May 6, 2013 1 ESSENTIAL INTRAPARTUM CARE From Evidence to Practice Cynthia Tan, MD, FPOGS Medical Specialist IV Chief, Human Resource Development Services, Fabella Hospital Co-convenor, Team EINC
5/6/2013 Prepared by Team EINC for APDCN Faculty Objectives Discuss the problem of maternal mortality rates and its impact on the attainment of MDG 5 Discuss interventions that are recommended and are not recommended during: o Antepartum o Labor o Delivery o Immediate post-partum
5/6/2013 Prepared by Team EINC for APDCN Faculty Too many mothers and newborns are dying every year 5/6/2013 Prepared by Team EINC for APDCN Faculty 5/6/2013 Prepared by Team EINC for APDCN Faculty ANTEPARTUM CARE 5/6/2013 Prepared by Team EINC for APDCN Faculty ANTENATAL CARE At lease 4 antenatal visits with a skilled health provider To detect diseases which may complicate pregnancy To educate women on danger and emergency signs & symptoms To prepare the woman and her family for childbirth
5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 2 To detect diseases which may complicate pregnancy Screen Anemia Pre-eclampsia Diabetes Mellitus Syphilis
Detect PROM Preterm labor Prevent Ferrous and folic acid supplementation Tetanus toxoid immunization Corticosteroids for preterm labor Treat Ferrous sulfate for anemia Antihypertensive meds and Magnesium sulfate for SEVERE pre-eclampsia REFER
5/6/2013 Prepared by Team EINC for APDCN Faculty Antenatal Corticosteroids Administer ANTENATAL STEROIDS to all patients who are at risk for preterm delivery with preterm labor between 24-34 weeks AOG or with any of the following prior to term: Antepartal hemorrhage/bleeding Hypertension (preterm) Pre-labor rupture of membranes
5/6/2013 Prepared by Team EINC for APDCN Faculty Antenatal Steroids Overall reduction in neonatal death
Reduction in RDS
Reduction in cerebroventricular hemorrhage
Reduction in sepsis in the first 48 hours of life
Roberts D, Dalziel SR. Cochrane Database of Systematic Reviews 2006, Issue 3.
Betamethasone 12 mg IM q 24 hrs x 2 doses OR DEXAMETHASONE 6 mg IM q 12 x 4 doses
5/6/2013 Prepared by Team EINC for APDCN Faculty DEXAMETHASONE PHOSPHATE 2ml ampules: 4mg/ml 6 mg 1.5 ml injected intramuscularly Even a single dose of 6 mg IM before delivery is beneficial
emergency drug should be available at the OPD and ER 5/6/2013 Prepared by Team EINC for APDCN Faculty
GSCH Dexa Area & Tray in the ER, DR, Ward 5/6/2013 Prepared by Team EINC for APDCN Faculty DANGER SIGNS and SYMPTOMS Vaginal bleeding Headache Blurring of vision Abdominal Pain Severe difficulty breathing Dangerous fever (T>38, weak) Burning on urination
Educate women on 5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 3 Prepare the woman and her family for childbirth Counsel on Proper nutrition and self care during pregnancy Breastfeeding and family planning BIRTH PLAN Where she will deliver; transportation Who will assist her delivery What to expect during labor and delivery What to prepare, estimated cost of delivery Possible blood donors; where will she be referred in case of emergency
5/6/2013 Prepared by Team EINC for APDCN Faculty SAMPLE BIRTH AND EMERGENCY PLAN 5/6/2013 Prepared by Team EINC for APDCN Faculty Birth and Emergency Planning in the OPD 5/6/2013 Prepared by Team EINC for APDCN Faculty INTRAPARTUM CARE 5/6/2013 Prepared by Team EINC for APDCN Faculty Updated, evidence based national guideline on intrapartum and immediate postpartum care To be used by health professionals (OB SPECIALISTS, OB PRACTITIONERS, NURSES and MIDWIVES) in all GOVERNMENT AND PRIVATE health facilities
Intrapartum Care Clinical Practice Guidelines 5/6/2013 Prepared by Team EINC for APDCN Faculty Evidence based approach Based on the results of studies with acceptable quality
Formal consensus approach Discuss issues on generalizing the evidence to the local scenario, taking into account Harms and benefits Costs Preferences Best available evidence
RECOMMENDATIONS THE CPG DEVELOPMENT PROCESS
5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 4 RECOMMENDED PRACTICES DURING LABOR 5/6/2013 Prepared by Team EINC for APDCN Faculty Recommended Practices During Labor Active phase labor: 2-3 contractions in 10 minutes Cervix is 4 cm dilated 1. Admission to labor when the parturient is already in the active phase.
