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Spring 2009

HCS 7372: Seminar in Cognitive Neuroscience of Aging

Meeting: Mondays, 1:00 – 4:00pm

Location: Center for BrainHealth – large classroom on the 1st floor

Instructor: Denise C. Park

BBS, Center for BrainHealth
972-883-3255
denise@utdallas.edu

Office Hours: By appointment

CONTENT. This is a discussion-based seminar that will be focused on readings in the

cognitive neuroscience of aging. We will begin with an overview of cognitive aging
findings, integrate this with theoretical views of neurocognitive aging, and then consider
specific topics in the cognitive neuroscience of aging with an emphasis on memory,
individual differences, and normal aging.

CLASS FORMAT. The class will be discussion-based. We will review four articles per
week. Each member of the class will turn in two questions about the article. One person
will present a 15-minute summary of the article, along with a series of questions for the
class to discuss. This individual will also prepare a written outline of the article which we
will compile into a document for the entire class. This is the only written product for
individuals taking the class for two credits. Attendance and completion of readings are
required.

In addition to your presentations, you are required to prepare a research proposal on

some aspect of the cognitive neuroscience of aging that is approximately 10 pages in
length.

AVAILABILITY OF READINGS. The readings will be available on the course webpage:

https://pal.utdallas.edu/class/

Note: This page can only be accessed when connected to the UTD network. In order to access course
materials when off campus, you will have to download and install the VPN client that UTD has made freely
available.
• Go to https://netid.utdallas.edu/download/login
• Click on “VPN Registration and Downloads” and then “I accept”
• Under the heading for your operating system (Window, Mac, etc.) click on the
link labeled “Installer” to begin download and then install the VPN client
• Start the VPN client, double click the “UTD-ISP” profile and go to course site
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SCHEDULE

January 12 Introduction

January 26 Overview of cognitive neuroscience of aging

Davis, S. W., Dennis, N. A., Daselaar, S. M., Fleck, M. S., & Cabeza, R. (2008). Que PASA? The
posterior-anterior shift in aging. Cerebral Cortex (New York, N.Y.: 1991), 18(5), 1201-9. doi:
10.1093/cercor/bhm155.
Park, D. C., & Reuter-Lorenz, P. (2009). The adaptive brain: aging and neurocognitive scaffolding.
Annual Review of Psychology, 60, 173-96. doi: 10.1146/annurev.psych.59.103006.093656.
Poldrack, R. A. (2008). The role of fMRI in cognitive neuroscience: where do we stand? Current Opinion
in Neurobiology, 18(2), 223-7. doi: 10.1016/j.conb.2008.07.006.
Reuter-Lorenz, P. A., & Cappell, K. A. (2008). Neurocognitive Aging and the Compensation Hypothesis.
Current Directions in Psychological Science, 17(3), 177-182. doi: 10.1111/j.1467-8721.2008.00570.x.
Stevens, W. D., Hasher, L., Chiew, K. S., & Grady, C. L. (2008). A neural mechanism underlying
memory failure in older adults. The Journal of Neuroscience: The Official Journal of the Society for
Neuroscience, 28(48), 12820-4. doi: 10.1523/JNEUROSCI.2622-08.2008.

February 2 Cognitive control and speed of processing

Kaufmann, L., Ischebeck, A., Weiss, E., Koppelstaetter, F., Siedentopf, C., Vogel, S. E., et al. (2008). An
fMRI study of the numerical Stroop task in individuals with and without minimal cognitive impairment.
Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 44(9), 1248-55. doi:
10.1016/j.cortex.2007.11.009.
Pagnoni, G., & Cekic, M. (2007). Age effects on gray matter volume and attentional performance in Zen
meditation. Neurobiology of Aging, 28(10), 1623-7. doi: 10.1016/j.neurobiolaging.2007.06.008.
Velanova, K., Lustig, C., Jacoby, L. L., & Buckner, R. L. (2007). Evidence for frontally mediated
controlled processing differences in older adults. Cerebral Cortex (New York, N.Y.: 1991), 17(5), 1033-
46. doi: 10.1093/cercor/bhl013.
Waiter, G. D., Fox, H. C., Murray, A. D., Starr, J. M., Staff, R. T., Bourne, V. J., et al. (2008). Is retaining
the youthful functional anatomy underlying speed of information processing a signature of successful
cognitive ageing? An event-related fMRI study of inspection time performance. NeuroImage, 41(2),
581-95. doi: 10.1016/j.neuroimage.2008.02.045.
Zysset, S., Schroeter, M. L., Neumann, J., & Yves von Cramon, D. (2006). Stroop interference,
hemodynamic response and aging: An event-related fMRI study. Neurobiology of Aging. doi:
10.1016/j.neurobiolaging.2006.05.008.

