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The American Journal of Clinical Nutrition

ajcn.nutrition.org
Am J Clin Nutr February 1995 vol. 61 no. 2 312-319
Copyright 1995 by The American Society for Clinical Nutrition, Inc
Brain tryptophan concentrations and
serotonin synthesis remain responsive to
food consumption after the ingestion of
sequential meals.
M H Fernstrom and J D Fernstrom
Author Affiliations
Abstract
The response of brain tryptophan concentration and serotonin synthesis to the
ingestion of two sequential meals was examined in rats. Fasted rats ingested a
carbohydrate meal followed 2 h later by a protein-containing meal and were
examined 2 or 4 h after the first meal. Other rats ingested a protein meal first,
followed by a carbohydrate meal. When the carbohydrate meal was fed first, brain
tryptophan concentrations and serotonin synthesis increased at 2 h; these
changes were reversed at 4 h if the second meal contained protein. When the
protein meal was fed first, there were no changes in brain tryptophan or
serotonin at 2 h, and a second carbohydrate meal at 2 h did not raise brain
tryptophan or serotonin 2 h later. Carbohydrate ingestion 3 h after a protein
meal, however, did raise brain tryptophan and serotonin 2 h later. Brain
tryptophan concentrations and serotonin synthesis are thus responsive to the
sequential ingestion of protein and carbohydrate meals if there is a sufficient
interval between meals.
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Brain tryptophan concentrations and serotonin synthesis remain responsi... http://ajcn.nutrition.org/content/61/2/312.abstract
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