of alkaloids, glycosides, terpenoids, 0teroids and fla&oring agents. *. Plant tissue culture*'ntroduction, and description of techni(ues, likes cell-culture, micropropogation, hairy root culture, biotransformation, biocon&ersion and recent ad&ances of the techni(ue )ith special emphasis of medicinal plants. -. Re&ie) of recent literature appearing on Phytopharmaceuticals used as antiallergic, anticancerous, antidiabetic, antihepatoto-ic, anti-inflammatory agents, and immunomodulators etc. P+R 7!"@cA F.0 . 1F M.P+#RM @ PF olA ,'N' #, P+#RM# 1,1/8 Theory 4hrs !ee" M#$ 3#r"s:1%% 1. P#'ho6hys(o)o4y > Tre#'3e2' o8 CNS 5(sor5ers )("e #). 0chi.ophrenia :). %epression &). #n-iety 5). 2pilepsy e). #l.heimerFs E Parkinsonism

+. P#'ho6hys(o)o4y > Tre#'3e2' o8 C@S 5(sor5ers #) ongesti&e ardiac Failure :) #ngina E Myocardial 'nfraction &) #therosclerosis 5) #rrhythmias e) +ypertension ,. P#'ho6hys(o)o4y > Tre#'3e2' o8 I3372o)o4(&#) 5(sor5ers )("e #).+ypersensiti&e reaction, :). #sthma, &).'nflammation, 5). Rheumatoid arthritis, e)./out etc. 4. Neoplastic %iseases E their Treatment. ell biology of ancer Neoplasm of &arious organs E their treatment 5. I28e&'(o7s 5(se#ses E 'he(r Tre#'3e2'. %iseases caused by 1r#3 Pos('(9e :#&'er(# E 'he(r 're#'3e2'. %iseases caused by 1r#3 Ne4#'(9e :#&'er(# E 'he(r 're#'3e2'. @(r#)B 8724#)B 6ro'oDo#) 5(se#ses E 'he(r 're#'3e2'. *. E25o&r(2o)o4y > Me'#:o)(s3. D(sor5ers o8 A5re2#) 4)#25 > 'he(r 're#'3e2'. D(#:e'es 3e))('7s #25 ('s 're#'3e2'. -. %isorders of o&ary E female reproducti&e tract E their treatment.1steoporosis E its treatment. .. Pediatric Pharmacology, 1cular Pharmacology, %rug treatment in elderly patients, Rational drug therapy. To-icity of &arious %rugs E hemicals.

/. linical Pharmacokinetics )ith reference to impaired hepatic and renal functions 1%. Pharmacogenetics and %rug interactions. PHR 51, (5) F.S. M. PHARM. (DDD) AD@ANCED TECHNIAUES IN DRU1 DE@ELOPMENT AND SCNTHESIS-I Theory: 4 ho7rs !ee" M#$. M#r"s: 1%%

Techni(ues in drug de&elopment )ill be dealt at ad&anced le&el. These include a deep kno)ledge of the follo)ing topics* hemical bonding @localised, delocalised and bonding )eaker than co&alentA, 'ntermediary species like carbocations, carbanions, free radicals, carbenes and nitrenes, #cids and Bases, 5arious types of mechanisms, 2ffect of structure on reacti&ity to)ards a particular type of reaction. %etailed kno)ledge to be imparted in the follo)ing topics* Nucleophilic substitution @aliphatic, aromatic and free radicalA, 2lectrophilic substitution @aliphatic and aromaticA, #ddition reactions @both carbon- carbon and carbon- heteroatom multiple bondsA, 2limination reactions and Rearrangement reactions. ;oo"s re&o33e25e5: 1.EA59#2&e5 Or4#2(& Che3(s'ryB Re#&'(o2 Me&h#2(s3s #25 S'r7&'7reE,9. March, 9ohn :iley and 0ons, N.8. +.EMe&h#2(s3s #25 s'r7&'7re (2 Or4#2(& Che3(s'ryE,2.0./ould, +old Rinchart and :inston, Ne) 8ork. PHR 514 F.S.M.PHARM ( Ph#r3. Te&h2o)o4y Pr#&'(&#)-IB Ph#r3. A7#)('y Ass7r#2&e Pr#&'(&#)-I Her:#) Dr74 Te&h2o)o4y Pr#&'(&#)-I Ph#r3#&o)o4y Pr#&'(&#)-I Dr74 Des(42 #25 De9e)o63e2' Pr#&'(&#)-I) Pr#&'(&#) (2&). TF #25 @(9# : 1+Hrs !ee" M.M.+%% The practical syllabus comprises of the e-ercises based on the topics mentioned in the Theory syllabus of Paper No. P+R 7!$ E P+R 7!". of respecti&e branch. 0cheme of Teaching and 2-amination of M. Pharm. ourse in Pharmaceutical Technology @PTABPharmaceutical Duality #ssurance @PD#AB+erbal %rug Technology @+%TAB Pharmacology @PF olAB%rug %esign and %e&elopment @%%%A.

