The patents and publications affiliated to the faculty of Pharmacy and Biotechnology German University in Cairo In the period

from 2005-2013
Year 2013: 1. Abu el Maaty M. A., Hassanein S. I., Hanafi R. S., Gad M. Z. Insights on vitamin D's role in cardiovascular disease: investigating the association of 25hydroxyvitamin D with the dimethylated arginines. Journal of Nutritional Science and Vitaminology. 59, 172-177 (2013). 2. Abadi A. H., Hany M. S., Elsharif S. A., Eissa A. A., Gary B. D., Tinsley H. N., Piazza G. A. Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line. Chemical and Pharmaceutical Bulletin (Tokyo). 61, 405-410. (2013). 3. Wagdy H. A., Hanafi R. S., El-Nashar R. M., Aboul-Enein H. Y. Determination of the design space of the HPLC analysis of water-soluble vitamins. Journal of Separation Science. 36, 1703-1710 (2013). 4. Wagdy H. A., Hanafi R. S., El-Nashar R. M., Aboul-Enein H. Y. Predictability of Enantiomeric Chromatographic Behavior on Various Chiral Stationary Phases Using Typical Reversed Phase Modeling Software. 25, 506-513. Chirality (2013). 5. Handoussa H., Hanafi R., Eddiasty I., El-Gendy M., El Khatib A., Linscheid M., Mahran L., Ayoub N. Anti-inflammatory and cytotoxic activities of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera. Journal of Functional Foods. 5, 1204-1216 (2013). 6. El Tayebi H. M., Omar K., Hegy S., El Maghrabi M., El Brolosy M., Hosny K. A., Esmat G., Abdelaziz A. I. Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular carcinoma and enhancement of cell growth upon reversing this expression pattern . Biochemical and Biophysical Research Communications. 434, 421-427 (2013). 7. Aboelenein H. R., Abdelhakam S. S., Lashine Y. A., Abdelaziz A.I. Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. Rheumatology International. 33, 13331338 (2013). 8. Zaghloul M. A. S., Abadi A. H., Abdelaziz A. I. Functional evaluation of imatinib mesylate in hepatocellular carcinoma cells. Recent Patents on Biomarkers. 3, 65-71 (2013). 9. Sherifa G., Zaghloul M. A. S., Elsayed O. F., Rueck A., Steiner R., Abdelaziz A. I., Abdel-Kader M. H. Functional characterization of Fospeg, and its impact on

cell cycle upon PDT of Huh7 hepatocellular carcinoma Photodiagnosis and Photodynamic Therapy. 10, 87-94 (2013).

cell

model.

10. Mekky R. Y., Abdelaziz A. I. Sex hormones and HCV: an unresolved mystery. Expert Review of Gastroenterology & Hepatology. 7, 69-75 (2013). 11. Tayel S. S., Helmy A. A., Ahmed R., Esmat G., Hamdi N., Abdelaziz A.I. Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus. Archives of virology. 158, 1755-64 (2013). 12. Rezk M. S., El Nashar R. M. Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids. Bioelectrochemistry. 89, 26-33 (2013). 13. Hamed M.M., Abou El Ella D. A., Keeton A. B., Piazza G. A., Abadi A. H., Hartmann R. W. Engel M. 6-Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib-Sensitive and Resistant Tumor Cell Lines. ChemMedChem. 10.1002/cmdc.201300147 (2013). 14. El-Gamil D. S., Ahmed N. S., Gary B. D., Piazza G. A., Engel M., Hartmann R. W., Abadi A. H. Design of novel -carboline derivatives with pendant 5bromothienyl and their evaluation as phosphodiesterase-5 inhibitors. Archiv der Pharmazie (Weinheim). 346, 23-33. (2013). 15. Safwat Y., Yassin N., Gamal El Din M., Kassem L. Modulation of Skeletal Muscle Performance and SERCA by Exercise and Adiponectin Gene Therapy in InsulinResistant Rat. DNA and Cell Biology. 32, 378-385. (2013). 16. Taher A. T., Kadry H. H., Allar M., Di Marzo V., Abadi A. H., Abouzid K. A. Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes. Journal of Enzyme Inhibition and Medicinal Chemistry. 28, 436-439 (2013). 17. Arafa R. K., Hegazy G. H., Piazza G. A., Abadi A. H. Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents. European Journal of Medicinal Chemistry. 63, 826-832 (2013). 18. Farag N., Mahran L., Abou-Aisha K., El-Azizi M. Assessment of the efficacy of polyclonal intravenous immunoglobulin G (IVIG) against the infectivity of clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in vitro and in vivo. European Journal of Clinical Microbiology and Infectious Diseases. 32, 1149-60(2013). 19. Hassan S. S. M., El-Nashar R. M., El-Tantawy A. S. M. A New Validated Potentiometric Method for Batch and Continuous Quality Control Monitoring of Oseltamivir Phosphate (Taminil) in Drug Formulations and Biological Fluids. Electroanalysis. 25, 408-416 (2013).

