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CURRICULUM VITAE

NAME: Victor P. Fomin

THE U.S. STATUS: American citizen

OFFICE ADDRESS: V.P. Fomin, Ph.D.


Department of Biological Sciences
University of Delaware
206 Wolf Hall, Newark
Delaware, 19716, USA
Phone (302) 831-6094; Fax:(302) 831-2884
E-mail: vfomin@udel.edu

EDUCATION:

Ph.D., Biochemistry (1980) the A.V. Palladin Institute of Biochemistry


Kiev, UKRAINE

B..S., Biophysics (1974) Kiev State University


Kiev, UKRAINE

TEACHING EXPERIENCE:
.
BISC276 - “Human Physiology” - the course for undergraduate students at University of
Delaware. Spring 2008 (Enrollment – 57).

BISC276 - “Human Physiology” - the course for undergraduate students at University of


Delaware. Fall 2008 (Enrollment – 186).

Upward Bound Math and Science Program at Delaware Technical and Community College
(summer 2008) – teaching chemistry and biochemistry for high school students. (Enrollment –
18).

BIO208 - “Human Anatomy and Physiology” - the course at Cecil College ( North East,
Maryland). Fall 2009( Enrollment – 25).

INVITED LECTURER:

“Introduction to Pharmacology and Toxicology II” (section on "Regulation of muscle


contractility") - the course for the graduate students at Indiana University School of
Medicine ( Professor H.R. Besch) Winter 2000 (Enrollment – 20).

BISC605 - “Advanced Mammalian Physiology” (the reproductive physiology section) – the


course for the graduate students at University of Delaware (Professor R.L.Duncan)
( Fall 2006 and 2007) Enrollment – 30 and 31, respectively).
BISC276 - “Human Physiology” - the course for undergraduate students at University of
Delaware. ( Professor B. Butler) , Winter 2009 (Enrollment – 31).

BISC 675 - “Cardiovascular Physiology” (the smooth muscle physiology and hypertension
section) - the course for graduate students at University of Delaware (Professor U. Naik),
(Fall 2009) . (Enrollment – 20).

STUDENTS MENTORED:

Students Name Level Project title


1. Ram Vanam undergrad Role of PKCalpha in human uterine contraction (2003-4).
2.Akira Morimiya undergrad Effect of MgSO4 on uterine Ca/ contractile activity(2003).
3. Amy Servas undergrad PKC effect on myometrial contraction (2006).
4. Andrew Matamoros undergrad Analysis of Ca-contraction relationship in uterine muscle
(2007).
5. Patricia Timothee undergrad Role of PKC in osteoblasts cytoskeleton ( 1st place at
University of Maryland Baltimore County
Undergraduate Research Symposium –October 2008).

AREAS OF RESEARCH EXPERTISE:

• membrane biochemistry and biophysics; mechanisms of smooth muscle contractility; cellular


calcium homeostasis in smooth muscle and bone tissue, signal transduction, intracellular imaging,
mammalian cells culture, Western blotting, PCR, genotyping.

PROFESSIONAL EXPERIENCE:

Research Specialist September 2009 - present


University of Delaware, Newark, Delaware

Responsibilities: Designing, planning and performing scientific experiments relevant to the research
projects performed. The data analysis, writing scientific papers, grant proposals, making presentations at
national and international meetings. Mentoring undergraduate students research projects.

Adjunct Professor September 2009 - present


Cecil College, North East, Maryland
Responsibilities: Teaching human anatomy and physiology (BIO208) course, advising students during
the course.

Research Assistant Professor August 2005 –September 2009


University of Delaware, Newark, Delaware

Responsibilities: Designing, planning and performing scientific experiments relevant to the research
projects performed. The data analysis, writing scientific papers, grant proposals, making presentations at
national and international meetings. Teaching a research technician and students experimental assays
employed in the laboratory. Mentoring undergraduate students research projects. Teaching a human
physiology course to undergraduate students at University of Delaware.

Accomplishments: Determined the mechanisms of protein kinase C alpha in regulation of uterine muscle
contraction. Gathered data on the role of protein kinase C in growth of bone cells. Presented the data at
five scientific meetings. Published in collaborations 4 papers in peer-reviewed journals.

Assistant Scientist/Assistant Professor May 1997 – July 2005


Indiana University School of Medicine, Indianapolis, Indiana

Responsibilities: Designing, planning and performing scientific experiments relevant to the research
projects performed. The data analysis, writing scientific papers, grant proposals, making presentations at
national and international meetings. Teaching a research technician and undergraduate students
experimental assays employed in the laboratory. Teaching a course on regulation of muscle contractility
to pharmacology students at the Indiana University Medical School.

