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Table of Contents
Table of Contents...........................................................................................................1 Brain Trauma Foundation Guidelines............................................................................3 Surgical Management of Acute Epidural Hematomas...............................................3 ndications for Surger!...........................................................................................3 Timing....................................................................................................................3 Met"ods..................................................................................................................3 Surgical Management of Acute Subdural Hematomas..............................................3 ndications for Surger!...........................................................................................3 Timing....................................................................................................................3 Met"ods..................................................................................................................3 Surgical Management of Traumatic #arenc"!mal $esions........................................% ndications..............................................................................................................% Timing and Met"ods..............................................................................................% Surgical Management of #osterior Fossa Mass $esions............................................% ndications..............................................................................................................% Timing....................................................................................................................% Met"ods..................................................................................................................& Surgical Management of 'epress Cranial Fractures..................................................& ndications..............................................................................................................& Timing....................................................................................................................& Met"ods..................................................................................................................& #ost(Traumatic Mass )olume Measurement in Traumatic Brain n*ur! #atients.....+ E,aluation of -ele,ant Computed Tomograp"ic Scan Findings................................ Basal Cisterns at t"e Midbrain $e,el...................................................................... Midline S"ift at t"e Foramen of Monro.................................................................. Traumatic Subarac"noid Hemorr"age..................................................................... 'iffuse A/onal n*ur! ...................................................................................................0 Adam1s 2europat"ological Grading 3 Classification of 'A .....................................0 'iffuse A/onal n*ur! 4 -adiological Grading..........................................................0 Traumatic $oss of Consciousness..............................................................................0 Grading S!stems............................................................................................................5 Cantu and Colorado Head n*ur! Grading S!stems...................................................5 Cantu6s Guidelines for -eturn to #la! after Concussion............................................5 7"en to -eturn to #la!8Colorado Medical Societ! Guidelines..............................5 C9MA..........................................................................................................................1: Breat"ing #atterns....................................................................................................1: #upils........................................................................................................................11 C#................................................................................................................................1; Compliance and Elastance........................................................................................1; T!pes of Edema........................................................................................................13 )icious C!cle of C#................................................................................................1% C# 7a,es................................................................................................................1& Abnormal 7a,es......................................................................................................1+ H................................................................................................................................1. T"e modified 'and! criteria suggested b! 7all .....................................................1. <e! 9nline -esources for Medicos..............................................................................10 Multiple ring(en"ancing lesions of t"e brain...............................................................;: @targetpg * www.facebook.com/targetpg * www.targetpg.in * 984211172
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Causes of multiple ring(en"ancing lesions of t"e brain...........................................;: 'ifferential diagnosis of multiple en"ancing lesions of t"e brain according to t"e si=e of t"e lesions.....................................................................................................;: Modified diagnostic criteria for neuroc!sticercosis.................................................;1 Met"ods used for establis"ing t"e diagnosis in patients >it" multiple en"ancing lesions of t"e brain...................................................................................................;1 Algorit"m for t"e differential diagnosis in an immunocompetent patient >it" multiple en"ancing lesions of t"e brain....................................................................;3 Algorit"m for t"e differential diagnosis in a "uman deficienc! ,irus infected patient >it" multiple en"ancing lesions of t"e brain............................................................;% Brain Abscess ( Stages.............................................................................................;% ......................................................................................................................................;% Endoscop!....................................................................................................................;& Entr! #oints and Tumour $ocation..........................................................................;& -adiation......................................................................................................................;+ T"e Four -s of -adiobiolog!...................................................................................;+ Cerebral Blood Flo> T"res"olds.............................................................................;. Code Stro?e Algorit"m ...........................................................................................;0 mmediate 'iagnostic Studies@ E,aluation of a #atient >it" Suspected Acute sc"emic Stro?e........................................................................................................;5 C"aracteristics of #atients >it" sc"emic Stro?e 7"o Could Be Treated >it" Tissue #lasminogen Acti,ator..................................................................................3: 'e,elopmental Milestones...........................................................................................31 Gross Motor Milestones...........................................................................................31 Fine Motor Milestones.............................................................................................31 Communication and $anguage.................................................................................31 Cogniti,e Milestones................................................................................................3;
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Timing
t is strongl! recommended t"at patients >it" an acute E'H in coma AGCS score C 5B >it" anisocoria undergo surgical e,acuation as soon as possible.
Methods
T"ere are insufficient data to support one surgical treatment met"od. Ho>e,erD craniotom! pro,ides a more complete e,acuation of t"e "ematoma.
Timing
n patients >it" acute S'H and indications for surger!D surgical e,acuation s"ould be performed as soon as possible.
Methods
f surgical e,acuation of an acute S'H in a comatose patient AGCS C 5B is indicatedD it s"ould be performed using a craniotom! >it" or >it"out bone flap remo,al and duraplast!.
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Timing
n patients >it" indications for surgical inter,entionD e,acuation s"ould be performed as soon as possible because t"ese patients can deteriorate rapidl!D t"usD >orsening t"eir prognosis.
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Methods
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Suboccipital craniectom! is t"e predominant met"od reported for e,acuation of posterior fossa mass lesionsD and is t"erefore recommended.
Timing
Earl! operation is recommended to reduce t"e incidence of infection.
Methods
Ele,ation and debridement is recommended as t"e surgical met"od of c"oice. #rimar! bone fragment replacement is a surgical option in t"e absence of >ound infection at t"e time of surger!. All management strategies for open AcompoundB depressed fractures s"ould include antibiotics.
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E%aluation of Findings &ele%ant Computed
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Tomographic
Scan
Computed tomograp"ic ACTB scanning is t"e imaging modalit! of c"oice for traumatic brain in*ur! because of its >idespread a,ailabilit!D t"e rapid imaging timeD t"e lo> associated costsD and its safet!. CT scanning measures t"e densit! of tissues using /( ra!s. To standardi=e t"e imaging procedureD &(mm slices s"ould be obtained from t"e foramen magnum to t"e sella and 1:(mm slices s"ould be obtained abo,e t"e sellaD parallel to t"e orbitomeatal line. T"e follo>ing earl! CT scan findings correlate >it" outcome@ Status of t"e basal cisterns. Midline s"ift. Subarac"noid "emorr"age in t"e basal cisterns.
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'iagnostic Criteria
2o 2o
2o Mes 2o
2o Mes Mes
Compression of Brain 2o Stem Cisterns Midline S"ift L & mm 2o ncidence A9,erall &+ JB Mortalit! -ate A9,erall ;% JB .J 1: J
2o ;% J 1% J
2o ;1 J 3% J
Mes %J &+ J
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Grading Systems
Cantu and Colorado Head #n$ury )rading Systems Grade Grade 8mild Grade ;8moderate Grade 38se,ere Cantu 2o $9C #TA C 3: min $9C C & min #TA L 3: min $9C L & min #TA L ;% "rs Colorado 2o $9C Confusion >3o amnesia 2o $9C Confusion >it" amnesia $9C
Grade ;8 Ma! return to pla! after Minimum of 1 mont" out of Same as abo,e moderate as!mptomatic for 1 competitionD ma! return to pla! t"en if >ee? as!mptomatic for 1 >ee? and consider termination of season dependent on s!mptoms Grade 38 Minimum of 1 mont"D se,ere ma! return to pla! if as!mptomatic for 1 >ee? Terminate seasonD alt"oug" ma! return to pla! ne/t season if as!mptomatic
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C#M
"reathing Patterns
'ifferent abnormal respirator! patterns are associated >it" pat"ologic lesions As"aded areasB at ,arious le,els of t"e brain. Tracings b! c"est(abdomen pneumograp"!D inspiration reads up. AAB C"e!ne(Sto?es respiration is seen >it" metabolic encep"alopat"ies and >it" lesions t"at impair forebrain or diencep"alic function. ABB Central neurogenic "!per,entilation is most commonl! seen in metabolic encep"alopat"iesD but ma! rarel! be seen in cases of "ig" brainstem tumors. ACB ApneusisD consisting of inspirator! pausesD ma! be seen in patients >it" bilateral pontine lesions. A'B Cluster breat"ing and ata/ic breat"ing are seen >it" lesions at t"e pontomedullar! *unction. AEB Apnea occurs >"en lesions encroac" on t"e ,entral respirator! group in t"e ,entrolateral medulla bilaterall!.
