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Cyproheptadine and amitriptyline were extracted from plasma by liquid-liquid extraction using a diethyl-ether / dichloromethane solvent. The extracts were analyzed by high performance liquid chromatography coupled to electrospray tandem mass spectrometry (LC-MS / MS) the method had a linear calibration curve ranging from 0.05 to 10 ng / mL (r2 >0.99) the bioequivalence of
Cyproheptadine and amitriptyline were extracted from plasma by liquid-liquid extraction using a diethyl-ether / dichloromethane solvent. The extracts were analyzed by high performance liquid…