Infection the implantation and successful replication of an organism in the tissue of the host Carrier individual who harbors the organism and is capable of transmitting to a susceptible host but does not show manifestations of the disease Communicable disease an illness caused by an infectious agent or its toxic products that are transmitted directly or indirectly to a well person through an agent, vector or inaminate object Contact any person or animal that is in close association with an infected person, animal or freshly soiled materials Contagious disease one that is easily transmitted from one person to another throught direct or indirect means Disinfection destruction of pathogenic microorganisms outside of the body through direct physical or chemical burns o Concurrent Disinfection method done immediately after the infected individual discharges infection material or secretions; is done while the patient is still the source of infection o Terminal Disinfection applied when the patient is no longer the source of infection (either the patient has died or has been discharged); everything the patient used including his/her room is disinfected Habitat a place where an organism is usually found/lives Host a person, animal or plant which a parasite depend for its survival
Isolation the separation of an individual suffering from a communicable disease from other persons Quarantine the limitation of freedom of movement of persons or animals which have been exposed to communicable disease/s for a period of time equivalent to the longest incubation period of that disease Reservoir composed of one or more specie of animal or plant in which an infectious agent lives and multiply for survival and reproduce itself in such a manner that it can be transmitted to man Surveillance the act of watching
Infectious Disease are those that are transmitted not only by ordinary contact but require direct inoculation of the organism through a break on the skin or mucous membrane; hence all contagious diseases are infectious
Communicable Disease a disease that can be transmitted from one person to the other either by direct or indirect method of transmission
Contagious Disease a communicable disease that is easily transmitted from one person to the other
All communicable diseases are infectious but, not all infectious diseases are contagious or communicable
The Components of Epidemiological Triad: Agent, Host and Environment The development of infection depends on the interplay between the three components of the epidemiologic triad.
Severity of Infection depends on: 1. Microbial characteristics and virulence a. Virulence pertains to the capacity of the pathogens to produce an infection 2. Number of pathogens that enter the body 3. The way in which the microbes enter the body and spread 4. The host resistance to infection
AGENT: The organism (or etiologic agent) that causes the disease. Has two types based on origin. 1. Endogenous found on the skin and other body substances like feces, sputum, and saliva 2. Exogenous originate from outside the body
Modes of Action: 1. Colonization presence of the organisms in the surface of the tissues (does not penetrate the tissues) 2. Invasion penetrates the tissues layer by layer
CLASSIFICATION OF ETIOLOGICAL AGENTS:
A. CAUSATIVE AGENT: 1. Virus - the smallest form of organism - they can pass through filters of the body - they multiply in living host only - usually has longer incubation period - usually gives lifetime immunity - self-limiting 2. Bacteria - Cant pass through filters of the body o Example: Placenta: Except T. pallidum that can gain entrance only after the 6 th
week of pregnancy - Usually has shorter incubation period - Temporary immunity is acquired - Can multiply both in living and non-living things - Disease is easy to treat due to the advent of antibiotics 3. Rickettsia - Usually transmitted by anthropods (lice, fleas, ticks); transfer the organism by their bites or waste products 4. Spirochete - Spiral chaped bacteria that can move in helical, or inch-worm manner 5. Chlamydia - Usually transmitted through sexual contact 6. Fungi - Are found almost anywhere, some are beneficial and some are harmful 7. Protozoa - Parasitic protozoa usually absorb blood from the body of the host 8. Parasites - Usually dont kill their host - Only take the nutrients they need from the host
B. Host - Susceptible population
Types of Human Host: 1. Patient (case) is a person who is infected manifesting the signs and symptoms of the disease 2. Carrier a person who appears healthy but harbors the organism, capable of transmitting the disease but does not manifest the signs and symptoms of the disease 3. Suspect a person whose medical history, and signs and symptoms suggest that such person is suffering from that particular disease 4. Contact a person who has been in close association with an infected person, animal or thing
Types of Carriers: 1. Incubatory carrier with organism can pass to others 2. Convalescent carrier one who is recovering from the infection; body still releasing salmonella 3. Intermittent carrier one who releases organism in an on and off manner depending on his level of immunity 4. Chronic or sustained carrier releases the organism steadily
C. Environment anything that supports the survival and replication/reproduction of the organism
CHAIN OF INFECTION There are six components in the infectious disease process, known as the Chain of Infection.
