Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There An Association With Severe Obesity and Weight Loss in Morbidly Obese Subjects?
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It is an abstract from an article published in the Journal:Metabolic Syndrome and Related Disorders
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Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There an Association with Severe Obesity and Weight Loss in Morbidly Obese Subjects?
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Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There An Association With Severe Obesity and Weight Loss in Morbidly Obese Subjects?
Obesity and Weight Loss in Morbidly Obese Subjects? To cite this article: Dimitrios Papazoglou, Pantelis Papathanasiou, Nikolaos Papanas, Konstantinos Papatheodorou, Eleni Chatziangeli, Ioannis Nikitidis, Stamatia Kotsiou, and Efstratios Maltezos. Metabolic Syndrome and Related Disorders. August 2012, 10(4): 307-311. doi:10.1089/met.2012.0003. Published in Volume: 10 Issue 4: July 19, 2012 Online Ahead of Print: May 8, 2012 Full Text HTML Full Text PDF (114.5 KB) Full Text PDF with Links (183.6 KB) Author information Dimitrios Papazoglou, M.D., Ph.D., Pantelis Papathanasiou, B.S., Nikolaos Papanas, M.D., Ph.D., Konstantinos Papatheodorou, M.D., Eleni Chatziangeli, M.D., Ioannis Nikitidis, B.S., Stamatia Kotsiou, M.D., Ph.D., and Efstratios Maltezos, M.D., Ph.D. Outpatient Clinic of Obesity, Diabetes, and Metabolism in the Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. Address correspondence to: Dimitrios Papazoglou, M.D., Ph.D. Associate Professor of Internal Medicine Patriarhou Grigoriou 97-99 68100 Alexandroupolis Greece E-mail: dpapazog@med.duth.gr ABSTRACT Background: Uncoupling proteins are attractive candidate genes for obesity and type 2 diabetes mellitus. Our aim was to investigate the potential association of the uncoupling protein-2 (UCP2) 45-bp insertion/deletion (ins/del) polymorphism with obesity, as well as the potential effect of this polymorphism on weight loss variability in severely obese subjects. Methods: A total of 158 severely obese subjects (94 without and 64 with metabolic syndrome) and 91 age and sex-matched lean controls were recruited. A subgroup of 124 obese patients participated in a 3-month weight loss program. Anthropometric and metabolic variables were measured. Participants were genotyped for the UCP2 ins/del polymorphism. Results: Allelic frequency differed neither between obese subjects and controls (P=0.56), nor between obese subjects with versus without metabolic syndrome (P=0.58). At 3 months, metabolically healthy subjects carrying the insertion allele had significantly greater reduction in body mass index (P=0.029) and fat-free mass (P=0.013) and a borderline significant improvement in the homeostatic model assessment index (P=0.048). Conclusion: There is no association of the UCP2 ins/del polymorphism with morbid obesity in our population, but this genotype appears to be linked with a favorable response to dietary changes in metabolically healthy obese subjects.