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5/22/2014 L-Tryptophan reagent grade, 98% (HPLC) | Sigma-Aldrich

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T0254 SIGMA-ALDRICH
L-Tryptophan
reagent grade, 98%(HPLC)
Synonym: (S)-2-Amino-3-(3-indolyl)propionic acid, L--Amino-3-indolepropionic acid
CAS Number 73-22-3 Empirical Formula (Hill Notation) C
11
H
12
N
2
O
2
Molecular Weight 204.23
Beilstein Registry Number 86197 EC Number 200-795-6 MDL number MFCD00064340
PubChem Substance ID 24278135
POPULAR DOCUMENTS: SPECIFICATION SHEET (PDF)

Description
Other Notes
Amino acid precursor of serotonin and melatonin
Packaging
1 kg in poly bottle
1, 5, 25, 100, 500 g in poly bottle
Properties
Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe
Vera, Amino Acid, Amino Acids,
More...
grade reagent grade
assay 98%(HPLC)
mp 280-285 C (dec.)(lit.)
Gene Information human ... TDO2(6999), TPH1(7166), TPH2(121278)
Price and Availability
SKU-Pack Size Availability
Price
(SGD)
Quantity
T0254-1G Available to ship on 22.05.2014 - FROM 30.00 0
T0254-5G Available to ship on 22.05.2014 - FROM 43.80 0
T0254-25G Available to ship on 22.05.2014 - FROM 75.30 0
T0254-100G Available to ship on 22.05.2014 - FROM 228.00 0
T0254-500G Estimated to ship on 03.06.14 913.00 0
T0254-1KG Estimated to ship on 03.06.14 1,405.00 0
Suggested Laboratory Gloves
This substance has been tested against several types of hand protection for CE
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5/22/2014 L-Tryptophan reagent grade, 98% (HPLC) | Sigma-Aldrich
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Effects of L-tryptophan on indoleamines and catecholamines in discrete brain regions of wild type and Lurcher mutant mice.
T A Reader et. al
Neurochemical Research, 24(9), 1125-1134 (1999)
The biochemical parameters of the serotoninergic system were examined in wild type mice and Lurcher mutants af ter chronic treatment (40 days) with the serotonin (5-HT) precursor L-tryptophan (50
mg/kg; i.p.). Tissue contents in 5-HT, dopamine and no...Read More
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WGK Germany 1
RTECS YN6130000
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Articles
Serotonin Synthesis and Metabolism
Serotonin (5-hydroxytryptamine) is principally f ound stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaf f in cells in the muc...
Keywords: Anti-depressants, Catalysis, Clinical, Decarboxylations, Dopamine agents, Gastrointestinal, Hormones, Metabolism, Metabolites, Oxidations
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Indoles, Purines, and Their Isosteres
Substituted indoles and purines have f requently been ref erred to as privileged structures since they are capable of binding to multiple receptors with high af f inity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry
Technical information & documentation associated with this product are available in the Safety & Documentation tab.
Set your institution to view f ull text papers.



read abstract

1. Effects of L-tryptophan on indoleamines and catecholamines in discrete brain regions of wild type and Lurcher mutant mice.
T A Reader et. al
Neurochemical Research, 24(9), 1125-1134 (1999)
The biochemical parameters of the serotoninergic system were examined in wild type mice and Lurcher mutants af ter chronic treatment (40 days) with the serotonin (5-HT) precursor L-tryptophan (50
mg/kg; i.p.). Tissue contents in 5-HT, dopamine and no...Read More

read abstract

2. Role of decreased plasma tryptophan in memory deficits observed in type-I diabetes.
Saara Ahmad et. al
JPMA. The Journal of the Pakistan Medical Association, 63(1), 65-68 (2013)
To investigate the relationship between plasma tryptophan and the occurrence of memory dysf unctions in male and f emale type 1 diabetics. The case-control study was conducted at two urban healthcare
f acilities in Karachi f rom January to June 2009, an...Read More

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3. Structural and functional implications of the yeast high-affinity tryptophan permease Tat2.
Naoko Kanda and Fumiyoshi Abe
Biochemistry (Washington), 52(25), 4296-4307 (2013)
Tryptophan is hydrophobic, bulky, and the rarest amino acid f ound in nutrients. Accordingly, the import machinery can be specialized evolutionarily. Our previous study in Saccharomyces cerevisiae
demonstrated that tryptophan import by the high-af f in...Read More

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4. Membrane depth-dependent energetic contribution of the tryptophan side chain to the stability of integral membrane proteins.
Heedeok Hong et. al
Biochemistry (Washington), 52(25), 4413-4421 (2013)
Lipid solvation provides the primary driving f orce f or the insertion and f olding of integral membrane proteins. Although the structure of the lipid bilayer is of ten simplif ied as a central hydrophobic core
sandwiched between two hydrophilic interf ac...Read More

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5. A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines.
Tobias W Giessen et. al
Biochemistry (Washington), 52(24), 4274-4283 (2013)
5/22/2014 L-Tryptophan reagent grade, 98% (HPLC) | Sigma-Aldrich
http://www.sigmaaldrich.com/catalog/product/sial/t0254?lang=en&region=ID 3/3
Copyright 2014 Sigma-Aldrich Co. LLC. All Rights Reserved. Reproducti on of any materi al s from the si te i s stri ctl y forbi dden
wi thout permi ssi on. Si gma-Al dri ch brand products are sol d excl usi vel y through Si gma-Al dri ch Co. LLC. Si te Use Terms | Pri vacy
A large number of bioactive natural products containing a 2,5-diketopiperazine (DKP) moiety have been isolated f rom various microbial sources. Especially tryptophan-containing cyclic dipeptides (CDPs)
show great structural and f unctional diversity, ...Read More

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6. The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Miki Terakata et. al
Journal of Nutrition, 143(7), 1046-1051 (2013)
In mammals, nicotinamide (Nam) is biosynthesized f rom l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-TrpNam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-
dioxygenase (IDO). We aimed to determine whether tdo-kn...Read More

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7. Glutathione and tryptophan metabolism are required for Arabidopsis immunity during the hypersensitive response to hemibiotrophs.
Kei Hiruma et. al
PNAS, 110(23), 9589-9594 (2013)
The hypersensitive response (HR) is a type of strong immune response f ound in plants that is accompanied by localized cell death. However, it is unclear how HR can block a broad range of pathogens
with dif f erent inf ective modes. In this study, we re...Read More

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8. Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation.
Irina Smirnova et. al
PNAS, 110(22), 8876-8881 (2013)
Trp replacements f or conserved Gly-Gly pairs between the N- and C-terminal six-helix bundles on the periplasmic side of lactose permease (LacY) cause complete loss of transport activity with little or no
ef f ect on sugar binding. Moreover, the deterg...Read More

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10. Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study.
Kene N Piasta et. al
Biochemistry (Washington), 52(22), 3866-3880 (2013)
The three core components of the ubiquitous bacterial chemosensory array - the transmembrane chemoreceptor, the histidine kinase CheA, and the adaptor protein CheW - assemble to f orm a membrane-
bound, hexagonal lattice in which receptor transmembran...Read More
78. Merck 14,9797
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