DEPARTMENT OF PHARMACOLOGY BPT QUESTION BANK GENERAL PHARMACOLOGY AND ANS Long Essay: 1. 2. 3. #. $. Classify blockers.

. Write the pharmacological actions and therapeutic uses of propranol. Classify blockers. Write the adverse effects and therapeutic uses of propranolol. Classify SM s. !iscuss the pharmacology of tubocurarine"succinylcholine. Classify SM s. Write the therapeutic uses and adverse effects of any one of them. Classify drugs act as SM s indicating their site of action. Write the uses and adverse effects of d%c. &. 'neumerate anticholinergic of drugs. Write the pharmacological actions( uses and side effects of atropine. ). 'numerate the various routes of drug administration *ith one e+ample each. Write the advantages and disadvantages of oral route",- route"pareneteral route",M .. !iscuss the factors that influence the dosage of drugs *ith suitable e+amples. /. What are the routes of drug administration0 !iscuss *ith suitable e+amples. 11. !efine bioavailability. '+plain the factors affecting bioavailability. 11. !escribe in detail ho* the action of drug is terminated. 12. 'numerate sympathomimetic drugs. Write briefly the action and uses of adrenaline. 13. !iscuss various factors modifying drug action *ith e+ample 1#. !efine absorption. !iscuss all the factors influencing absorption 1$. Classify blockers. !iscuss the pharmacology of propranolol 1&. !escribe in detail ho* the action of drug is terminated Shor Essays: 1. d2tubocurarine 2. 3ses of blockers"propranolol. 3. Succinylcholine #. 4eostigmine $. 5hysostigmine &. blocker ). !rug antagonism .. 5rodrug /. Merits and demerits of ,- route of drug administration 11. ,nhalational route of drug administration 11. What are the routes of e+cretion of drugs0 12. Write briefly on adverse drug reactions 13. !efine bioavailability. 6actors affecting bioavailability 1#. !rug tolerance 1$. Synergism 1&. %eratogenic drugs 1). 5lacental transfer of drugs 1.. Contraindications of blockers 1/. State the mode of action of pancuronium. !iscuss ho* the action of the drug can be antagoni7ed. 21. Mention mode of action and uses of propronolol0 21. What is atenolol0 Mention the therapeutic uses of this drug0 22. Centrally acting skeletal muscle rela+ants. 23. 3ses of atropine. 2#. %achyphyla+es 2$. 4asal decongestants 2&. 5eripheral skeletal muscle rela+ants 2). Special drug delivery system 2.. 6actors influencing absorption of a drug 2/. 5lasma half life 31. eceptor 31. 3ses of anticholinesterases 32. 'phedrine 33. 8mphetamine 3#. -asopressors 3$. 4ame the 9 blockers and mention the uses of 9 blockers. 3&. !rugs and e+ercise 3). '+plain the methods prolonging duration of action of drugs