Re9(se5 !.e.8. #&#5e3(& ye#r +%%+-+%%,

S.S. M. PHARM.-I
PHR 5+1 S.S. M. PHARM. (A)) D(s&(6)(2es) PHARMACEUTICAL ;IOTECHNOLO1C
Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. S'r7&'7re #25 872&'(o2s o8 DNA - 0uperhelical structure and folding in prokaryotes and eukeryotes, semiconser&ati&e replication of %N#, &arious en.ymes in&ol&ed in replication, different types of replications &i.. bacterial, &iral-%N#, &iral-RN#, Transcription -initiation, elongation, terminationG factors and en.ymes in&ol&ed in

Translation, Recombination, different models of . +. 1e2e E$6ress(o2 #25 Re47)#'(o2s - ,actose operon, Tryptophan operon, ,ysogeny of phage ,ambda. ,. 1e2e &)o2(24 - types of &ectors employed in cloning of genes, Restriction endonucleases, other en.ymes in&ol&ed in cloning of genes, &arious approaches to gene cloning. 4. A66)(&#'(o2s o8 4e2e'(& e24(2eer(24 (2 6h#r3#&e7'(&#) 8(e)5 : 5arious products deri&ed from the use of this technology, present status of research in the field and future prospects. 5. Hy:r(5o3# Te&h2o)o4y - Production and application of monoclonal antibodies. *. T(ss7e C7)'7res - Techni(ue used for production of tissue cultures, its applications to)ards impro&ement of medicinally important plants. -. Mo)e&7)#r ;(o)o4y o8 re&e6'or sys'e3s - 0tructures and in&ol&ement of secondary messengers in &araious biological processes. Role of ion channels. ;oo"s Re&o33e25e5 : 1. 9.%.:atson, <Mo)e&7)#r ;(o)o4y o8 'he &e))=. +. 9.%.:atson and Too.e, <Re&o3:(2#2' DNA 'e&h2(G7es= * # short course. ,. BenHamin ,e&in, <1e2es @=. 4. Peppler, <M(&ro:(#) Te&h2o)o4y= ' E ''. 5. 1ld E Primrose, <1e2e'(& M#2(67)#'(o2s= PHR 5++ (#) S.S. M. PHARM. (PT)DESI1N > DE@ELOPMENT OF NO@EL DELI@ERC SCSTEMS. Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. Theory o8 &o2'ro))e5 re)e#se 5r74 5e)(9ery sys'e3s : >ero order kinetics, theory of diffusion * Release and diffusion of drugs from polymers - mechanism and kinetics /eneral methods of design and e&aluations of controlled release products. +. M(&roe2&#6s7)#'(o2 - Methods of encapsulation, kinetics of drug release from microcapsules, technology and applications. ,. Tr#2s5er3#) 5r74 5e)(9ery sys'e3s - Theory, formulation, production and e&aluation. 4. I36)#2's #25 I2ser's - Types of implants, 1smotic pumps, design and e&aluation methods. Types of 'nserts, design and e&aluataion methods. 5. T#r4e''e5 5r74 5e)(9ery sys'e3s - concept of drug targeting, importance in therapeuticsG Principles of molecular biology - ell recognition and signalling - signal transduction - cell surface receptors - Methods in %rug Targetting. *. L(6oso3es - 0tructure and stability, composition of liposomes, methods of

