made by award-winning director Brian Golden Davis as an
entry into the 2012 Focus Forward Filmmaker Competition that has now gone viral, Maher El-Kady, a Ph.D. candidate in Professor Richard Kaners group, can be seen throwing a handful of batteries into the battery recycling bin, in favor of running everyday gadgets with a superior replacement the graphene supercapacitor. Graphene supercapacitors are not only biodegradable, but are also able to charge and discharge about 100 to 1000 times faster than the average alkaline battery. Think of electric carsthe higher the capacity of the battery, the farther you can go on a single charge, and the higher the power, the faster you can run your car, El-Kady said. This is what you want in the end, so we ended up making a supercapacitor that has twice as much energy density as commercial supercapacitors, and twenty times as much power. The look of enthusiasm on El-Kadys face when he says, Lets talk about the future, during an interview in Davis film, is parallel to the large number of potential applications that have been linked to graphene supercapacitors, and to greener energy prospects, including flexible technology and improved hybrid vehicles. Although Kaners group is not the first to build graphene supercapacitors, the teams scalable, environmentally friendly method is the most likely to be commercially reproduced at this time. El-Kady was one of two recipients of the 2012 Herbert Newby McCoy Award, which honors the most significant research of the year, for his research with Kaner that piqued the interest of scientific journals, major news outlets, industry professionals, and Davis, a film director with Los Angeles- based company DocRiot. Davis was one of about 100 people who contacted Kaner following the March 2012 publication of an article in Science, which described how graphite pieces are transformed into graphite oxide, and, finally, into graphene, using common LightScribe software designed for printing text and images on CDs and DVDs, thus providing the active material in supercapacitors. Davis read an article about Kaner and El-Kadys research and wished to turn their discovery into a human interest film, entering it into the Focus Forward competition, which offered up to $200,000 in prizes to the best cinematographic features showcasing pioneering research capable of world change. I had done film work for Kia (continued on p. 13)
Chemistry N E W S L E T T E R & Biochemistry Department of In This Issue Page Chairs Message................2 Awards...........................2-5 Happenings.......................6 Seaborg Symposium........7-8 Distinguished Lectures......8-9 Alumni & Friends...........10-12 Research......................13-15 In Memoriam....................15 Calendar..........................16 Spring 2013 Volume 32 - Number 2 Graduate Student Maher El-Kady Puts the Super in The Super Supercapacitor 2 Dear Alumni & Friends, Even as this newsletter goes into production, news keeps coming of faculty, student, and postdoctoral fellow awards. In fact, if you visit our Web site frequently, you will see that news items have a rather limited lifetime on our home page, as more news rapidly moves on to the fore. We highlight, here, the transformative discoveries of Ric Kaner and Maher El-Kady (see p. 1), but you will also find recent research by Jim Gimzewski, Sarah Tolbert, Carla Koehler, and Sabeeha Merchant, and their students, which has been widely covered in the press, on our Web site. Juli Feigons elucidation of the entire telomerase enzyme complex, in collaboration with Professor Hong Zhou, is another remarkable achievement (see our Web site). The creativity and productivity of our department members is remarkable. The breadth of our research, with chemistry, biochemistry and molecular biology extending far into the physical, biological and medical sciences, is unique. Furthermore, our department gives just as much importance to top-notch, innovative teaching and to community outreach. Soon you will hear about a drive to improve the equipment in our undergraduate teaching labs, and plans to create instructional space for academic activities beyond the classroom. We will need your help increasing our students academic experiences even further. Next time you visit Young Hall, you will discover several displays in the hallways, highlighting various aspects of the department and its members. Notably, these displays are a donation from the Alpha Chi Sigma (AXE) student group, which also sponsors the AXE Glenn T. Seaborg Faculty award, which was presented to Margot Quinlan this year. You will also not be surprised to learn that our department had the most popular booth during Bruin Day this year (see p. 6). The excitement conveyed by our ACS student affiliates and AXE undergraduates will yield another freshmen bumper crop! In these pages, you will also read an interview with Ray and Dot Wilson, where Ray traces their generosity to his experiences as an undergraduate in our department (see p. 12). We are also pleased to share with you some highlights of recent named lectures, in which we honored the memory and legacy of department members (see pp. 8-9). We also have a number of exciting events coming up. Among these, we are thrilled to present our Alumni Awards to Doctors Judith and Julie Swain, B.S. 1970. They will deliver our commencement address on June 15. We are delighted that Prof. Ken Houk will be the 2013 Seaborg Award Medalist, and we are eager to announce the Distinguished Lecturer Seminar Series as a quarterly event for all members of the department, alumni, and friends to celebrate the breadth of science that brings us together. We are looking forward to Prof. Frances Arnolds Inaugural Lecture, to be held on November 6, 2013. I invite you to read this newsletter and keep an eye on our Web site: www.chemistry.ucla.edu. As always, I look forward to thanking you in person for your support hasta pronto! Raphael Levine Receives 2012 Israel Chemical Society Gold Medal Professor Raphael Levine was awarded the 2012 Israel Chemical Society (ICS) Gold Medal for his fundamental contributions for understanding chemical reactivity on the molecular-scale, with special reference to the role of energy and for discovering that the methods of thermodynamics can be applied to nonequilibrium few-atom systems. The award ceremony took place at the opening ceremony of the 78th annual meeting of the ICS in Tel Aviv on February 12. The ICS was founded in 1933 and aims at advancing pure and applied chemistry at the national and international levels. The ISC Gold Medal is the highest honor awarded annually since 2002 to chemists by the organization. Professor David Eisenberg Wins the Senior Scientist Accomplishment Award from the International Society of Computational Biology
