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http://journals.tums.ac.ir/abs.aspx? org_id=59&culture_var=en&journal_id=9&issue_id=61 &manuscript_id=5!

""&segmen t=#a Tehran University Medical Journal (TUMJ)$%&&&'5"( )$:$6*+69$$$ [ Application of Apium Graveolens in treatment of hypertension ] ,-rticle$in$.ersian/
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Abstract: -pium$graveolence$has$an$small$bro6n$ol7ptical$seed$6ith$pharmacological$activit7.$8o$ evaluate$it9s$application$in$treatment$o#$h7pertension2$ *$h7pertensive$patients$(%&$ #emale2$1*$male)$6ith$the$age$range$o#$!5+65$6ere$given$6$grams$o#$po6der$o#$-pium$ graveolence$seed$and$then$the$blood$pressures$be#ore$and$a#ter$the$remed7$6ere$ compared.$:e#ore$treatment2$the$mean$s7stolic$blood$pressure$6as$1*1. 5$ml;g$and$the$ mean$diastolic$blood$pressure$6as$9!$ml;g.$-#ter$the7$became$15!. $ml;g$and$"9.6$ ml;g$respectivel7.$8he$di##erence$o#$blood$pressure$be#ore$and$a#ter$treatment$6as$ statisticall7$signi#icant$(.<&.&5)2$so$6e$concluded$that$-pium$graveolence$seed$can$be$ used$as$is$a$sa#e$and$e##ective$treatment$#or$high$blood$pressure.$=urther$controlled$ studies$should$be$done$to$compare$it$6ith$available$anti+h7pertensive$drugs.

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Triterpenoids and (lavonoids from )elery (Apium graveolens)


@ >ailan$?hou@2$=eng$?haoA2$?hihui$Biu@2$Culei$?huang@2$Bixia$Dhen@$and$=eng$EiuF $$$ Gepartment$o#$Hatural$.roducts$Dhemistr72$3chool$o#$8raditional$Dhinese$1ateria$ 1edica2$3hen7ang$.harmaceutical$Iniversit72$3hen7ang$11&&162$.eopleJs$5epublic$o#$ Dhina2$and$3chool$o#$.harmac72$Cantai$Iniversit72$Baishan$Gistrict2$Cantai$%6!&&52$ .eopleJs$5epublic$o#$Dhina J. Nat. Prod.2$%&&92$*%$(9)2$pp$156 K156* *+,: 1&.1&%1/np9&&11*v .ublication$Gate$(Leb):$-ugust$ 12$%&&9 Dop7right$M$%&&9$8he$-merican$Dhemical$3ociet7$and$-merican$3ociet7$o#$ .harmacognos7

3hen7ang$.harmaceutical$Iniversit7. Cantai$Iniversit7.

2$ F$Dorresponding$author.$8el:$N"6$%!$% 9"6!6 .$=ax:$N"6$%!$% 99 99!.$O+mail:$ #engPiu%&&&Qtom.com.

Abstract
8hree$ne6$triterpenoids2$112%1+dioxo+%R2 R215S+trih7drox7urs+1%+ene+%+O+R+d+ glucop7ranoside$(#)2$112%1+dioxo+ R215S2%!+trih7drox7urs+1%+ene+%!+O+R+d+ glucop7ranoside$(%)2$and$112%1+dioxo+ R215S,%!+trih7drox7olean+1%+ene+%!+O+R+d+ glucop7ranoside$(-)2$and$t6o$ne6$#lavonoids2$apigenin+*+O+,%TT+O+(5TTT+ O+#erulo7l)+R+d+ apio#uranos7l/+R+d+glucop7ranoside$(.)$and$chr7soeriol+*+O+,%TT+O+(5TTT+ O+#erulo7l)+R+d+ apio#uranos7l/+R+d+glucop7ranoside$(/)2$6ere$isolated$#rom$the$6hole$plant$o#$#resh$ celer7$(Apium graveolens)2$together$6ith$1&$4no6n$#lavonoids.$8he$structures$o#$the$ne6$ compounds$6ere$elucidated$b7$anal7sis$o#$spectroscopic$data.$8he$inhibitor7$e##ects$o#$ the$compounds$isolated$on$nitric$oxide$production$in$lipopol7saccaride+activated$ macrophages$6ere$evaluated.