preparation, application in drug deli&ery and drug targetting. ommercial concepts in liposomes. Neosomes and pharamacosomes - ,ong circulating liposomes. -. A59#2&e5 &o2&e6's- %esign, de&elopment and production of sustained release products. ;oo"s Re&o33e25e5 : 1. 9oseph R. Robinson, <S7s'#(2e5 #25 Co2'ro))e5 Re)e#se Dr74 De)(9ery Sys'e3s=, %rugs E Pharm. 0ci. 0eries, 5ol. ?, Marcel %ekker 'nc., N.8. +. 8ie :. hien, <No9e) Dr74 De)(9ery Sys'e3s=, %rugs and Pharm. 0ci. 0eries, 5ol. !=, Marcel %ekker 'nc., N.8. ,. 9.N.Ni-on, <M(&roe2&#6s7)#'(o2=, %rugs and Pharm. 0ci. 0eries, 5ol. ", Marcel %ekker 'nc., N.8. 4. /. 9olles and R.+.:ooldridge, <Dr74 Des(42 - F##&' or F#2'#syH= #cademic Press, !;I=. 5. 9.R.Robinson and 5incent +.,. ,ee, <Co2'ro))e5 Dr74 De)(9ery=, %rugs and Pharm. 0ci. 0eries, 5ol.$;, Marcel %ekker 'nc., N.8. *. R.,.9uliano, <Dr74 De)(9ery Sys'e3s=, 1-ford 6ni&ersity Press, 1-ford, !;IC. -. M.'./utcho, EM(&ro&#6s7)es #25 M(&roe2&#6s7)#'(o2 Te&h2(G7esE, Noyes %ata orporation, !;<?. .. 2.B.Roche, <Des(42 o8 ;(o6h#r3#&e7'(&#) Pro6er'(es 'hro74h 6ro5r74 #25 #2#)o4s=, #m. Pharm. #ssoc. #cademy of Pharm. 0ci., !;<<. /. ,isbeth, 'llum E 0tanley 0. %a&is * <Po)y3ers (2 Co2'ro))e5 Dr74 De)(9ery=, :right, Bristol @!;I<A. PHR 5++ (:) S.S.M.PHARM (DDD > P?Co))ASAR AND DRU1 DESI1N Theory: 4 ho7rs !ee" M#$. M#r"s: 1%% I 1. Co29e2'(o2#) 3e'ho5s o8 Dr74 Des(42: ,ead, %isco&ery of lead, ,ead optimisation, 1bHecti&e of lead optimisation, #nalog approach of drug designing. +. @#r(o7s #66ro#&hes (2 ASAR: 1bHecti&es of D0#R, +ansch approach, Free-:ilson model, statistical methods, Non-computer-assisted search operations like Topliss decision tree, 0imple- method, Fibonacci search techni(ue. ,. P#r#3e'r(s#'(o2 o8 4ro76s 3o)e&7)es* 2lectronic, 0teric and ,ipophilic molecular descriptions, Duantum chemical parameters. 4. Des(42(24 o8 2o2-&o9#)e2')y-:o725 e2Dy3e (2h(:('ors: 5arious aspects of 2n.yme inhibition, Rapid re&ersible en.yme inhibitors, 0lo)-tight binding en.yme inhibitors, Transition 0tate analogs, Multisubstrate analogs. %esigning of co&alently-bound en.yme inhibitors*

5. Mechanism-based en.yme inhibitors, #ffinity labels, Pseudo irre&ersible en.yme inhibitors. *. DNA (2'er#&'(9e 5r74s: %N# intercalators, #lkylators and 0trand breakers. Prodrugs and metabolic considerations in prodrug design* #ims of prodrug designing, Types of prodrugs, Functional groups in&ol&ed in prodrug designing. Bioprecursor prodrugs. -. Molecular modeling and omputer-aided drug designing. ;oo"s re&o33e25e5: 1. ECo36rehe2s(9e Me5(&(2#) Che3(s'ryE, 5ol. '5, Duantitati&e %rug %esign, .+ansch, 2d., Pergamon Press, 1-ford, !;;C. +.E;7r4er?s Me5(&(2#) Che3(s'ry #25 Dr74 D(s&o9eryE, 5ol. ', 5 edition, M.2. :olff, 2d., 9ohn :iley and 0ons, Ne) 8ork, !;;7. ,. EA7#2'('#'(9e Dr74 Des(42B A Cr('(&#) I2'ro57&'(o2E, 8. . Martin, Marcell %ekker 'nc,Ne)8ork, !;<I. 4. ETheore'(&#) Dr74 Des(42 Me'ho5sE, 5ol. <, R. Franke, 2lse&ier, !;II 5. EThe Or4#2(& Che3(s'ry o8 Dr74 Des(42 #25 A&'(o2E, R. B. 0il&erman, #cademic Press 'nc., 0an %iego, !;;$. PHR 5++(&) S.S.M.PHARM. (HDT > PAA) STANDARDIJATION AND STA;ILIJATION METHODS Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. 1e2er#) Me'ho5s. 1.1 Re&ie) of general methods of e&aluation of drugs and foods. Morphological, microscopical, 1.+ ytomorphological e-aminations of ra) materials and finished products. 1., %etermination of Physical and hemical constants. 2-tracti&e &alues. Techni(ues of separation, 1.4 'dentification, estimation and characteri.ation of acti&e principles. 1.5 Microbial counts, bioburden and other related determinations. +. S'#:()('y : +.1 Factors affecting the stability of a formulation. Methods in&ol&ed in stabili.ation and stability testing. ,.S'#25#r5(D#'(o2 : ,.1 Foo5 Pro57&'s - oncepts of nutritional re(uirements at different age, se-, and in different conditions like normal, diseases, pregnancy etc.. %ifferent types of additi&es used. #nalysis of these nutritional and other ingredients in ethical and nonethical foods. ,.+ Cos3e'(&s - 'nformation on ingredients used in &arious products such as creams, po)ders, lotions, hair products nail polishes, lipsticks, depilatories,

toiletaries etc. and their analysis. ,., Her:#) Pro57&'s - 2&aluation of herbal products using physico-chemical studies in )hole form. 'dentification of acti&e principles, e-cipients, additi&es and their estimation using different techni(ues. #nalysis of a fe) selected indigenous herbal formulations. PHR 5+, (#) S.S. M. PHARM (PT) AD@ANCES IN PHARMACEUTICAL TECHNOLO1C Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. Production Management, Production Planning, Fundamentals of production, organisation, economic policy, manufacturing economics, production capacities, production lines, and Hob balancing. +. onsideration for design of large scale manufacturing unit including intricate design criteria for units to manufacture of sterile and nonsterile products )ith special reference to Tablets, apsules and 'nHections. ,. %esign and de&elopment of packaging units including recent ad&ances in packaging techni(ues for &arious types of sterile and non sterile dosage forms. 0tability aspects of packaging. 4. Process automation in Pharmaceutical manufacturing. ;oo"s Re&o33e25e5 : 1. +.#. ,iebermen E ,. ,achman, <Ph#r3#&e7'(&#) Dos#4e For3s : T#:)e's=,5ols. ' to ''', Marcel %ekker 'ncN.8. +. 4.2.#&is, <Ph#r3#&e7'(&#) Dos#4e For3s : P#re2'#) Me5(&#'(o2=, 5ol. ', Marcel %ekker 'nc., N.8. ,. 0. Turco and R.2.4ing, <S'er()e Dos#4e For3s=, $nd edition PHR 5+, (:) - S.S. M.PHARM. (H.D.T.) HER;AL DRU1 TECHNOLO1C - II Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. %efinition and concepts as per :+1 /uidelines for assessment of herbal medicines. /MP and other regulatory and safety re(uirements as per schedules of %rugs and osmetic #ct and Rules for +erbal ,#yur&edic and other %rugs of traditional origin.. Preparation of documents for ne) drug application and e-port registration. +. /eneral principles of formulations including physico-chemical properties like p+, solubility, distribution coefficient, and state of the indi&idual component added and preparation of different dosage forms of herbal formulation. ,. ;#s(& 6r(2&(6)es o8 're#'3e2' (2 Ay7r9e5(& Sys'e3s o8 3e5(&(2e. ,.1 0alient features of the techni(ues of preparation and standardi.ation @including chromatographic methodsA of some of the important class of formulations

