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BME 354

Molecular Sensors and Nanodevices for

BME Applications
Tim Yeh
Department of Biomedical Engineering
University of Texas at Austin
L1: Introduction
Tim Yeh (Hsin-Chih Yeh)
1990-1994: B.S. in Mechanical Engineering
National Taiwan University, Taiwan
1996-1998: M.S. in Mechanical Engineering
University of California, Los Angeles
1998-2003: R&D engineering in optical MEMS industry
Optical Micromachines, San Diego, California
2003-2008: Ph.D. in Mechanical Engineering
Johns Hopkins University, Baltimore, Maryland
2009-2012: Postdoc in a nanoscience center
Los Alamos National Laboratory
2012- : Assistant professor in BME at UT Austin
Human hair
Teaching Assistants
Cong Liu
Expertise: Optical engineering, electrical engineering
Office: BME 5.202K
Office hour: T 3:45-4:45pm or by appointment
Allen Liu
Expertise: Biomaterials, tissue engineering
Office: BME 5.202K
Office hour: M 5:30-6:30pm or by appointment
BME 354 Molecular Sensors and Nanodevices
Fall 2014 MWF11am-12pm, CPE 2.206
Instructor: Professor Tim Yeh (Hsin-Chih Yeh)
Office hours: MF 12-1pmor by appointment, BME 5.202C
Please send me an email in advance if you are coming to my office.
Textbook (required):
Molecular Sensors and Nanodevices: Principles, Designs and
Applications in Biomedical Engineering
John X.J. Zhang and Kazunori Hoshino, Elsevier 2014
References (optional):
Selected papers posted on BlackBoard.
Micromachined Transducers Sourcebook, Kovacs, McGraw-Hill 1998
Fundamental of Microfabrication, Madou, CRC Press 2002
Chemical Sensors and Biosensors, Eggins, Wiley 2002
Biomolecular Sensors, Gizeli and Lowe, Taylor and Francis 2002
Commercial Biosensors, Ramsay, Wiley 1998
BME 314. Engineering Foundations of Biomedical Engineering
Fundamental biology (311C), physics (303K), chemistry (302),
math (427K), and engineering (BME 102L, EE 319K)
BME 352. Engineering Biomaterials
Mechanical and chemical properties of biomaterials
Electronics (BME 221 Measurement and instrumentation lab)
Desire to learn, common sense, being able to enjoy challenges,
ability to work alone, curiosity, aptitude to modify and control
sleep habits.
Grading Policy
8 Homework assignments
Project presentation
Final exam
Totally 8 homework assignments
Assigned on Wednesday and due next Wednesday
before class (i.e. 10:59am) you have a week to work
on HW assignments
A deadline is a deadline no late homework will be
Dropping the lowest HW grade? No
Assignment extension?
Ask the instructor before the assignment is due
Granted for medical and personal emergencies only
You may be asked to provide written proof
Syllabus and schedule
Course documents
Lecture notes
Rubric for project
Articles (i.e. review
papers) to read
HW assignments
My Grades
Check your grades
Disability and Religious Holidays
Check the syllabus
Academic Integrity
All students must follow the Code of Honor:
I affirm the solutions represented in my response to the following exam questions are
solely mine. Information contained within has not been distributed or obtained from
other sources.
Cheating will be dealt with in as severe a manner as possible.
You will fail this course if you cheat. Cheating includes, but is
not limited to, copying and plagiarism. Please see the following
points to clarify the above situations for this course.
1. Assignments and homework are to be the work of the individual student. Utilizing
computer codes, notes, answer sheets, assignment banks, etc. that have not been
explicitly authorized by the Instructor is considered cheating.
2. For the purposes of this course, plagiarism consists of, but is not limited to, any of the
following: copying exact text from a published source without citation (> 10 words),
inaccurately citing sources, paraphrasing text or ideas from a published source without
citation (>3 sentences), copying text but changing only selected words without citation (>3
sentences), and constructing a text that is primarily anothers work (whether cited or not).
3. Students may be suspended or expelled permanently from the University for scholastic
Check the syllabus
Academic Integrity
Please check the following website for the official UT Austin policy:
It is OK to ask questions now about what constitutes cheating. It is
not OK later once an event has happened. Additionally, claiming
ignorance regarding cheating does not excuse an individual. It is up
to you to determine what constitutes academic dishonesty.
Check the syllabus
Class Goals
To know the basic elements and major classes of molecular
sensors, nanodevices and biomedical microsystems (i.e.
Micro- Electro-Mechanical Systems, MEMS);
To demonstrate an understanding of the fundamental
principles behind the operation of molecular sensors, nano-
devices and biomedical microsystems.
To understand the unique requirements, environments, and
applications of molecular sensors, nano-devices and
biomedical microsystems.
To gain an understanding of standard micro- and nano-
fabrication techniques for sensors
To apply knowledge of the above to the design and manufacturing
of such microsystems.
Introduction (1 lecture)
Principles of Molecular Sensors (1 lecture)
Introduction to Silicon, MEMS, Microfabrication, Scaling Law (4 lectures)
Microfluidics and Soft Lithography (5 lectures)
Electrical Transducers: electrochemical sensors, FET-based sensors (4 lectures)
Exam 1
Optical Transducers and Optical Spectroscopy (6 lectures)
Mechanical Transducers: cantilevers, acoustic biosensors, thermal sensors (4 lectures)
Exam 2
Introduction to Nanotechnology (7 lectures)
Project presentation
Final Exam
BME 354 Topics
Class Schedule
Class Schedule
10/22-25 BMES conference in San Antonio
Your attendance is required during the project presentation!
Focus on sensors, actuators, MEMS
Journal of Microelectromechanical Systems (JMEMS)
Journal of Micromechanics and Microengineering
Sensors and Actuators A(Physical)
Sensors and Actuators B (Chemical)
Micro Total Analysis Systems (Micro-TAS)
Lab on a Chip, Analytical Chemistry
Biomedical Microdevices
Nanotechnology, Nanomaterials
Nature nanotechnology
Nano Letters, Small, Nanotechnology
Advanced materials, Advanced functional materials, biomaterials
Nature materials
Supporting Information: Journals
Electrical Engineering
IEEE journals, such as IEEE Electron Device Letters
Journal of the Electrochemical Society
Journal of the Vacuum Society
Nature photonics
Optics express, Optics letters
Proceeding of the SPIE International Society for Optical Engineering
Applied Physics
Applied Physics Letters
Journal of Applied Physics
Physics Review series
Supporting Information: Journals
International Conference on Solid-State Sensors and Actuators, or
Large, international, alternate years, 91, 93, , 11, 13, ..
Solid-State Sensor and Actuator Workshop, or Hilton Head
North American only, alternate years, 92, 94, , 10, 12, ..
European, alternate years, 92, 94, , 10, 12, ..
IEEE Micro Electro Mechanical Systems Workshop, or MEMS
Single session, highly selective, international, annually
Micro Total Analysis Systems, or TAS
Interantional annual
Supporting Information: Conferences
University Microfilms International
(ProQuest Dissertations and Theses)
Websites (MEMS-talk)
Supporting Information: Internet Resources
Special requests?