1. The Causative Agent any microorganism capable of producing a disease
1.1 Bacteria: - Simple, one-celled microbe with double cell membrane that protect them from harm - Reproduced rapidly and considered as the most common cause of fatal infectious disease - Classified According to: o Cell morphology (shape, size) Cocci round or spherical Bacilli rod-shape Spirillae spiral shape o Atmospheric requirements based on their relationship to oxygen and carbon dioxide Aerobic requires oxygen in concentration comparable to room air Anaerobic organism that do not require oxygen for life and reproduction o Response to staining Blue stain gram (+) bacteria Rod shape gram (-) bacteria o Motility (motile, non-motile) o Tendency to capsulate (encapsulated, capsulated) o Capacity to form spores (spore forming, non-spore forming
1.2 Spirochete - Bacteria with flexible, slender, undulating spiral rods that possess the wall - 3 forms: o Treponema (syphilis) o Leptospira (leptospirosis) o Borrelia (lyme disease)
1.3 Mycoplasma - Also depends on the host cell for replication - Does not contain a cell wall - Only has membranes - The absence of cell wall makes it resistant to penicillin and other antibiotics that work by inhibiting cell wall formation or synthesis
1.4 Viruses - Smallest known microbe - Cant replicate independently in the hosts cells - Invades a host cell and stimulate it to participate in producing additional viruses
1.5 Rickettsiae - Small, gram negative (-) bacteria-like microbe that can induce life-threatening infections - Require a host cell for replication - Transmitted through a bite of anthropod carriers like lice, fleas, ticks, as well as through waste products - Rickettsial Diseases are: o Rocky mountain spotted fever o Typhus fever o Q fever
1.6 Chlamydia - Smaller than rickettsia but larger than a virus - Common cause of infections of the urethra, bladder, fallopian tubes, and prostate gland - Most common chlamydial infection is transmitted through sexual contact
1.7 Fungi - Found almost everywhere - Live in organic matter, soil, water, on animals and plants; can live inside and outside the body - Maybe harmful and beneficial - Beneficial in cheese, yogurt, beer, wine and certain drugs
1.8 Protozoa - Much larger than bacteria - Simplest single-celled organism of animal kingdom - Parasitic protozoa absorb nutrients from the body of the host
1.9 Parasites - Live on or within other organisms; live on the expense of others - They dont kill their host but take only the nutrients they need 2. Reservoir of Infection the environment and objects on which an organism can survive and multiply
2.1 Non-living 2.2 Animals 2.3 Human Reservoir 2.3.1 Frank cases or the very ill 2.3.2 Sub-clinical or ambulatory 2.3.3 Carriers 2.3.3.1 Incubatory carrier one who is incubating the illness 2.3.3.2 Convalescent carrier the recovery stage of illness but continue to shed the pathogenic organism 2.3.3.3 Intermittent carrier occasionally shades the pathogenic organism 2.3.3.4 Chronic or sustained carrier always has infectious organism in his system
3. The Portal of Exit the path or way in which the organism leaves the reservoir; usually were the organism grows 3.1 Common portals of Exit: 3.1.1 Respiratory 3.1.2 Genitourinary tract (GUT) 3.1.3 Gastrointestinal tract (GIT) 3.1.4 The skin and mucous membrane 3.1.5 The placenta ( transplacental or vertical transmission) 4. Mode of Transmission - The means by which the infectious agents passes from the portal of exit from the reservoir to the susceptible host. - Easiest link to break the chain of infection - Infectious agents can be transmitted through the four models: 4.1 Contact Transmission most common mode of transmission a. Direct Contact person to person transfer of organism Direct skin to skin contact by headshaking Direct mucous membrane to mucous membrane contact by kissing or sexual intercourse b. Indirect contact occurs when the susceptible person comes in contact with a contaminated object Indirectly via contamination of food and water by fecal materials Indirectly by transfusion of contaminated blood or blood products from ill persons or by parenteral infections c. Droplet spread contact with respiratory secretions, when the infected person coughs, sneezes, or talks. Microbes carried in droplets can travel up to 3 feet or one meter The organism is not suspended in the air but settle on a surface 4.2 Air-borne transmission occurs when fine microbial particles or dust particles containing microbes remain suspended in the air for a prolong period (spread by air current and inhaled) 4.3 Vehicular transmission articles or substances that harbour the organism until it is ingested or inoculated into the host, transmission by inanimate objects, such as food, water, dust, fomites 4.4 Vector-borne transmission occurs when an intermediate carriers, such as flea, flies, mosquitoes, transfer the microbes to another living organism; brought about by bites of anthropods. 5. Portal of Entry the venue where the organism gain entrance into the susceptible host. The infective microbes use the same avenues when they exit from the reservoir. 6. Susceptible host the human body have many defences against the entry and multiplication of organism; defenses are good, no infection will take place; weakened host, the microbes will launch an infectious disease