as per #yur&edic Pharmacopoeia and te-ts.. 4. Her:#) Cos3e'(&s : The scope, historical background and present status of herbal cosmetics technology. The sources and description of ra) materials of herbal origin used like fi-ed oils, )a-es, gums, hydrophillic colloids, colours, perfumes, protecti&e agents, bleaching agents, preser&ati&es, antio-idants and other ancillary agents. 4.1 Formulation aspects incorporating herbal e-tracts in &arious preparations like 0kin care creams, deodorants, antiperspirants, hair preparations,and toiletries etc. PHR 5+,(&) S.S. OF M.PHARM MOLECULAR PHARMACOLO1C Theory 4hrs !ee" M#$ 3#r"s 1%% 1. 2ndothelin @2TA receptors, agonists and antagonists and their importance in &arious cardio&ascular diseases. +. The role of Nitric o-ide in &arious physiological functions and its importance in pharmacotherapy of disorders like +ypertension, #ngina E 2rectile dysfunction. ,. %rug Receptor interaction. 4. Pharmacology of &oltage-gated ion channels. 5. / protein-coupled receptors* 0tructure and function. *. / protein-coupled receptors* 0ignal Transduction and termination of receptor acti&ity. -. Free radicals, lipid per o-idation and the role of anti o-idants in &arious diseases. .. ,eptin in the Pathogenesis and treatment of 1besity /. Molecular mechanism of PPAR g- agonist 1%. Recent ad&ances in the Purines E Peptides 11. Role of ytokines, Prostaglandins, TNF-a, bradykinens, adhesion molecules and NF kB in &arious immunological and inflammatory disorders. 1+. Molecular mechanism of action of 'mmunomodulators and 'mmunosuppressi&es 1,. Molecular mechanism of immune disorder )ith reference to #'%0. 14. Recent classifications and Pharmacology of #drenergic receptors agonistE antagonist. 15. Recent classifications and Pharmacology of holinergic receptors agonistE antagonist 1*. Recent ad&ances in the pharmacology of NM%# receptors. 1-. 0erotonin receptors and the role of 7-+T in the &arious physiological and pathological

conditions. 1.. Role of 7-+T agonist and antagonist in the treatment of &arious disorders. 1/. Pharmacology of /#B# receptors PHR 5+, (5) S.S.M. PHARM. AD@ANCED TECHNIAUES IN DRU1 DE@ELOPMENT AND SCNTHESIS-II Theory: 4 Ho7rs !ee" M#$. M#r"s: 1%% 1. #d&anced kno)ledge to be imparted in the follo)ing topics* 1-idation Reduction reactions and the reagents used for such reactions, Protection and deprotection of &arious groups, ertain selected name reactions not co&ered earlier. +. hirality and the importance of chiral drugs, Techni(ues for preparing chiral drugs @ hirality pool, 2n.ymatic transformation and #symmetric synthesisA. ,. 0ynthetic methodologies for obtaining drugs* %isconnection approach, 0ynthons for carbon-carbon bond formation, %ifunctional compounds, 0electi&e functional group intercon&ersions @F/'A, Retrosynthetic analysis. 4. 0ynthetic approaches for attaching heterocyclic ring systems in drug molecules ha&ing fi&e membered and si- membered heteroaromatic rings, Fused ring systems. 5. Photochemical reactions* Basic theory, 1rbital symmetry rules and their applications. ;oo"s Re&o33e25e5: 1. EA59#2&e5 Or4#2(& Che3(s'ryB Re#&'(o2 Me&h#2(s3s #25 S'r7&'7reE, 9. March, 9ohn :iley and 0ons, N.8. +. EMe&h#2(s3s #25 s'r7&'7re (2 Or4#2(& Che3(s'ryE, 2.0./ould, +old Rinchart and :inston, Ne) 8ork. ,. ECh(ro'e&h2o)o4yE, R.#. 0heldon, Marcell %ekker 'nc., Ne) 8ork, !;;". 4. EAsy33e'r(& Sy2'hes(sE, R.#. #itken and 0.M. 4ilengi, 2d., Blackie #cademic and Professional, ,ondon, !;;$. PHR 5+, (e) S.S.M. PHARM. (PAA)- SPECIAL TECHNIAUES IN DRU1 ANALCSIS Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. Io2 Se)e&'(9e E)e&'ro5es: lassification, instrumentation and applications in drug analysis. +. @o)'#3e'ry : Theory and Principles, # pulse polarography and 0(uare )a&e polarography. ,. Che3()73(2es&e2&e : Principle, instrumentation and applications. 4. E)e&'ro2 s6(2 Reso2#2&e: Principle, 'nstrumentation, interpretation of spectra, applications.