The International Society of Computational Biology (ISCB) will award Professor David Eisenberg with the Senior Scientist Accomplishment Award at the 21st Annual Intelligent Systems for Molecular Biology Conference, which takes place with the 12th European Conference on Computational Biology (ISMB/ ECCB 2013) in Berlin, Germany on July 19-23, for his contributions to the field of computational biology through research, education, and service. As part of the conference, Eisenberg will deliver a keynote address, discussing his recent work in protein interactions by X-ray crystallography, bioinformatics, and biochemistry, with an emphasis on amyloid- forming proteins. ISCB, formed in 1997, is a global community of over 3000 scientists committed to increasing the scientific understanding of living systems through computation. The ISCB hosts annual meetings, including the ISMB, the world's largest bioinformatics conference. Chair Miguel Garcia-Garibay Photo Credit: Reed Hutchinson - Raphael Levine CHAI R S MESSAGE/ AWARDS David Eisenberg Chair Miguel Garcia-Garibay 3 Richard Kaner Selected as the Recipient of the 115th Faculty Research Lectureship, Awarded by the UCLA Academic Senate The UCLA Academic Senate selected Professor Richard Kaner as the recipient of the 115th Faculty Research Lectureship for his outstanding record of accomplishment, placing him among the universitys most distinguished scholars. As a recipient of the 115th Faculty Research Lectureship, Kaner will give a public lecture on the topic of his choice in Fall 2013, to be followed by a reception held in his honor. Every year, the Academic Senate awards lectureships to two faculty members, one from the natural sciences and one from the humanities, social disciplines, or creative arts, with the purpose of acknowledging faculty achievements and giving the campus and community the chance to learn about them from the perspectives of the faculty honored. The first Faculty Research Lecture was given in 1925, and the lectureship series was expanded to include two a year in 1986. Faculty Research Lectureships are presented biannually, in the Fall and Spring quarters. Past recipients of Faculty Research Lectureships within the Department of Chemistry & Biochemistry include William G. Young (1947), Saul Winstein (1955), Donald J. Cram (1970), Paul D. Boyer (1982), David Eisenberg (1989), Mostafa A. El-Sayed (1991), M. Frederick Hawthorne (1995), Kendall N. Houk (1998), and Steven G. Clarke (2009). Neil Garg Receives S.T. Li Prize for Achievements in Science and Technology
The S.T. Li Foundation awarded Professor Neil Garg the 2012-2014 Li Prize for Achievements in Science and Technology. The award is given to a distinguished scholar in a scientific or technological field at a public university and is delivered as an unrestricted research grant. The award honors Professor Shu-tian Li (1900-1988) for whom the S.T. Li prize is named after. Miguel Garcia-Garibay Wins 2012 Inter- American Photochemical Society Award in Photochemistry Professor Miguel Garcia-Garibay won the 2012 Inter-American Photochemical Society (I-APS) Award in Photochemistry. This award was established in 1988 to recognize outstanding contributions to the advancement of the photochemical and photophysical sciences, recognizing achievements made during the past 10 years of the nominee's career. He was recognized for his research on excited state processes and reactivity in the solid state. The award was presented to Garcia-Garibay at the I-APS meeting in Sarasota, Florida, in January 2013. Paul Weiss and Co-workers Receive $1 million W.M. Keck Foundation Grant Professor and CNSI Director Paul Weiss, Professor and Director of Computational and Applied Mathematics at UCLA Andrea Bertozzi, Professor of Psychiatry and Director of the UCLA Semel NeuroImaging Training Program Mark Cohen, and Professor Stanley Osher, who teaches mathematics, computer science and electrical engineering, were awarded a two-year, $1 million W.M. Keck Foundation grant to fund their research in practical uses of compressive sensing, a process in which mathematical algorithms are used to increase the accuracy of health and science related pictures and data sets. Our goal is to leverage mathematical advances to transform the way imaging and related data are acquired, analyzed, and understood, Weiss said. The result will be richer, more meaningful data through significant changes in how experiments are currently conducted and analyzed. In so doing, we hope to advance the science of imaging. Practical uses of compressive sensing may include detecting epilepsy and improving brain-imaging, both of which will be further examined by the researchers. Keck Foundation grants fund innovative research in the areas of science, engineering, and medicine. SPRING 2013 NEWSLETTER FACULTY, STAFF & CONTRIBUTORS Editorial Board Miguel Garcia-Garibay, Heather Maynard, Shahla Raissi Editing & Production Kady Bell-Garcia, Jin Lee College Development & Alumni Relations Kerri Yoder, Erica Marentes, Silvia Orvietani Busch Contributors Mandy Bell, Thomas Cahoon, Carol Canedo, Maher El-Kady, Miguel Garcia-Garibay, Neil Garg, David Gingrich, Adam Goetz, Kendall Houk, Reed Hutchinson, David Imai, Penny Jennings, Richard Kaner, Genevieve Lee, Margaret MacDonald, Timothy Mahlanza, Denise Mantonya, Heather Maynard, Robert McMahon, Craig Merlic, Yves Rubin, Melissa Woehrstein, and Lufeng Zou UCLA Department of Chemistry & Biochemistry 607 Charles E. Young Drive East, Los Angeles, California 90095-1569 Neil Garg Miguel Garcia-Garibay Paul Weiss AWARDS Richard Kaner *More faculty and student awards can be viewed on our Web site at www.chemistry.ucla.edu. 4 Heather Maynard Selected as 2013 Fellow of the Division on Polymer Chemistry Professor Heather Maynard was one of six individuals chosen as a 2013 Fellow of the Division of Polymer Chemistry (POLY Fellow) by the Division of Polymer Chemistry, of the American Chemical Society. She was recognized for her contributions made to the academic field and profession of polymer science. All POLY Fellows were awarded plaques during the Spring ACS National Meeting, during the Division of Polymer Chemistry/Division of Polymeric Materials: Science and Engineering Award Reception on April 10. The Division of Polymer Chemistry was founded in 1951 and is the second largest division of ACS, following the Division of Organic Chemistry. Shimon Weiss Wins Humboldt Research Award Professor Shimon Weiss received a Humboldt Research Award for his lifetime achievements in research. As a recipient of a Humboldt Research Award, Weiss will have the opportunity to collaborate on research projects of his choice with likeminded experts at a university in Germany for one year. The Humboldt Research Award recognizes researchers who have made significant contributions to their fields and are expected to continue to do so, considering their full academic careers to date. The foundation maintains a network of 25,000 Humboldt Foundation alumni worldwide, known as the Humboldtians. Anastassia Alexandrova Awarded a 2013 Alfred P. Sloan Research Fellowship Professor Anastassia Alexandrova was one of 126 nationwide early-career scientists and scholars to receive a 2013 Alfred P. Sloan Research Fellowship. The fellowship selection was based on Professor Alexandrova's independent research accomplishments and contributions to the field of chemistry. Sloan Research Fellowships, which recognize exceptional early-career scientists and scholars in science, mathematics, economics, and computer science, are awarded for two years and include a $50,000 research stipend. Sloan research fellows are nominated by their peers and selected by a distinguished panel of senior scholars. They represent the next generation of leaders in the natural sciences, economics, and mathematics. Jorge Torres Named 2013 Cottrell Scholar by Research Corporation for Science Advancement
Professor Jorge Torres was named one of thirteen 2013 Cottrell Scholars by the Research Corporation for Science Advancement (RCSA), recognizing his scientific contributions to research and his commitment to undergraduate education. Cottrell Scholar Awards are awarded to exceptional early-career educators in the physical sciences and related fields, and only about 10 percent of applicants pass the rigorous peer-review process. Professor Torres proposed project was centered on compounds that inhibit cell division. This study will have an immediate impact on the field of cell biology by providing critical tools which can be used to dissect and increase our understanding of the fundamental mechanisms required for cell division, Torres said. Cottrell Scholars also become members of the Cottrell Scholars Collaborative, a network of educators who meet annually to discuss techniques for increasing the number of undergraduate science majors. RCSA was founded in 1912, and is a private foundation that aids basic research in the physical sciences (astronomy, chemistry, physics, and related fields) at U.S. colleges and universities. James Liao Elected to National Academy of Engineering Professor James Liao was elected to the National Academy of Engineering (NAE) for his advances in metabolic engineering of microorganisms to produce fuels and chemicals. Election to the National Academy of Engineering is one of the highest honors bestowed upon engineers. Those elected as members represent exceptional contributions to engineering research, practice, or education, including, where appropriate, significant contributions to the engineering literature, and to the pioneering of new and developing fields of technology, making major advancements in traditional fields of engineering, or developing/implementing innovative approaches to engineering education. James Liao Anastassia Alexandrova Shimon Weiss Jorge Torres Heather Maynard AWARDS 5 2012 Departmental Awards Ceremony