Factors Affecting the Entrance of Organism into the body: 1. Age, Sex, genetic, constitution of the host 2. Nutritional status, fitness, environmental factors 3. General condition, physical, emotional, mental state 4. Absence of or abnormal immunoglobulin 5. Presence of underlying disease (Diabetes mellitus, lymphoma, leukemia, neoplasm or uremia) 6. Patients treated with certain antimicrobials, corticosteroids, irradiation, or immunosuppressive drugs
INFECTION CONTROL MEASURES
A. General - Universal precaution shall be observed to prevent contact with blood and other potentially infectious materials. - UNIVERSLA PRECAUTION means that all patients shall be assumed to be infectious with HIV/AIDS and other blood-borne pathogens
B. Infectious Control Measures Requires that: 1. Employees shall wash their hands immediately as soon as possible after removal of gloves or other personal protective equipment and after hand contact with blood or other potentially infectious materials 2. All personal protective equipments shall be removed immediately upon leaving the work area or as soon as possible if overtly contaminated and place in an appropriately designated area or container for storage, washing, decontamination or disposal 3. Used needles and other sharps shall not be sheared, bent, broken, recapped, or re-sheathed by hand. Used needles should not be removed from disposable syringes 4. Eating, drinking, smoking, applying cosmetics or lip balm, or handling contact lenses are prohibited in work areas where there is potential for occupational exposure 5. Food drinks shall not be stored in refrigerators, freezers, or cabinets where blood or other potentially infectious materials are stored or in other areas of possible contamination 6. All procedures involving blood or other potentially infectious materials shall be performed in such so as to minimize splashing these substances 7. Mouth pipetting or suctioning is prohibited
Suggested control measures for primary care clinics: 1. Masking All staff should wear mask Patients should be asked to wear mask if they have respiratory problems 2. Handwashing Practice proper handwashing with the use of soap and water Before and after patient contact and after removing gloves 3. Gloving For all direct patient contact Change gloving in between patient and wash hands 4. Gowning During procedures likely to generate splashes or sprays of blood and body fluids, secretions, or excretions 5. Eye protection (googles) For aerosol/splashes generating procedures Avoidance or aerosols 6. Environmental disinfection Clean surfaces daily with disinfectant (diluted household bleach, 70% alcohol)
Aspects of Care for Patients with Communicable Disease:
I. Preventive aspect A. Health Education educate the family and the client with respect to: Availability and importance of prophylactic immunization Manner in which infectious illness are spread and methods in avoiding the spread Importance on seeking medical advice in any sign of health problem Importance of environmental cleanliness and personal hygiene Means of preventing contamination of food and water supply B. Immunization is the introduction of specific protective antibodies in a susceptible person or animal, or the production of cellular immunity in such person or animal Immunity a condition of being secured or protected against any particular disease Acquired immunity immunity that results from the active production or receipt of antibodies during ones lifetime Types of Acquired Immunity: 1. Active Immunity results if antibodies are actually produce within the persons body a. Natural Active Immunity immunity that is acquired in response to the entry of a live pathogen into the body (i.e. in response to an actual infection); immunity of this types is usually lifelong b. Artificial active immunity immunity that is acquired in response to vaccines, like Tetanus toxoid 2. Passive Acquired Immunity the person receives antibodies that were produced by another person or by animals. Protection is usually temporary. a. Natural Passive immunity that is acquired by a fetus when it receives maternal antibodies in utero or by an infant when it receives maternal antibodies contained in colostrum b. Artificial passive immunity that is acquired when a person receives antibodies contains antisera or gamma globulin
Types of Antigen: 1. Inactivated (killed organism) Not long lasting Multiple dose needed Booster dose needed to acquire lifetime immunity 2. Attenuated (live organism) Single dose needed Long lasting immunity Note: All vaccines lost their potency after a certain time. Expiry date should be noted on the label
What Damages the Vaccines? 1. Heat and sunlight damage vaccine, especially the live ones 2. Freezing damages the killed vaccines and toxoids 3. In cleaning the refrigerator/freezer use water only because antiseptics, disinfectants and detergents or alcohol may lessen the potency of vaccines Safest thing to do is to keep all vaccines at the correct cold temperature (0-8 C)
The Cold Chain System
Maintenance of the correct temperature for vaccines starts with the manufacturer and followed by the airport, the central vaccine store, regional store, district hospital, health centers or outreach service units, dispensary, immunizing staff, and the client.