3.. Clinical uses of atropine substitutes 3/. Write a note on metabolism of drugs #1. 4ame the topical routs of drug administration *ith e+amples #1. 8naphyla+is and its treatment Shor Ans!"rs: 1. Why adrenaline is used in anaphylactic shock. 2. 8dvantages of ,- route of administration. 3. !rug synergism *ith e+amples. #. What is baclofen0 Mention the use of this drug. $. Why 5ysostigmine used in the treatment of atropine poisoning0 &. Why adrenaline is combined *ith lidocain. ). What is drug dependence0 :ive t*o e+amples. .. 4ame the drugs used in ;.5. poisoning /. 'numerate symathomimetic agents 11. State drug antagonism and its importance. 11. 4ame # drugs used in glaucoma0 12. 4ame 2 beta( agonists and *rite their 2 uses0 13. !efine pharmacogenetics. :ive one e+ample. 1#. What is therapeutic inde+. :ive t*o points of its significance. 1$. Why is neostigmine preferred in the treatment of myasthenia gravis0 1&. 4ame # nasal decongestants. 1). 4ame # adverse effects of atropine 1.. 4ame # e+amples of drug antagonism 1/. What is drug allergy0 4ame 2 drugs causing it. 21. 4ame 2 blockers0 Mention 2 uses0 21. !efine prodrug. :ive t*o e+amples. 22. What is receptor0 :ive e+amples. 23. What do you understand by contraindication0 :ive t*o e+amples. 2#. 4ame t*o drugs administered by inhalational route 2$. !efine tachyphyla+is. :ive 2 e+amples 2&. :ive the therapeutic uses of neostigmine 2). <ist # adverse drug effects *ith e+amples 2.. Compare central and peripheral acting SM s 2/. !efine the term idiosyncrasy 31. <ist 2 contraindication to use of propranolol 31. <ist 2 important 8! of succinylcholine 32. Mention the natural sources of drugs *ith e+amples 33. What is myasthenia gravis0 4ame the 2 drugs used to treat it 3#. <ist the drugs administered as transdermal patch 3$. What is drug allergy0 4ame 2 drug causing it G#$" r"ason 3&. 4eostigmine is used in myasthenia gravis. 3). 8tropine is used in ; poisoning. 3.. 4eostigmine is used in curare poisoning 3/. 5ropranolol is given an+iety states #1. !opamine is given in shock. #1. 5ilocarpine is used in glaucoma #2. What are adverse drug reactions0 :ive an e+ample. #3. 4ame # 9 blockers ##. 4ame # blockers #$. 4ame # atropine derivatives #&. 4ame t*o catecholamines and 2 non catecholamines #). What is succinl choline apnoea. #.. Why insulin is not administered orally and 8ch is not used clinically #/. :lucocorticoids are beneficial in bronchial asthma. =o*0 $1. 5ropronolol is contraindicated in bronchial asthma. =o*0 $1. 6resh blood transfusion is given in succinylcholine apnoea $2. 5lacental transfer of drugs

CHEMOTHERAPY 1. !efine >a? Chemotherapy >b? 8ntibiotic >c? @acterial esistance to antimicrobials 2. Classify antimicrobial agents based on their mechanism of action 3. Combinaton of antimicrobials #. Chemoprophyla+is $. Superinfection &. Cotrimo+a7ole ). Ciproflo+acin .. 4orflo+acin /. 8mo+icillin 11. 3ses of 5enicillins 11. 8mpicillin 12. Cephalosporins 13. !o+ycycline 1#. Chloramphenicol 1$. %hird generation cephalosporins 1&. 3ses of tetracycline 1). @acterial esistance to antimicrobials 1.. Common properties of aminoglycosides 1/. Streptomycin 21. :entamicin 21. 'rythromycin 22. 3ses of macrolides 23. ifampicin 2#. ,4= 2$. 5yra7inamide 2&. !apsone 2). 8mphotericin 2.. 87ole antifungals 2/. Clotrima7ole 31. 8cylovir 31. Aidovudin 32. 8ntiretroviral drugs 33. ChloroBuine 3#. Metronida7ole 3$. 8lbenda7ole 3&. Mebenda7ole 3). !'C 3.. Methotre+ate 3/. Common adverse effects to anticancer drugs #1. Cyclosporine #1. -accines #2. !iscuss the chemotherapy of leprosy. #3. Mention the main advantages of multi2drug chemotherapy in leprosy. ##. 'numerate antimalarial drugs. #$. Classify penicillins. Write the preparation of penicillin and its therapeutic uses and adverse effect. 8dd a note on the treatme nt of anaphylactic shock due to 5enicillin : inCection #&. Classify opioid analgesics. Write the pharmacological action( therapeutic uses and contraindication for morphine therapy. #). Duinolones Shor Ans!"rs: 1. Mention the methods of transfer of resistance 2. Mention the adverse effects of sulfonamides 3. 4ame 2 topical sulfonamides #. Mention the uses of sulfonamides $. M;8 of penicillins > lactam antibiotics? &. lactamase inhibitors ). 4ame # cephalosporins each belonging to a different generation. .. 4ame 2 carbapenems /. 4ame # lactam antibiotics 11. 87tronam