Year 2012 20. Breitinger, H.G., Drug synergy-mechanisms and methods of analysis Toxicity and Drug Testing. 143-166 (2012). 21. El-Ekiaby N., Hamdi N., Negm M., Ahmed R., Zekri A., Esmat G., Abdelaziz A.I. Repressed induction of interferon-related microRNAs miR-146a and miR-155 in peripheral blood mononuclear cells infected with HCV genotype 4. FEBS Open Bio. 2, 179-186 (2012). 22. Gomaa I., Ali S. E., El-Tayeb T. A., Abdel-kader M. H. Chlorophyll derivative mediated PDT versus methotrexate: An in vitro study using MCF-7 cells. Photodiagnosis and Photodynamic Therapy. 9, 362-368 (2012). 23. Ahmed N. S.; Ali A. H.; El-Nashar S. M., Gary B. D., Fajardo A. M., Tinsley H. N., Piazza G. A., Negri M., Abadi A. H. Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel carboline derivatives. European Journal of Medicinal Chemistry.57, 329-343 (2012). 24. Saleh M. A., Mekky R. Y., El-Ekiaby N., Hamdi N., Ahmed R., Zekri A., Esmat G., Abdelaziz A. I. Potent inhibitory effects of p7 inhibitors on genotype 4 HCVinfected peripheral blood mononuclear cells. Recent Patents on Biomarkers. 2, 227-233 (2012). 25. Abdel Karim S. E., El-Nashar R.M., Abadi A. H. Potentiometric determination of imatinib under batch and flow injection analysis conditions .International Journal of Electrochemical Science. 7, 9668-9681 (2012). 26. Khalifa N. M., Gad M. Z., Hataba A. A., Mahran L. G. Changes in ADMA and TAFI levels after stenting in coronary artery disease patients. Molecular Medicine Reports. 6, 855-859 (2012). 27. Piazza G. A., Abadi A.H. Use and preparation of derivatives of Celecoxib. PCT Int. Appl. (2012), WO 2012125884 A1 20120920. 28. Zlotos D. P. Recent progress in the development of agonists and antagonists for melatonin receptors. Current Medicinal Chemistry. 19, 3532-3549 (2012). 29. Salama I., Abdel-Fattah M. A. O., Hany M. S., El-Sharif S. A., El-Naggar M. A. M., Rashied R. M. H., Piazza G. A., Abadi A. H. CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents. Medicinal Chemistry. 8, 372-383 (2012). 30. El Nashar R. M. Flow injection catalase activity measurement based on gold nanoparticles/carbon nanotubes modified glassy carbon electrode. Talanta. 96, 161-167 (2012).

