DIGITAL HEALTH OPPORTUNITIES ENABLED BY WEARABLE SENSORS March 2014 Technology Grow We enable your technologies to achieve their full potential, your products to have the widest benefit and your franchises to deliver maximum value. We deploy scientific and market knowledge with broad strategy expertise and tailored analytics to translate innovative technologies into novel products that restore and enhance health. VALAMONT Need integrated scalable platform for consumers, caretakers and clinicians that: - aggregates data from multiple sensor health, wellness, and fitness devices, across settings & uses - is interoperable with these devices and apps - can apply intelligent, personalized, and contextual analytics to the data, and - can enable social experiences. KEY NEED: Holistic health monitoring & management Wearable Sensor Perspectives 2 Health sensors enable continuous monitoring at the point-of-patient, anywhere Range of wearable sensor biometrics expanding rapidly across whole body Capturing data with contextually relevant information enables provision of personalized, localized, and relevant aided decision making no matter where the patient is Engagement and interaction, whether via gamification, social interaction, location-based services or interacting with the users environment to provide real-time feedback (e.g. music, lighting, gameplay) GOAL: Enable Contextual Relevance and Compelling User Experiences that Drive Sustained Behavioral Change Smart Data, not just Big Data Anything, Anytime, Anywhere Engage, Interact, Adapt VALAMONT Biometric-Enabled Applications The convergence between biometric sensors and mobile platforms is driving explosive growth in innovative wellness and medical applications, as well as biometric-enhanced consumer apps 3 Wearable Sensor Perspectives Mobile Platforms Biometric Sensors Biometric Mobile Apps Social networking Gaming Dating Entertainment Productivity Mind/Body Wellness Apps Fitness, Strength Food, Diet, Nutrition Sleep Stress, Mood Attention, Memory Mobile Medical Apps Chronic Disease Mgmt Medication Adherence Post-Discharge Mgmt Connected Healthcare Wearable Diagnostics Digital Therapeutics Physical Motion Pressure Temperature Perspiration Electrical Heart Rate / EKG EEG Chemical Microneedles Microfluidics Prep & detect Chemicals, proteins, nucleic acids Communication Low-energy Bluetooth WiFi, RFID Body Area Networks Physical Meters Clock Accelerometer GPS/location Data Use patterns Calendar, contacts Messaging, mail Social networks Mind/Body Wellness Apps Biometric Mobile Apps Mobile Medical Apps Physical Electrical Chemical Communication Time & Location Data & Usage VALAMONT Technology Elements / Sectors Stakeholder Settings Applications M o b i l e
A p p l i c a t i o n s W e a r a b l e
S e n s o r s B o d y A r e a
N e t w o r k s C l o u d
S e r v i c e s D a t a A n a l y t i c s A d a p t i v e
A l g o r i t h m s D x / R x
L o o p
M i c r o d e v i c e s Consumer Fitness & Wellness Quantified Self / Fitness Preventative Health Mgmt Personalized Health Regimens Aging in Place Connected Home / Auto Disease Monitoring / Tracking Chronic Disease Mgt. Disease Detection / Screening Medication Adherence Physician Digital Therapeutics Prescription Therapy Closed Loop Dx/Rx Systems Remote Diagnosis/ Imaging Emergency Medicine Post-Discharge Management Hospital Acute Care Post-Surgical Management Inpt. Continuous Monitoring Wearable Sensor Perspectives 4 Digital Health Technology and Application Landscape Digital product categories are emerging across fitness and wellness, chronic disease management, prescribed interventions and acute care B 2 C
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B 2 B 2 C B 2 B Fitness (activity, body comp) Metabolic / Diabesity (glucose, insulin pumps) Cardiovascular (hr, bp, EEG, connected implants) Respiratory (O2, res rate, FEV1) Neuro/Psych (attention, memory, sleep, mood) Musculoskeletal (dynamic implants) Inflamm/ Rheumatology ? Gastrointestinal / Hepatic ? Renal Function ? Endocrinology ? Womens Health / Fertility ? Hematology / Oncology ? Infectious Disease ? VALAMONT Wearable Connected Health Sensors Key Success Factors To capitalize fully on the potential of wireless patient monitoring, and drive market growth, form factor, price, and network enablement must be primary design considerations 5 Form Factor & Design Price & Convenience Network Enablement Consumer and medical convergence requires simple, consumer-friendly sensors and UIs - Must meet high medical standards, but utility and clinical effectiveness not sufficient Comfortable, fashionable, wearable, and unobtrusive design essential - Adoption and sustained engagement requires seamless fit into daily life The data generated by wearable, low-cost sensor devices and disposables will drive a growing market for data interpretation software and services Low energy wireless communications technologies using mobile body area network spectrum will need to adapt to interoperable standards as they emerge Miniatur- ization Integration & Interoperability Scale & Commodit- ization Key Trends Wearable Sensor