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2009 PDR GUIDE TO DRUG INTERACTIONS,

SIDE EFFECTS AND INDICATIONS FOR TINNITUS


As listed in the 2009 Physicians Desk Reference Companion Guide
When taken at recommended dosages, the following prescription and over-the-counter drugs have caused tinnitus in a small percentage
of patients. Note: These drugs were not specifically tested on people who already had tinnitus. More information about these
listed drugs can be found in the 2009 Physicians Desk Reference (PDR). PDR page numbers follow the drug names on this list.

A
Abelcet Injection...
Accutane Capsules......
Aceon Tablets (2 mg, 4 mg, 8 mg) (1.5%)..
Actiq (1% or greater).......
Aggrenox Capsules (less than 1%)....
cAgrylin Capsules (1% - 5%)...
Alferon N Injection (one patient)..
Aloxi Injection (less than 1%).
Ambien Tablets (infrequent)...
Ambien CR Tablets (infrequent to 1%).
Amerge Tablets (infrequent).....
cAnaprox Tablets (3% - 9%)......
cAnaprox DS Tablets (3% - 9%)...
Anzemet Injection (infrequently)..
Anzemet Tablets (infrequently)....
Aricept Tablets (infrequent)....
Aricept ODT Tablets (infrequent)..
Asacol Delayed-Release Tablets...
Atacand HCT (0.5% or greater).
Atripla Tablets.
Atrovent Nasal Spray 0.06% (less than 1%) .....
Avelox (less than 0.1%)
Axert Tablets (rare).....
B
Bayer Aspirin ..
Biaxin/Biaxin XL..
Bicillin C-R Injectable Suspension
Bicillin L-A Injection .
C
Campral Tablets (infrequent)..
Capastat Sulfate for Injection..
Carbatrol Capsules.....
Cardene I.V. (rare) ...
Cardizem LA Extended Release
Tablets (less than 2%)
Celebrex Capsules (0.1% - 1.9%).....
Celexa (infrequent).......
cCellCept Capsules (3% to less than 20%).
cCellCept Intravenous (3% to less than 20%)
cCellCept Oral Suspension (3% to less than 20%).
cCellCept Tablets (3% to less than 20%).
Chantix Tablets (infrequent)..
Cialis Tablets (less than 2%)
Cipro I.V. (1% or less).....
Cipro (less than 1%) .
Cipro XR Tablets .....
Clinoril Tablets (greater than 1%).....
Combigan Ophthalmic Solution
Copaxone for Injection (at least 2%)
Coreg Tablets (greater than 0.1% - 1%)......
Coreg CR Extended-Release Capsules
(0.1% to less than or equal to 1%) ..
Cosopt Sterile Ophthalmic Solution....
Cozaar Tablets (less than 1%) ...
Cubicin......
Cuprimine Capsules .
Cymbalta Delayed-Release Capsules (Infrequent)..

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819
3017
1726
1059
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2632
2632
2701
2704
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2579
642
938
836
2803
2431
750
411
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1777
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1791
3019
1093
421
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2622
2622
2511
1792
2817
2810
2823
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553
3110
1387
1393
1969
1973
995
1986
1801

D
Dapsone Tablets USP...
Demadex Injection.........
Demadex Tablets ..
cDepakote ER Tablets (greater than 1% - 7%).
Diovan HCT Tablets (greater than 0.2%)...
Doxil Injection (less than 1%).....
E
cEC-Naprosyn Delayed-Release Tablets (3%-9%)
Edecrin..
Effexor XR Extended-Release Tablets (frequent)..
Eldepryl Capsules....
Elmiron Capsules (less than or equal to 1%)...
cEmend Capsules (3.7%)....
cEmend for Injection (3.7%) .
Emsam Transdermal System (frequent).
Engerix-B Vaccine...
Equerto Extented-Release Capsules..
Evoxac Capsules (less than 1%).
Exelon Capsules (frequent).
Exelon Oral Solution (frequent)
Exelon Patch (infrequent)..
Exforge Tablets
(greater than 0.1% but less than 1%) .

1746
2630
2630
423
2216
2378
2632
698
3195
3052
2435
1992
1999
905
1409
3174
1013
2229
2233
2233
2238

F
cFabrazyme for Intravenous Infusion (8%) .
Fansidar Tablets
Flumadine (0.3 to 1%) .
Frova Tablest (frequent)
Furosemide Tablets

1241
2636
1167
1111
2186

G
Gabitril Tablets (frequent)...
Gantrisin Pediatric Suspension.
Gengraf Capsules (1% to less than 3%)
Geodon Capsules (infrequent)....
Gleevec Tablets (infrequent)...

973
2638
435
2520
2255

I
Imitrex Nasal Spray .
Indocin (greater 1%)..
cIntron A for Injection (less than 5%)

1470
2024
2859

K
Kaletra (less than 2%).

452

L
Lamictal (1.1%).
Levaquin.
Levaquin in 5% Dextrose Injection
Levitra Tablets (less than 2%)
Lexapro Oral Suspension (frequent)
Lexapro Tablets (frequent)
Lidoderm Patch
Lipitor Tablets (less than 2%)
Lunesta Tablets (infrequent).
Lyrica Capsules (greater than or equal to 1%)

1488
2416
2416
2876
1174
1174
1114
2501
2994
2527

M
Marinol Capsules (less than 1%)..
Maxalt Tablets (infrequent).
Maxalt-MLT Oral Disintegrating Tablets (infrequent)
Meridia Capsules
Miacalcin Nasal Spray (less than 1%)..
Micardis Tablets (more than 0.3%)......
Micardis HCT Tablets.....
Mirapex Tablets (greater than or equal to 1%)..
Mobic Oral Suspension (less than 2%)
Mobic Tablets (less than 2%)......
Mustargen for Injection (infrequent)....