The department recognized the efforts of our accomplished students and faculty at the annual Departmental Awards Ceremony, held on November 19, 2012. Several faculty members and administrative officers/deans were able to attend the ceremony to present awards to the students being honored. Dean Joseph Rudnick presented the Herbert Newby McCoy Award, and Associate Dean of the Graduate Division, Carlos Grijalva, presented the Excellence in Second Year Academics and Research and the Hanson- Dow Teaching Assistant Awards. Professor Roberts Smith was also on hand to present his named research award with Professor Catherine Clarke. The award recipients are listed below. Hosmer Stone Prize for Excellence in General Chemistry: Justin Ondry Bruce Merrifield Undergraduate Research Award: Jason Chang Christopher Foote Fellows: Adam Goetz, Elizabeth Noey, Stephen Ramgren, Amanda Silberstein Excellence in Second Year Academics and Research: Noah Nathel, Cuiwen He, Xin Hong, Zhao Li Hanson-Dow Teaching Assistant Awards: Devin Brandt, Jonathan Brosmer, Elizabeth Guenther, Alexander Huters, Argyris Kahros, Juneyoung Lee, Jeremy Oria, Stephanie Quan, Courtney Roberts, Shane Stone, Evan Styduhar, Brianna Upton, Lisa Wang Ralph & Charlene Bauer Award for Research in Inorganic Chemistry: Yue (Jessica) Wang George Gregory Award for Research in Physical Chemistry: Mauricio Comas-Garcia John Stauffer Fellowship for Outstanding Research in the Department of Chemistry & Biochemistry: Alexander Huters Majeti-Alapati Fellowship for Research in Organic Chemistry: Thi (Kathy) Nguyen Samson H. Cheng Biochemistry Teaching Award: Michael Thompson John M. Jordan Memorial Award for Research in Biochemistry: Alexander Patananan Roberts A. Smith Award for Research in Biochemistry: Letian Xie Ernest F. Hare, Jr., Memorial Scholarship for Research: Reza Malmirchegini Hanson-Dow Award for Excellence in Teaching: Sarah Tolbert Herbert Newby McCoy Award: Maher El-Kady (student award), Jorge Torres (faculty award) Audree Fowler Fellows in Protein Science In 2008, an endowment from Dr. Audree Fowler (B.S. in chemistry, 1956 and Ph.D. in biochemistry, 1963) established the Audree Fowler Fellows in Protein Science for Ph.D. students in the Molecular Biology Interdepartmental Ph.D. Program, Biological Chemistry, Biochemistry and Molecular Biology. Two students from the Department of Chemistry & Biochemistry were recipients of 2012 Audrey Fowler Fellowships: Letian Xie (Clarke lab) and Anni Zhao (Eisenberg lab). If you are interested in permanently endowing an award in honor of someone special in your life, please contact Kerri Yoder, Director of Development for the Division of Physical Sciences, at (310) 794-9045 or by e-mail at kyoder@support.ucla.edu. Hanson Dow Awardee Sarah Tolbert with Michael Jung Herbert Newby McCoy Awardees with Dean Joseph Rudnick: From Left to Right: Maher El-Kady, Jorge Torres Excellence in Second Year Academics and Research Awardees with Associate Dean of the Graduate Division Carlos Grijalva: Cuiwen He, Noah Fine Nathel, Xin Hong, and Zhao Li Christopher Foote Fellows with Professor Kendall Houk: Stephen Ramgren, Amanda Silberstein, Adam Goetz, and Elizabeth Noey Departmental Awards Photo Credit: Ale Wu AWARDS 6 2013 UCLA Bruin Day On April 13th, The Department of Chemistry & Biochemistry welcomed thousands of future Bruins and their families for UCLAs annual Bruin Day event. The event provides an opportunity for prospective students to visit UCLA and to find out more about academics and life on campus. The department event was hosted by Denise Mantonya, Tim Mahlanza, and Mary Stirchak from the Undergraduate Student Affairs Office, while undergraduates from Alpha Chi Sigma and the Student Affiliates of the American Chemical Society were also on hand to greet the visitors. Chair Miguel Garcia-Garibay and Professor Neil Garg were also present to meet the students and families, and Professor Garg gave a mock lecture for his Fiat Lux course, titled Chemicals: Friends or Foes? Families took home fun souvenirs including pens, flyers, and Chemistry & Biochemistry beach balls. Heather Maynard and Co-workers Develop New Therapeutics for Accelerating Wound Healing
Professor Heather Maynard, graduate students Thi Nguyen and Caitlin Decker, former postdocs Sung-Hye Kim and Darice Wong, and Professor Joseph Loo have developed new bio-mimicking therapeutics that can be used to quicken the wound healing process. A signaling molecule known as basic fibroblast growth factor, or bFGF, is secreted by our cells to activate healing processes, as well as embryonic development, tissue regeneration, bone regeneration, the development and maintenance of the nervous system, and stem cell renewal. It has potential applications in medicine for stimulating or quickening these processes, but has previously been too unstable for use outside of the body. The researchers discovered how to stabilize bFGF, synthesizing a polymer that mimics the structure of heparin, a naturally occurring complex sugar found on the surface of our cells, and attaching it to bFGF, thus rendering it a more suitable candidate for medical applications. This stable bFGFpolymer conjugate may also be useful in diseases other than wound healingfor example, vocal chord repair, cardiac repair and bone regeneration, Maynard said. More generally, we think that this idea of making polymers that mimic natural stabilizers is useful in a wide range of fields. The research was published February 17 in the online edition of Nature Chemistry and appeared in the March 2013 edition of the journal. Judith and Julie Swain to Receive Alumni Awards at Graduation Doctors and alumnae Judith and Julie Swain will accept the second annual UCLA Chemistry & Biochemistry Alumni Awards and will also give speeches at the departmental graduation ceremony on June 15. Dr. Julie Swain, who received her B.S. degree in chemistry at UCLA in 1970, before earning her M.D. from Baylor College of Medicine, currently serves as a cardiovascular surgeon at the Food and Drug Administration. She also previously served as the acting Deputy Associate Administrator of the Office of Biological and Physical Research at NASA Headquarters, managing the International Space Station research program and other science research programs in biology, biotechnology, biomedical research and the physical sciences. Dr. Judith L. Swain, who received her B.S. degree in chemistry at UCLA in 1970, before earning her M.D. from UC San Diego, currently serves as the Executive Director of the Singapore Institute for Clinical Sciences within A*STAR, and as the Lien Ying Chow Professor of Medicine at the National University of Singapore. She previously served as the Dean for Translational Medicine and the Founding Director of the College of Integrated Life Sciences (COILS) at UC San Diego. Judith Swain Julie Swain Professor Neil Garg, Chair Miguel Garcia-Garibay (left), and Undergraduate Student Affairs Ofcer Denise Mantonya (right) with undergraduates from Alpha Chi Sigma and the Student Afliates of the American Chemical Society HAPPENI NGS Heather Maynard 7 2012 Seaborg Symposium & Dinner The Department of Chemistry & Biochemistry, UCLAs Johnsson Comprehensive Cancer Center, and UCLAs David Geffen School of Medicine co-sponsored the 2012 Glenn T. Seaborg Symposium & Medal Presentation, titled Can Scientists Make the World a Better Place Through Discovery, Dissemination, and Application of Knowledge?, held on December 7, 2012 at CNSI. The 2012 Glenn T. Seaborg Medal was awarded to Harold Varmus, M.D., the 1989 Nobel Laureate in Physiology or Medicine (with Michael Bishop) and Director of the National Cancer Institute. Discovery is the thing that still drives me and drives my colleagues, but also how do we disseminate, store, and use our knowledge, and how do we apply it to the real life problems faced by the people who pay for that research in this country and in other places in the world, especially in the developing world? Varmus asked during his introductory speech. Professor Levi Garraway, M.D, Ph.D., Dana-Farber Cancer Institute, Broad Institute of Harvard and MIT, Professor Michael Eisen, Ph.D., Lawrence Berkeley National Lab, University of California Berkeley, and Professor Prabhat Jha, M.D., Ph.D., Centre for Global Health Research, University of Toronto, served as the symposium speakers, representing what Varmus called next generation scientists. Garraway presented on the topic of Discovery of Scientific Knowledge, giving a speech titled, The Cancer Genome in Biology and Therapy, Eisen presented on the topic of Dissemination of Scientific Knowledge, giving a speech titled, Building a Public Library of Science, and Jha presented on the topic of Application of Scientific Knowledge, giving a speech titled, Advancing Science to Improve Health of the Global Poor. Varmus also presented on the topic of How the National Cancer Institute is Trying to Make the World a Better Place. A poster session was also held as part of the Seaborg Symposium, and Dean Joseph Rudnick presented award certificates at the evening banquet and award ceremony. The graduate student winners were Ronik Khachatoorian (1st place), Michael Lake (2nd place), and Alexander Patananan (3rd place). The undergraduate student winners were Thuy Tran (1st place), Jaideep Dudani (2nd place), and Taylor Whitaker (3rd place). Glenn T. Seaborg, a UCLA chemistry alumnus, was one of the most influential chemists of the 20th century. He was the recipient of the 1951 Nobel Prize in Chemistry for the discovery and character- ization of ten transuranium elements and had the distinction of having element 106, Seaborgium, named after him during his lifetime. The Department of Chemistry & Biochemistry has awarded the Glenn T. Seaborg medal to an internationally renowned scientist to honor groundbreaking advances in chemistry or biochemistry, or transformational contributions to science policy, since 1987. View Seaborg presentations at www.seaborg.ucla.edu/seaborg2012.html. Top Left: Chair Miguel Garcia-Garibay, Levi Garraway, Prabhat Jha, Dean of the David Geffen School of Medicine, A. Eugene Robinson, JCCC Director Judith Gasson, Harold Varmus, David Eisenberg, Michael Eisen, William Gelbart, and Albert Courey Top Right: Chair Miguel Garcia Garibay and his wife, Beatriz Ruiz Silva Bottom Left: Charles West, Atsuko Fujimoto, Roberts Smith, Adela Smith, and Audree Fowler Bottom Right: Charlene and Ralph Bauer Seaborg Photo Credit: Penny Jennings Harold Varmus and Director of UCLAs Johnsson Comprehensive Cancer Center Judith Gasson 2013 Glenn T. Seaborg Medalist The 2013 Glenn T. Seaborg Medal will be awarded to Professor Kendall Houk. Houk received A.B., M.S., and Ph.D. degrees at Harvard, working with R. B. Woodward as a graduate student in the area of experimental tests of orbital symmetry selection rules. He has taught at Louisiana State University, the University of Pittsburgh, and UCLA since 1986. From 1988-1990, he was Director of the Chemistry Division of the National Science Foundation. He was chair of the Department of Chemistry and Biochemistry from 1991-1994, and became the Saul Winstein Chair in Organic Chemistry in 2009. Professor Houk is an authority on theoretical and computational organic chemistry. Beginning as an experimental organic chemist, he is now on the forefront of the applications of computation and theory, working to understand and predict chemical and biological reactivity. He collaborates prodigiously with chemists all over the world, has published nearly 900 articles, and has given named lectures throughout the United States. Among his honors are the von Humboldt Foundation U.S. Senior Scientist Award, Arthur C. Cope (continued on p. 8) Kendall Houk Kendall Houk Photo Credit: Reed Hutchinson SEABORG SYMPOSI UM 8 David S. Sigman Memorial Lecture & Symposium The 2013 David S. Sigman Memorial Lecture & Symposium honored Professor Baldomero Toto Olivera and was held on January 17 at CNSI. Olivera is the Distinguished Professor Of Biology at the Howard Hughes Medical Institute at the University of Utah, and is a National Academy of Sciences member. His research lecture, titled Investigating the Cellular Complexity of the Nervous System, focused on the venoms of predatory cone snails. A large number of peptide neurotoxins (conopeptides) are present in these venoms and their characterization led Oliveras research group to a broad involvement with molecular neuroscience. Several of these peptides reached human clinical trials and one (Prialt) was approved for the treatment of intractable pain. The lecture was followed by a reception and poster session in the CNSI Foyer. The Molecular Biology Institute, with generous contributions from family and friends, established the David. S. Sigman Memorial Fund in 2002. The fund ensures that the Sigman Lectureship will continue in perpetuity to honor individuals for their significant contributions to chemical biology. Sigman was an internationally renowned UCLA professor, with joint appointments in the Department of Chemistry and Biochemistry and the Department of Biological Chemistry, who discovered chemical nucleases and illuminated the molecular mechanisms by which enzymes catalyze biological reactions. He was one of the founding members of UCLAs Molecular Biology Institute, serving as its associate director from 1994-2001. He died November 11, 2001, at the age of 62, after a two-and-a-half-year battle with brain cancer. Scott Lecture Professor Daan Frenkel, from the University of Cambridge, England, presented the Fall Scott lecture, held on November 5, 2012. Frenkels lecture, titled, The Unexpected Side of Entropy, centered on the topic of the role of entropy as an ordering force, the importance of entropy in the self- assembly of DNA-functionalized colloids, and its possible relevance for targeted drug delivery. The Scott Lecture honors Professor Emeritus Bob Scott, and was established in 2004. The Inaugural Dorothy Wilson Lecture, held to honor Scott, featured lectures by Professor Benjamin Widom (Cornell University) and Anneke Sengers (National Institute of Standards and Technology). Daniel Kivelson Lecture
Professor Itai Cohen (Department of Physics, Cornell University) presented An Homage to Dan at the annual Kivelson Lecture, held on January 28. Cohen began his lecture by discussing his undergraduate experience in Professor Daniel Kivelsons group, sharing personal anecdotes. I am very proud to have been asked to give this lecture in honor of Dan Kivelson, Cohen said. During my undergraduate years at UCLA, I worked in Dans lab, and, through this experience, became hooked on science. Cohen also discussed his groups current work on linking structure with mechanics in soft squishy materials, using their newly developed Confocal Rheoscope to simultaneously measure changes in the mechanical behavior and structural organization of materials, ranging from shear thinning and thickening colloidal suspensions to various strain stiffening biological tissues. The Kivelson Lecture series was established in 2003 to honor Daniel Kivelson, who was an active faculty member even after his retirement, pursuing research in the area of liquid state dynamics and the theory of the glass transition. The inaugural lecture was held on January 23, 2003.
