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Oxor! Journals
Me!icine
"u#an $epro!uction
%olu#e &'( Nu#ber )
*p+ ,,-.,/)
*hysiology: Menstruation is associated with disordered
expression o desmoplakin I/II and
cadherin/catenins and conversion o F- to G-actin in
endometrial epithelium
! "a#i#$adeh
%&'
& (! )a#aknia
*
& +!F! ,on-& .! /upi
0
& 1! 2arconi
0
& 3! Romanini
0
and
4!G! at5aswaroop
6

&
0epart#ent of *athology( University of South 1lori!a( "ealth Sciences Center an! Mofitt Cancer Center
Ta#pa( 12
3
4o#en5s "ealth Institute Costa Mesa( CA
6
0epart#ent of Obstetrics an! 7ynecology(
"ershey Me!ical Center( "ershey *A( USA
)
0epart#ent of Obstetrics an! 7ynecology( 8Tor %ergata9
University of $o#e $o#e( Italy
Correspon!ence:
;
To <ho# correspon!ence shoul! be a!!resse! at: 0epart#ent of *athology( Mofitt
Cancer Center( &;='; Magnolia 0rive( Ta#pa( 12 33-&;( USA
>n!o#etriu# is uni?ue since it is the only tissue that un!ergoes

regular cyclic blee!ings+
Menstrual she!!ing is associate! <ith

the break!o<n of en!o#etriu#( inclu!ing the
rag#entation of

en!o#etrial glan!s+ To gain insight into the un!erlying basis

of
rag#entation of the en!o#etrial epitheliu# !uring the #enstrual

phase( <e exa#ine! the
expression of proteins i#plicate! in

epithelial cell@cell bin!ing in hu#an en!o#etria
throughout

the entire #enstrual cycle+ 4estern blotting aile! to reveal

!ierences in the
relative a#ount of >.ca!herin( . or .catenin

or actin in the #enstrual en!o#etria
co#pare! <ith those in

the prolierative or secretory phases+ "o<ever( speciic changes

in
the expression pattern of these proteins as <ell as !es#oplakin

IAII <ere !etecte! by
i##unohistoche#ical staining in epithelial

cells of #enstrual en!o#etria+ 0es#oplakin
IAII( >.ca!herin(

. an! .catenins an! .actin <ere localiBe! to intercellular bor!ers

as
<ell as the lu#inal an! basal regions of glan!ular epitheliu#

!uring the prolierative an!
secretory phases+ I##unoreactivity

of >.ca!herin an! .catenin <as conine! to
epithelial cells(

<hereas .catenin an! .actin <ere present in epithelial cells(

as <ell as in
stro#a an! en!othelial cells+ Bin!ing of 1.actin

to luorescein isothiocyanate.labelle!
phalloi!in localiBe!

this or# of actin to the intercellular bor!ers( an! the basal

an!
lu#inal cytoplas# of epithelial cells in prolierative an!

secretory en!o#etria+ Menstrual
she!!ing <as associate! <ith

!isorganiBation of the site.speciic !istribution of
!es#oplakin

IAII( >.ca!herin an! . an! .catenins+ This inclu!e! ocal patchy

expression
of these proteins or their total loss ro# cell@cell

bin!ing sites( as <ell as loss of 1.actin
in epithelial cells

of #enstrual en!o#etrial glan!s+ "o<ever( these changes <ere

not
observe! in the basalis region that is not she! !uring the

#enstrual phase+ These in!ings
suggest that rag#entation of

the en!o#etrial glan!s !uring the #enstrual phase is relate!
to the !isorganiBation an!Aor loss of the proteins at the a!herens

an! !es#oso#al
Cunctions( as <ell as loss of 1.actin+

Key words: actinAa!hesion #oleculesAcateninA>.ca!herinAen!o#etriu#
CiteU2ike Connotea 0el+icio+us 4hat5s thisD
"his article has #een cited #5 other articles:
S. Tabibzadeh, P.G. Satyaswaroop, M. von Wolff, and T. Strowitzki
Regulation of TNF-{alpha} mRNA expression in endometrial cells
by TNF-{alpha} and by oestrogen withdrawal
Mol. Hum. eprod., !e"ember #, #$$$% &'#()* ##+# , ##+$.
-.bstra"t/ -0ull Te1t/ -P!0/
G. 2. Gorodeski
Estrogen increases the permeability of the cultured human
cerical epithelium by modulating cell deformability
.m 3 Physiol 4ell Physiol, September #, #$$5% (6&'7)* 4555 , 45$$.
-.bstra"t/ -0ull Te1t/ -P!0/
Online ISSN &)-'.;36' . *rint ISSN ';-/.&&-&
Copyright E ;''/ >uropean Society of "u#an $epro!uction an! >#bryology
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