Acknowledgement

We would like to thank the Calvin Mckain Library for providing us with worthwhile information
aiding in the completion of our project. We would also like to thank Skoog 8
th
/9
th
edition the
book has been a very useful source throughout our research. We would like to thank various
certified internet sources for providing us with necessary information. We also express our
gratitude to Mrs.Gordon-Smith and Mr. OBrien for giving us this project to do and guiding us
throughout the entire process
Introduction
The advancement of Spectroscopic methods is very important to the Pharmaceutical Industry. A
wide variety of spectroscopic methods have been employed in the Pharmaceutical Industry for
drug analysis for example ultra violet and visible spectroscopy which incorporates the principle
that drug molecules absorb radiation in the ultraviolet region of the spectrum as well as the
visible region. Infrared spectroscopy uses electromagnetic radiation. Nuclear Magnetic
Resonance Spectroscopy commonly known as NMR has become the one of the most excellent
technique for determining the structure of organic compounds. Of all the spectroscopic methods,
it is the only one for which a complete analysis and interpretation of the entire spectrum is
normally expected. To be successful in using NMR as an analytical tool, it is necessary to
understand the physical principles on which the methods are based. (IOCD, 2013)
NMR is a research technique that uses radiation in the radiofrequency region.
Mass Spectroscopy, Mass spectrometry has been expressed as the smallest scale in the world not
due to the mass of the spectrometers size but due to the size of what the molecule weighs. Over
the past decade, mass spectrophotometry has went through remarkable technological
development so it can be applied to drugs,protein,DNA and a wide variety of biologically
important molecules. Mass spectrometry is the method of measuring atoms and molecules to find
out their molecular weight.
Raman Spectroscopy, Raman spectroscopy is classified as one of the most sensitive techniques
for sample analysis. Raman Spectroscopy, named after Indian physicist, Sir Chandrasekhara
Raman, involves the observation of the altering of wavelength and frequency of light as it
scatters the electrons of a particular medium. This phenomenon is known as the Raman Effect,
also named after Sir Raman (Collins, 2003).
Raman Spectroscopy applications and contributions to society are vast ranging from the
pharmaceutical industry and industrial chemistry to forensic sciences and art
Spectroscopic methods can be used to analyze and test various pharmaceutical drugs. For
example spectrophotometry can be used to analyze the drug aspirin to determine the amount of
acetylsalicylic acid present in the commercial product. Spectrophotometry is a technique used
to measure how much a chemical substance absorbs light by measuring the intensity of light as a
beam of light passes through sample solution. The basic principle involves each compound
absorbing or transmitting light over a certain range of wavelength. This measurement can also be
used to determine the amount of a known chemical substance. Spectrophotometry is one of the
most common and helpful methods of quantitative analysis in a variety of fields such as
chemistry, biochemistry, physics, and clinical applications. (Ucdavis n.d)

Reference

Harper Collins. (2003). Collins English Dictionary. Harper Collins.
Harper Collins. (2003). Collins English Dictionary -Complete and Unbridged. Harper Collins.
IOCD, (2013) Nuclear Magnetic Resonance Spectroscopy retrieved from
http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/Spectrpy/nmr/nmr1.htm
Scripps Center(2014) Mass Spectrophotometry. Retrieved from
http://masspec.scripps.edu/mshistory/whatisms_details.php#Basics
Ucdavis(n.d)Spectrophotometry. Retrieved
fromhttp://chemwiki.ucdavis.edu/Physical_Chemistry/Kinetics/Reaction_Rates/Experimental_D
etermination_of_Kinetcs/Spectrophotometry