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Acute bronchitis
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Acute Bronchitis
Classification and external resources

This image shows the consequences of acute bronchitis.

ICD-10

J20-J21

ICD-9

466

MedlinePlus

001087

eMedicine

article/297108

MeSH

D001991

Acute bronchitis or chest cold is an inflammation of the large bronchi(medium-size airways) in the lungs that is usually caused by viruses or bacteriaand may last several days or weeks.[1] Characteristic symptoms include cough,sputum (phlegm) production, and shortness of breath and wheezing related to the obstruction of the inflamed airways. Diagnosis is by clinical examination and sometimes microbiological examination of the phlegm. Treatment for acute

bronchitis is typically symptomatic. As viruses cause most cases of acute bronchitis, antibiotics should not be used unless microscopic examination ofgram-stained sputum reveals large numbers of bacteria.
Contents [hide] 1 Signs and symptoms 2 Cause 3 Diagnosis 4 Prevention 5 Treatment o o o 5.1 Antibiotics 5.2 Smoking cessation 5.3 Antihistamines

6 Prognosis 7 References 8 External links

Signs and symptoms[edit]

Bronchitis may be indicated by an expectorating cough, shortness of breath (dyspnea), and wheezing. On occasion, chest pains, fever, and fatigue or malaise may also occur. In addition, bronchitis caused by Adenoviridae may cause systemic and gastrointestinal symptoms as well. However, the coughs due to bronchitis can continue for up to three weeks or more even after all other symptoms have subsided.

Cause[edit]
Acute bronchitis can be caused by contagious pathogens, most commonly viruses. Typical viruses include respiratory syncytial virus, rhinovirus, influenza, and others. Bacteria are uncommon pathogens but may include Mycoplasma pneumoniae, Chlamydophila pneumoniae, Bordetella pertussis, Streptococcus pneumoniae, and Haemophilus influenzae.[citation needed]

Damage caused by irritation of the airways leads to inflammation and leads to neutrophils infiltrating the lung tissue.

Mucosal hypersecretion is promoted by a substance released by neutrophils.

Further obstruction to the airways is caused by more goblet cells in the small airways. This is typical of chronic bronchitis.

Although infection is not the reason or cause of chronic bronchitis, it is seen to aid in sustaining the bronchitis.

Diagnosis[edit]
A physical examination will often reveal decreased intensity of breath sounds, wheezing, rhonchi, and prolonged expiration. Most physicians rely on the presence of a persistent dry or wet cough as evidence of bronchitis. A variety of tests may be performed in patients presenting with cough and shortness of breath:

A chest X-ray that reveals hyperinflation; collapse and consolidation of lung areas would support a diagnosis ofpneumonia. Some conditions that predispose to bronchitis may be indicated by chest radiography.

A sputum sample showing neutrophil granulocytes (inflammatory white blood cells) and culture showing that has pathogenic microorganisms such as Streptococcus species

A blood test would indicate inflammation (as indicated by a raised white blood cell count and elevated C-reactive protein).

Prevention[edit]
In 1985, University of Newcastle, Australia Professor Robert Clancy developed an oral vaccine for Haemophilus influenza. This vaccine was commercialised four years later.[2]

Treatment[edit]
Antibiotics[edit]
Only about 5-10% of bronchitis cases are caused by a bacterial infection. Most cases of bronchitis are caused by a viral infection and are self-limited and resolve themselves in a few weeks. Acute bronchitis should not be treated with antibiotics unless microscopic examination of the sputum reveals large numbers of bacteria. Treating non-bacterial illnesses with antibiotics leads to the promotion of antibiotic-resistant bacteria, which increase morbidity and mortality.[3]

Smoking cessation[edit]
For more details on this topic, see Smoking cessation. Many physicians recommend that, to help the bronchial tree heal faster and not make bronchitis worse, smokers should quit smoking completely in order to allow their lungs to recover from the layer of tar that builds up over time.

Antihistamines[edit]
An effect of antihistamines is to thicken mucus secretions. Expelling infected mucus via coughing can be beneficial in recovering from bronchitis. Expulsion of the mucus may be hindered if it is thickened. Antihistamines can help bacteria to persist[4] and multiply in the lungs by increasing its residence time in a warm, moist environment of thickened mucus.

Prognosis[edit]
Acute bronchitis usually lasts a few days or weeks.[5] It may accompany or closely follow a cold or the flu, or may occur on its own. Bronchitis usually begins with a dry cough, including waking the

sufferer at night. After a few days, it progresses to a wetter or productive cough, which may be accompanied by fever, fatigue, and headache. The fever, fatigue, and malaise may last only a few days; but the wet cough may last up to several weeks. Should the cough last longer than a month, some physicians may issue a referral to an otorhinolaryngologist (ear, nose and throat doctor) to see if a condition other than bronchitis is causing the irritation. It is possible that having irritated bronchial tubes for as long as a few months may inspire asthmatic conditions in some patients. In addition, if one starts coughing mucus tinged with blood, one should see a physician. In rare cases, physicians may conduct tests to see whether the cause of the bloody sputum is a serious condition such as tuberculosis or lung cancer.

References[edit]
1. Jump up^ Wenzel RP, Fowler AA (2006). "Clinical practice. Acute bronchitis". N. Engl. J. Med. 355 (20): 2125 30.doi:10.1056/NEJMcp061493. PMID 17108344. 2. Jump up^ Clancy RL, Cripps AW, Gebski V (Apr 1990). "Protection against recurrent acute bronchitis after oral immunization with killed Haemophilus influenzae". Med J Aust. 152 (8): 4136. PMID 2184330. 3. Jump up^ Hueston WJ (March 1997). "Antibiotics: neither cost effective nor 'cough' effective". The Journal of Family Practice 44 (3): 2615. PMID 9071245. 4. Jump up^ Metz M, Doyle E, Bindslev-Jensen C, Watanabe T, Zuberbier T, Maurer M. (2011). "Effects of Antihistamines on Innate Immune Responses to Severe Bacterial Infection in Mice". Int Arch Allergy Immunol 155 (4): 355 60. doi:10.1159/000321614.PMID 21346365. 5. Jump up^ Bronchitis. Mayo Foundation for Medical Education and Research. 2007-04-20. Retrieved 2008-05-30.

External links[edit]
Wikisource has the text of the1911 Encyclopdia Britannica article Bronchitis.

Acute Bronchitis FamilyDoctor.org (American Academy of Family Physicians)

MedlinePlus entry on acute bronchitis

[show]

V T E

Pathology of respiratory system (J, 460519), respiratory diseases

[show]

V T E

Common cold Categories:

Inflammations Acute lower respiratory infections General practice Bronchus disorders

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