5/6/2013 Prepared by Team EINC for APDCN Faculty Recommended Practices During Labor: Admit when the parturient is already in ACTIVE LABOR No difference in Apgar score need for Cesarean Section by 82% No difference in need for labor augmentation
Rahnama, P., et.al., 2006: prospective cohort study on 810 low risk nulliparas (474 in latent phase; 336 in active phase )
5/6/2013 Prepared by Team EINC for APDCN Faculty Recommended Practices During Labor 1. Admission to labor when the parturient is already in the active phase. 2. Continuous maternal support
5/6/2013 Prepared by Team EINC for APDCN Faculty Continuous maternal support Need for pain relief by 10% Duration of labor SHORTER by half an hour spontaneous vaginal delivery by 8% Instrumental vaginal delivery 10% 5 minute Apgar < 7 by 30%
Source of evidence: Cochrane review (21 trials, 15,061 women) comparing one-to-one intrapartum support given by variety of providers (nurses, midwives, doulas, partner, female relative, friend) versus usual care (Hodnett, E.D., et.al., 2011)
5/6/2013 Prepared by Team EINC for APDCN Faculty Having a LABOR COMPANION can result in: Less use of pain relief drugs Increased alertness of baby Baby less stressed , uses less energy Reduced risk of infant hypothermia Reduced risk of hypoglycemia Early and frequent breastfeeding Easier bonding with the baby 5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 5 1. Admission to labor when the parturient is already in the active phase. 2. Continuous maternal support 3. Upright position during first stage of labor Recommended Practices During Labor 5/6/2013 Prepared by Team EINC for APDCN Faculty Freedom of movement - distract mothers from the discomfort of labor, release muscle tension, and give a mother the sense of control over her labor (Storton, 2007).
5/6/2013 Prepared by Team EINC for APDCN Faculty UPRIGHT POSITION DURING LABOR First stage of labor shorter by about 1 hour Need for epidural analgesia by 17% No difference in rates of SVD , CS, and Apgar score < 7 at 5 minutes
Source of Evidence: Cochrane review (21 studies involving 3,706 women) comparing upright versus recumbent position (Lawrence, A., et.al., 2009)
5/6/2013 Prepared by Team EINC for APDCN Faculty Restricting practices limit a mothers freedom to move and/or her position of choice. 1. IV lines* 2. fetal monitoring 3. labor stimulating medications that require monitoring of uterine activity, 4. small labor rooms, 5. epidural placement 6. absence of support persons to be with the intrapartum client 5/6/2013 Prepared by Team EINC for APDCN Faculty Recommended Practices During Labor 1. Admission to labor when the parturient is already in the active phase. 2. Continuous maternal support 3. Upright position during first stage of labor 4. Routine use of WHO partograph to monitor progress of labor
For early identification of abnormal progress of labor 5/6/2013 Prepared by Team EINC for APDCN Faculty Recommended Practices During Labor No difference in endometritis UTI lower by 34% An observational study on 161,077 women (with or w/o PPROM) who had < 5 exams (Ayzac, L., et.al., 2008)
Chorioamnionitis by 72% Neonatal sepsis by 61% 1 RCT on 5,018 women with PROM comparing < 3 exams vs 3 exams (Seaward, P.G., et.al., 1998)
1. Admission to labor when the parturient is already in the active phase. 2. Continuous maternal support 3. Upright position during first stage of labor 4. Routine use of WHO partograph to monitor progress of labor 5. Limit total number of IE to 5 or less.
5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 6 PRACTICES NOT RECOMMENDED DURING LABOR 5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are NOT recommended during labor No difference in rates of maternal fever, perineal wound infection, and perineal wound dehiscence No neonatal infection was observed
1. Routine perineal shaving on admission for labor and delivery.
Evidence: Cochrane review (3 trials) comparing it with no shaving (Basevi, V. and Lavender, T., 2000 updated 2008)
5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are NOT recommended during labor Fecal soiling during delivery reduced by 64% No difference in maternal puerperal infection, episiotomy dehiscence, neonatal infection, and neonatal pneumonia 1. Routine perineal shaving on admission for labor and delivery. 2. Routine enema during the first stage of labor.