Accomplishments: Was instrumental in obtaining NIH RO1 Grant on “Cellular Mechanisms of MgSO 4 in
Human Uterus”. Obtained the American Cancer Society Grant and the Lilly Centre for Women's Health
Grant to study human uterine leiomyomas. Gathered data on the effect of MgSO 4 on human pregnant
uterus, and the role of protein kinase C in human uterus. R03 grant on “The Role of Protein Kinase C
Isoforms in Human Uterus” was funded. Presented his data at various scientific meetings. Published in
collaborations 5 papers in peer-reviewed journals.

Assistant Scientist 1995 – May 1997


Indiana University School of Medicine Indianapolis, Indiana

Responsibilities: Designing, planning and performing scientific experiments relevant to the research
projects performed. The data analysis, writing scientific papers, grant proposals, making presentations at
national and international meetings. Teaching a research technician experimental assays and methods
employed in the laboratory.

Accomplishments: Received the Indiana University Biomedical Research Grant to study effect of cocaine
on human pregnant uterus. Obtained the data on the cellular mechanisms of cocaine effect on human
uterine muscle. Presented the findings at the scientific meetings.

Postdoctoral Fellow 1993 – 1995


University of Texas Southwestern Medical Center, Dallas, Texas

Responsibilities: Learning new techniques and employing them in the laboratory. Designing, planning
and performing scientific experiments relevant to the research projects. Working closely with a scientific
mentor and other members of the laboratory.

Accomplishments: Gathered the data on the role of steroid hormones (progesterone) in regulation of
cellular calcium homeostasis in human uterus. Made an oral presentation on the role of the progesterone
in the uterine calcium regulation at the Meeting of the Society for Gynecological Investigation.
Visiting Scientist 1991 - 1992
Department of Biomedical Sciences McMaster University Hamilton, Canada

Responsibilities: Learning new methods and employing them in the laboratory. Designing, planning and
conducting scientific experiments relevant to the research projects. Working closely with a scientific
mentor and other members of the host laboratory.

Accomplishments: Obtained the data on the effect of free radicals on cellular calcium regulation in
vascular smooth muscle. Presented the findings at the Experimental Biology Annual Meeting 1992.
Based on the results obtained 3 experimental papers and 1 review were published.

Senior Researcher 1980 - 1991


Researcher
Junior Researcher
Department of Biochemical Kinetics Institute of Biochemistry, Kiev, Ukraine

Responsibilities: Designing, planning and conducting scientific experiments relevant to the research
projects performed. The data analysis, writing scientific papers, making presentations at national and
international meetings. Supervising a research technician and Ph.D. student.

Accomplishments: Obtained and analyzed the data on the cellular mechanisms of calcium regulation (Ca
channels, Ca pumps) in uterine smooth muscle. Learned and implemented new experimental methods for
measuring intracellular calcium into the arsenal of methods used in the Department of Biochemical
Kinetics. Published 13 papers devoted to different aspects of cellular Ca regulation in smooth muscle.

SELECTED PUBLICATIONS:

1. Fomin VP, Kronbergs A, Gunst S, Tang DT, Simirski V, Hoffman M and Randall Duncan RL.
(2009) Role of Protein Kinase Cα in Regulation of [Ca2+]I and Force in Human Myometrium.
Reproductive Sciences.16 (1):71-79.
2. Shao Y, Czymmek KJ, Akanbi KA, Fomin VP, Jones P, Duncan RL, Farach-Carson MC (2009)
Fluorescence resonance energy transfer (FRET) reveals dynamic interactions between L-type
voltage sensitive calcium channel (VSCC) Cav1.2 (alpha 1C) subunits and ahnak in osteoblastic
cells. Am. J. Physio l .296(5): C1067-78.
3. Fomin VP, Kronbergs A, Feng J, Usatyuk PV, Natarajan V and Duncan RL (2009, In Preparation)
The Role of Protein Kinase C (PKC) in Regulation of Osteoblasts [Ca2+]I Responses to
Mechanical Load. Am J Physiol .
4. Fiske JL, Fomin VP, Brown ML, Duncan RL, Sikes RA.(2006) Voltage-sensitive ion channels
and cancer. Cancer Metastasis Rev (electronic publication- DOI 10.1007/s10555-006-9017-z)
5. Fomin VP, Gibbs SG, Vanam R, Morimiya A and Hurd WW (2006) Effect of magnesium sulfate
on contractile force and intracellular calcium concentration in pregnant human myometrium. Am
J Obstet and Gynecol. 194:1384-90.
6. Bermeo ME, Fomin VP, Ventolini G, Gibbs SG, McKenna DS and Hurd WW. (2003)
Magnesium Sulfate Induces Translocation of Protein Kinase C Isoenzymes Alpha and
Delta in Myometrial Cells from Pregnant Women. Am J Obstet and Gynecol 190(2): 522-7.
7. Usatyuk PV, Fomin VP, Shi S, Garcia JGN, Schaphorst K, and Natarajan V. (2003) Role of Ca 2+
in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function. Am J
Physiol.285:L100-L1017.
8. Hurd WW, Fomin VP, Natarajan V, Singh DM, Brown HL and Bigsby RM (2000) Expression of
protein kinase C isoenzymes in pregnant human myometrial tissue and primary myometrial
cultures. Amer.J Obstetrics and Gynecol.;183:1525-31.
9. Fomin VP, Singh DM, Brown HL, Natarajan V and Hurd WW.(1999) Effect of cocaine on
intracellular calcium regulation in myometrium from pregnant women. J.of the Society for
Gynecologic Investigation,6:147-52.
10. Fomin VP, Cox BE and Word RA. (1999) Effect of progesterone on intracellular Ca2+
homeostasis in human myometrial smooth muscle cells. Am.J.Physiol .276(45): C379-C385.
11. Hurd WW, Betz AL, Dombrowski MP and Fomin VP.(1998) Cocaine Augments Contractility of
the Pregnant Human Uterus by Both Adrenergic and Non-adrenergic Mechanisms. Amer.J.
Obstet.Gynecol. 178:1077-81.
12. Grover AK, Samson SE, Fomin VP, and Werstiuk ES (1995) Eftects of peroxide and superoxide
on coronary artery: angiotensin II response and sarcoplasmic reticulum Ca 2+ pump. Am. J.
Physiol.269(38): C546-C553.
13. Kosterin SA, Burdyga ThV, Fomin VP, and Grover AK (1994) Mechanisms of Ca2+ transport in
myometrium. In: Control of Uterine Contractility, ed. by RE Garfield, CRC Press, Boca Raton,
p.129-159.
14. Grover AK, Fomin VP, and Samson SE (1994) Angiotensin II contractions in coronary artery:
nature of receptors and calcium pools. Molecular and Cellular Biochemistry, 135:11-19.
15. Khan I, Tabb T, Garfield RE, Jones LW, Fomin VP, Samson SE, and Grover AK (1993)
Expression of the internal calcium pump in pregnant rat uterus. Cell Calcium, 14:111-117.
16. Grover AK, Samson SE, and Fomin VP (1992) Peroxide inactivates calcium pumps in pig
coronary artery. Am J Physiol 263(32):H537-H543.
17. Fomin VP, Shinlova OP, Burdyga ThV, and Kosterin SA (1991) Effects of sodium gradient on
the cytosolic free Ca2+ and contractility of the rat pregnant myometrium smooth muscle. General
Physiology and Biophysics, 10:217-221.

AWARDS and DISTINCTIONS:


• Medical Research Council of Canada Visiting Scientist Award for 1991-92

MEMBERSHIPS:
• Member of American Physiological Society since 1998.

GRANT SUPPORT:
• National Institute of Health R03/R55 Grant – Principal Investigator, (2004-2006).
• Eli Lilly Centre for Women’s Health Grant – Principal Investigator, (2002).
• National Institute of Health R01 Grant - Co-Investigator, (1998-2001).
• American Association for Cancer Research Indiana University Institutional Grant -Principal
Investigator, (2000).
• Indiana University Biomedical Research Grant Award- Principal Investigator (1997).

INVITED LECTURES:
1. Protein kinases in regulation of uterine contraction. September 2007. A.I. DuPont Children
Hospital Research Seminars Series. Wilmington, Delaware.
2. Protein kinase C and its role in regulation of uterine smooth muscle contraction ( invited lecture
at Myometrium Symposium during Society for Gynecologic Investigation Meeting). March
2007. Reno, Nevada.
3. Protein kinases in human uterine contractility. October 2006. Christiana Health Care,
Newark, Delaware (popularized lecture for the OB/GYN nurses and the staff).
4. The role of kinases in the regulation of human myometrial contractility. August 2006. Duke
University, Durham, North Carolina.
5. On the mechanisms of PKC regulation of human uterine contraction. July 2006. Colorado State
University. Fort Collins, Colorado.
6. Protein kinase C in human uterine contractility. February 2006. Christiana Health Care, Newark,
Delaware.
7. Role of protein kinase C in regulation of human uterine contraction. November 2005. University
of Vermont, Burlington, Vermont.
8. Phospholipid signaling in regulation of uterine contractility. June 2003 . University of
Liverpool, Liverpool, UK.
9. Protein kinase C isoforms as modulators of uterine contraction. April 2003. Wright State
Universtity, Dayton, Ohio.
10. Role of protein kinase C in regulation of uterine contractility. April 2003. Ferring
Research, San Diego, California.

REVIEWING:
• Grant reviewer for U.K. Medical Research Council.
• Ad hoc reviewer for Am Journal of Obstetrics and Gynecology,
• Journal of the Society for Gynecological Investigation, and Biology of Reproduction.

LANGUAGE SKILLS:
• English
• Russian
• Ukrainian