Designed to Support a Dogs

Endogenous Antioxidants
Bioactive
Chewable Scored Tablets
Veterinary Exclusive Formula

Orally Effective
Superoxide Dismutase
(Superoxide Dismutase)
Reactive oxygen species (ROS) free radicals are
produced during normal cellular respiration within cells.
During periods of imbalance, excessive ROS may alter
cells by reacting with:
Lipids Proteins Cellular DNA.
xidative stress occurs when there
is a significant imbalance between
production of reactive oxygen species
and antioxidant defenses.
Managing Oxidative Stress
Non-Enzymatic
Antioxidant
Enzymatic
Antioxidant
Decreased Oxidative Stress
Primary Responders
Superoxide Dismutase
Catalase
Glutathione Peroxidase
Secondary Responders
Glutathione*
Vitamin E

Silybin

Zinc

Coenzyme Q10

Vitamin C
Lipoic Acid
Selenium
O
*Denosyl

contains S-Adenosylmethionine, a precursor to glutathione.

These secondary responders can be found in Marin

Coenzyme Q
10
is the primary ingredient in Comal

Q
10
.
What is Oxidative Stress?
Considered the most important antioxidant of the body.
Combines reactive oxygen to form hydrogen peroxide,
which glutathione peroxidase (GPx) and catalase can reduce
to water and oxygen.
Indications for SOD supplementation:
Inflammatory conditions
of oxidative stress
Overall cellular health and
organ support.
Enzymatic antioxidants are considered to constitute
the bodys primary response to oxidative stress as
non-enzymatic antioxidants can be rapidly depleted.
SOD found in cytoplasm, mitochondria, and extracellular matrix.
2
2
H O + O
2 2
H O
Reactive
Oxygen
WHY SUPEROXIDE DISMUTASE (SOD)?
Glutathione
GPx
CATALASE
SOD
GSSG

O
2
WHY SUPPLEMENT SOD?
Oxstrin

is a Patented
Bioactive SOD Complex
70000
60000
50000
40000
30000
20000
10000
0
S
O
D
U
/
g

w
e
t

w
t
Liver
Kidney
G.I. Tract
Heart
Lung
Muscle
Pancreas
Liver and Kidney
H
a
v
e

H
ig
h
e
s
t

L
e
v
e
l
s
PRIMARY
RESPONDERS
SECONDARY
RESPONDERS
FREE RADICAL
PRODUCTION
Successful Management of Oxidative Stress Requires
BALANCE
SOD is lower in dogs
SOD distribution in canine tissues
(extracellular fluids)
Mouse
Rat
Man
Horse
DOG
Cat
450
400
350
300
250
200
150
100
50
0
P
l
a
s
m
a

S
O
D

A
c
t
i
v
i
t
y
U
/
m
l
C
a
n
i
n
e

S
O
D

L
o
w
C
o
m
p
a
re
d
t
o

O
t
h
e
r

S
p
e
c
ie
s
Adapted from Marklund SL, Holme E, & Hellner L. Clinica Chimica Acta 1982;126:41-51.
Adapted from Marklund SL. Extracellular superoxide dismutase and other superoxide dismutase
isoenzymes in tissues from nine mammalian species. Biochem. J. 1984;222: 649-655.
14
12
10
8
6
4
2
0
Control
SOD Complex
SOD (U/g Hb)
SOD Increased 440%
Catalase increased 70%
GPx Increased 220%

HOWIS OXSTRINDIFFERENT?
Non-animal source of Superoxide
Dismutase (SOD) providing measurable
amounts of SOD.
Gluten-coated:
Gluten is derived from wheat protein
Facilitates transport of SOD across enteric
membranes
Helps up-regulate production of
endogenous SOD as well as other
primary enzymatic antioxidants.

3500
3000
2500
2000
1500
1000
500
0
Control
Non-Protected
SOD Complex
SOD (U/g Hb)
SOD Increased 89%
Catalase increased 171%
GPx Increased 51%

Melon extract
naturally rich
in SOD
Gluten
Chart above and to the right adapted from: Vouldoukis I, Conti M, Krauss P, et al.
Supplementation with gliadin-combined plant superoxide dismutase extract pro-
motes antioxidant defences and protects against oxidative stress. Phytother. Res
2004;18: 957-962.
Effects of supplementation on
mouse liver primary response enzymes
Effects of supplementation on
mouse circulating primary response enzymes
50
40
30
20
10
0
0 3 6 12
Months After Treatment
C
R
P

(
m
g
/
L
)
SOD protected from
gastric degradation.
Administration of
SOD complex found in
Oxstrin lowered c-reactive
protein (CRP) levels.
Animal studies show increases
in erthrocyte SOD activity
(mice and dogs).
Oral ingestion of SOD complex
found in Oxstrin results in
increased SOD levels for up to
three weeks after usage ends.
0 2 5 10 30 60
100
80
60
40
20
0
In-vitro model of gastric degradation
S
O
D

A
c
t
i
v
i
t
y

(
%
)
Time (min)
Free SOD
SOD Complex
Adapted from: Vouldoukis I, Conti M, Krauss P, et al. Supplementation with gliadin-combined
plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress.
Phytother. Res 2004;18:957-962.
In-vitro simulation of gastric degradation on quadruplicate samples of six experiments.
Reduction in serum acute phase protein (CRP)
in dogs administered the SOD Complex.*

*Data on file.
Designed to support the dogs natural enzymatic anti-oxidant system.
Exclusive veterinary formulation of SOD:
Protected from gastric degradation
Bioactive.
Scored tablets for ease of administration.
Helps protect and maintain cellular health.
Supports resistance to oxidative stress for organ systems including:
Hepatic Renal Pancreatic Vision
Immune Cardiac Pulmonary Musculoskeletal.

OXIDATIVE
STRESS
OXSTRIN
OXSTRIN
Oxstrins Up-Regulation
Helps SHIELD Against
Oxidative Stress

Nutramax Laboratories, Inc.

2208 Lakeside Boulevard Edgewood, Maryland 21040
1-800-925-5187 nutramaxlabs.com
03-1014-00

Orally Bioactive Superoxide

Dismutase Supplement
Up-regulates enzymatic antioxidant systems
Helps protect and maintain cellular health
Supports resistance to oxidative stress
Designed for veterinary usage
Denosyl

, Marin

, and Comal

Q
10
are registered trademarks of
Nutramax Laboratories, Inc.
To order, call Nutramax Laboratories, Inc. at 1-800-925-5187,
or contact your local authorized Oxstrin distributor.