Sie sind auf Seite 1von 2


Tweet Tweet 117 20
| 145
Tweet Tweet 117
Share This:
See Also:
Health & Medicine
Mental Health
Brain Tumor
Mind & Brain
Mental Health
Disorders and
Sensory neuron
ScienceDaily (Aug. 12, 2012) Major depression
or chronic stress can cause the loss of brain volume,
a condition that contributes to both emotional and
cognitive impairment. Now a team of researchers led
by Yale scientists has discovered one reason why
this occurs -- a single genetic switch that triggers
loss of brain connections in humans and depression
in animal models.
The findings, reported in the Aug. 12
issue of the journal Nature Medicine,
show that the genetic switch known
as a transcription factor represses
the expression of several genes that
are necessary for the formation of
synaptic connections between brain
cells, which in turn could contribute
to loss of brain mass in the prefrontal
"We wanted to test the idea that
stress causes a loss of brain
synapses in humans," said senior
author Ronald Duman, the Elizabeth
Mears and House Jameson
Professor of Psychiatry and
professor of neurobiology and of
pharmacology. "We show that
circuits normally involved in emotion,
as well as cognition, are disrupted
when this single transcription factor
is activated."
The research team analyzed tissue
of depressed and non-depressed
patients donated from a brain bank
and looked for different patterns of
gene activation. The brains of
patients who had been depressed
exhibited lower levels of expression
in genes that are required for the
function and structure of brain
synapses. Lead author and
postdoctoral researcher H.J. Kang discovered that at least five
of these genes could be regulated by a single transcription
factor called GATA1. When the transcription factor was
activated, rodents exhibited depressive-like symptoms,
suggesting GATA1 plays a role not only in the loss of
connections between neurons but also in symptoms of
Duman theorizes that genetic variations in GATA1 may one
day help identify people at high risk for major depression or
sensitivity to stress.
"We hope that by enhancing synaptic connections, either with
novel medications or behavioral therapy, we can develop more
effective antidepressant therapies," Duman said.
The study was funded by the National Institutes of Health and
the Connecticut Department of Mental Health and Addiction
Other Yale authors of the paper are Bhavya Voleti, Pawel
Licznerski, Ashley Lepack, and Mounira Banasr.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by
Yale University.
Note: Materials may be edited for content and length. For
further information, please contact the source cited above.
Journal Reference:
1. Hyo Jung Kang, Bhavya Voleti, Tibor Hajszan, Grazyna
Rajkowska, Craig A Stockmeier, Pawel Licznerski, Ashley
Lepack, Mahesh S Majik, Lak Shin Jeong, Mounira Banasr,
Expression of a single gene dramatically decreases
synaptic connections between brain cells. Yale
scientists believe this may explain why people
suffering from chronic stress and depression suffer
loss of brain volume (Credit: Courtesy Yale
Ads by Google
Jay Dudley Hypnotherapist Stop Smoking -
weight - anxiety etc Hypnosis - NLP - Confidence
Coachin ... >
Clinical Trials Healthy, aged 18-45? Be a paid
clinical trial volunteer. ... >
Vitamins for your Memory Advanced Vitamins
for Concentration One-A-Day. Buy 3 for 2 + Free
P&P ... >
HCP Depression Resource Diagnosis,
Treatment Understanding & Treating Depression
... >
Natural Stress Remedies Make Stress a Thing
of the Past Experience & Expertise.
... >
Related Stories
Molecular Mechanism Links Stress With
Predisposition for Depression (Jan. 26, 2011)
A new study provides insight into how stress
impacts the brain and may help to explain why
some individuals are predisposed to depression
when they experience chronic stress. The research
reveals ... > read more
Depression Associated With Sustained Brain
Signals: Genetic Mutation in Mice Elevates
Their Risk of Stress-Induced Depression (Apr. 8,
2010) Genetics may have some role in the
predisposition of some people to the effects of
stress, as changes in a gene that regulates brain
signals are associated with depression. Scientists
have now ... > read more
Childhood Stress Such as Abuse or Emotional
Neglect Can Result in Structural Brain Changes
(Feb. 26, 2010) New research using magnetic
resonance imaging shows that childhood stress
such as abuse or emotional neglect, in particular
when combined with genetic factors, can result in
structural brain changes, ... > read more
Depression Increases Risk Of Alzheimer's
Disease, Study Suggests (Apr. 10, 2008)
People who have had depression are more likely to
develop Alzheimer's disease than people who have
How Stress and Depression Can Shrink the Brain
| 32.1K
Breaking News
Just In:
Power to Heal at the Tips of Your Fingers
more breaking science news
Social Networks
Recommend ScienceDaily on Facebook, Twitter,
and Google +1:
Tweet Tweet 11.1K