11. 8dverse effects of tetracyclines 12. 4ame # fluoroBuinolones 13. 5rophylactic uses of penicillins. 1#. 'numerate aminoglycosides 1$. 8dverse effects of aminoglycosides 1&. 4ame # macrolides 1). 4ame # drugs that act by inhibiting protein synthesis 1.. 4ame # antibiotics used topically 1/. Streptogramins 21. 4ame # drugs used in 3%, 21. 4ame the first line anti tubercular drugs 22. 4ame # tuberculocidal drugs 23. 4ame # drugs used in leprosy 2#. <epra reactions. 4ame 2 drugs that are used in E<epra reactionsF 2$. 'numerate the antifungal drugs 2&. 4ame # topical antifungal drugs 2). 'numerate the antiviral drugs 2.. 4ame # drugs used in 8,!S 2/. 4ame # drugs used in malaria 31. 4ame # drugs used in falciparum malaria 31. %reatment of P.vivax malaria 32. Mention the uses of chloroBuine 33. 4ame the drugs used in amobiasis 3#. Mention # uses of metronida7ole 3$. 4ame 2 drugs used in round *orm infestation 3&. 4ame 2 drugs used in hook *orm infestation 3). 4ame 2 drugs used in pin *orm infestation 3.. 4ame 2 drugs tape *orm infestation 3/. 4ame # anticancer drugs #1. 4ame the immuno suppressants #1. 8ctive immuni7ation #2. 5assive immuni7ation #3. Mention # differences bet*een morphine and pethidine ##. Mention 2 immunosuppressive agents and one 8! of each #$. Morphine is contraindicated in head inCury *hy0

G#$" r"ason: #&. 5robenecid is given along *ith 5enicilin #). Sulbactam is used *ith ampicillin #.. ,mipenem is combined *ith cilastatin #/. 8ntitubercular drugs are given in combination. $1. ationale of combining sulfametho+a7ole *ith trimethoprim $1. @en7yl penicillin is less effective by oral route. $2. Clofa7imine is used in lepra reaction *hy0 $3. Multi drug regimen is used in leprosy *hy0 $#. !o+ycycline is preferred to tetracycline in patients *ith renal insufficiency0 $$. Clavulanic acid is combined *ith amo+icillin *hy0 $&. 4ame 2 6Ds and mention their uses

HORMONES
Long Essay:
1. Classify oral hypoglycaemic drugs. Write the M;8 and adverse effects of sulfonylureas of any one group 2. 4ame the preparations of glucocorticoids. Write their uses and adverse effects. 3. 4ame the preparation of insulin and *rite the M;8 and side effects of insulin. #. Classify anti diabetic drugs. Mention the uses and adverse effects of any one group.

Shor Ans!"rs:
1. 4ame the anterior pituitary hormones. 2. Write t*o uses of gro*th hormone. 3. 4ame the antithyroid drugs. #. 3ses of thyroid hormones $. 4ame four oral hypoglycaemics &. '+plain the anti2inflammatory actions of glucocorticoids. ). 4ame t*o oral contraceptive preparations .. 4ame t*o antiestrogens /. 4ame t*o anabolic steroids 11. 3ses of anabolic steroids 11. 4ame t*o antiandrogens 12. Sildenafil 13. 3ses of Calcium. 1#. Write a note on insulin preparation 1$. 3ses and adverse effects of glucocorticoids 1&. Write a note on sulfonylureas 1). ,nsulin 1.. Mannitol 1/. ;+ytocin 21. ;ral hypoglycaemic agents 21. %hyro+in 22. M' of ;C Shor No "s: 1. ,odides 2. adioiodine 3. Side effects of insulin #. :libenclamide"sulfonylureas $. 5reparations of glucocorticoids &. 3ses of glucocorticoids ). 8dverse effects of glucocorticoids .. 8dverse effects of oral contraceptives /. Mifepristone 11. 8nabolic steroids 11. -itamin !. 12. Why glucocorticoids should not be stopped abruptly follo*ing long term administration 13. What are biguanides 1#. ational of using <ugolFs iodine before thyroid surgery 1$. ationale of combining oestrogen and progesterone in ;C >Combined pill? 1&. <ist # =2 antagonists 1). 8dverse effects of insulin 1.. Write the advantages of ne*er insulin over conventional insulin