Source of Evidence: Cochrane review (4 trials) comparing it with no enema (Reveiz, L., et.al. 2007 updated 2010)
5/6/2013 Prepared by Team EINC for APDCN Faculty Practices that are NOT recommended during labor No difference in chorioamnionitis, postpartum endometritis, perinatal mortality, neonatal sepsis No side effects reported 1. Routine perineal shaving on admission for labor and delivery. 2. Routine enema during the first stage of labor. 3. Routine vaginal douching.
Source of Evidence: Cochrane review (3 trials that used different concentrations and volumes of Chlorhexidine) comparing it with sterile saline (Lumbiganon, P., et.al., 2004 updated 2009)
5/6/2013 Prepared by Team EINC for APDCN Faculty Practices that are NOT recommended during labor Risk of dysfunctional labor by 25% No difference in duration of labor, CS rate, cord prolapse, maternal infection and Apgar score < 7 at 5 minutes 1. Routine perineal shaving on admission for labor and delivery. 2. Routine enema during the first stage of labor. 3. Routine vaginal douching. 4. Routine amniotomy to shorten spontaneous labor
5/6/2013 Prepared by Team EINC for APDCN Faculty Oxytocin Augmentation Should only be used to augment labor in facilities where there is immediate access to caesarean section should the need arise.
Use of any IM oxytocin before the birth of the infant is generally regarded as dangerous because the dosage cannot be adapted to the level of uterine activity. 5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 7 Routine IVF Advantage to have ready access for emergency medications to maintain maternal hydration
Disadvantage Interferes with the natural birthing process restricts womans freedom to move IVF not as effective as allowing food and fluids in labor to treat/prevent dehydration, ketosis or electrolyte imbalance POGS CPG on NORMAL LABOR AND DELIVERY, 2009 5/6/2013 Prepared by Team EINC for APDCN Faculty Routine IVF No study found showing that having an IV in place improves outcome Even the prophylactic insertion of an IV line should be considered unnecessary intervention.
Philippine Ob-Gyn Society CPG on Normal Labor and Delivery, 2009
5/6/2013 Prepared by Team EINC for APDCN Faculty Routine NPO During Labor Possible risk of aspirating gastric contents with the administration of anesthesia One study evaluated the probable risk of maternal aspiration mortality, which is approximately 7 in 10 million births. No evidence of improved outcomes for mother or newborn. Use of epidural anesthesia for intrapartum anesthesia in an otherwise normal labor should not preclude oral intake. Sleutel, M., and Golden, S., 1999 POGS CPG on Normal Labor and Delivery, 2009 5/6/2013 Prepared by Team EINC for APDCN Faculty Routine NPO During Labor For the normal, low risk birth, there is no need for restriction of food except where intervention is anticipated. A diet of easy to digest foods and fluids during labor is recommended. Isotonic calorific drinks consumed during labor reduce the incidence of maternal ketosis without increasing gastric volumes. Singata M, Tranmer J, Gyte GML. Restricting oral fluid and food intake during labour. Cochrane Database of Systematic Reviews 2010, Issue 1. POGS CPG ON NORMAL LABOR AND DELIVERY, 2009 WHO Care in Normal Birth, 1996 5/6/2013 Prepared by Team EINC for APDCN Faculty CARE DURING LABOR RECOMMENDED Admission to labor when in the active phase. Companion of choice to provide continuous maternal support Mobility and upright position Allow food and drink Use of WHO partograph to monitor progress of labor Limit IE to 5 or less. NOT RECOMMENDED Routine perineal shaving on admission Routine enema Routine NPO Routine IVF Routine vaginal douching. Routine amniotomy Routine oxytocin augmentation
5/6/2013 Prepared by Team EINC for APDCN Faculty PRACTICES RECOMMENDED DURING DELIVERY 5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 8 Please wash your hands! 5/6/2013 Prepared by Team EINC for APDCN Faculty Traditional
Defined by a fully dilated cervix Coached to push though out-of-phase with her own sensation