3163
2056
2056
475
2274
852
854
857
863
863
2492

N
Nadolol Tablets (1 to 5 of 1000 patients) ..
cNalfon Capsules (4.5%)......
Namenda (infrequent)......
cNaprosyn Suspension (3% to 9%) ..
cNaprosyn Tablets (3% to 9%).
Neoral Oral Solution (1% to less than 3%) .
Neoral Soft Geletin Capsules (1% to less than 3%).
Neupro Transdermal System ..
Nexavar Tablets (uncommon) .
Nexium Delayed-Release Capsules (less than 1%)
Nexium I.V. (less than 1%)
Nexium Delayed-Release Oral Suspension (less than 1%)
Noroxin Tablets..
Norvir (less than 2%) .

2192
2508
1180
2632
2632
2280
2280
3149
784
645
652
645
2069
489

O
Orthoclone OKT3 Sterile Solution ....
OxyContin Tablets (less than 1%) .

2387
2589

P
Parnate Tablets...
Paxil (frequent)
Paxil CR Controlled-Release Tablets (frequent).
Pepcid Tablets(infrequent)..
Pepto-Bismol Original Liquid, Maximum Strength Liquid,
Original and Cherry Tablets, Chewable Tablets and
Easy-To Swallow Caplets
Percocet Tablets..
Percodan Tablets.
Pletal Tablets (less than 2%).....
Primaxin I.M. ...........
Primaxin I.V. (less than 0.2%)......
Prinivil Tablets (0.3% to 1.0%).....
Prinzide Tablets (0.3% to 1%) ..........
Pristiq Extended-Release Tablets (1% to 2%)
cPrograf Capsules and Injections (3% to 15%)..
Protonix Delayed-Release Oral Suspension (less than 1%)
Protonix Delayed-Release Tablets (less than 1%)
Protonix I.V. (less than 1%) .....
Proventil HFA Inhalation Aerosol (less than 3%)...
Prozac Weekly Capsules (frequent).
Prozac Pulvules and Liquid (frequent)...
Pylera Capsules..

(Continued on next page)

Please consult with your physician before making any changes in medication.
AMERICAN TINNITUS ASSOCIATION
P.O. Box 5 Portland, OR 97207-0005 503-248-9985 800-634-8978
tinnitus@ata.org www.ata.org

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2009 PDR GUIDE TO DRUG INTERACTIONS,


SIDE EFFECTS AND INDICATIONS FOR TINNITUS
As listed in the 2009 Physicians Desk Reference Companion Guide
When taken at recommended dosages, the following prescription and over-the-counter drugs have caused tinnitus in a small percentage
of patients. Note: These drugs were not specifically tested on people who already had tinnitus. More information about these
listed drugs can be found in the 2009 Physicians Desk Reference (PDR). PDR page numbers follow the drug names on this list.

R
Recombivax HB (less than 1%)..
Requip Tablets (infrequent)....
Romazicon Injection (less than 1%)
Rythmol Tablets (less than 1% to 2%)
Rythmol SR Capsules .....
S
St. Joseph 81 mg Aspirin Chewable and
Enteric Coated Tablets ...
Salagen Tablets (1% to 2%)
Sandimmune (2% or less) ...
Solodyn Extended Release Tablets (2%) .
cSoriatane Capsules (less than 1% to 10%).........
Sular Extended-Release Tablets
(less than or equal or 1%).
Sustiva Capsules (less than 2%)...
Sustiva Tablets (less than 2%) .
Symbyax Capsules (frequent)....

2107
1561
2646
1586
1590

1903
1082
2296
1938
3062
2975
930
930
1871

T
Tarka Tablets (less frequent)..
Teveten Tablets (less than 1%)...
Teveten HCT Tablets (less than 1%) ..
Timoptic Sterile Ophthalmic Solution
Timoptic in Ocudose
Timoptic-XE Sterile Ophthalmic
Gel Forming Solution..
Toprol-XL Tablets.......
Treximet Tablets.
Tricor Tablets .
cTrisenox Injection (5%).
Twinrix Vaccine..

511
515
517
2121
2124
2125
666
1616
520
986
1628

U
Ultram ER Extended-Release Tablets
(1% to greater than 5%).

2428

V
Venlaflaxine Hydrochloride Tablets (2%).
Vicoprofen Tablets (less than 3%)......
cVoltaren Tablets (1% to 10%)......
cVoltaren-XR Tablets (1% to 10%)....

2199
533
2334
2337

W
Wellbutrin Tablets.......
cWellbutrin SR Sustained-Release Tablets
(5% to 6%)
cWellbutrin XL Extended-Release Tablets
(3% to 6%).....
X
Xifaxan Tablets (less than 2%) .
cXyrem Oral Solution (5.9%)..
Z
Zomig Tablets (infrequent)
Zomig Nasal Spray (infrequent)..
Zomig-ZMT Tablets .......
Zonegran Capsules (frequent)...
Zosyn for Injection (1% or less)......
Zyban Sustained-Release Tablets (1%).....
Zyprexa Tablets (infrequent)..
Zyprexa ZYDIS Orally Disintegrating Tablets
(infrequent) .
Zyrtec Chewable Tablets (less than 2%)..
Zyrtec Syrup (less than 2%).
Zyrtec Tablets (less than 2%)...
Zyrtec-D 12 Hour Extended Relief Tablets
(less than 2%) .....

Please consult with your physician before making any changes in medication.
( Described in PDR for Nonprescription Drugs)

(Incidence data in parenthesis : c 3% or more)

AMERICAN TINNITUS ASSOCIATION


P.O. Box 5 Portland, OR 97207-0005 503-248-9985 800-634-8978
tinnitus@ata.org www.ata.org

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