February 9 Memory

Cook, I. A., Bookheimer, S. Y., Mickes, L., Leuchter, A. F., & Kumar, A. (2007). Aging and brain
activation with working memory tasks: an fMRI study of connectivity. International Journal of Geriatric
Psychiatry, 22(4), 332-42. doi: 10.1002/gps.1678.
Grady, C. L., Yu, H., & Alain, C. (2008). Age-related differences in brain activity underlying working
memory for spatial and nonspatial auditory information. Cerebral Cortex (New York, N.Y.: 1991),
18(1), 189-99. doi: 10.1093/cercor/bhm045.
Hazlett, E. A., Byne, W., Brickman, A. M., Mitsis, E. M., Newmark, R., Haznedar, M. M., et al. (2008).
Effects of sex and normal aging on regional brain activation during verbal memory performance.
Neurobiology of Aging. doi: 10.1016/j.neurobiolaging.2008.10.005.
Mayes, A., Montaldi, D., & Migo, E. (2007). Associative memory and the medial temporal lobes. Trends
in Cognitive Sciences, 11(3), 126-35. doi: 10.1016/j.tics.2006.12.003.
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February 16 Memory
Brassen, S., Büchel, C., Weber-Fahr, W., Lehmbeck, J. T., Sommer, T., & Braus, D. F. (2007).
Structure-function interactions of correct retrieval in healthy elderly women. Neurobiology of Aging.
doi: 10.1016/j.neurobiolaging.2007.10.005.
Duarte, A., Graham, K. S., & Henson, R. N. (2008). Age-related changes in neural activity associated
with familiarity, recollection and false recognition. Neurobiology of Aging. doi:
10.1016/j.neurobiolaging.2008.09.014.
Duverne, S., Motamedinia, S., & Rugg, M. D. (2008). The Relationship between Aging, Performance,
and the Neural Correlates of Successful Memory Encoding. Cereb. Cortex, bhn122. doi:
10.1093/cercor/bhn122.
Trivedi, M. A., Schmitz, T. W., Ries, M. L., Hess, T. M., Fitzgerald, M. E., Atwood, C. S., et al. (2008).
fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors
for Alzheimer's disease. Neuropsychologia, 46(6), 1667-78. doi:
10.1016/j.neuropsychologia.2007.11.035.

Februrary 23 Memory

Cabeza, R., Ciaramelli, E., Olson, I. R., & Moscovitch, M. (2008). The parietal cortex and episodic
memory: an attentional account. Nature Reviews. Neuroscience, 9(8), 613-25. doi: 10.1038/nrn2459.
Czernochowski, D., Fabiani, M., & Friedman, D. (2008). Use it or lose it? SES mitigates age-related
decline in a recency/recognition task. Neurobiology of Aging, 29(6), 945-58. doi:
10.1016/j.neurobiolaging.2006.12.017.
Dennis, N. A., Daselaar, S., & Cabeza, R. (2007). Effects of aging on transient and sustained successful
memory encoding activity. Neurobiology of Aging, 28(11), 1749-58. doi:
10.1016/j.neurobiolaging.2006.07.006.
Miller, S. L., Celone, K., DePeau, K., Diamond, E., Dickerson, B. C., Rentz, D., et al. (2008). Age-related
memory impairment associated with loss of parietal deactivation but preserved hippocampal
activation. Proceedings of the National Academy of Sciences of the United States of America, 105(6),
2181-6. doi: 10.1073/pnas.0706818105.
Viard, A., Piolino, P., Desgranges, B., Chételat, G., Lebreton, K., Landeau, B., et al. (2007).
Hippocampal activation for autobiographical memories over the entire lifetime in healthy aged
subjects: an fMRI study. Cerebral Cortex (New York, N.Y.: 1991), 17(10), 2453-67. doi:
10.1093/cercor/bhl153.
Wilson, I. A., Gallagher, M., Eichenbaum, H., & Tanila, H. (2006). Neurocognitive aging: prior memories
hinder new hippocampal encoding. Trends in Neurosciences, 29(12), 662-70. doi:
10.1016/j.tins.2006.10.002.