31. Sakr M. M., El Nashar R. M. Potentiometric determination of tolterodine in batch and flow injection conditions. Talanta. 96, 153-160 (2012). 32. Gad M. Z., Abdel Rahman M. F., Hashad I. M., Abdel-Maksoud S. M., Farag N. M., Abou-Aisha K. Endothelial Nitric Oxide Synthase (G894T) Gene Polymorphism in a Random Sample of the Egyptian Population: Comparison with Myocardial Infarction Patients. Genetic Testing and Molecular Biomarkers. 16, 695-700 (2012). 33. Tammam S. Mathur S., Afifi N. Preparation and biopharmaceutical evaluation of tacrolimus loaded biodegradable nanoparticles for liver targeting. Journal of Biomedical Nanotechnology. 8, 439-449 (2012). 34. Abadi A. H., Abou-Seri S. M., Hu Q., Negri M., Hartmann R. W. Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors. MedChemComm. 3, 663-666 (2012). 35. Seoudi A. M., Lashine Y. A., Abdelaziz A. I. MicroRNA-181a - a tale of discrepancies. Expert Reviews in Molecular Medicine. 14, 1-14 (2012). 36. Hamdi N., El-Akel W., El-Serafy M., Esmat G., Sarrazin C., Abdelaziz A. I. Transcriptional Response of MxA, PKR and SOCS3 to Interferon-Based Therapy in HCV Genotype 4-Infected Patients and Contribution of p53 to Host Antiviral Response. Intervirology. 55, 210-218 (2012). 37. Abu El Maaty M. A., Hanafi R. S., EL Badawy S., Gad M. Z. Association of suboptimal 25-hydroxyvitamin D levels with knee osteoarthritis incidence in post-menopausal Egyptian women. Rheumatology international 42, 1311-6 (2012). 38. Fawzy I. O., Negm M., Ahmed R., Esmat G., Hamdi N., Abdelaziz A. I. Tamoxifen alleviates hepatitis C virus-induced inhibition of both toll-like receptor 7 and JAK-STAT signalling pathways in PBMCs of infected Egyptian females. Journal of viral hepatitis. 19, 854-61 (2012). 39. El Nashar R. M., El-tantawy A. S. M., Hassan S. S. M. Potentiometric membrane sensors for the selective determination of memantine hydrochloride in pharmaceutical preparations. International Journal of Electrochemical Science. 7, 10802-10817 (2012). 40. Omar N. N., Abdel Maksoud S. M., Ali O. S. Association of insulin like growth factor 1 (IGF 1) and its binding protein-1 with nephropathy among type 2 diabetes. Acta Endocrinologica. 8, 539-549 (2012). 41. Khalifa N. M., Gad M. Z., Hataba A. A., Mahran L. G. Changes in ADMA and TAFI levels after stenting in coronary artery disease patients. Molecular Medicine Reports. 6, 855-859 (2012). 42. Wang G.-S., Grammel H., Abou-Aisha K., Sgesser R., Ghosh R. High-level production of the industrial product Lycopene by the photosynthetic Bacterium

rhodospirillum rubrum .Applied and Environmental Microbiology. 78, 7205-7215 (2012). 43. El Tayebi H. M., Hosny K. A., Esmat G., Breuhahn K., Abdelaziz A. I. MiR-6155p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma. FEBS Letters. 586, 3309-3316 (2012). 44. El-Askary H. I., El-Olemy M. M., Salama M. M., Sleem A. A., Amer M. H. Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt. Natural Product Research. 26 , 17551758 (2012). 45. Von Hahn T., Schiene-Fischer C., Van N. D., Pfaender S., Karavul B., Steinmann E., Potthoff A., Strassburg C., Hamdi N., Abdelaziz A. I., Sarrazin C., Mller T., Berg T., Trpo E., Wedemeyer H., Manns M. P., Pietschmann T., Ciesek S. Hepatocytes that express variants of cyclophilin a are resistant to HCV infection and replication. Gastroenterology. 143, 439-447 (2012). 46. Abdel-Mageed H. M., El-Laithy H. M., Mahran L. G., Fahmy A. S., Mder K., Mohamed S. A. Development of novel flexible sugar ester vesicles as carrier systems for the antioxidant enzyme catalase for wound healing applications. Process Biochemistry. 47, 1155-1162 (2012). 47. Abdel-Fattah M. A. O., El-Naggar M. A. M., Rashied R. M. H., Gary B. D., Piazza G. A., Abadi A. H. Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents. Medicinal Chemistry. 8, 392-400 (2012). 48. Hanafi R., Spahn-Langguth H., Mahran L., Heikal O., Hanafy A., Rieger H., Molnr I., Aboul-Enein H. Y. Computer-assisted HPLC method development for determination of tolmetin and possible kinetic modulators of its oxidative metabolism in vivo. Chromatographia. 75, 469-477 (2012). 49. Okyar A., Dressler C., Hanafy A., Baktir G., Lemmer B., Spahn-Langguth H. Circadian variations in exsorptive transport: In situ intestinal perfusion data and in vivo relevance. Chronobiology International. 29, 443-453 (2012). 50. Salama I., Abdel-Fattah M. A. O., Hany M. S., El-Sharif S. A., El-Naggar M. A. M., Rashied R. M. H., Piazza G. A., Abadi A. H. CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents. Medicinal Chemistry. 8, 372-383 (2012). 51. Nitsche C., Behnam M. A. M., Steuer C., Klein C. D. Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease. Antiviral Research. 94, 72-79 (2012). 52. Mekky R. Y., Hamdi N., El-Akel W., Esmat G., Abdelaziz A. I. Estrogen-related MxA transcriptional variation in hepatitis C virus-infected patients. Translational Research. 159 ,190-196 (2012).