Daan Frenkel and Robert Scott Baldomero Toto Olivera is presented with the David S. Sigman Memorial Lectureship Award Itai Cohen 2013 Seaborg Medalist (continued from p. 7) Scholar, James Flack Norris Award in Physical Organic Chemistry, Computers in Chemical and Pharmaceutical Sciences Award, the Tolman Medal, and the Arthur C. Cope Award, all from the American Chemical Society. He was awarded the Schrdinger Medal of the WATOC, the Faculty Research Lectureship at UCLA, the Bruylants Chair from the University of Louvain-la-Neuve in Belgium, the Dr. rer. nat. h. c. from the University of Essen, Germany, an Erskine Fellowship in New Zealand, a Lady Davis Fellow at the Technion in Haifa, Israel, a JSPS Fellowship in Japan and the Robert Robinson Award of the UK Royal Society of Chemistry. He was also elected to the American Academy of Arts and Sciences, the International Academy of Quantum Molecular Sciences, and the National Academy of Sciences. He has been named as Fellow of the AAAS, WATOC, ACS, and RSC. Houk has served on the boards of a variety of funding agencies and journals, including NIH Study Sections and the PRF Advisory Board. He was Chair of the Chemistry Section of the AAAS, and is now a Senior Editor of Accounts of Chemical Research. He was Director of the UCLA Chemistry-Biology Interface Training Program from 1999 until 2011, and is a member of the UCLA Molecular Biology Institute and California NanoSystems Institute. SEABORG/ DI STI NGUI SHED LECTURES 9 Norma Stoddart Prize Lecture The second annual Norma Stoddart Prize Lecture was presented by Dr. Sarah M. Bronner (formerly of the Garg Group, currently a postdoctoral scholar with the Department of Chemistry at the California Institute of Technology) on February 27, 2013. It was titled Indolynes as Electrophilic Indole Surrogates: Fundamental Reactivity and Synthetic Applications. The Norma Stoddart Prize for Exemplary Citizenship and Excellence in Graduate Research was established by an endowment at UCLA from the Stoddart Family Trust. Norma Stoddart was the wife of Fraser Stoddart, Saul Winstein Chair in Organic Chemistry (1997-2003) and Fred Kavli Chair of NanoSystems Sciences (2003-2007) while he was the director of the California NanoSystems Institute (CNSI), and a faculty member of UCLA. Norma was a caring and loving mother to Fiona McCubbin and Alison Stoddart-Ho, both of whom were chemistry majors at Imperial College London (ICL) and Cambridge University, respectively, going on to obtain their Ph.D. degrees in chemistry (Fiona at ICL and Alison at Durham University). Norma was also a chemistry major at Edinburgh University, where she subsequently obtained a Ph.D. degree in biochemistry within the Medical School. She was an active participant in many activities organized by the Department of Chemistry & Biochemistry at UCLA from 1997 until the time of her passing in 2004. The Norma Stoddart Prize honors graduate students who best represent the outstanding science, service and humanity that Norma brought to UCLA. Recipients receive a $5,000 award and a commemorative plaque. Distinguished Lecturer Seminar Series Coming in Fall 2013 We are delighted to invite you to join us for the inaugural UCLA Department of Chemistry & Biochemistry Distinguished Lecturer Series. The lecture series will be geared toward students, faculty, friends, and alumni whose interests range from systems biology and complex molecule synthesis to nanomaterials and chemical theory. The Fall Quarter lecture will be presented by Professor Frances H. Arnold, the Dick and Barbara Dickinson Professor of Chemical Engineering and Biochemistry at California Institute of Technology, and will be held on November 6, 2013. Arnold is an internationally recognized scientist and engineer. She earned her B.S. in mechanical and aerospace engineering from Princeton University in 1979, and her Ph.D. in chemical engineering from the University of California, Berkeley. She has received many awards, including the 2011 Draper Prize and a 2011 National Medal of Technology and Innovation. She was elected to the American Academy of Arts and Sciences in 2011. Arnold also has the distinct honor of being elected to all three National Academies in the United States. Left: Fraser Stoddart and Sarah Bronner Right: Kendall Houk, Heather Maynard, Fraser Stoddart, Sarah Bronner, Neil Garg, and Miguel Garcia-Garibay Norma Stoddart Prize Lecture Photo Credit: Steevens Alconcel Supporting our Seminar Series Your help is needed to support our world-renowned departmental seminar series! Each division has an outstanding seminar program. Lecturers from all over the globe visit the department and share their cutting-edge research. Students, post-docs, and faculty have the opportunity to meet and exchange ideas with famous academic and industrial researchers. This is not only crucial to their education, but also to their future careers, as the seminar series allows them to make vital contacts. Your funds will support these exciting and critical lectures, allowing the Department of Chemistry and Biochemistry to maintain its competitive edge and reputation for academic excellence. Your gift, however large or modest, is greatly appreciated. To make your contribution, visit https://giving.ucla.edu/ChemAndBioChem. If you are interested in permanently endowing a seminar series in honor of someone special in your life, please contact Kerri Yoder, Director of Development for the Division of Physical Sciences, at (310) 794-9045 or by e-mail at kyoder@support.ucla.edu for more information. *For more information about events, please visit www.chem.ucla.edu or contact the Chairs Office at 310-825-3958. DI STI NGUI SHED LECTURES Frances H. Arnold being awarded the National Medal of Technology and Innovation Award by President Obama Frances H. Arnold Photo Credit: U.S. Department of Commerce blog 10 Alumnus Robert McMahon Presents the Inaugural Orville L. Chapman Lecture Professor Robert McMahon, from the University of Wisconsin-Madison, joined Orville L. Chapmans group as a Ph.D. candidate in 1980, and, despite the fact that he reminded departmental staff of Robert Sheridan, another favored graduate student, he said he developed his own relationship with The Big O that majorly impacted his academic career. Chapman allowed his students independence in pursuing their research interests and emphasized the importance of communicating their findings through well-written articles, leaving a lasting impression on McMahon. He shared memories of Chapman at the Inaugural Orville L. Chapman Lecture, which was held on February 28, 2013. I consider this to be one of the most significant honors Ive had professionally, because Professor Chapman was so important to my graduate experience, my education, the way I think about science, the way I run my research group, and the way I treat my graduate students, McMahon said. McMahon received a bachelors degree in chemistry from the University of Illinois at Urbana-Champaign in 1980, and a Ph.D. in organic chemistry from UCLA in 1985, studying mechanisms of carbene rearrangements with Chapman. After researching excited-state electron transfer as a postdoctoral research associate with Professor Mark S. Wrighton at the Massachusetts Institute of Technology, McMahon joined the faculty at the University of Wisconsin-Madison in 1988, where he now serves as the Helfaer Professor of Chemistry and as Vice Chair of his department. McMahons lecture, titled Mechanistic Organic Chemistry of Harsh Reaction Environments, was an extension of his work with Chapman, as his group was studying carbenes when they discovered the presence of some of these molecules in space. His groups research is now focused on an emerging field of science known as astrochemistry, in which the origins of organic molecules and matter in interstellar space and Earth are studied. There are 150 different organic molecules that have been detected in space, and these molecules are hundreds of light years away, so the idea that people have that space is empty is not right, McMahon said. Its really a fundamental scientific problem, in the sense that it underpins profound questions about the origin of life. McMahon said Chapman was the most extraordinarily creative person he has ever known, demonstrated in his ability to conjure up chemical possibilities and make them realities. Chapman taught organic chemistry at UCLA for 30 years, also serving as Associate Dean for Educational Innovation for 10 years, and was widely recognized as a leader in various scientific fields, including photochemistry, matrix isolation spectroscopy, reaction intermediates, polymers, and materials design. He received his bachelors degree in chemistry and English from Virginia Polytechnic Institute, and his Ph.D. from Cornell University in 1957, before joining the chemistry faculty at Iowa State University. In 1974, Chapman was elected to the National Academy of Sciences and transferred to UCLA, where he investigated organic reactive intermediates, such as carbenes, nitrenes, and propadienones. Chapmans ideas concerning the novel molecule, C60, developed in 1980, when McMahon was working as a graduate student in his group, and, in 1981, he initiated efforts directed at C60s chemical synthesis, pioneering contributions to materials chemistry. It was a manifestation of this mans tremendous creativity that he had envisioned this, and not just C60, but also other related fullerene type structures, like C70 and C84, McMahon said. During his career, Chapman received many awards, including the Pure Chemistry Award and the Arthur C. Cope Medal from the American Chemical Society. In collaboration with Arlene Russell, a senior lecturer, he also led the UCLA Science Challenge, which Professor Kendall Houk said was a case-study based approach to revamping lower-division science education using technology. In 1995, he received the ComputerWorld Smithsonian Institute Award for the best use of computers in education and academia. Chapman and Russell also developed Calibrated Peer Review TM