March 2 Dedifferentiation and the default mode

Dedifferentiation
Riis, J. L., Chong, H., Ryan, K. K., Wolk, D. A., Rentz, D. M., Holcomb, P. J., et al. (2008).
Compensatory neural activity distinguishes different patterns of normal cognitive aging. NeuroImage,
39(1), 441-54. doi: 10.1016/j.neuroimage.2007.08.034.

Default Mode
Andrews-Hanna, J. R., Snyder, A. Z., Vincent, J. L., Lustig, C., Head, D., Raichle, M. E., et al. (2007).
Disruption of large-scale brain systems in advanced aging. Neuron, 56(5), 924-35. doi:
10.1016/j.neuron.2007.10.038.
Damoiseaux, J. S., Beckmann, C. F., Arigita, E. J. S., Barkhof, F., Scheltens, P., Stam, C. J., et al.
(2008). Reduced resting-state brain activity in the "default network" in normal aging. Cerebral Cortex
(New York, N.Y.: 1991), 18(8), 1856-64. doi: 10.1093/cercor/bhm207.
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March 9 No Class

March 16 No Class

March 23 Neuroanatomy and cognition

Fotenos, A. F., Mintun, M. A., Snyder, A. Z., Morris, J. C., & Buckner, R. L. (2008). Brain volume decline in
aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and
reserve. Archives of Neurology, 65(1), 113-20. doi: 10.1001/archneurol.2007.27.
Head, D., Rodrigue, K. M., Kennedy, K. M., & Raz, N. (2008). Neuroanatomical and cognitive mediators of
age-related differences in episodic memory. Neuropsychology, 22(4), 491-507. doi: 10.1037/0894-
4105.22.4.491.
Kramer, J. H., Mungas, D., Reed, B. R., Wetzel, M. E., Burnett, M. M., Miller, B. L., et al. (2007).
Longitudinal MRI and cognitive change in healthy elderly. Neuropsychology, 21(4), 412-8. doi:
10.1037/0894-4105.21.4.412.

March 30 White matter

Chua, T. C., Wen, W., Slavin, M. J., & Sachdev, P. S. (2008). Diffusion tensor imaging in mild cognitive
impairment and Alzheimer's disease: a review. Current Opinion in Neurology, 21(1), 83-92. doi:
10.1097/WCO.0b013e3282f4594b.
Gunning-Dixon, F. M., Brickman, A. M., Cheng, J. C., & Alexopoulos, G. S. (2008). Aging of cerebral
white matter: a review of MRI findings. International Journal of Geriatric Psychiatry. doi:
10.1002/gps.2087.
Thomas, C., Moya, L., Avidan, G., Humphreys, K., Jung, K. J., Peterson, M. A., et al. (2008). Reduction
in White Matter Connectivity, Revealed by Diffusion Tensor Imaging, May Account for Age-related
Changes in Face Perception. Journal of Cognitive Neuroscience, 20(2), 268-284. doi:
10.1162/jocn.2008.20025.
Zahr, N. M., Rohlfing, T., Pfefferbaum, A., & Sullivan, E. V. (2009). Problem solving, working memory,
and motor correlates of association and commissural fiber bundles in normal aging: a quantitative fiber
tracking study. NeuroImage, 44(3), 1050-62. doi: 10.1016/j.neuroimage.2008.09.046.
Ziegler, D. A., Piguet, O., Salat, D. H., Prince, K., Connally, E., & Corkin, S. (2008). Cognition in healthy
aging is related to regional white matter integrity, but not cortical thickness. Neurobiology of Aging. doi:
10.1016/j.neurobiolaging.2008.10.015.