53. Hamdi N., El-Akel W., El-Serafy M., Esmat G., Sarrazin C., Abdelaziz A. I. Transcriptional response of MxA, PKR and SOCS3 to interferon-based therapy in HCV genotype 4-infected patients and contribution of p53 to host antiviral response. Intervirology. 55, 210-218 (2012). 54. Abass H., Kamel R., Abdelbary A. Metronidazole bioadhesive vaginal suppositories: Formulation, in vitro and in vivo evaluation. International Journal of Pharmacy and Pharmaceutical Sciences. 4, 344-353 (2012). Year 2011 55. Abdel-Kader M. H., El-Tayeb T. A., Field trial using chlorophyll derivatives with sunlight for malaria and filaria vectors control in Sub-Saharan Africa International Photodynamic Association World Congress, 13th, Innsbruck, Austria, 71-80 (2011). 56. Abdel-Haleem A. M., El-Zeiry M. I., Mahran L. G., Abou-Aisha K., Rady M. H., Rohde J., Mostageer M., Spahn-Langguth H. Expression of RFC/SLC19A1 is associated with tumor type in Bladder cancer patients. PLoS ONE. 6, e21820 (2011). 57. El-Mesallamy H. O., Rizk K. A., Hashad I. M. Role of oxidative stress, inflammation and endothelial dysfunction in the pathogenesis of diabetic retinopathy. Institute of Integrative Omics and Applied Biotechnology Journal. 2, 91-97 (2011). 58. Attia M. A., Al-Azizi M., Hashish M. S. Design and evaluation of ciprofloxacin hydrochloride ocular inserts. International Journal of PharmTech Research. 3 1750-1763 (2011) 59. El Tayebi H. M., Salah W., El Sayed I. H., Salam E. M., Zekri A. R. N., Zayed N., Salem E. S., Esmat G., Abdelaziz A. I. Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients. Biomarkers. 16, 346-354 (2011) 60. Omran N. H., El Nashar R. M., Aboul-Enein H. Y. Dissolution testing and potentiometric assay of sertraline hydrochloride in batch and fia conditions. Analytical Letters. 44, 1713-1727 (2011). 61. Khairallah M. I., Kassem L. A. A. Alzheimer's disease: Current status of etiopathogenesis and therapeutic strategies. Pakistan Journal of Biological Sciences. 14, 257-272 (2011). 62. El-Bahy A. A., Kassem L. A., Heikal O. A., Mahran L. G. Antiapoptotic effect of DDB against hepatic ischemiareperfusion injury. Journal of Toxicological Sciences. 36, 145-154 (2011). 63. Gad M. Z., Hassanein S. I., Abdel-Maksoud S. M., Shaban G. M., Abou-Aisha K. Association of DDAH2 gene polymorphism with cardiovascular disease in Egyptian patients. Journal of Genetics. 90, 161-163. (2011).