(CPR), a computer network set up to track submissions and peer reviews of student work. McMahon said this effort was another demonstration of Chapmans creativity and his combined love of chemistry and English. It was a very sophisticated and forward looking use of technology to try and help students learn to write without the instructor having to read each individual sample, McMahon said. McMahon also said Chapman demonstrated great pride in his research group, a feeling that was mutual, treating his students as extensions of his family. He even regularly invited them to Thanksgiving dinner, hosted by Chapman and his wife, Susan, who attended the lecture. I remember him saying, Well cook a turkey thats roughly the size of the oven, McMahon said, recalling one such Thanksgiving dinner. He really loved being at the center of things, helping people to have a good time. At the inaugural lecture, McMahon said Chapman was remembered by many as a kind and gregarious person, who served as a mentor to students and faculty alike. Houk echoed these sentiments in his introductory speech. All of us who knew Orville had wonderful personal experiences of his kindnesses and consideration, Houk said. We take this occasion to honor the life and memory of Orville Chapman for his contributions to science, to education, and to all the people whom he enriched at UCLA. Robert McMahon and Susan Chapman Chapman Lecture Photo Credit: Lufeng Zou Orville Chapman ALUMNI & FRI ENDS 11 OUR GENEROUS SUPPORTERS SEABORGIUM ($5000+) 3M Company Alpha Chi Sigma Fraternity Amgen Inc. Anonymous California Community Foundation - Ralph & Shirley Shapiro Don, Dennis Fortney, Andrew D. Gelbart Family Trust Gilead Sciences, Inc. Hoffmann-La Roche Inc. Jim & Barbara Tsay Foundation John P. McTague Revocable Trust Knobler, Charles M. & Carolyn B. Maxwell Technologies Pfizer, Inc. 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12 Chemistry grabbed hold of Raymond A. Wilson (class of 43) as a teenager, and never let go. Born in Boyle Heights and raised in Inglewood, Wilson recalled having a bent for the sciences, and in high school he took all the science courses that were offered. He enrolled at UCLA in 1939 and never wavered from his decision to major in chemistry. In his first two years as a Bruin, Wilson was a member of the UCLA Rally Committee. He helped organize the massive card tricks at football games and decorate the goal posts in blue and gold. However, when the U.S. entered the war in 1941, many such extracurricular activities were curtailed. Around that time, Wilson began working in the Chemistry Department to help pay for his tuition and his small rented room near campus. Although he graduated nearly seventy years ago, he has enduring memories of several UCLA chemistry professors who profoundly affected his life. Among them were Professors Charles D. Coryell and James D. McCullough, who team-taught an introductory chemistry course. The two of them really convinced me I was in the right place, that chemistry was the right subject for me, Wilson said. And there was Prof. James B. Ramsey, who taught physical chemistry. He was very demanding and gave us pop quizzes once or twice a week, Wilson recalled. You always did your homework in that classor else. Wilson graded papers for pioneering organic chemist Saul Winstein, and worked as an assistant to Professor William R. Crowell, a professor of quantitative analysis. A particular event stands out in Wilsons memory. One evening during a rare war-related blackout, a light bulb that maintained a constant-temperature bath for experiments kept flashing on and off. Thinking it might be a code transmission of some sort, the authorities swiftly arrived and unplugged the bulb causing all of the experiments to fail. To prevent a repeat of this mishap, Wilson was immediately assigned to find an alternative heat source for the constant-temperature bath. Wilson credits his UCLA education for giving him an excellent start to an immensely satisfying 40-year career with Shell Oil Company. Looking back, he noted, Im tickled pink that I got such a great education, which helped me get a good job straight out of college. After he retired, Wilson decided to start giving back to UCLA. In the 1990s, Wilson and his wife, Dorothy (Dot), donated a piece of real estate to the Chemistry Department, to help fund the new Chemistry building. During a visit to see the nearly completed building, they were so impressed by Professor Richard Kaner (their tour guide) that they decided to donate funds to support his researchand have done so ever since. Wilsons next major gift came in 2001, when he named UCLA as the beneficiary of a large IRA and established the Ray and Dorothy Wilson Endowment in Chemistry, which supports visiting professors and student fellowships in the Department. Over the years, the Shell Oil matching gift program has added generously to the endowment. Through their generosity, Dot and Ray Wilson have built a solid legacy in the Department that is also a lasting tribute to the chemistry professors who, seventy years ago, had such a profound impact on a bright young chemistry student. The generous support of our donors keeps UCLA at the forefront of innovation and discovery. If you would like to inquire about ways to give to the Department of Chemistry and Biochemistry, please contact Kerri Yoder, Director of Development for the Division of Physical Sciences, at (310) 794-9045 or by e-mail at kyoder@support.ucla.edu. Why We Donate: Raymond & Dorothy Wilson Raymond and Dorothy Wilson BruinWorks is an online networking site exclusively for UCLA alumni. It allows alumni to connect professionally and personally to a network of nearly 400,000 UCLA alumni. BruinWorks is a UCLA graduate's most valuable resource. BruinWorks enables you to Network with other UCLA alumni from our department Search for jobs, rsums and other alumni Post a job or your own rsum Access a comprehensive UCLA alumni directory Explore a global calendar of UCLA events Join interest and geographic alumni groups Sign up for BruinWorks: Go to www.bruinworks.com and click on Log in. First-time users will be directed to sign up to establish an account. If you already have an account, you can log in with your e-mail address and password. ALUMNI & FRI ENDS 13 Motors on their hybrid cars, and everyone there basically expressed that the key to hybrid vehicles was developing a new type of battery, Davis said. Since battery technology develops very slowly, I was super excited to read about Ric and Maher's work. I didn't think, and don't think, even now, that people realize how big a discovery a new energy storage device is. Although The Super Supercapacitor did not win the grand prize in the competition, it ranked as the second most viewed film of 95 finalists, was viewed by over 1 million people on Web sites such as Reddit, Vimeo, YouTube, and Upworthy, and was translated into Portuguese, serving as a promotional vehicle for possibilities to come. It's not exactly Gangnam Style numbers, but for a three- minute documentary on a science subject, it should be considered very successful, Davis said. Following publication of Kaner and El-Kadys Science article, a leading supercapacitor company also offered them a contract and large donation to fund further research on supercapacitors, for potential applications in transportation and energy grid storage. If you go to China, the new buses run on carbon-based supercapacitors, and the reason they do that is a supercapacitor can be charged and discharged relatively quickly, Kaner said, describing one such application. While people are getting on and off at a bus stop, you can charge your bus, and instead of having an entire grid system, you just make the bus stop the charging station. As long as theres a bus stop every 10 to 20 miles, where the bus can be recharged, its very happy to go along, and you need very little infrastructure. El-Kady and Kaner have made several more breakthroughs over the past year. Although their graphene supercapacitors can already be charged 1000 times faster than batteries, El-Kady is working on further boosting their capacity by making a supercapacitor-battery hybrid that requires limited charging time to store a large amount of power. If you specially design the supercapacitor-battery hybrid, you can get the best attributes of the two, El-Kady said. They also developed mini versions of their supercapacitors, called micro-supercapacitors, which is especially important since the current portable electronics trend has spurred the miniaturization of various technologies. Standard micro-fabrication techniques have enabled on-chip micro-supercapacitors, but the devices are expensive and are produced in a labor-intensive process, thereby limiting their commercial applications. Using the inexpensive LightScribe technique, El-Kady was able to make more than 100 micro-supercapacitors on a single DVD disc in less than 30 minutes, a terrific feat that may lead to direct power