(From Saper, C. Brain stem modulation of sensation, movement, and consciousness. Chapter 45 in: Kandel, ER, Schwart , !", !essel, #$. %rinciples of &eural Science. 4th ed. $c'raw("ill, &ew )or*, +,,,, pp. -./01,1. B2 permission of $c'raw("ill.)
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Pupils
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3From Saper, C. Brain stemmodulation of sensation,movement, and consciousness. Chapter 45 in: Kandel, ER, Schwart , !", !essel, #$. %rinciples of &eural Science. 4th ed. $c'raw("ill, &ew )or*, +,,,, pp. -./01,1. B2 permission of $c'raw("ill.4
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IC$
Compliance and Elastance
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Types of Edema
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!icious Cycle of #CP
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#CP .a%es
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Abnormal .a%es
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IIH
The modified Dandy criteria suggested by .all
1. Signs and s!mptoms of increased intracranial pressure ;. Absence of locali=ing neurological findings A2ote@ abducens paresis is nonlocali=ing andD t"usD allo>edB 3. Absence of deformit!D displacementD and obstruction of t"e ,entricular s!stem and ot"er>ise normal results on neurodiagnostic studiesD >it" t"e e/ception of an increase in cerebrospinal fluid pressure Agreater t"an ;& cm H;9E pressures bet>een ;: and ;& cm H;9 pro,ide less certaint!B. %. 7a?efulness and alertness &. 2o ot"er cause of increased intracranial pressure present
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Book Re iews and Latest Boosk www!"edicalbooks!in
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$or %octors
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Differential diagnosis of multiple enhancing lesions of the brain according to the si0e of the lesions
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Methods used for establishing the diagnosis in patients 1ith multiple enhancing lesions of the brain
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Algorithm for the differential diagnosis in an immunocompetent patient 1ith multiple enhancing lesions of the brain
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Algorithm for the differential diagnosis in a human deficiency %irus infected patient 1ith multiple enhancing lesions of the brain
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)ndosco'y
Entry Points and Tumour Location
$ES 92 $9CAT 92 SO TAB $ TM F9E2'9SC9# C B 9#SM Anterior t"ird ,entricle 1 cm posterior to t"e KKK coronal suture ;(3 cm lateral to t"e midline Floor of t"e t"ird ,entricle 1 cm anterior to t"e KKK coronal suture ;(3 cm lateral to t"e midline #osterior t"ird ,entricle . cm posterior to t"e KKK nasion ; cm lateral to t"e midline Anterior lateral ,entricle 0 cm posterior to t"e KKK nasion %(+ cm lateral to t"e midline Atrium of t"e lateral 0 cm posterior to t"e KK ,entricle midline 1 cm lateral to t"e midline ,s. t"e superior parietal lobule Temporal "orn Superior parietal lobule K 9ccipital "orn 0 cm posterior to t"e K midline 1 cm lateral to t"e midline Fourt" ,entricle 1: cm posterior to t"e K3: nasion ; cm lateral to t"e midline ,s. suboccipital OSOA$ E2T-M #9 2T
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&adiation
The Four &s of &adiobiology
C92CE#T -AT 92A$E -eo/!genation H!po/ic cells or "!po/emic areas >it"in tumors are relati,el! more resistant to a gi,en dose of radiation. '!namic biologic c"anges >it"in t"e tumor suggest t"at cells t"at are "!po/ic during one fraction ma! be less so during subsePuent fractionsD and fractionation >ill t"us increase t"e c"ances of desired effect on t"e largest number of cells. -eassortment A gi,en dose of p"otons is most li?el! to irre,ersibl! damage '2A if t"e cell is in mitosis and t"e '2A is condensed as c"romosomes. Cells t"at are not in mitosis during one fraction ma! be so during subsePuent fractionsD so fractionation >ill increase t"e c"ances of desired effect on t"e largest number of cells. -epair T"e time bet>een fractions allo>s for repair of sublet"all! damaged cells before t"e ne/t dose. T"is is an ad,antage for fractionation onl! if normal tissue in t"e treatment ,olume is more efficient at t"is process t"an tumor cellsD >"ic" is usuall! t"e case. -epopulation T"e time bet>een fractions allo>s for replacement of lost cells before t"e ne/t dose. T"is is an ad,antage for fractionation onl! if normal tissue in t"e treatment ,olume is more efficient at t"is process t"an tumor cellsD >"ic" ma! or ma! not be t"e case for a gi,en tumor t!pe.