64. Saleh A. I., Abdel Maksoud S. M., El-Maraghy S. A., Gad M. Z. Protective effect of L-arginine in experimentally induced myocardial ischemia: Comparison with aspirin. Journal of Cardiovascular Pharmacology and Therapeutics. 16, 53-62 (2011). 65. Ahmed N. S., Gary B. D., Tinsley H. N., Piazza G. A., Laufer S., Abadi A. H. Design, synthesis and structure-activity relationship of functionalized tetrahydro--carboline derivatives as novel PDE5 inhibitors. Archiv der Pharmazie. 344, 149-157 (2011). 66. Te Velthuis A. J. W., Sakalis P. A., Fowler D. A., Bagowski C. P. Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction network. PLoS ONE. 6, e16047. (2011). 67. Danielyan L., Schfer R., Von Ameln-Mayerhofer A., Bernhard F., Verleysdonk S., Buadze M., Lourhmati A., Klopfer T., Schaumann F., Schmid B., Koehle C., Proksch B., Weissert R., Reichardt H. M., Van Den Brandt J., Buniatian G. H., Schwab M., Gleiter C. H., Frey W. H. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of parkinson disease. Rejuvenation Research. 14, 3-16 (2011). 68. El Gohary N. A., El Nashar R. M., Aboul-Enien H. Y. Potentiometric determination of sibutramine using batch and flow injection analysis. Analytical Letters. 44, 241-257 (2011). 69. Markl C., Zlotos D. P. A novel synthesis of the antidepressant agomelatine. Synthesis, 1, 79-82 (2011). 70. Al-Said M. S., Ghorab M. M., Al-Dosari M. S., Hamed M. M. Synthesis and in vitro anticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety. European Journal of Medicinal Chemistry. 46, 201-207 (2011). 71. Kassem L. A., Gamal El-Din M. M., Yassin N. A. Mechanisms of vincristineinduced neurotoxicity: Possible reversal by erythropoietin. Drug discoveries & therapeutics. 5, 136-43 (2011). 72. Attia M. A., Al-Azizi M., Hashish M. S. Design and evaluation of ciprofloxacin hydrochloride ocular inserts. International Journal of PharmTech Research. 3, 1750-1763 (2011). 73. Hanafi R., Mosad S., Abouzid K., Niess R., Spahn-Langguth H. Baclofen ester and carbamate prodrug candidates: A simultaneous chromatographic assay, resolution optimized with DryLab. Journal of Pharmaceutical and Biomedical Analysis. 56, 569-576 (2011). 74. Affifi N. N., Heikal O. A., Hanafi R. S., Tammam S. N. Application of biodegradable nanoparticles in liver targeting of tacrolimus. AIP Conference Proceedings, 1326 (Biology, Nanotechnology, Toxicology, and Applications). 36, 120-127 (2011).

75. Abadi A. H., Lehmann J., Piazza G. A., Abdel-Halim M., Ali M. S. M. Synthesis, molecular modeling, and biological evaluation of novel tetrahydro--carboline hydantoin and tetrahydro--carboline thiohydantoin derivatives as phosphodiesterase 5 inhibitors. International Journal of Medicinal Chemistry. 2011, 9 (2011). 76. Mohamed H. A., Girgis N. M. R., Wilcken R., Bauer M. R., Tinsley H. N., Gary B. D., Piazza G. A., Boeckler F. M., Abadi A. H. Synthesis and Molecular Modeling of Novel Tetrahydro--carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties. Journal of Medicinal Chemistry. 54, 495-509 (2011). 77. Alqazzaz M., Thompson A. J., Price K. L., Breitinger H.-G., Lummis S. C. R. Cys-loop receptor channel blockers also block GLIC. Biophysical Journal. 101, 2912-2918 (2011). 78. Heckman D., Attia M. I., Behnam M. A. M., Mohsen A. M. Y., Markl C., Julius J., Sethi S., Witt-Enderby P. A., Zlotos D. P. 2-[(1,3-Dihydro-2H-isoindol-2yl)methyl]melatonin - A novel MT 2-selective melatonin receptor antagonist. MedChemComm. 2, 991-994 (2011). 79. Abd El Aziz A. E., El Sayed N. S., Mahran L. S. Anti-asthmatic and anti-allergic effects of thymoquinone on airway-induced hypersensitivity in experimental animals. Journal of Applied Pharmaceutical Science. 1, 109-117 (2011). 80. Vermehren J., Colucci G., Gohl P., Hamdi N., Abdelaziz A. I., Karey U., Thamke D., Zitzer H., Zeuzem S., Sarrazin C. Development of a second version of the Cobas AmpliPrep/Cobas TaqMan hepatitis C virus quantitative test with improved genotype inclusivity. Journal of Clinical Microbiology. 49, 3309-3315 (2011). 81. Bunaciu A. A., El Nashar R. M., Aboul-Enein H. Y. Mini review: Determination of sildenafil citrate in pharmaceutical prepaprations. Analytical Letters. 44, 20852093 (2011). 82. El-Sayed N. S., Mahran L. G., Khattab M. M. Tempol, a membrane-permeable radical scavenger, ameliorates lipopolysaccharide-induced acute lung injury in mice: A key role for superoxide anion. European Journal of Pharmacology. 663, 68-73 (2011). 83. Ciesek S., Westhaus S., Wicht M., Wappler I., Henschen S., Sarrazin C., Hamdi N., Abdelaziz A. I., Strassburg, C. P., Wedemeyer H., Manns M. P., Pietschmann T., von Hahn T. Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles. Journal of Virology0. 85, 7613-7621 (2011). 84. Lashine Y. A., Seoudi A. M., Salah S., Abdelaziz A. I. Expression signature of microRNA-181-a reveals its crucial role in the pathogenesis of paediatric systemic lupus erythematosus. Clinical and Experimental Rheumatology. 29, 351-357 (2011).