Follow Follow 38.4K f ollowers
+2342 Recommend this on Google
Other bookmarking and sharing tools:
ads not by this site
Chromebooks Are Here
The Next Generation Of Computers. From
Just 279. Learn More Now!
HCP Depression Resource
Diagnosis, Treatment Understanding &
Treating Depression
High dose of 3 B Vitamins
TrioBe Plus supports your memory and
mental vitality
Taking Statin drugs?
When it comes to your heart,dont put all
your eggs in one basket.
... from
Parasites may get
nastier with climate
swings: study
After Curiosity,
uncertainty lingers
on NASA's Mars
Mars rover flight
engineer with the
Mohawk becomes
Internet hit
Nobel prize-winning
crystals fell to earth
in meteorites
NASA's Morpheus
lander in fiery crash
at Cape Canaveral
microbes may
generate electricity
World over-using
underground water
reserves for
Plane uses ice
runway to evacuate
American from
Antarctic outpost
more science news
In Other News ...
Senior Syrian
policeman defects:
Insight: The greatest
Olympian and his
Insight: Mormon
church made
wealthy by donations
Arab ministers
meeting on Syria postponed
All threats "dwarfed" by Iran nuclear work: Israel
Science News ... from universities, journals, and other research organizations Save Email Print Share
318 Like
318 Like
Send Like 29,862 people like this. Be the f irst
of your f riends.
Health & Medicine Mind & Brain Plants & Animals Earth & Climate Space & Time Matter & Energy Computers & Math Fossils & Ruins
Search ... Go
News Articles Videos Images Books Reference
Find with keyword(s):
Search ScienceDaily
Hyeon Son, Ronald S Duman. Decreased expression of
synapse-related genes and loss of synapses in major
depressive disorder. Nature Medicine, 2012; DOI:
Need to cite this story in your essay, paper, or report? Use
one of the following formats:
Yale University (2012, August 12). How stress
and depression can shrink the brain.
ScienceDaily. Retrieved August 13, 2012, from
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical
advice, diagnosis or treatment. Views expressed here do not
necessarily reflect those of ScienceDaily or its staff.
never had depression, according to a new study.
The study involved 486 people age 60 to 90 who had
... > read more
Ads by Google
Taking Statin drugs? When it comes to your
heart,dont put all your eggs in one basket.
... >
High dose of 3 B Vitamins TrioBe Plus
supports your memory and mental vitality
... >
Struggling with Anxiety? Feel like nothing
helps? Discover a new answer for anxiety problems.
... >
Freight Gatwick Affordable, Fast, Reliable. Fast
Reliable Freight Service. ... >
Shipping to Brunei Regular Container Services
Part or Full Load. ... >
Number of stories in archives: 122,133
Enter a keyword or phrase to search ScienceDaily's archives for related news topics,
the latest news stories, reference articles, science videos, images, and books.

Your Name:
Your Email:
Click button to submit feedback:
Send It
Free Subscriptions
Save Email Print Share
After unrest, divisions grip Anaheim, Disneyland's
Ryan a foreign policy question in a campaign
about economy
For wary Tea Party, Ryan could make Romney
easier to swallow
more top news
Copyright Reuters 2008. See Restrictions.
... from ScienceDaily
Get the latest science news with our free email
newsletters, updated daily and weekly. Or view
hourly updated newsfeeds in your RSS reader:
Email Newsletters
RSS Newsfeeds
... we want to hear from you!
Tell us what you think of ScienceDaily -- we
welcome both positive and negative comments.
Have any problems using the site? Questions?

About ScienceDaily

| Editorial Staff | Awards & Reviews | Contribute News | Advertise With Us | Privacy Policy | Terms of Use
Copyright 1995-2012 ScienceDaily LLC All rights reserved Contact:
Note: This web site is not intended to provide medical advice, diagnosis or treatment.
Part of the iVillage Your Total Health Network