CURRICULUM VITAE

Dr. Uta GRIESENBACH Diplom Biologin PhD Reader/Associate Professor in Molecular Medicine Department of Gene Therapy National Heart and Lung Institute, Faculty of Medicine, Imperial College London
PERSONAL DETAILS Name: Present Address: GRIESENBACH, Uta DEPARTMENT OF GENE THERAPY Faculty of Medicine, Imperial College Manresa Road London SW3 6LR +44 207 351 8333 +44 207 351 8340 u.griesenbach@imperial.ac.uk EDUCATION Diplom Thesis Ph.D. Institut fuer Strahlenbiologie University of Bonn, Germany Hospital for Sick Children, Toronto, Canada University of Bonn, Germany 1990-1991 1992-1996

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CAREER SUMMARY Research Assistant, Institute fuer Strahlenbiologie, University of Bonn, Germany, 1989-1991 Research Assistant, Department of Genetics at the Hospital for Sick Children, Toronto, Canada 1992- 1996 Post-doctoral Research Fellow, Department of Genetics at the Hospital for Sick Children, Toronto, Canada, 1997 Post-doctoral Research Fellow, Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London, England, 1997- 2001 Research Lecturer, Department of Gene Therapy, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, England, 2001- 2003 Lecturer, Department of Gene Therapy, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, England, 2003-2006 Cystic Fibrosis Research Trust Senior Fellowship, November 2002-2010 Registered Practitioner of the Higher Education Academy 2004-present Senior Lecturer, Department of Gene Therapy, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, England, 2006- 2009 Graduate Tutor, Imperial College, Faculty of Medicine from 2007-present Post-graduate Tutor, Imperial College, Faculty of Medicine from 2009-present Reader/Associate Professor in Molecular Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, England, 2009-present

EDITORIAL BOARDS/BOOKS EDITED Review Series Editor for Nature Gene Therapy review series:

Progress and Prospects in Nature Gene Therapy Member of Editorial Board Nature Gene Therapy Co-Editor for the book Progress in Respiratory Research -Cystic Fibrosis Publisher S Karger AG, Basel Editorial Board Member of ISRN Pulmonology MEMBERSHIPS OF PROFESSIONAL BODIES American Society for Gene Therapy British Society for Gene Therapy (Board Member and Treasurer) European Society for Gene Therapy Institute for Learning and Teaching in Higher Education British Association for Lung Research

2002-2011 2008-2011 2004 from 2011

from 2000 from 2003 from 2003 from 2004 from 2005

MEMBERSHIPS OF PROFESSIONAL BOARDS British Society for Gene Therapy Executive Board Nature Gene Therapy Editorial Board

2007-present 2009-2011

RELEVANT PROFESSIONAL ACTIVITES Member of the UK Cystic Fibrosis Gene Therapy Strategy Group and in part responsible for CF Gene Therapy Research carried out by approximately 80 people at three different locations (London, Oxford and Edinburgh) Responsible for overseeing production of gene transfer vectors under GMP guidelines to support gene therapy trials Responsible for toxicology studies performed at Contract Research Organizations to support gene therapy trials In part responsible for writing and submitting applications to MHRA, GTAC and ethics committees to obtain clinical trial authorization Holds patents related to viral gene transfer agents

AWARDS AND PRIZES Imperial College Gene Therapy, First Prize in Poster Competition Royal Brompton Hospital Cystic Fibrosis Travel Award Medical Innovations Future Award MRC Translational Research Award and Best Therapeutic Innovation in the respiratory category

2006 2007 2011 2011

RECENT (2010-12) PEER REVIEWED PUBLICATIONS Alex R Horsley, Jane C Davies, Robert D Gray, Kenneth A Macleod, Jackie Donovan, Zelena A Aziz, Nicholas J Bell, Margaret Rainer, Shahrul Mt-Isa, Nia Voase, Maria H Dewar, Clare Saunders, James S Gibson, Javier Parra-Leiton, Mia D Larsen, Sarah Jeswiet, Samia Soussi, Yusura Bakar, Mark G Meister, Philippa Tyler, Ann Doherty, David M Hansell, Deborah Ashby, Stephen C Hyde, Deborah R Gill, Andrew P Greening, David J Porteous, J Alastair Innes, A Christopher Boyd, Uta Griesenbach*, Steve Cunningham, Eric WFW Alton. Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation. Thorax 2013 (in press), * UG and CB corresponding author
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Natalie G Kernan, Eric WFW Alton, Paul Cullinan*, Diana Bilton*,Uta Griesenbach* . Oral contraceptives do not appear to affect cystic fibrosis disease severity. Eur Respir J. 2013 Jan;41(1):67-73. *PC, DB and UG joint senior authors $ UG corresponding author