April 6 Vascular issues and white matter

Braskie, M. N., Small, G. W., & Bookheimer, S. Y. (2008). Vascular health risks and fMRI activation
during a memory task in older adults. Neurobiology of Aging. doi:
10.1016/j.neurobiolaging.2008.08.016.
Madden, D. J., Spaniol, J., Costello, M. C., Bucur, B., White, L. E., Cabeza, R., et al. (2008). Cerebral
White Matter Integrity Mediates Adult Age Differences in Cognitive Performance. Journal of Cognitive
Neuroscience. doi: 10.1162/jocn.2009.21047.
Raz, N., Rodrigue, K. M., Kennedy, K. M., & Acker, J. D. (2007). Vascular health and longitudinal
changes in brain and cognition in middle-aged and older adults. Neuropsychology, 21(2), 149-57. doi:
10.1037/0894-4105.21.2.149.
Vernooij, M. W., de Groot, M., van der Lugt, A., Ikram, M. A., Krestin, G. P., Hofman, A., et al. (2008).
White matter atrophy and lesion formation explain the loss of structural integrity of white matter in
aging. NeuroImage, 43(3), 470-7. doi: 10.1016/j.neuroimage.2008.07.052.
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April 13 Markers of aging

Green, A. E., Munafò, M. R., Deyoung, C. G., Fossella, J. A., Fan, J., & Gray, J. R. (2008). Using
genetic data in cognitive neuroscience: from growing pains to genuine insights. Nature Reviews.
Neuroscience. doi: 10.1038/nrn2461.
Mattay, V. S., Goldberg, T. E., Sambataro, F., & Weinberger, D. R. (2008). Neurobiology of cognitive
aging: insights from imaging genetics. Biological Psychology, 79(1), 9-22. doi:
10.1016/j.biopsycho.2008.03.015.
Mueller, S. G., Schuff, N., Raptentsetsang, S., Elman, J., & Weiner, M. W. (2008). Selective effect of
Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T.
NeuroImage, 42(1), 42-8. doi: 10.1016/j.neuroimage.2008.04.174.
Nagel, I. E., Chicherio, C., Li, S., von Oertzen, T., Sander, T., Villringer, A., et al. (2008). Human aging
magnifies genetic effects on executive functioning and working memory. Frontiers in Human
Neuroscience, 2, 1. doi: 10.3389/neuro.09.001.2008.
Jack, C. R., Lowe, V. J., Senjem, M. L., Weigand, S. D., Kemp, B. J., Shiung, M. M., et al. (2008). 11C
PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and
amnestic mild cognitive impairment. Brain: A Journal of Neurology, 131(Pt 3), 665-80. doi:
10.1093/brain/awm336.

April 20 Amyloid and dementia

Braskie, M. N., Klunder, A. D., Hayashi, K. M., Protas, H., Kepe, V., Miller, K. J., et al. (2008). Plaque
and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiology of Aging.
doi: 10.1016/j.neurobiolaging.2008.09.012.
Forsberg, A., Engler, H., Almkvist, O., Blomquist, G., Hagman, G., Wall, A., et al. (2008). PET imaging of
amyloid deposition in patients with mild cognitive impairment. Neurobiology of Aging, 29(10), 1456-65.
doi: 10.1016/j.neurobiolaging.2007.03.029.
Fripp, J., Bourgeat, P., Acosta, O., Raniga, P., Modat, M., Pike, K. E., et al. (2008). Appearance
modeling of 11C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild
cognitive impairment and healthy aging. NeuroImage, 43(3), 430-9. doi:
10.1016/j.neuroimage.2008.07.053.
Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., et al. (2008).
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.
Brain: A Journal of Neurology. doi: 10.1093/brain/awn320.

April 27 Do plaques always lead to Alzheimer’s?

Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., et al. (2008).
Frequent amyloid deposition without significant cognitive impairment among the elderly. Archives of
Neurology, 65(11), 1509-17. doi: 10.1001/archneur.65.11.1509.
Cummings, J. L., Doody, R., & Clark, C. (2007). Disease-modifying therapies for Alzheimer disease:
challenges to early intervention. Neurology, 69(16), 1622-34. doi:
10.1212/01.wnl.0000295996.54210.69.
Pike, K. E., Savage, G., Villemagne, V. L., Ng, S., Moss, S. A., Maruff, P., et al. (2007). Beta-amyloid
imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease. Brain:
A Journal of Neurology, 130(Pt 11), 2837-44. doi: 10.1093/brain/awm238.
Villemagne, V. L., Pike, K. E., Darby, D., Maruff, P., Savage, G., Ng, S., et al. (2008). Abeta deposits in
older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease.
Neuropsychologia, 46(6), 1688-97. doi: 10.1016/j.neuropsychologia.2008.02.008.
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May 4 Training, cognitive intervention, and personality

Training and Cognitive Intervention
Acevedo, A., & Loewenstein, D. A. (2007). Nonpharmacological cognitive interventions in aging and
dementia. Journal of Geriatric Psychiatry and Neurology, 20(4), 239-49. doi:
10.1177/0891988707308808.
Boyke, J., Driemeyer, J., Gaser, C., Büchel, C., & May, A. (2008). Training-induced brain structure
changes in the elderly. The Journal of Neuroscience: The Official Journal of the Society for
Neuroscience, 28(28), 7031-5. doi: 10.1523/JNEUROSCI.0742-08.2008.
Draganski, B., & May, A. (2008). Training-induced structural changes in the adult human brain.
Behavioural Brain Research, 192(1), 137-42. doi: 10.1016/j.bbr.2008.02.015.
Papp, K. V., Walsh, S. J., & Snyder, P. J. (2009). Immediate and delayed effects of cognitive
interventions in healthy elderly: a review of current literature and future directions. Alzheimer's &
Dementia: The Journal of the Alzheimer's Association, 5(1), 50-60. doi: 10.1016/j.jalz.2008.10.008.

Personality
Wright, C. I., Feczko, E., Dickerson, B., & Williams, D. (2007). Neuroanatomical correlates of personality
in the elderly. NeuroImage, 35(1), 263-72. doi: 10.1016/j.neuroimage.2006.11.039.
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BIBLIOGRAPHY in Alpha Order from Previous Class

Baltes, P. B., and Lindenberger, U. (1997). Emergence of a powerful connection

between sensory and cognitive functions across the adult life span: A new window to the
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Brodtmann, A., Puce, A., Syngeniotis, A., Darby, D., & Donnan, G. (2003). The
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Cabeza, R., Anderson, N. D., Locantore, J. K., & McIntosh, A. R. (2002). Aging
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Cabeza, R., Daselaar, S. M., Dolcos, F., Prince, S. E., Budde, M., & Nyberg, L.
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Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N., Friston, K. J., &
Frackowiak, R. S. (2001). A voxel-based morphometric study of aging in 465 normal adult
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Gron, G., Bittner, D., Schmitz, B., Wunderlich, A. P., Tomczak, R., Riepe, M. W.
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Gunning-Dixon, F. M., Gur, R. C., Perkins, A. C., Schroeder, L., Turner, T.,
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Gunning-Dixon, F. M. & Raz, N. (2003). Neuroanatomical correlates of selected

executive functions in middle-aged and older adults: A prospective MRI study.
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Kensinger, E. A., Anderson, A., Growdon, J. H., & Corkin, S. (2004). Effects of
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Levine, B. (2004). Autobiographical memory and the self in time: Brain lesion
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Mather, M., Canli, T., English, T., Whitfield, S., Wais, P., Ochsner, K., Gabrieli, J. D.
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McAuley, E., Kramer, A. F., & Colcombe, S. J. (2004). Cardiovascular fitness and
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McConnell, D. A., Bohning, D. E., Nahas, Z., Shastri, A., Teneback, C.,
Lorberbaum, J. P., Lomarev, M. P., Vincent, D. J., George, M. S. (2003). BOLD fMRI
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