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Hyperparathyroidism secondary to renal dysplasia in an English bulldog

Diego F Echeverry
1
; Juanita Otazua!; Edwin F Buritica
1

1
Clnica de Pequeos Animales, Facultad de Medicina Veterinaria y Zootecnia, Universidad del Tolima, Colombia
Fig 3. A. ulLrasonographlc appearance of Lhe kldneys revealed lrregular shape, poor corucomedullary denluon, lncreased echogenlclLy and small dlameLer (2.2cm). !. AL
necropsy, rlghL kldney (8) was crlucally reduced ln slze and le kldney (L) had rough shape. C. PlsLophaLologlcal evaluauon revealed pyelonephrlus, exLenslve lnLersuual brosls,
glomerular and Lubular aLrophy and cysuc dllauon of 8owman's capsule.

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8enal dysplasla ls a dlsorganlzed renal parenchyma developmenL durlng embryogenesls.
1
Cllnlcal evldences are Lhose of chronlc renal
ln[ury. A frequenL ouLcome ls Lhe developmenL of secondary hyperparaLhyroldlsm
2
, whlch may orlglnaLe skeleLal deformauons.
2,3
1o Lhe
auLhor's knowledge Lhls ls Lhe rsL case reporL of secondary hyperparaLhyroldlsm assoclaLed wlLh renal dysplasla ln Lngllsh 8ulldogs.
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,/01 4 monLh-old dog. !20031 Lngllsh 8ulldog. 405/671 3,2 kg.
)8595:;8 <;95=0>7;?@9>1 severe maxlllary swelllng, gums lnammauon, polydlpsla, polyurla, and small slze for Lhe age.
!8@@3 ;9;8A>5>: hypocalcemla (6,42mg/dL), hypercreaunemla (3,26mg/dL), hyperphosphaLemla (13,89mg/dL), anemla (vC 13,1), and
lncreased serum 1P (810,3pg/dL). (259;8A>5>1 showed low speclc gravlLy (1.006), bacLerlurla and pyurla.
Fig 1. 1here was evldence of gums lnammauon, oral ulcerauons and severe
maxlllary swelllng. Mandlble had low denslLy and hardness.
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1he developmenL of secondary hyperparaLhyroldlsm and renal dysfuncuon ls very common ln renal dysplasla
2
and may orlglnaLe
skeleLal deformauons LhaL oen aecLs Lhe face bones mosL promlnenLly speclally Lhe maxllla.
2,3

1he brown Lumor ls a locallzed form of brous osLeodysLrophy observed ln Lhese pauenLs due Lo alLerauons ln Lhe regulauon of
osLeoblasL/osLeoclasL acuvlLy.
1

uenluve dlagnosls should be made upon demonsLrauon of characLerlsuc leslons ln kldneys obLalned by necropsy or blopsy.
4
1hese
leslons have been classled as compensaLory, lnammaLory, and degenerauve dlsorders.
4

Cllnlcal and hlsLopaLhologlc ndlngs ln Lhls pauenL revealed slmllar leslons Lo Lhose descrlbed prevlously,
1,3,4
whlch may suggesL LhaL
renal dysplasla should be conslder as a dlerenual dlagnosls of renal dlseases ln young dogs.

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1. 8rum k8, !ullano 8S, Souza MA, lleury Lll, uamasceno, Au. 8enal dysplasla ln a 8oxer dog: case reporL. . Arq 8ras Med veL
ZooLec 2008, 1084-1088.
DE Lazarem , koglka MM, Paglwara Mk, eL al: ConcenLrao serlca de paraLormnlo em ces com lnsuclncla renal crnlca.
Arq 8ras Med veL ZooLec 2006, 38(1): 489-494. orLuguese.
FE Sarklala LM, uambach u, Parvey CL: !aw leslons resulung from renal hyperparaLhyroldlsm ln a young dog - a case reporL. !
veL uenL 1994, 11(1): 121-124.
GE lcuL CA, Lewls 8M: Mlcroscoplc feaLures of canlne renal dysplasla. veL aLhol 1987, 24(1): 136-163.
October 16-18
Barcelona, Spain
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Fig 2. Maxlllarles presenLed Lrabecular aspecL of brown-reddlsh color aL saglual
cumng.