5. E3(ss(o2 Me'ho5s: 0park emission and Plasma emission, instrumentation and application. *. F)o! (2Ke&'(o2 A2#)ys(s. -. R#5(o&he3(&#) A2#)ys(s: 'nstruments used - analytical and screening instruments, 'sotopic dilution, neutron acti&ation, and Positron 2mission Tomography @P2TA. .. Pho'o#&o7s'(& s6e&'ros&o6y : Principle, instrumentation and applications. /. L#ser : Basic principles, lassification, instrumentation and applications. 1%.R#3#2 S6e&'ros&o6y : Principle, 'nstrumentation E applications, 'nterpretation of Raman 0pectra. ;oo"s Re&o33e25e5 : 1. +.M.:illard, ,.,.Meritt, 9.#.%ean and F.#.0ettle, <I2s'r73e2'#) 3e'ho5s o8 A2#)ys(s=, B0 Publishers, %elhi. +. %.#.0koog E P.M.:est, <Pr(2&(6)es o8 I2s'r73e2'#) A2#)ys(s=. ,. :. 4emp, <Or4#2(& S6e&'ros&o6y=. 4. /.+.:.2)ing, <I2s'r73e2'#) Me'ho5s o8 Che3(&#) A2#)ys(s=. PHR - 5+4 S. S. M. PHARM. (ALL DISCIPLINES) Pr#&'(&#) TF (2&)75(24 @(9# 1+ hrs !ee" Ph#r3. Te&h2o)o4y Pr#&'(&#)-II Pharm. Quality Assurance Practical II Her:#) Dr74 Te&h2o)o4y Pr#&'(&#)-II Ph#r3#&o)o4y Pr#&'(&#)-II Dr74 Des(42 > De9e)o63e2' Pr#&'(&#)-II The sy))#:7s 8or 6r#&'(&#) sh#)) :e :#se5 o2 'he 'o6(&s 3e2'(o2e5 (2 'he 'heory 6#6ers Nos.5++ #25 5+,.

S&he3e o8 Te#&h(24 #25 E$#3(2#'(o2 o8 M. Ph#r3. Co7rse (2 Ph#r3#&e7'(&#) Te&h2o)o4y (PT) Ph#r3#&e7'(&#) A7#)('y Ass7r#2&e (PAA) Her:#) Dr74 Te&h2o)o4y (HDT) Ph#r3#&o)o4y (P?Co)) Dr74 Des(42 #25 De9e)o63e2' (DDD).
Re9(se5 !.e.8. #&#5e3(& ye#r +%%,-+%%4

PHR 511 F.S. M.PHARM. (ALL DISCIPLINES) METHODS IN PHARMACEUTICAL RESEARCH Theory: 4 hrs !ee".

