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33
Appendix 2 Example of detailed National Theoretical
Maximum Daily Intake (NTMDI)
calculation for tebufenozide
National Theoretical Maximum Daily Intake (NTMDI)
Pesticide Code 196
Name Tebufenozide
ADI = 0.02 mg/kg bodyweight or 1.1 mg/person (55 kg)
National
Commodity MRL Note Diet NTMDI
Code Name mg/kg g/day mg/day
FB 269 Grapes 0.5 18.00 0.0090
CM 649 Rice, Husked 0.1 12.00 0.0012
FP 9 Pome fruits 1 45.00 0.0450
VR 589 Potato 0.5 1/ 240.00 0.1200
TN 678 Walnuts 0.05 1.00 0.0001
TOTAL = 0.18
% ADI = 16%
1/ National maximum limit (Rounded) % ADI = 20%
These guidelines describe procedures that can be used by national anthorities to predict the
dietary intake of pesticide residues and thus reach conclusions concerning the acceptability of
Codex Maximun Residue Limits from a public health point of view. Prepared in collaboration
with the Codex Committee on Pesticide Residues, the guidelines respond to the need for a
method of reaching reasonnable assurance that the intakes of pesticide residues for different
populations do not exceed safety limits.
The book opens with background information on methods used to establish daily intake and
maximum residue limits for pesticides. Methods for predicting the dietary intake of pesticide
residues are then introduced in terms of general considerations, indices of residue levels, and
indices of food consumption, including those appropriate for use in p[redicting intake at inter-
national and national levels.
Now in its second edition, the book reflects several improvements in methods for estimating levels
of residues in food. Readers are given details for calculating intake levels using theoretical maxi-
mum daily intake, and estimated daily intake. To illustrate the use of these guidelines, the book
features sample calculations of theoretical maximum daily intake, and international estimated daily
intake values as well as estimates of exposure performed at the national level. The book con-
cludes with a glossary of key terms and a series of notes on the correct use of the guidelines
Sw.fr. 12./US $10.80
In developing countries: Sw.fr. 8.40
Order no. 1930106