NOVEL ACADEMY

Graduate School of Pharmacy

Lecture Plan for Bachelor of Pharmacy
Subject: Pharmaceutical Organic chemistry Sem: 3
rd
Batch:2
nd
Teacher :Ganesh Parajuli
Lecture
Hour
unit Unit Topic Objective/Learning outcomes Assignment
seven 1 Nucleophilic
aromatic
substitution
Introduce about Nucleophilic substitution
in aromatic compound.
Compare the Nucleophilic substitution in
aromatic substrate and aromatic substrate
Explain about the Mechanism of aromatic
substitution
* SNAr mechanism ,reactivity and its
orientation and evidences
* Benzyne Mechanism and its evidences


Four hours 2 Unsaturated
Carbonyl
Compounds
Give concept about the unsaturated
carbonyl compounds
Explain about the preparation of
unsaturated carbonyl compounds
by different methods
*Aldol Condensation
*Perkin Condensation
*From -halo acids
Electrophilic addition reaction
Nucleophilic addition reaction
Michael Reaction
Diels Alder reaction

Ten hours 3 Conservation of
Orbital Symmetry
Give concept about the molecular orbital
with respect to organic molecules like
benzene and methane
Concept about the conservation of
molecular orbital symmetry
Introduce about the pericyclic reaction and
its types
Electrocyclic reaction
Frontier Orbital theory
Cycloaddition reaction
Sigmatropic Reaction

3 hours 4 Neighboring group
effect
Effect of neighboring group in Nucleophilic
Substitution
Stereochemistry of product
Explain about the anchimeric assistance

Two hours 5 Catalysis By
transition Metal
Complexes
Importance of role of transition metal
complex in Organic reaction
Role of Wilkinson Catalyst IN
hydrogenation of alkene and its
stereochemistry
Role of octacarbonyl Dicobalt in
oxoprocess

Two hours 6 Stereoselective
and stereospecific
reaction
Give knowledge about the Stereoselective
and stereospecific reaction with suitable
examples

Twelve
hours
7 Heterocyclic
Compounds
Introduce about the heterocyclic
compounds
Preparation and properties of
Pyrrole,Furan andThiophane.
Preparation and properties of Pyridine
Preparation and properties of Indole,
Quinoline and Isoquinoline




Eight hours 8 Carbohydrates Definition of carbohydrate
Classification of carbohydrate
Glucose chain structure and ring chain
form structure
Mutarotion and epimers
Discuss about the
classification,sources,and structure of
Fructose ,Sucrose Maltose and starch,
Amylose ,Amylopectin ,Cellulose
Chain lengthening of aldose- Killani Fisher
Synthesis
Shortening of carbon chain of aldose-Ruff
degradation and formation of osazone


Four hours 9 Lipids Occurrence and composition of fats
Saponification of fats
Detergents
Hydrogenation of oils
Phosphoglyceride and phospholipids

Five hours 10 Proteins and
nucleic acids
Structure of amino acids
Amino acid as a dipolar ions
Isoelectric point of amino acid
Peptide linkage
Protein and classification
Structure of protein

Denaturation of protein
Nucleic acid
Structure of DNA and RNA
Watson and Crick Model

Three hours 11 Uses and
preparation of
some new
reagents used in
drug synthesis
Salicylic acid
Cinamic acid
Quinoline
Ethylacetoacetate
Acetic anhydride
Pyridine
Benzaldehyde
Acetophenone
Dimethylaniline
Tosyl chloride
Diphenyl
Succinic anhydride