Beruflich Dokumente
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C for 1
hour. Dissolve it in 100 ml of water and add 0.l ml of methyl red solution. Add the acid slowly from a burette. with
constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool and continue the
titration.. Heat again to boiling and titrate further as necessary until the faint pink colour is no longer affected by
continued boiling. 1 ml of 0.5 M hydrochloric acid is equivalent to 0.0265 g of Na
2
CO
3
.
0.1M hydrochloric acid with (f) = Wt. of Na
2
CO
3 .
=
0.0265g X Vol. of HCl
ii)Limit test for salicylic acid(0.3percent):
Shake a quantity of the powdered tablets containing 0.2 g of Aspirin with 4 ml of ethanol (95 per cent), dilute to
100.0 mi with water, filter immediately, transfer 50 ml of the filtrate to a Nessler cylinder, add 1.0 ml of freshly
prepared acid ferric ammonium sulphate solution, mix and allow to stand for 1 minute; the violet colour
produced is not more intense than that produced by adding 1 ml of freshly prepared acid ferric ammonium
sulphate solution to a mixture of 3.0 ml of a freshly prepared 0.01 per cent w/v solution of salicylic acid, 2 ml of
ethanol( 95 per cent) and sufficient water to produce- 50m l contained in a second Nessler cylinder (0.3 per cent).
3
iii)Assay:
Weigh and powder 20 tablets. Weigh accurately a quantity of the powder containing about 0.5 g of Aspirin, add
30.0m l of 0.5M sodium hydroxide,boil gentlyf or l0minutes, cool and titrate the excess of alkali with 0.5 M
hydrochoric acid using phenol red solution as indicator. Repeat the operation w ithout the substance under
examination. T he diff'erence between the titrations represents the amount of sodium hydroxide required.
1 ml of 0.5 M sodium hydroxide is equivalent to 0.04504g of C
9
H
8
O
4
.
Observation:
i)Standardisation:
S.NO Wt. of Initial burette Final burette Total vol. of
titrand(Na
2
CO
3
) reading(ml) reading(ml)
titrant
consumed(ml)
1
2
3
ii) Limit test for salicylic acid(0.3percent):
Complies/Does not comply.
iii)Assay:
S.NO Wt. of Initial burette Final burette Total vol. of
titrand(sample) reading(ml) reading(ml) titrant consumed(ml)
1
2
3
Blank(30ml,
0.5M NaOH)
Calculation:
i)Standardisation of 0.5M hydrochloric acid:
f
1
= Wt. of Na
2
CO
3 .
=
0.0265g X Vol. of HCl
f
2
= Wt. of Na
2
CO
3 .
=
4
0.0265g X Vol. of HCl
Mean (f)=
iii)Assay:
Each table contains aspirin =
1.(Vol. of titrant consumed by blank Vol. of titrant consumed by sample) X f X0.04504g X Avg.Wt. of a tablet
Wt of sample taken(g)
=
2.(Vol. of titrant consumed by blank Vol. of titrant consumed by sample) X f X0.04504g X Avg.Wt. of a tablet
Wt of sample taken(g)
=
Mean=
Result:
Conclusion: