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Systemic Inflammatory Response

Syndrome(SIRS) Prognosis

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Phase Angle a Prognostic Factor for Survival in SIRS

Systemic Inflammatory Response Syndrome


(SIRS) is an inflammatory state affecting the
whole body, frequently in response to infection.

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Phase Angle a Prognostic Factor for Survival in SIRS

SIRS is nonspecific and not always related to


infection. It is related to Sepsis,a condition in
which individuals both meet criteria for SIRS and
have a known or highly suspected infection.

INFECTION SEPSIS SIRS

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Phase Angle a Prognostic Factor for Survival in SIRS

SIRS is defined as 2 or more of the following


variables:
Fever of more than 38°C or less than 36°C
Heart rate of more than 90 beats per minute
Respiratory rate of more than 20 breaths per
minute or a PaCO2 level of less than 32 mm Hg
Abnormal white blood cell count (>12,000/µL or
<4,000/µL or >10% bands)

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Phase Angle a Prognostic Factor for Survival in SIRS

Burns

Trauma
Infection

Irradiation SIRS
??
Pancreatitis

Bacteraemia

SIRS is one of several conditions related to


systemic inflammation, organ dysfunction, and
organ failure.

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Phase Angle a Prognostic Factor for Survival in SIRS

Platelets Endothelial
cells

Complement
Leucocytes

Plasmatic
hemocoagulation
system

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Phase Angle a Prognostic Factor for Survival in SIRS

Causes:
The causes of SIRS are broadly classified as
infectious or noninfectious.
When SIRS is due to an infection, it is
considered sepsis.

Noninfectious causes of SIRS include trauma,


burns, pancreatitis, ischemia and
haemorrhage.

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Phase Angle a Prognostic Factor for Survival in SIRS

Septic shock is severe sepsis with hypo tension


(systolic BP < 90mmHg) despite adequate fluid
resuscitation or the requirement for
vasopressors/inotropes to maintain blood
pressure.

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Phase Angle a Prognostic Factor for Survival in SIRS

Here is an excerpt of the clinical observation


study from 23rd International Symposium on
Intensive Care and Emergency Medicine.
It was concluded from the study that phase
Angle acts as a predictor for survival in patients
with SIRS.

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Phase Angle a Prognostic Factor for Survival in SIRS

PrognostiCheck® for prognosis based upon a


noninvasive diagnostic test measures the
resistance,reactance and phase angle (in
degrees).A low phase angle has been associated
with an altered cellular membrane function.

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Phase Angle a Prognostic Factor for Survival in SIRS

Tests were conducted on 30 consecutive


patients( 11 female, 19 male ,median age of 67
[ 16.5 ] years ) after admitting them to the
intensive care unit ,all of whom met 2 or more
SIRS Criteria.

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Phase Angle a Prognostic Factor for Survival in SIRS

In Septic shock patients,a phase angle of less


than 4 degree has been reported to be
associated with increases mortality.

Severity of the illness was characterized


according to APACHE II(Acute Physiology and
Chronis Health Evaluation)

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Phase Angle a Prognostic Factor for Survival in SIRS

Non-invasive impedance analysis was performed


using a tetra-polar hand-to-foot measuring device
and derived phase angle was calculated as arc
tan (reactance/resistance).

increasing
Reactance ( )

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Phase Angle a Prognostic Factor for Survival in SIRS

All measurements were performed in the


supine position of the patient with special care.
After 28 days, out of the 30 patients
investigated, 10 had died and 20 survived.

In seven out of 20 survivors,a phase angle of


more than 4 degree was measured on the first
day study,whereas in all patients who died,the
phase angle was less than 4 degree (P=0.038)

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Phase Angle a Prognostic Factor for Survival in SIRS

The conclusion was that an initial phase angle


of more than 4 degree may be correlated with
survival,in patients suffering with SIRS.

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PrognostiCheck
R

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partnerships please contact below.

By IPGDx, LLC
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michaealsinger@ipgdx.com
jdkutzko@ipgdx.com