M#$. M#r"s Theory: 1%% Pr#&'(&#)s: * hrs !ee" M#$. M#r"s Pr#&'(&#)s: 1%% 1. Basic theoretical background of NMR spectroscopy, interpretation of PMR spectra of common organic compounds, Basics of FT-NMR, !" NMR, #pplications of $%-NMR. +. Basic fundamentals of mass spectroscopy, &arious ion sources, analyses. 'nterpretation of mass spectra of simple compounds. ,. 'nterpretation of 'R spectra of compounds, Basics of FT-'R, #d&antages of FT-'R o&er disperse 'R. 4. hromatography - Basic concepts, recent trends in the techni(ues and pharmaceutical applications of the follo)ing* +P, , and its &arious modes like adsorption, partition, re&ersed-phase, chemically bonded phase, ion-e-change, ionic, ion-pair, affinity, si.ee-clusion, and hiral separations. +PT, and / . 5. Thermal Methods - 'ntroduction of &arious thermal methods. T/#, %T# and %0 theory, instrumentation of thermographs and applications. *. 1ptical Rotatory %ispersion and ircular %ichroism * /eneral principle, instrumentation and applications. -. 2lectron Microscopy, 2lectron %iffraction, 3-ray diffraction methods. .. Principles and applications of R'#. /. Bio-statistics and its applications in Pharmaceutical Research. 1%.To-icology in Pharmaceutical Research * #cute, 0ub-acute and chronic to-icity studies * Teretogenicity, mutagenicity and carcinogenic studies. Pr#&'(&#)s : Pr#&'(&#) e$er&(ses :#se5 o2 'he 'o6(&s 3e2'(o2e5 (2 'he 'heory sy))#:7s. PHR 51+ (5) F.S.M.PHARM. ( NDDS) THEORITICAL PRINCIPLES OF DELI@ERC DESI1N Theory : 4 ho7rs !ee" M#$. M#r"s Theory: 1%%
1. %rug diffusion and dissolution from reser&oirBmatri- systems and related kinetics +. %issolution rate, bioa&ailability and bioe(ui&alence ,. %rug targeting concepts and methodologies 4. Molecular biology 5. ellular biology *. Biochemical and biotechnological principles in design of drug deli&ery systems -. Polymer science-types , synthesis, characteri.ation, bio-degradation, safety and applications in pharmaceuticals and biomedical engineering.

PHR 51,( e) F.S.M.PHARM. ( NDDS) ORAL NO@EL DELI@ERC SCSTEM Theory : 4 ho7rs !ee" M#$. M#r"s Theory:1%% 1. #natomy and physiology of oral ca&ity and gastro-intestinal tract +. Buccal drug deli&ery systems-mouth dissol&ing and sublingual tablet and che)ing gum type products, buccal patches-design and e&aluation. ,. 2-tended release dosage forms-purpose, types, designs and e&aluations 4. Targetting to different parts of gastroJintestinal tract() 0tomach targeted products such as floating tablets, needs, concepts and designs (() PeyerFs patch targeted drug deli&ery systems-lymphatic deli&ery. ((() %eli&ery systems targeted to small intestine. (9) olon targeted drug deli&ery systems 5. %ental implants and periodontal products