Redefined as complete cervical dilatation + spontaneous explusive efforts (Simkin, 1991) Pelvic phase of passive descent Perineal phase of active pushing Non-Traditional Diagnosis of the 2 nd Stage of Labor 5/6/2013 Prepared by Team EINC for APDCN Faculty 5/6/2013 Prepared by Team EINC for APDCN Faculty Management of the 2 nd Stage of Labor Traditional DIRECTED PUSHING Valsalva pushing
Venous Return
Perfusion to Uterus, Placenta & Fetus
FHR Changes
Fetal hypoxia & acidosis
Roberts,1996; Simkin, 2000;Roberts,1987 as cited in Roberts, Joyce,Journal of Midwifery and Womens Health.Vol. 47,No.1 Jan/Feb 2002 Non-Traditional INVOLUNTARY BEARING DOWN Exhalation pushing Let air out Parturient-directed Physiologic: force of bearing down efforts increases as fetal descent occurs Avoids hypoxia and acidosis
Nikodem,VC. Beaaring down Methods during second stage labour (Cochrane Review) In: The Cochrane Library, Issue 2, 2001 as cited by Roberts, 2002 5/6/2013 Prepared by Team EINC for APDCN Faculty UPRIGHT POSITION DURING DELIVERY 5/6/2013 Prepared by Team EINC for APDCN Faculty UPRIGHT position during delivery More efficient uterine contractions Improved fetal alignment Larger anterior-posterior and transverse diameters of pelvic outlet enhances fetal movement through the maternal pelvis in descent for birth Faster delivery Leads to less interventions : less episiotomies.
Shilling, Romano, & DiFranco, 2007
5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 9 5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are recommended during delivery 1.Upright position during delivery 2.Selective (non-routine) episiotomy 5/6/2013 Prepared by Team EINC for APDCN Faculty Perineal Support and Controlled Delivery of the Head Keep one hand on the head as it advances during contractions while the other hand supports the perineum. During delivery of the head, encourage woman to stop pushing and breathe rapidly with mouth open. 5/6/2013 Prepared by Team EINC for APDCN Faculty Non-Routine Episiotomy Anterior perineal trauma by 84% Posterior perineal trauma by 12% 2 nd -4 th degree tears by 33% Need for suturing by 29% No difference in infection rate Source of Evidence: Cochrane review (8 trials) that include both primis and multis and used median or mediolateral episiotomy (Carroli, G., and Mignini, L., 2009)
5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are recommended during delivery 1. Upright position during delivery 2. Selective episiotomy 3. Use of prophylactic oxytocin for management of third stage of labor OXYTOCIN 10 U intramuscular Palpate abdomen to rule out a second baby 5/6/2013 Prepared by Team EINC for APDCN Faculty Prophylactic OXYTOCIN for the 3 rd stage of labor Postpartum blood loss 500 ml reduced by 39% Need for additional uterotonic reduced by 47% No difference in need for maternal blood transfusion, need for manual removal of placenta, and duration of third stage
Source of Evidence: Cochrane review (4 trials on 2,213 women) using varied doses, route, and timing of administration of oxytocin (Cotter, A.M., et.al., 2002 updated 2004)
5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 10 Interventions that are recommended during delivery Early clamping : <1 min after birth Delayed (properly timed) :1-3 minutes after birth or when pulsations stop
1. Upright position during delivery 2. Selective episiotomy 3. Use of prophylactic oxytocin for mgt of 3rd stage of labor 4. Delayed cord clamping 5/6/2013 Prepared by Team EINC for APDCN Faculty Lower infant hemoglobin at birth and at 24 hrs after birth prevented Fewer infants requiring phototherapy for jaundice No difference in rates of polycythemia, need for neonatal resuscitation, and NICU admission
PROPERLY TIMED CORD CLAMPING Source of Evidence: Cochrane review (8 trials; 2,399 women) comparing early versus delayed cord clamping (McDonald, S.J., and Middleton, P., 2008)
5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are recommended during delivery 1. Upright position during delivery 2. Selective episiotomy 3. Use of prophylactic oxytocin for management of third stage of labor 4. Delayed cord clamping 5. Controlled cord traction with countertraction to deliver the placenta 5/6/2013 Prepared by Team EINC for APDCN Faculty Controlled Cord Traction Postpartum blood loss >500ml by 7% Postpartum blood loss >100ml by 24% No difference in rates of maternal mortality or serious morbidity and need for additional uterotonics.