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Stro*e
Cerebral "lood Flo1 Thresholds
Cerebral blood $low t'res'olds $or critical $unctions! (#dapted $ro" #strup &) S*"on L) Branston +M) et al! Cortical e oked potential and e,tracellular -. and /. at critical le els o$ brain isc'e"ia! Stroke! 012234560762!8
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#mmediate Diagnostic Studies3 E%aluation of a Patient 1ith Suspected Acute #schemic Stro2e
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Characteristics of Patients 1ith #schemic Stro2e .ho Could "e Treated 1ith Tissue Plasminogen Acti%ator
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Develo'mental Milestones
)ross Motor Milestones
Milestones Head stead! in sitting #ull to sitD no "ead lag Hands toget"er in midline As!mmetric tonic nec? refle/ gone Sits >it"out support -olls bac? to stomac" 7al?s alone -uns ;.: 3.: 3.: %.: +.: +.& Developmental Implications Allo>s more ,isual interaction Muscle tone Self4disco,er! C"ild can inspect "ands in midline ncreasing e/ploration Truncal fle/ionD ris? of falls
ncreasing autonom! during boo? time 13.: )isuomotor coordination 1&.: Oses ob*ects in combination ;;.: -ePuires ,isualD grossD and fine motor coordination
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Smiles in response to faceD ,oice 1.& Monos!llabic babble n"ibits to FnoF Follo>s one4step command >it" gesture Follo>s one4step command >it"out gesture Ae.g.D FGi,e it to meFB Spea?s first real >ord Spea?s %(+ >ords Spea?s 1:41& >ords Spea?s t>o4>ord sentences Ae.g.DFMomm! s"oeFB +.: ..: ..:
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C"ild more acti,e social participant E/perimentation >it" soundD tactile sense -esponse to tone Anon,erbalB 2on,erbal communication
1:.: )erbal recepti,e language 1;.: Beginning of labeling 1&.: AcPuisition of ob*ect and personal names 10.: AcPuisition of ob*ect and personal names 15.: Beginning grammatici=ationD corresponds >it" &:K >ord ,ocabular!
Cogniti%e Milestones
Milestones Developmental Implications
Stares momentaril! at spot >"ere ;.: $ac? of ob*ect permanence Aout of ob*ect disappeared Ae.g.D !arn ball sig"tD out of mindB droppedB Stares at o>n "and Bangs t>o cubes Onco,ers to! Aafter seeing it "iddenB Egocentric pretend pla! Ae.g.D pretends to drin? from cupB Oses stic? to reac" to! %.: Self4disco,er!D cause and effect 0.: Acti,e comparison of ob*ects 0.: 9b*ect permanence 1;.: Beginning s!mbolic t"oug"t 1..: Able to lin? actions to sol,e problems
#retend pla! >it" doll Agi,es doll 1..: S!mbolic t"oug"t bottleB