source integration into computer processing chips. This research was published in Nature Communications on February 12, 2013. Its something that I believe is a very important step forward towards the commercialization of graphene microsupercapacitors, El-Kady said. Kaner said El-Kadys educational background played a crucial role in the discovery that graphene was ideal for building supercapacitors, enabling him to take the lead in the continuation of their research, and making him more than deserving of the McCoy award. This would not have come about unless Maher came with his masters degree in electrochemistry, and, literally, after measuring the speed of electron transfer on graphene, realized that this was a good application, Kaner said. I have some background in electrochemistrymy Ph.D. was on making the first batteries out of conducting polymersbut I hadnt actually done much electrochemistry since Id been here, so it was refreshing to see him come, and he definitely deserves whatever accolades come his way. El-Kady has always pushed himself to succeed. An almost middle child of a family of nine children, five boys and four girls, El-Kady grew up in Egypt and was strongly encouraged to pursue an education by his parents, both of whom lacked the opportunities available to him. My mother didnt get an education and my father didnt get an education either, although he later learned how to read and write some words, El-Kady said. They made sacrifices so I could pursue what I love to do. I would like to take this opportunity to remember my father who passed away when I was about to join UCLA. Without his help, I wouldnt be here today. I would also like to thank my mother, who gave me a lot of support during my school studies to do something, to be an effective member of society. Even though she didnt know exactly what that could be, she was giving me the support to get a nice education, because then I would eventually know my way and do better than they did. El-Kady said science became a career path at an early age, as he has looked up to Ahmed Zewail, the 1999 Nobel Laureate in chemistry, since he was 12, and was first fascinated by his sixth to eighth grade science teachers lab experiments. Fulfilling his parents aspirations, he received his bachelors of science in chemistry from Cairo University, in 2004, ranking as the top student in his department and gaining a position as a professor at Cairo University, to commence upon the completion of his doctorate. His collaboration with Kaner, who he admired for his work in conducting polymers, began while he was working on his masters thesis, as his committee selected Kaner as an external reviewer. Soon after completing his masters in physical chemistry, in 2009, El-Kady received a graduate fellowship to earn his doctorate in the United States, choosing to join Kaners group. He intended to study conducting polymers, but became interested in graphene, a newer material discovered in 2004. Ric started at the time when conducting polymers were actually the golden material, but, after 40 years, most of their interesting applications had been done already, El-Kady said. Current research has taught us that graphene is the new star material of our time. Measurements showed that graphene is one of the strongest materials known to man, conducts electricity better than copper, and is completely flexible. Most interestingly, graphene has extrememly high surface area. For example, you can cover an entire football field with less than one gram of graphene. These interesting properties suggested that graphene could be used for a variety of applications. However, the question was if we could make a useful device out of graphene, and before that, we needed to ask a more important questioncould we make graphene using an inexpensive and scalable process? Kaner originally set out to find a scalable method for making graphene, as the one made famous by 2010 Nobel Laureates Andre Geim and Konstantin Novoselov was difficult (continued on p. 14) The Super Supercapacitor (continued from p. 1) RESEARCH 14 The Super Supercapacitor (continued from p. 14) Research Highlight: Pyridynes Many commercially available drugs contain organic molecules known as heterocycles, and one of the most common heterocycles prevalent in drugs is called the pyridine ring. Over 100 medications on the market today include pyridine rings, such as Lunesta, commonly used to treat insomnia, Actos, commonly used to treat Type II diabetes, Nexium, commonly used to treat acid reflux, and Singulair, commonly used to treat asthma. By making compounds called pyridynes, Professor Neil Garg and Adam Goetz, a Ph.D. candidate in Gargs laboratory, introduced a new tool to allow chemists to construct various molecular structures that can potentially aid in future drug discovery. This research was published online in Nature Chemistry on November 25. You need basic chemistry to be able to access potential drugs, and we think this is a very useful tool that drug companies will be able to use to make new chemicals that they have not been able to make before, Garg said. Pyridine rings consist of six atoms that can be numbered for classification purposes. Garg and Goetz wanted to introduce new arrangements of atoms, or substituents, on pyridine rings in a controlled process, in order to form new molecular structures to aid chemists in drug discovery. They aimed at producing 3,4-pyridynes, in which the third and fourth atoms in a pyridine ring are attached to one another by a very reactive triple bond. The high reactivity of the pyridyne allows for many possible chemical reactions, Garg said. Although chemists have been producing these types of pyridynes for over 30 years, Garg and Goetz recognized some limitations in their methods, as they were not user-friendly, not often used in drug discovery, and were more likely to result in two, rather than one, product, which is not helpful to those trying to make very specific compounds. To simplify the process, Garg and Goetz prepared pyridyne precursors, which are stable chemicals that can be stored in bottles. Pyridyne precursors can be put into chemical reactions to be converted into pyridynes. They can then be used to quickly react with another ingredient, which can be chosen by the researcher, to form a new product. Since the last ingredient will vary in different reactions, according to a chemists preference, many new substituted pyridines can be made. Garg and Goetz are currently focused on making their pyridyne precursors commercially available. A leading chemical supplier has already purchased three compounds to test market viability, the first step toward drug companies widely using pyridynes in drug discovery. Theres a popular quote by one of the former directors of the National Institutes of Health, and he said that the No. 1 stumbling block in drug discovery is synthetic organic chemistry, Garg said. I think a lot of industrial researchers agree. Were good at synthetic organic chemistry, but we will always need new ways to build molecules, and new ways to build molecules that have never been made before. Our pyridyne chemistry is a contribution along those lines. *This is the first article in our Research Highlights series. Please look for future Research Highlights online at www.chemistry.ucla.edu. to reproduce. Geim and Novoselovs method used tape to peel layers from a piece of graphite until one layer, graphene, resulted. Kaners method instead involved chemical exfoliation of graphene sheets from graphite oxide, documented in the most-cited article in Nature Nanotechnology, and El-Kady said he wanted to take this finding to the next step. My goal at that time was to make a graphene supercapacitor that could store more energy than commercially available supercapacitors and also provide more power, El-Kady said. However, researchers have faced the common challenge that the single layers of graphene stick together, reducing its surface area. To produce graphene sheets that remained separate once combined into supercapacitors, El-Kady, Veronica Strong, a former graduate student, Sergey Dubin, another Ph.D. candidate in Kaners group, and Kaner decided to use a laser to convert graphite oxide into graphene, settling on the laser inside a LightScribe drive, because it was inexpensive and accessible. A few years earlier, they discovered that graphite oxide could convert into graphene when exposed to intense light, and the LightScribe method provided control over the speedy conversion process. We looked at the microscopic structure of graphene and found that the graphene sheets were separated nicely and were highly conductive, El-Kady said. So I thought this was the material that we were after for making an ideal battery or supercapacitor. El-Kady hurried to build a supercapacitor, running to Radio Shack to buy several LEDs, ordering electrolytes, and using 10- year-old electrolytes found in the lab for the time being. Once the supercapacitor was ready, El-Kady charged it and attached it to an LED. Amazingly enough, it worked, El-Kady said. It lit up the LED for several minutes, and I was so excited about it, so I called Veronica (Strong) and said, Here is the interesting application that were after. I was convinced that it would be very important, because youre always wondering whether scientists can discover a wonderful battery that you can have in your cell phone for several days instead of one, El-Kady added. The second thing is that we can make it completely flexible. Flexible