C. Environmental Sanitation Environmental sanitation is still a health problem in the country Diarrheal disease still ranks second among the leading causes of morbidity in the population Others sanitation-related diseases: intestinal parasitism, infectious hepatitis, dengue/hemorragic fever DOH-EHS (DOH-Environmental Health Services) has the authority to act on all issues and concerns in environment health, in accordance with the Code on Sanitation of the Philippines (PD 856, 1978)
1. Water Supply Sanitation Program a. Approved types of water facilities such as: Level I (Point of Source) a protected well or a developed spring with an outlet but without a distribution system generally adaptable to rural areas Level II (Communal Faucet System or Stand-Posts) composed of a source reservoir, a piped distribution network, and communal faucets Level III waterworks system or individual house connection b. Unapproved types of water facility or water coming from doubtful sources such as open dug wells, unimproved springs, and wells that need priming, are not allowed for drinking unless treated through proper container disinfection c. Access safe and potable drinking water all households should be provided with a safe and adequate water supply d. Water quality and monitoring Examination of drinking water shall be performed only in private and government laboratories duly accredited by the DOH Certification of potability of an existing water source is done by the Secretary of Health or his/her duly authorized representative The following water supply sources need to be disinfected: - Newly constructed water supply facilities - Water supply facility that has been repaired or improved - Water supply sources found to be bacteriologically positive through laboratory analysis e. Waterworks/water system and well construction The well site shall require approval of the Secretary of Health or his duly authorized representative Well construction shall comply with the sanitary requirements of the DOH The water supply system shall supply safe and potable water in adequate quantity Water shall be made readily available to consumer/users 2. Policies on proper excreta and sewage disposal a. Approved Type of toilet facilities Level I Non water carriage toilet facility (pit latrines, reed odourless earth closet) - Toilet facility requiring small amount of water to wash the waste into receiving space (pour flush, aqua privies) Level II water-sealed and flush type with septic vault/tank disposal facilities Level III water carriage toilet connected to a septic tank or sewerage system and treatment plant b. In rural areas, a blind drainage type of waste water collection and disposal facility 3. Policies on Food Sanitation Program a. Food establishments shall be appraised as to the following sanitary conditions: Inspection/approval of all food sources, containers, and transport vehicles Compliance to sanitary permit requirements Provision of updated health certificates for food handlers, cook, and kitchen helpers Destruction/banning of food unfit for human consumption Training food handlers and operators on food sanitation b. Ambulant food vendors shall also comply with the requirements as to the issuance of health certificates c. Household food sanitation is to be promoted and monitored and food hygiene sanitation is to be intensified 4. Policies on Hospital Waste Management a. All newly constructed/renovated government and private hospitals shall prepare and implement a hospital waste management (HWM) program as a requirement for the registration/renewal of licenses b. The use of appropriate technology and indigenous materials for HWM shall be adopted c. Training of hospital personnel involved in waste management shall be an essential part of the hospitals training program d. Local ordinances regarding the collection and disposal techniques, especially incinerators, shall be institutionalized 5.