DRUG NAME MECHANISM OF

ACTION
INDICATION CONTRAINDICATION SIDE
EFFECTS/ADVERSE
REACTION
NURSING
RESPONSIBILITY
Cisplatin
Antineoplastic
Platinum Agent
Alkylating drug

DOSE:
1mg/mL
FREQ:
IV
Inhibits DNA
synthesis by
producing cross-
linking of parent
DNA strands (cell-
cycle phase
nonspecific).

Alone or in
combination (with
other
antineoplastics,
surgery, or
radiation) in the
management of:
Metastatic
testicular and
ovarian carcinoma;
Advanced bladder
cancer; Head and
neck cancer;
Cervical cancer;
Lung cancer; Other
tumors.

Hypersensitivity;
Pregnancy or
lactation.

CNS- malaise,
weakness

GIT- vomiting,
diarrhea

>Monitor blood
pressure, pulse,
respiratory rate,
and temperature
frequently during
administration.
Report significant
changes.
>Monitor intake
and output and
specific gravity
frequently
throughout
therapy. Report
discrepancies
immediately. To
reduce the risk of
nephrotoxicity, a
urinary output of at
least 100 ml/hr
should be
maintained for 4 hr
before initiating
and for at least 24
hr after
administration.
>Encourage patient
to drink 20003000
ml/day to promote
excretion of uric
acid. Allopurinol
and alkalinization
of the urine may be
used to help
prevent uric acid
nephropathy.
>Assess patency of
IV site frequently
during therapy.
Cisplatin may cause
severe irritation
and necrosis of
tissue if
extravasation
occurs.
DRUG NAME MECHANISM OF
ACTION
INDICATION CONTRAINDICATION SIDE
EFFECTS/ADVERSE
REACTION
NURSING
RESPONSIBILITY

Fluorouracil
5-FU
Antimetabolite
Antineoplastic

DOSE:
500 mg/sq.meter IV on
Days 1-5

FREQ:
IV
Fluorouracil is
part of a group of
chemotherapy
drugs known as
the anti
metabolites. Anti
metabolites are
similar to normal
body molecules
but they have a
slightly different
structure. These
differences mean
that anti
metabolites stop
cells working
properly. They
stop cells making
and repairing
DNA. Cancer cells
need to make and
repair DNA in
order to grow and
multiply. Anti
metabolites also
stop normal cells
working properly.
This is why you
get side effects.
Used to treat
malignant
neoplasms of
breast, colon,
urinary bladder,
liver, pancreas,
adjuvant to
surgery,
radiotherapy &
other
chemotherapeutic
drugs.
Topical application
in cutaneous basal
cell carcinoma.

Pregnancy,
Depressed bone
marrow function,
Poor nutritional
state, Serious
infections
CNS- malaise,
weakness

GIT- vomiting,
diarrhea,nausea

> Lab tests: Obtain
total and
differential
leukocyte counts
before each dose is
administered.
>Report
disorientation or
confusion; drug
should be
withdrawn
immediately.
> Report
intractable
vomiting to
physician.
> Establish a
reference data
base for body
weight, I&O ratio
and pattern, food
preferences and
dietary habits,
bowel habits, and
condition of
mouth.