PHR 5+1 S.S. M. PHARM. (A)) D(s&(6)(2es) PHARMACEUTICAL ;IOTECHNOLO1C


Theory : 4 Ho7rs !ee" M#$. M#r"s : 1%% 1. S'r7&'7re #25 872&'(o2s o8 DNA - 0uperhelical structure and folding in prokaryotes and eukeryotes, semiconser&ati&e replication of %N#, &arious en.ymes in&ol&ed in replication, different types of replications &i.. bacterial, &iral-%N#, &iral-RN#, Transcription -initiation, elongation, terminationG factors and en.ymes in&ol&ed in Translation, Recombination, different models of . +. 1e2e E$6ress(o2 #25 Re47)#'(o2s - ,actose operon, Tryptophan operon, ,ysogeny of phage ,ambda. ,. 1e2e &)o2(24 - types of &ectors employed in cloning of genes, Restriction endonucleases, other en.ymes in&ol&ed in cloning of genes, &arious approaches to gene cloning. 4. A66)(&#'(o2s o8 4e2e'(& e24(2eer(24 (2 6h#r3#&e7'(&#) 8(e)5 - 5arious products deri&ed from the use of this technology, present status of research in the field and future prospects. 5. Hy:r(5o3# Te&h2o)o4y - Production and application of monoclonal antibodies. *. T(ss7e C7)'7res - Techni(ue used for production of tissue cultures, its applications to)ards impro&ement of medicinally important plants. -. Mo)e&7)#r ;(o)o4y o8 re&e6'or sys'e3s - 0tructures and in&ol&ement of secondary messengers in &arious biological processes. Role of ion channels. ;oo"s Re&o33e25e5 :

1. 9.%.:atson, <Mo)e&7)#r ;(o)o4y o8 'he &e))=. +. 9.%.:atson and Too.e, <Re&o3:(2#2' DNA 'e&h2(G7es= * # short course. ,. BenHamin ,e&in, <1e2es @=. 4. Peppler, <M(&ro:(#) Te&h2o)o4y= I > II. 5. 1ld E Primrose, <1e2e'(& M#2(67)#'(o2s= PHR 5++ (e) S.S. M. PHARM. ( NDDS) PARENTRAL ;RAIN AND OPHTHALMIC DELI@ERC SCSTEM Theory : 4 ho7rs !ee" M#$. M#r"s : 1%% 1. Targeted Particulate @ nano and macroA drug deli&ery-liposomes, niosomes, microspheres, nanoJ particles, microJemulsions +. 'mplantable de&ices and 'nserts ,. /ene therapy-concepts and techni(ues of deli&ery of genetically engineered products. 4. %eli&ery of 'mmunological products 5. Target drug deli&ery to Brain-'ntroduction, #natomy and physiology of N0, Barriers to N0 drug deli&ery, 2fflu- mechanisms in drug transport to the brain, Physicochemical factors that influence Brain 6ptake, 'n &itro and 'n &i&o models of the Blood-Brain and Blood- 0F Barriers, 0trategies for enhanced N0 drug deli&ery, 'nterstitial deli&ery, Promising strategiesBde&ices. *. ancer therapy -. 'ntracellular drug deli&ery-concepts and methodology. PHR 5+,(A) S.S. M. PHARM. ( NDDS) NASOPULMONARC AND TRANSDERMAL DELI@ERC SCSTEM Theory : 4 ho7rs !ee" M#$. M#r"s 1%% 1. N#s#) 5r74 5e)(9ery sys'e3s-'ntroduction, #natomy and physiology of Nose, mechanisms of drug transport across nasal mucosa and related issues, physiochemical factors influencing drug 6ptake. 'n &itro and 'n &i&o models of the nasal drug deli&ery, 0trategies for enhanced nasal drug deli&ery, Promising strategiesBde&ices. +. P7)3o2#ry Dr74 5e)(9ery sys'e3s-'ntroduction, #natomy and physiology of ,ungs, physicochemical characteristics of particles influencing the deli&ery of drugs in to different regions of the lungs, in &i&o and in &itro e&aluation techni(ues, Metered dose inhalers, %ry po)der inhalers and inhalation techni(ues and de&ices. ,. Tr#2s5er3#) 5r74 5e)(9ery sys'e3s - 'ntroduction, #natomy and physiology of the skin, barrier functions of the skin, drug deposition and diffusion across the skin and factors influencing it, different transdermal drug deli&ery systems-)ith and )ithout rate controlling membranes, matri- systems and reser&oir systems etc. 2&aluation of transdermal patches.

4. O'her 5e)(9ery sys'e3s 9#4(2#) 5r74 5e)(9ery sys'e3s-s'#'7s #25 3e'ho5o)o4(es. re&'#) 5r74 5e)(9ery sys'e3s-s'#'7s #25 3e'ho5o)o4(es. o'(& 5r74 5e)(9ery sys'e3s-s'#'7s #25 3e'ho5o)o4(es.