Perspectives VALAMONT EXAMPLE: ClickMedix Mobile eHealth Platform Wearable Sensor Perspectives 6 Mobile care protocols enable field caregivers to provide first line diagnoses and connects specialists to patients and caregivers remotely VALAMONT EXAMPLE: Acute Care & Post-Discharge Patient Monitoring Opportunity Wearable Sensor Perspectives 7 Acute Care Patient Monitoring Opportunity In-Patient Hospital Emergency Department & Transport Recently Discharged Chronic Disease Home 1 2 3 4 Multi-billion dollar growth opportunity for remote patient monitoring telehealth: - InMedica predicts will be applied to 1.8 million patients worldwide by 2017, versus 308,000 today - Majority of revenue from software/services Innovations in consumer healthcare will drive growth in the monitoring of high cost patient VALAMONT EXAMPLE: MC10 Flexible Wearable Patch Sensors Wearable Sensor Perspectives 8 Stretchable epidermal sensor technology that conforms to the body's complex shapes - developing multiple applications for patient monitoring. Multiple applications in development in sports, fitness, and medical markets. Received investment from major firms. MC10 Mission: Reshape rigid, conventional electronics into thin, flexible devices that can stretch, bend and twist seamlessly with our bodies and the natural world. Comfortable, disposable wearable sensors enable a breadth of biometric monitoring applications VALAMONT Mobile Apps: A Wide Range of Business Models are Emerging Wearable Sensor Perspectives 9 Physicians pay to download a premium version of the EPOCRATES RX app to their smartphones (6% of total revenue) Drug companies pay EPOCRATES for marketing access to physicians using the EPOCRATES RX app (over 90% of revenue) Physicians prescribe CardioNets mobile arrhythmia diagnostic service to patients to save both parties time to make an accurate diagnosis Insurers reimburse CardioNet on a pre-negotiated rate for each prescription Healthcare providers license WellDocs mobile disease management software to proactively manage patients with diabetes Healthcare providers and insurers can outsource their DM program to WellDoc Clinical Research Organizations pay to use WellDocs applications to manage patients in various clinical trials Consumers pay directly to Independa for drug reminder services Institutional and long-term care providers license Independas platform, accessories, and software for managing fragile seniors Providers and home health agencies pay AirStrip to access their mobile patient monitoring apps Apps are utilized by physicians and nurses both in and out of the hospital VALAMONT Wellness & Disease Management Apps Fitness, Nutrition, Weight, Body Composition Stress, Sleep and Mood Diabetes Management Cardiovascular Measures Etc. Mobile Health Tools & Services Telehealth Consultations Remote Patient Monitoring Caregiver Tools Connected Home Personal Emergency Response Appointment Reminders Medication Reminders: Adherence Healthcare/Benefit Financial Planning mHealthApp Developers Wearable Sensor Perspectives 10 Samsung and Apple are vying to be the leading digital health and wellness integrators HealthBook S Health VALAMONT Hurdles to Achieving Real Outcomes from Digital Health and Wellness Applications Wearable Sensor Perspectives Early adopters and adherent users typically have the least to gain from the products - Those who have the most to gain tend to adopt late and adhere poorly Applications can only improve outcomes while the user is actively engaged in their use - Most users disengage, drop out within 3-6 months (~25% single use; only ~25% >10 uses) - People who benefit most from high touch approach are least likely to seek it out Meaningful data interpretation with adaptive feedback that motivates sustained behavioral change - Raw data read-outs (weight, body fat, heart rate, etc.) not engaging or motivational Regulatory and reimbursement paradigms required to capture value of improved health outcomes - Insurer reimbursement best way to capture full economic value, but requires investment to collective evidence to support claims The most successful digital health and wellness applications will: - Passively & unobtrusively capture data with little effort by user - Provide multiple levels of engagement, such as gamified reward systems, adaptive automated in-app feedback, caretaker/clinician prompts for active communications and social network engagement - Demonstrate an ability to sustain engagement and active use beyond initial period - Demonstrate improved outcomes or risk reduction on meaningful health measures Broad Adoption Motivate Behaviors Sustain Engagement Measurable Benefits 11 VALAMONT ADVISORS, LLC Science Driven Strategy Design 300 Technology Square, Suite 802, Cambridge, MA 02139 Technology Grow We enable your technologies to achieve their full potential, your products to have the widest benefit and your franchises to deliver maximum value. We deploy scientific and market knowledge with broad strategy expertise and tailored analytics to translate innovative technologies into novel products that restore and enhance health.