Causes

By Mayo Clinic Staff

Anemia occurs when your blood doesn't have enough red blood cells. This can
happen if:
Your body doesn't make enough red blood cells
Bleeding causes you to lose red blood cells more quickly than they can be
replaced
Your body destroys red blood cells
What red blood cells do
Your body makes three types of blood cells white blood cells to fight infection,
platelets to help your blood clot and red blood cells to carry oxygen throughout
your body.
Red blood cells contain hemoglobin a red, iron-rich protein that gives blood its
red color. Hemoglobin enables red blood cells to carry oxygen from your lungs to
all parts of your body and to carry carbon dioxide from other parts of the body to
your lungs so that it can be exhaled.
Most blood cells, including red blood cells, are produced regularly in your bone
marrow a red, spongy material found within the cavities of many of your large
bones. To produce hemoglobin and red blood cells, your body needs iron,
vitamin B-12, folate and other nutrients from the foods you eat.
Causes of common types of anemia
Common types of anemia and their causes include:
Iron deficiency anemia. Iron deficiency anemia is caused by a shortage of
the element iron in your body. Your bone marrow needs iron to make
hemoglobin. Without adequate iron, your body can't produce enough
hemoglobin for red blood cells.
This type of anemia is often caused by blood loss, such as from heavy
menstrual bleeding, an ulcer, cancer, a polyp somewhere in your digestive
system, and prolonged use of aspirin or drugs known as nonsteroidal anti-
inflammatory drugs (NSAIDs).
Vitamin deficiency anemias. In addition to iron, your body needs folate and
vitamin B-12 to produce sufficient numbers of healthy red blood cells. A diet
lacking in these and other key nutrients can cause decreased red blood cell
production.
Additionally, some people may eat enough B-12, but their bodies aren't able
to process the vitamin. This can lead to vitamin deficiency anemia, also
known as pernicious anemia.
Anemia of chronic disease. Certain chronic diseases such as cancer,
HIV/AIDS, rheumatoid arthritis, Crohn's disease and other chronic
inflammatory diseases can interfere with the production of red blood cells,
resulting in chronic anemia. Kidney failure also can cause anemia.
Aplastic anemia. This very rare life-threatening anemia is caused by a
decrease in the bone marrow's ability to produce red blood cells. Causes of
aplastic anemia include infections, drugs and autoimmune diseases.
Anemias associated with bone marrow disease. A variety of diseases,
such as leukemia, myelodysplasia or myelofibrosis, can cause anemia by
affecting blood production in your bone marrow. The effects of these types of
cancer and cancer-like disorders vary from a mild alteration in blood
production to a complete life-threatening shutdown of the blood-making
process.
Other cancers of the blood or bone marrow such as multiple myeloma,
myeloproliferative disorders and lymphoma also can cause anemia.
Hemolytic anemias. This group of anemias develops when red blood cells
are destroyed faster than bone marrow can replace them. Certain blood
diseases can cause increased red blood cell destruction. You can inherit a
hemolytic anemia, or you can develop it later in life.
Sickle cell anemia. This inherited and sometimes serious anemia is caused
by a defective form of hemoglobin that forces red blood cells to assume an
abnormal crescent (sickle) shape. These irregular-shaped red blood cells die
prematurely, resulting in a chronic shortage of red blood cells.
Other anemias. There are several other rarer forms of anemia, such as
thalassemia and anemias caused by defective hemoglobin.
Symptoms
Risk factors
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Aug. 19, 2014
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