C%S
Long Essay: 1. 2. 3. #. Classify antihypertensive drugs. Write the uses and adverse effects of any t*o of them. Classify antianginal drugs. Write the adverse effects and uses of nitrates. 'numerate antihypertensives. Write the pharmacology of 8C' inhibitors. 'numerate the drugs used in the treatment of cardiac arrhythmias. Write briefly the pharmacology of CC@Fs. $. 'numerate the drugs used in the treatment of hyperthyroidism. Write briefly the pharmacology of carbima7ole. &. Classify sedative hypnotics. Write the M;8( adverse effects and uses of dia7epam"@A!s ). Classify <s. Write the M;8( adverse effects and therapeutic uses of lignocaine. 8dd a note on different types of <s Shor Essays: 1. %reatment of !igo+in to+icity( M;8 and therapeutic uses of digo+in 2. Classify antiarrhythmics 3. Duinidine #. 8C' inhibitors $. CC@s &. 4ifedipine"verapamil ). 'numerate the drugs used in angina pectoris .. 4itrates /. <osartan 11. 5lasma e+panders 11. <ist the therapeutic uses @A!s 12. '+plain uses and adverse effects of %C8 13. 4ame # lipid lo*ering agents 1#. 'nalapril 1$. -asodilators 1&. 4ote on phenobarbitone 1). Mechanism of action of disulfiram 1.. !rugs used in the treatment of 5-!. Write the M;8 of any one of them 1/. Classify sedative hypnotics. <ist their therapeutic uses 21. Write a note on statins

Shor Ans!"rs: 1. 4ame # drugs used in CC6 2. 8dverse effects of nitrates 3. 4ame # drugs used in hypertensive emergencies"severe hypertension #. 4ame # CC@s $. 4ame # drugs used in mild hypertension &. 8naphylactic shock ). 4ame # plasma e+panders .. 4ame # vasoconstrictors /. 4ame # vasodilators 11. !iuretics are used in CC6 G :ive reason 11. -asodilators are used in CC6 G :ive reason 12. 5ropranolol is used in angina G :ive reason. 13. 4ifedipine is used in angina 2 :ive reason. 1#. 8spirin is used in angina 2 :ive reason. 1$. Combination of drugs is used in angina 2 :ive reason. 1&. !iuretics are used in hypertension G :ive reason 1). blockers are used in hypertension G :ive reason 1.. Captopril"8C' inhibitors are used in hypertension G :ive reason 1/. <osartan is used in hypertension G :ive reason 21. <ist # antiarrhythmics 21. 3ses of nitroglycerine 22. <ist 2 imortant side effects of imipromine 23. 3rine should be alkalini7ed in acute barbiturate poisoning

2#. What are the potassium channel opener. :ive e+ample 2$. Mention the uses of @A!s 2&. Write a drug that can be used in status epilepticus *ith its route of administration 2). Write # therapeutic uses of alcohol 2.. 5henobarbitone reduces the efficacy of oral contraceptives 2/. What is clona7epam0 Mention 2 uses of this drug 31. 'thyl alcohol is used in methyl alcohol poisoning *hy0

MUSCULOSKELATL RELA&ANTS Long "ssays: 1. Classify 4S8,!s. Write briefly the M;8 of 4S8,!s and list their therapeutic uses 2. !efine analgesic and antipyretic agents. !iscuss the pharmacological actions( adverse effects and therapeutic use of aspirin Shor Essays: 1. !iscuss the uses and adverse effects of aspirin 2. !rugs used in the treatment of osteophoresis 3. Write the M;8 and uses of 4S8,!s Shor ans!"rs 1. 2. 3. #. Mention 2 drugs used in the treatment of gout =2acetyl cystine is used in paracetamol poisoning What is osteoarthritis. 4ame 2 drugs used to treat it Why is aspirin prescribed for patients *ith ischaemic heart disease GIT Long "ssays: 1. Classify drugs useful in the treatment of peptic ulcer. e+plain the M;8 of 55, and =2 receptor antagonists Shor Essays: 1. 2. 3. #. $. 'numerate la+ative. Write the mode of action of any 2 of them 5roton pump inhibitors Classify the drugs used in peptic ulcer Write a note on bulk purgatives !iscuss the drugs used to treat constipation