Source of Evidence: Pooled analysis of 2 RCTs (23000 subjects) comparing it with the hands off approach. (Althabe, F et al, 2009; Gulmezoglu AM et al, 2012) 5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are recommended during delivery 1. Upright position during delivery 2. Selective episiotomy 3. Use of prophylactic oxytocin 4. Delayed cord clamping 5. Controlled cord traction with countertraction 6. Uterine massage after placental delivery Lower mean blood loss Less need for uterotonics
Source of evidence: Cochrane review (1 trial on 200 women who delivered vaginally and AMTSL done vs massage. ) Hofmeyr, GJ et al 2008 5/6/2013 Prepared by Team EINC for APDCN Faculty 1. Administration of uterotonic within one minute of delivery of the baby. 2. Controlled cord traction with counter traction on the uterus 3. Uterine massage POPPHI. Prevention of Postpartum Hemorrhage: Implementing Active Management of the Third Stage of Labor (AMTSL): A Reference Manual for Health Care Providers. Seattle: PATH; 2007. Active Management of the Third Stage (AMTSL) 5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 11 Approaches in the Mgt of the 3rd Stage of Labor Physiologic (Expectant) Active (AMTSL) Uterotonic NOT GIVEN before placenta is delivered GIVEN within 1 min. of babys birth Signs of placental separation WAIT DONT WAIT Delivery of the placenta By gravity with maternal effort CCT with counter traction on the uterus Uterine massage After placenta is delivered After placenta is delivered 5/6/2013 Prepared by Team EINC for APDCN Faculty PRACTICES NOT RECOMMENDED DURING DELIVERY 5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are NOT recommended during delivery Based on review, there is clear benefit (3 rd -4 th degree teaars) and no clear harm (no difference in 1sr and 2 nd degree tears, vaginal pain, blood loss) Commonly noted complications in practice (perineal edema, perineal wound infection, and perineal wound dehiscence) were not evaluated Further studies are needed.
1. Perineal massage in the 2 nd
stage of labor
5/6/2013 Prepared by Team EINC for APDCN Faculty Interventions that are NOT recommended during delivery 1. Perineal massage in the 2 nd stage of labor 2. Fundal pressure during the second stage of labor
5/6/2013 Prepared by Team EINC for APDCN Faculty Fundal Pressure during 2nd stage 2nd stage longer by 29 minutes Increased 3 rd and 4 th degree perineal tears No difference in rates of postpartum hemorrhage, instrumental vaginal delivery, Apgar score < 7 at 5 minutes, and NICU admission Uterine rupture was not evaluated
Source of Evidence: Pooled analysis of Cochrane review (with 1 trial only) (Verheijen, E.C., et.al., 2009) and 2 randomized trials (Cosner, K., 1996; Matsuo, K., et.al., 2009) with overall total of 1,229 patients
5/6/2013 Prepared by Team EINC for APDCN Faculty CARE DURING DELIVERY RECOMMENDED Upright position during delivery Selective episiotomy Use of prophylactic oxytocin for mgt of 3rd stage of labor Delayed cord clamping Controlled cord traction with countertraction to deliver the placenta Uterine massage NOT RECOMMENDED Coaching the mother to push Perineal massage in the 2 nd stage of labor Fundal pressure during the second stage of labor
5/6/2013 Prepared by Team EINC for APDCN Faculty Essential Intrapartum Care 5/6/2013 Prepared by Team EINC for APDCN Faculty May 6, 2013 12 POSTPARTUM CARE RECOMMENDED Routinely inspect the birth canal for lacerations Inspect the placenta & membranes for completeness Early resumption of feeding (<6 hours after delivery) Massage the uterus ensure uterus is well contracted Prophylactic antibiotics for women with a 3rd or 4th degree perineal tear Early postpartum discharge NOT RECOMMENDED Manual exploration of the uterus Routine use of icepacks over the hypogastrium. Routine oral methylergometrine
5/6/2013 Prepared by Team EINC for APDCN Faculty Summary- Key Points Maternal and neonatal mortality in the Philippines is still unacceptably high Prevention of postpartum hemorrhage through interventions like the use AMTSL will address the #1 cause of maternal mortality The evidence-based practices in the EINC Protocol are lifesaving for both mother and baby 5/6/2013 Prepared by Team EINC for APDCN Faculty Let us put it into practice! 5/6/2013 Prepared by Team EINC for APDCN Faculty