Year 2010 85. Kassem L. A., Yassin N. A. Role of erythropoeitin in prevention of chemotherapy-induced peripheral neuropathy. Pakistan Journal of Biological Sciences. 13, 577-587. (2010). 86. Serry A. M., Luik S., Laufer S., Abadi A. H. One-pot synthesis of 4,6-Diaryl-2oxo(imino)-1,2-dihydropyridine-3- carbonitrile; A new scaffold for p38 MAP kinase inhibition. Journal of Combinatorial Chemistry. 12, 559-565 (2010). 87. Gad M. Z. Anti-aging effects of L-arginine. Journal of Advanced Research. 1, 169-177 (2010). 88. Ghorab M. M., Ragab F. A., Hamed M. M. Synthesis and docking studies of some novel quinoline derivatives bearing a sulfonamide moiety as possible anticancer agents. Arzneimittel-Forschung/Drug Research. 60, 141-148 (2010). 89. Shirasaka Y., Kuraoka E., Spahn-Langguth H., Nakanishi T., Langguth P., Tamai I. Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. Journal of Pharmacology and Experimental Therapeutics. 332, 181-189 (2010). 90. Bagowski C. P., Bruins W., Te Velthuis A. J. The nature of protein domain evolution: shaping the interaction network. Current Genomics. 11, 368-376 (2010). 91. Kassem L. A., Yassin N. A. Role of erythropoeitin in prevention of chemotherapy-induced peripheral neuropathy. Pakistan Journal of Biological Sciences. 13, 577-587 (2010). 92. Ahmed N. S., Gary B. D., Piazza G. A., Tinsley H. N., Laufer S., Abadi A. H. A novel access to arylated and heteroarylated beta-carboline based PDE5 inhibitors. Medicinal Chemistry. 6, 374-387 (2010). 93. Wagdy H. A., El Nashar R. M. Vinpocetine chemical sensor for its dissolution testing, assay and as HPLC detector. Sensor Letters. 8, 838-847 (2010). 94. Osman N. A., Mahmoud A. H., Allara M., Niess R., Abouzid K. A., Di M. V., Abadi A. H. Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands. Bioorganic & Medicinal Chemistry. 18, 84638477(2010). 95. Gad M. Z., Hassanein S. I., Abdel-Maksoud S. M., Shaban G. M., Abou-Aisha K., Elgabarty H. A. Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and l-arginine in coronary artery disease. Biomarkers. 15, 746-752 (2010).

