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g
/
m
L
)
0
1
2
3
Time (h)
0 20 40 60 80 100 120 140 160
P
l
a
s
m
a
c
o
n
c
e
n
t
r
a
t
i
o
n
(
g
/
m
L
)
0.000
0.025
0.050
0.075
0.100
Fig. 3 The concentrationtime profiles for CBZ (a) and CBZ-E (b)
obtained from plasma from three human volunteers given an oral
administration of a 200 mg CBZ CR tablet
Table 3 CBZ and CBZ-E pharmacokinetic parameters in healthy
subjects (n=3)
Pharmacokinetic parameters CBZ CBZ-E
T
max
(h) 20.75.8 44.06.9
C
max
(g/mL) 2.40.5 0.080.01
AUC
0144 h
(gh/mL) 195.634.6 7.71.1
T
1/2
(h) 57.311.4 61.716.8
Anal Bioanal Chem (2006) 386:19311936 1935
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