technology suitable for roll-up displays has recently gained popularity among researchers. While batteries could break and lose conductivity if bent, graphene supercapacitors can be bent in several directions and maintain conductivity, paving the way for applications in military equipment and flat screen, bendable displays, such as the Samsung Youm Flexible OLED Displays, which were presented at the 2013 Consumer Electronics Show (CES). Kaner said El-Kadys discovery prompted him to recall his own days as a student, when his graduate advisor, Nobel Laureate Alan MacDiarmid, would make him demonstrate his findings before trusting that he had produced significant results. He didnt believe anything until he could actually see or touch it, so it just reminded me of when my advisor used to say, Ok, you say this battery works? I want to see how it works, Kaner said. After graduating in June, El-Kady said he plans to return to Egypt in time for Eid al-Fitr, the festival that follows Ramadan, to celebrate the end of a month of fasting with (continued on p. 15) Nexium Pyridyne Ring RESEARCH 15 his family. Determined to apply his valuable education to instruction at Cairo University, El- Kady also said he intended to teach his students various lab demonstrations. He even used his McCoy award to stock up on textbooks, either unavailable or too expensive in Egypt, which he said would provide necessary updates to the current curriculum. El-Kady will teach in Egypt for a year, before attempting to secure a post- doctoral position in the United States. Although he is still interested in graphene, he said he plans on finding applications for more recent discoveries, such as water splitting, which may lead to clean energy sources. He met Nobel Laureate Sir Harold Kroto at the Lindau Nobel Laureates Meeting in Germany, in 2009, and, while at the meeting, was featured in another short film, titled Nanotechnology: Use and Misuse, in which he discussed similar research interests with Kroto. He walked away with a lesson he continues to utilize todayembrace the scientific method, leaving others opinions behind. (Kroto) liked the dogma in science that we should not be affected by previous thoughts about things, El-Kady said. I think thats very important. It was inspiring, because scientists had a dogma about graphene; they thought that any two-dimensional crystal should not exist in nature, and thats actually why graphene was discovered very late. People considered it an unstable form of carbon that shouldn't exist, but the guys who won the Nobel Prize put an end to these thoughtsgraphene is stableand it was like a shock to the scientific community. Similarily, Kaner has urged his research group to move forward in innovation, rather than finding one solution to a problem and considering it solved, something that El-Kady said he wished to instill in his students. You can make a high surface material, and stop and say, Well this is a high surface material, and it will make a very nice battery, but then you need to prove that you made this material, and that it will perform better than others in the market or in previous literature, El-Kady said. So thats why Ric is always encouraging us to find applications; were always after applications that society is interested in, and if you talk about them, theyll get excited. The photo featured on p. 1 is a still from Brian Golden Davis The Super Supercapacitor. The short film can be viewed at: http://vimeo.com/ focusforwardfilms/semifinalists/51873011. Norma Bernstein Norma Olivier Bernstein, wife of Richard Barry Bernstein (a founding father of the field of chemical reaction dynamics, and professor of chemistry at UCLA from 1983-1990), passed away on August 30, 2012. Born in Pella, Iowa of Dutch immigrants, Norma pursued a career in nursing and was an operating room supervisor when she met her husband of 42 years. Her life was dedicated to supporting Richard's research and career, including helping him in his role as editor of Chemical Physical Letters, and raising their four children, all of whom survive her (Neil, Minda, Beth and Julie). Richard (Dick) Gillespie Richard (Dick) Gillespie, an alumnus and long-time staff member in the department, passed away on January 25, 2013, at the age of 90. Dick started working in our solutions preparation lab in 1951, while also finishing up his B.S., which he earned in 1953. He became head of the Freshman Storeroom, overseeing all chemistry undergraduate laboratory solutions, while he also studied part-time with Professor Ken Trueblood to earn an M.S. in X-ray crystallography, which he completed in 1958. Rather than pursuing a doctorate, Dick embraced his passion for instrumentation, and was the department's mainstay in its instrumentation facility from 1955 until his retirement in 1982. Joan Peter Joan Carol Peter, wife of James B. Peter (a postdoctoral scholar in Paul Boyer's group, School of Medicine faculty member, and 2001 Seaborg Medalist) passed away on November 6, 2012, at age 78. Born and raised in Omaha, Nebraska, Joan and Jim were married for 53 yearsfrom 1955 until his death in 2009. In 1963, Joan and Jim moved to Santa Monica, where they raised their seven children. They later had 13 grandchildren and three great grandchildren. Throughout her life, Joan excelled in her main roles as mother, grandmother, and great-grandmother, and also volunteered with various organizations, such as Meals on Wheels. Jim and Joan Peter also generously endowed the Paul D. Boyer chair in Biochemistry and Molecular Biology. George Rathmann George B. Rathmann, the first chief executive of Amgen, 1995 Seaborg Medalist, and a friend of the department, passed away at his home in Palo Alto, California on April 23, 2012. He was 84. Rathmann was widely known as one of the fathers of the biotechnology industry, leading Amgen in the development of two major drugs; Epogen, to treat anemia, and Neupogen, which prevents cancer patients undergoing chemotherapy from getting infections. He worked for 20 years at 3M before becoming head of research and development for the diagnostics division of Abbott Laboratories in 1975, where he stayed until he was recruited to run Amgen. He worked with Winston Salser, who started Amgen, at UCLA in the seventies. He is survived by his wife, Joy; his daughters, Margaret Rathmann, Laura Jean Rathmann and Sally Kadifa; his son, Richard; and 13 grandchildren. RESEARCH/ I N MEMORI AM Richard (Dick) Gillespie 1922 2013
Richard (Dick) Gillespie, an alumnus and long-time staff member in the department, passed away in his sleep on Friday, January 25 at the age of 90.
Dick was an extremely important member of our department for 31 years. He started working in our solutions preparation lab in 1951 while working towards his BS, which he earned 1953. Soon he was responsible for all chemistry undergraduate laboratory solutions and in charge of the Freshman Storeroom. At the same time, Dick continued his education by studying part-time with Professor Ken Trueblood for a Masters in X-ray crystallography, which he completed in 1958. Rather than pursuing a doctorate, Dick decided that his true interests lay in instrumentation, and from 1955 until his retirement in 1982, he was the Department's mainstay in its instrumentation facility. Dick was an expert in NMR, infrared, ultraviolet and mass spectrometry. He was concerned with the maintenance of the departmental instruments and instructed hundreds of researchers in their use. He loved the challenge of trouble-shooting problems with instruments and in designing new experiments. Dick was extremely supportive of faculty and students alike who often sought him out for his help, in-depth knowledge and advice. Jane Strouse, who overlapped with Dick for two years at the beginning of her career in instrumentation, found Dick to be not only an able mentor, but also a wonderful person to know and work with.
Dick is survived by his wife, Virginia, of 65 years, his daughter, Diane and son, Steve.
Visitation will be held at Forest Lawn, Glendale today, Tuesday, January 29 from 1-4 p.m. Joan Peter Dick Gillespie Norma and Richard Bernstein The Super Supercapacitor (continued from p. 14) In Memoriam George Rathmann
Department Graduation Ceremony and Awarding of Alumni Awards to Drs. Judith and Julie Swain June 15, 2013 (Reception at 4:00 p.m., Ceremony at 5:00 p.m., Court of Sciences) Hawthorne Lecture, Presented by Professor Philip Power, University of California, Davis October 9, 2013 (Contact Inorganic Divisional Office for time and location information: 310-825-4208)
Seaborg Symposium & Medal Award Banquet, Honoring Professor Kendall Houk October 26, 2013 (CNSI Auditorium, 12:00-5:45 p.m., Covel Commons, 6:30-8:30 p.m.) (see p. 7-8)
Distinguished Lecturer Seminar Series, Presented by Professor Frances H. Arnold, California Institute of Technology November 6, 2013 (4:00 p.m., Contact Jin Lee for location information: jinlee@chem.ucla.edu)
Departmental Awards Ceremony November 18, 2013 (Court of Sciences, Room 24, 4:00 p.m.) 115th Faculty Research Lectureship, Presented by Professor Richard Kaner Time and location information to be announced. 15 June 6 Nov. 2013 Upcoming Events in the Department of Chemistry & Biochemistry 9 Oct. 18 Nov. 26 Oct. TBA Fall *More lectures and events can be viewed on our calendar on our Web site at www.chemistry.ucla.edu. SEABORG 2013 October 26, 2013 Registration Available in Fall 2013 www.seaborg.ucla.edu Professor Kendall Houk Saul Winstein Chair, Organic Chemistry HONORING