96. Raafat K., Breitinger U., Mahran L., Ayoub N., Breitinger H. Synergistic Inhibition of Glycinergic Transmission In Vitro and In Vivo by Flavonoids and Strychnine.Toxicological Sciences. 118, 171-182 (2010). 97. Attia M. A., El Badawy H. Y. Film forming gel for treatment of oral mucositis: in vitro studies. International Journal of Drug Delivery. 2, 314-321 (2010). 98. El Hamshary M. S., Salem O. H., El Nashar R. M. Application of oxybutynin selective sensors for monitoring the dissolution profile and assay of pharmaceutical dosage forms. Analytical Sciences. 26, 437-442 (2010). 99. Abadi A. H., Gary B. D., Tinsley H. N., Piazza G. A., Abdel-Halim M. Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective. European Journal of Medicinal Chemistry. 45, 1278-1286 (2010). 100. Abadi A. H., Abouel-Ella D. A., Lehmann J., Tinsley H. N., Gary B. D., Piazza G. A., Abdel-Fattah M. A. O. Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach. European Journal of Medicinal Chemistry. 45, 90-97(2010). Year 2009 101. El Sayed N. S., Kassem L. A., Heikal O. A. Promising therapy for Alzheimer's disease targeting angiotensin-converting enzyme and the cyclooxygense-2 isoform. Drug Discoveries & Therapeutics. 3, 307-315 (2009). 102. Abd El-Ghany R. M., Sharaf N. M., Kassem L. A., Mahran L. G., Heikal O. A. Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury. Drug Discoveries & Therapeutics. 3, 296-306 (2009). 103. Handoussa H., Osmanova N., Ayoub N., Mahran L. Spicatic acid: a 4carboxygentisic acid from Gentiana spicata extract with potential hepatoprotective activity. Drug Discoveries & Therapeutics, 3, 278-286 (2009). 104. Abadi A. H., Abouel-Ella D. A., Ahmed N. S., Gary B. D., Thaiparambil J. T., Tinsley H. N., Keeton A. B., Piazza G. A. Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents. Arzneimittel Forschung, 59, 415-421 (2009). 105. Abadi A. H., Ibrahim T. M., Abouzid K. M., Lehmann J., Tinsley H. N., Gary B. D., Piazza G. A. Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors. Bioorganic & Medicinal Chemistry. 17, 5974-5982 (2009). 106. El Nashar R. M., Wagdy H. A., Aboul-Enein H. Y. Applications of calixarenes as potential ionophores for electrochemical sensors. Current Analytical Chemistry. 5, 249-270 (2009). 107. Alqasoumi S. I., Al-Taweel A. M., Alafeefy A. M., Hamed M. M., Noaman E., Ghorab M. M. Synthesis and biological evaluation of 2-amino-7,7-dimethyl4-

substituted-5-oxo-1-(3,4,5-trimethoxy)-1,4,5,6,7,8-hexahydro-quinoline-3carbonitrile derivatives as potential cytotoxic agents. Bioorganic and Medicinal Chemistry Letters. 19, 6939-6942. (2009). 108. Tinsley H. N., Gary B. D., Keeton A. B., Zhang W., Abadi A. H., Reynolds R. C., Piazza G. A. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Molecular Cancer Therapeutics. 8, 3331-3340. (2009). 109. Vlecken D. H., Bagowski C. P. LIMK1 and LIMK2 are important for metastatic behavior and tumor cell-induced angiogenesis of pancreatic cancer cells. Zebrafish0. 6, 433-439. (2009). 110. Breitinger H. -G., Villmann C., Melzer N., Rennert J., Breitinger U., Schwarzinger S., Becker C. -M. Novel regulatory site within the TM3-4 loop of human recombinant 3 glycine receptors determines chan nel gating and domain structure. Journal of Biological Chemistry. 284, 28624-28633. (2009). 111. Ghorab M. M., Ragab F. A., Hamed M. M. Design, synthesis and anticancer evaluation of novel tetrahydroquinoline derivatives containing sulfonamide moiety. European Journal of Medicinal Chemistry. 44, 4211-4217 (2009). 112. El-Sayed N. S., Rizk S. M. The protective effect of quercetin, green tea or malt extracts against experimentally-induced lung fibrosis in rats. African Journal of Pharmacy and Pharmacology. 3, 191-201 (2009). 113. Shirasaka Y., Li Y., Shibue Y., Kuraoka E., Spahn-Langguth H., Kato Y., Langguth P., Tamai I. Concentration-dependent effect of naringin on intestinal absorption of 1-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (oatp). Pharmaceutical Research. 26, 560-567 (2009). 114. Villmann C., Oertel J., Ma-Hgemeier Z. -L., Hollmann M., Sprengel R., Becker K., Breitinger H. -G., Becker C. -M. Functional complementation of Glra1spd-ot, a glycine receptor subunit mutant, by independently expressed CTerminal domains. Journal of Neuroscience. 29, 2440-2452. (2009). 115. Gad M. Z., El-Mesallamy H. O., Sanad E. F. hsCRP, sICAM-1 and TAFI in hemodialysis patients: Linking inflammation and hypofibrinolysis to cardiovascular events. Kidney and Blood Pressure Research. 31, 391-397 (2009).

Year 2008 116. El-Nashar R. M. Journal of Automated Methods & Management in Chemistry Flow injection potentiometric assay of hexoprenaline in its pure state, pharmaceutical preparations, and biological samples. 586310/1-586310/11 (2008).

117. El Nashar R. M. Determination of Orciprenaline Using a Flow Injection Analysis System with Sequential Potentiometric and Spectrophotometric Detection. Analytical Letters. 41, 949-964 (2008). 118. El-Nashar R. M. Flow injection potentiometric assay of hexoprenaline in its purestate, pharmaceutical preparations, and biological samples. Journal of Automated Methods and Management in Chemist.586310, (2008). 119. El-Mesallamy H .O., Salah R. S., Gad M. Z. Study of some inflammatory factors in type 2 diabetic patients with nephropathy. Journal of Medical Sciences. 8, 532-539 (2008). 120. Alemdaroglua N. C., Dietz U., Wolffram S., Spahn-Langguth H., Langguth P. Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: Potential risk of diminished folic acid bioavailability. Biopharmaceutics and Drug Disposition. 29, 335-348. (2008). 121. El-Mesallamy H. O., Abdel Hamid S. G., Gad M. Z. Oxidative stress and asymmetric dimethylarginine are associated with cardiovascular complications in hemodialysis patients: Improvements by L-arginine intake. Kidney and Blood Pressure Research. 31, 189-195. (2008). Year 2007 122. Awadallah F. M., Mueller F., Lehmann J., Abadi A. H. Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand. Bioorganic & Medicinal Chemistry. 15, 58115818 (2007). 123. El-Azizi M. Enhancement of the in vitro activity of amphotericin B against the biofilms of non-albicans Candida spp. by rifampicin and doxycycline.Journal of Medical Microbiology. 56, 645-649 (2007). 124. Kaiser A., Hammels I., Gottwald A., Nassar M., Zaghloul M. S., Motaal B. A., Hauber J., Hoerauf A. Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties. Bioorganic and Medicinal Chemistry. 15, 6200-6207 (2007). 125. Hanafy A., Spahn-Langguth H., Vergnault G., Grenier P., Tubic Grozdanis M., Lenhardt T., Langguth P. Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug. Advanced Drug Delivery Reviews. 59, 419-426 (2007). 126. Alemdaroglu N. C., Wolffram S., Boissel J. -P., Closs E., Spahn-Langguth H., Langguth P. Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells. Planta Medica. 73, 27-32 (2007). Year 2006

127. Ofer M., Langguth P., Spahn-Langguth H. Bidirectional membrane transport: Simulations of transport inhibition in uptake studies explain data obtained with flavonoids. European Journal of Pharmaceutical Sciences. 29, 251-258 (2006). 128. Kaiser A., Ulmer D., Goebel T., Holzgrabe U., Saeftel M., Hoerauf A. Inhibition of hypusine biosynthesis in plasmodium: A possible, new strategy in prevention and therapy of malaria. Mini-Reviews in Medicinal Chemistry 6, 1231-1241 (2006). 129. Njuguna J. T., Nassar M., Hoerauf A., Kaiser A.E. Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax. BioMed Central Microbiology. 6, art. no. 91 (2006). 130. Saeftel M., Sarite R. S., Njuguna T., Holzgrabe U., Ulmer D., Hoerauf A., Kaiser A. Piperidones with activity against Plasmodium falciparum. Parasitology Research. 99, 281-286 (2006). 131. Zaki M. E. A., Soliman H. A., Hiekal O. A., Rashad A. E. Pyrazolopyranopyrimidines as a class of anti-inflammatory agents. Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 61, 1-5 (2006). Year 2005 132. Paarmann I., Frermann D., Keller B. U., Villmann C., Breitinger H. G., Hollmann M. Kinetics and subunit composition of NMDA receptors in respiratory-related neurons. Journal of Neurochemistry. 93, 812-824 (2005).