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# Letter to the Editor

## Fibonacci Series and Coronary Anatomy

Keywords. Fibonacci; Coronary; Anatomy; Morphology; Phyllotaxis; Biomathematics

he thirteenth century mathematician, Leonardo of Pisa, nicknamed Fibonacci described a sophisticated number series that was subsequently named after him. The sequence follows 2, 3, 5, 8, 13, 21, 34, 55, 89, etc. and represents a trend observable in many natural settings. These include inheritance patterns, the design of owers and the branching of leaves (phyllotaxis) [1]. Its widespread existence is further signied by its ability to derive the Golden Ratio also known as natures mathematical holy grail. This ratio of approximately 1.61 is consistently seen not only in biology, but also in works of great art and architecture. We hypothesise that the structure of the coronary arterial tree can be considered analogous to the leaf branching seen in trees, and it has previously been reported [2] that diseased atherosclerotic lesions in coronary arteries follow a Fibonacci distribution. We further propose that the distribution of coronary arteries themselves can reveal a morphological spread that follows a Fibonacci series of 2, 3, 5, 8, and 13 (Fig. 1, Table 1). The arteries are distributed sequentially to closely resemble phyllotaxis seen elsewhere in nature, but also reveal an underlying association with the Golden Ratio. Studying data from 36 mammalian species, from mouse to giraffe [3], one can calculate that the association of cardiac diameters divided by the sum diameters of all 13 branches across these species is in the order of the golden ratios 1.61. Fibonacci number theory can be used to develop innovative bio-mathematical models of the coronary system

Figure 1. Anatomical branching of the coronary arterial tree corresponding to the Fibonacci series (authors interpretation).

Table 1. Sequence branching of the coronary arterial tree. LCA = Left Coronary Artery, RCA = Right Coronary Artery, LAD = Left Anterior Descending, LCX = Left Circumex, OM = Obtuse Marginal, AM = Acute Marginal, PDA = Posterior Descending Artery, LDiag = Left Diagonal, RDiag = Left Diagonal, PLV = Posterior Left Ventricular (1) = lateral; (2) = intermediate; (3) = medial, PRV = Posterior Right Ventricular (1) = lateral; (2) = intermediate; (3) = medial, Sep = Septal, RI = Ramus Intermedius (authors interpretation).

AM OM1 Sep3

## PDA Sep1 Sep4

PDA OM2

Rdiag1 LDiag2

AM Sep2

OM3

PLV2

PLV3

PRV2

PRV3

1443-9506/04/\$36.00 doi:10.1016/j.hlc.2011.02.008

## LETTER TO THE EDITOR

484
LETTER TO THE EDITOR

## Heart, Lung and Circulation 2011;20:483484

and its associated cardiovascular apparatus to enhance the depiction of myocardial metabolic maps and predict disease location and geometry. Examples include its use in radionuclide myocardial perfusion imaging (rMPI), uorodeoxyglucose positron emission tomography (FDGPET), iodine-123 meta-iodobenzylguanidine (123 I-MIBG) scintigraphy, single photon emission computed tomography (SPECT), positron emission tomography (PET) with novel tracers, computed tomography (CT), magnetic resonance imaging (MRI), cardiac nuclear magnetic resonance (NMR) and ground-breaking imaging modalites yet to be developed. Applying the Fibonacci series to our current understanding of coronary development can therefore increase our comprehension of the mechanisms of coronary vascular branching and may also contribute to the development of new techniques of cardiac arterial imaging.

Hutan Ashraan, MRCS Thanos Athanasiou, FETCS The Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM-Building, Praed Street, London W2 1NY, UK Corresponding author. Tel.: +44 0 20 33127651; fax: +44 0 20 3312 6309. E-mail address: h.ashraan@imperial.ac.uk (H. Ashraan) Available online 13 April 2011

References
[1] Mitchison GJ. Phyllotaxis and the Fibonacci Series. Science 1977;196:2705. [2] Gibson CM, Gibson WJ, Murphy SA, Marble SJ, McCabe CH, Turakhia MP, et al. Association of the Fibonacci Cascade with the distribution of coronary artery lesions responsible for ST-segment elevation myocardial infarction. Am J Cardiol 2003;92:5957. [3] Throff JW, Hort W, Lichti H. Diameter of coronary arteries in 36 species of mammalian from mouse to giraffe. Basic Res Cardiol 1984;79:199206.

Financial disclosure
None.