Short ans*ers 1. 2. 3. #. $. 4ame # purgatives <ist # antiemetics ;ral regulation therapy 4ame # antimotility drugs Write a note on oral rehydration therapy

CNS Long "ssays: 1. Classify opioid analgesics. Mention the adverse effect( therapeutic uses and contra indications to use of morphine 2. Classify antiepileptic drugs. e+plain the pharmacology of phenytoin and valproic acid Shor "ssays: 1. Carbama7epine 2. <2dopa 3. Write a note on uses and adverse effects of chlorproma7ine #. 5henytoin sodium $. =alothane &. Chlorproma7ine ). Hetamine hydrochloride .. Complications of spinal anaesthesis /. 5re anaesthetic medication 11. 5ethidine Shor ans!"rs: 1. <ist 2 indications and 2 contra indications of morphine 2. %reatment of cyanide poisoning 3. Mention the drugs used in 5arkinsonism #. !rugs used in grandmal epilepsy $. <ist # antiepileptic drug belonging to different group &. What is systemic lupus erythematosus. 4ame 2 drugs used to treat it ). 4ame 2 drugs used as ,- anaesthetics .. 4ame 2 drugs that induce e+trapyramidal symptoms /. '+plain the M;8 of <8s 11. 4ame for :8s 11. 4ote on M8; inhibitors

KIDNEY Long "ssays: 1. What are diuretics0 Classify them. State the M;8 and give the clinical uses of loop diuretics Shor ans!"rs 1. State the uses of loop diuretics

GERIATRIC Shor "ssays: 1. @riefly mention the 5H changes in the geriatric population Shor ans!"rs 1. 'lderly are more prone to adverse effects G give 2 reasons

BLOOD Shor "ssays: 1. 2. 3. #. $. =eparin 6ibrinolytics What are thrombolyic agents. :ive their clinical uses %hrombolytics Write a note on heparin

Shor ans!"rs 1. <ist 2 oral anticoagulants and 2 parenteral anticoagulants 2. !efine the term haemostatics. Mention 2 haemostatics

RS Shor "ssays: 1. 2. 3. #. $. @ronchodilators 8ntitussives Mast cell stabili7ers Miotics Cough suppressants

Shor ans!"rs 1. 2. 3. #. $. &. Mention # drugs used in bronchial asthma <ist 2 <% antagonist What is allergic rhinitis. 4ame 2 drugs used to treat it What is C;5!. 4ame 2 drugs to treat it 4ame 2 mucolytics *ith their mode of action ationale of using disodium chromoglycate as prophylactic in allergic bronchial asthma

AUTOCOIDS Long Essay: 1. 2. 3. #. $. &. 4ame some antihistamines. Write their uses and adverse effects. 4e*er non2sedative antihistmines. 4ame t*o serotonin antagonists Write t*o uses of ergot alkaloids 4ame # drugs used in the treatment of migraine 3ses of prostaglandins RESPIRATORY SYSTEM Long Essay: 1. 2. 3. #. $. &. ). .. 'numerate drugs used in bronchial asthma ,nhaled steroids in asthma Cromolyn sodium %heophyline 4ame the drugs used in status asthmaticus Central Cough Supressants '+pectrorants Mucolytics BLOOD 1. 5reparations of iron 2. What are the indications for parenteral iron0 3. %reatment of acute iron poisoning0 #. 3ses of iron $. 3ses of -it. @12 &. 3ses of 6olic 8cid ). 4ame the =aematopoietic gro*th factors and *rite their uses. .. 'numerate anticoagulants /. Write the mechanism of action and adverse effects of heparin 11. 4ame t*o <MW heparins 11. 8dverse effects of oral anticoagulants 12. Write the uses of anticoagulants 13. What are the contra indications to anticoagulants therapy0 1#. 6ibrinolytics 1$. 4ame some antiplatelet drugs and *rite their uses. 1&. What are styptics0 4ame some. 1). 3ses of -it. H. 1.. 4ame # hypolipidaemic drugs.

:,%
1. What are the drugs used in peptic ulcer0 2. 8utacoids 3. 6our receptor blockers $. ;ndansetron &. 4ame # la+atives ). 4ame # drugs used in the treatment of diarrhoea.