Uta Griesenbach*, Katherine M Wilson, Raymond Farley, Cuixiang Meng, Felix M Munkonge, Seng H Cheng, Ronald K Scheule, Eric WFW Alton. Assessment of the nuclear pore dilating agent TCHD in differentiated airway epithelium. J Gene Med. 2012 Jul;14(7):491-500. doi: 10.1002/jgm.2643 * UG corresponding author. Uta Griesenbach, Makoto Inoue, Cuixiang Meng, Raymond Farley, Mario Chan, Nikki K Newman, Andrea Brum, Jun You, Angela Kerton, Amelia Shoemark, A Christopher Boyd , Jane C Davies, Tracy E Higgins, Deborah R Gill, Stephen C Hyde, J Alastair Innes, David J Porteous, Mamoru Hasegawa, Eric WFW Alton. Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapy. Am J Respir Crit Care Med. 2012 Nov 1;186(9):846-56.

Griesenbach U, Vicente CC, Roberts MJ, Meng C, Soussi S, Xenariou S, Tennant P, Baker A, Baker E, Gordon C, Vrettou C, McCormick D, Coles R, Green AM, Lawton AE, Sumner-Jones SG, Cheng SH, Scheule RK, Hyde SC, Gill DR, Collie DD, McLachlan G, Alton EW. Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer. Biomaterials. 2011 Apr;32(10):2614-24 Griesenbach U, McLachlan G, Owaki T, Somerton L, Shu T, Baker A, Tennant P, Gordon C, Vrettou C, Baker E, Collie DD, Hasegawa M, Alton EW. Validation of recombinant Sendai virus in a non-natural host model. Gene Ther. 2011 Feb;18(2):182-8. Epub 2010 Oct 21.

Griesenbach U, Soussi S, Larsen MB, Casamayor I, Dewar A, Regamey N, Bush A, Shah PL, Davies JC, Alton EWFW. Quantification of PCL height in human airway biopsies is feasible, but not suitable as a biomarker. American Journal of Respiratory Cell and Molecular Biology Am J Respir Cell Mol Biol. 2011 Mar;44(3):309-15 Griesenbach U*, Meng C, Farley R, Wasowicz M, Munkonge FM, Chan M, Stoneham C, SumnerJones S, Pringle IA, Gill DR, Hyde SC, Stevenson B, Holder E, Ban H, Hasegawa M, Cheng SH, Scheule RK, Sinn PL, McCray Jr PB, Alton EWFW. The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways. Biomaterials 31(9):2665-72, 2010 Corresponding author Mitomo K, Griesenbach U*, *, Inoue M, Somerton L, Meng C, Akiba E, Tabata T, Ueda Y, Frankel GM, Farley R, Singh C, Chan M, Munkonge F, Brum A, Xenariou S, Escudero-Garcia S, Hasegawa M, Alton EWFW. Towards Gene Therapy for Cystic Fibrosis Using a Lentivirus Pseudotyped With Sendai Virus Envelopes. Molecular Therapy 2010 Jun;18(6):1173-82 UG and KM contributed equally to the work. MK and UG equal contribution Xenariou S, Liang HD, Griesenbach U*, Zhu J, Farley R, Somerton L, Singh C, Jeffery PK, Scheule RK, Cheng SH, Geddes DM, Blomley M, Alton EWFW. Low-Frequency Ultrasound Increases NonViral Gene Transfer to the Mouse Lung. Acta Biochimica et Biophysica Sinica (Shanghai). 2010 Jan;42(1):45-51. Corresponding author Holder E, Stevenson B, Farley R, Hilliard T, Wodehouse T, Somerton L, ODonoghue J, Coles RL, Scheule RK, Cheng SH, Gill DR, Hyde SC, Griesenbach U, Alton EWFW, Porteous DJ, Boyd AC. Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity. Journal of Gene Medicine (2010) (1):55-63.