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A New model of the Human Immuno Viridae and a way of HIV destruction

Matsaberidze M.I.

Georgian Technical University

Abstract. Based on Euler’s calculations and locked cover structures, a new model of spatial
structure of human immunodeficiency virus (HIV) and a way of HIV destruction are proposed.
Keywords: human immunodeficiency virus, pentamer, hexamer, viral protein, Leonard Euler.

AIDS - one of major and tragical problems, arising before the whole mankind at the end of
XX century. Till now the approaches to the decision of such problem were not known even
theoretically.
AIDS is a hardest economic problem. The contents and treatment of the ill infected,
development and the manufactures of diagnostic and medical preparations, realization of
fundamental scientific researches already now cost many billions of dollars. On an estimation of
scientists, [1] at adverse development of an epidemic AIDS all over the world the expenses on
AIDS by the beginning of XXI century can exceed the military budgets of the leading countries.
There was the sharpest problem of protection of the rights of the ill-infected AIDS, their children,
relatives.
Not only doctors and workers of public health services have to do with the problem of
AIDS, but also scientists of many specialities, statesman and the economists, lawyers and
sociologists.
All problems connected with "unusual variability" of human immuno-viridae (HIV) and the
absence of effective medical means against HIV, on our sight, are in direct of dependence with
absence (until today) from objective and is scientifically proved spatial model of human immuno-
viridae (HIV).
Lower we offer new model of HIV, and ideology of technology of medicinal preparations
against human immuno-viridae.
Human Immuno-Viridae (HIV)-retrovirus, virus appendices piercing through the
membrane, consist of 5 (five) and 6 (six) individual molecules of virus protein-glycoproteid (gp
120), this phenomenon in virology is called pentameral-hexameral clasterization [2].
Virus glycoproteids (gp 41) pierce through the virus membrane and form the centre of
symmetry of inner-virus net under it, it is an original “skeleton” which keeps the form of virus and
maintains the virus core in a definite state.
Some afore-named virus (HIV) data are cited to prove and advance the well-known
postulate about the virus destruction by means of all factors, which destruct the viroskeleton.
Most of viruses with locked cover (including HIV) possess icosaedric symmetry. This is the
most effective symmetry to construct the locked cover from a separate subunits (indivisible,
arranged in a definite order polypeptide chain-proteins).
On the surface of any structure with icosaedric symmetry there are 60 identical elements,
connected with one another by means of axes of symmetry of 2, 3 and 5 order.
Locked capsids (including HIV) with symmetry of higher order than icosaedric one, strictly
saying cannot exist.
Viroskeleton HIV locked spheroid, built from pentamers and hexamers, causes the
pentameral-hexameral clasterization occurring in case of human immuno-viridae.
Protuberances or virus appendices of five or six elements, visible in an electronic
microscope in a negative contrustiration, have sense in a scientific generalization only in case, if
these structures correspond chemically important elements. Human immuno-viridae relates to such
case (ibid. picture 1, virus appendices gp 120).
On the other hand, in 18-th century the Swiss mathematician Leonard Euler by means of
calculation proved [3,4] that any locked spheroid (in case of HIV-it is a viroskeleton) must have 12
(twelve) pentagons (in case of HIV-they are pentamers) but the number of hexagons (in case of
HIV-hexamers) can be modified within the wide limits. Only this fact can explain the unusual
variability of HIV virus.
In such locked spheroids (including HIV), two pentamers are disposed so that they do not
have the common rib, as the similar configuration (pentamers with common rib) is extremely
unstable and is generally stated that clearly divided pentamers on the surface of locked spheroid
stereochemically take up the most intensive places.
It is interesting to note that at the beginning of the 20-th century radiolaries were described;
they are a group of the simpliest, having silicic skeleton [5], which with their structural motives of
locked spheroid, have much common with HIV viroskeleton.
Coming out of the well-known postulates about the facts that 1. The destruction of
viroskeleton causes the destruction of virus itself and 2. The most vulnerable points of the
viroskeleton are places of disposition of all 12 (twelve) pentamers forming virus proteins of
glycoproteid (gp 41) and 12 (twelve) virus appendices consisting of 5 (five) individual molecules of
virus protein of glycoproteid (gp 120).
Taking into consideration the afro-said, it is possible to formulate the strategy of human
immuno-viridae (HIV) destruction in the following way: for the viroskeleton HIV “the elementary
cell” can be chosen (the constitutive structural element of viroskeleton, place and number of which
in connection with viroskeleton, always remain constant) in the form of pentamer (picture 2).
Viroskeleton has such 12 (twelve) pentamers with virus appendices - the consequence of pentamer
clasterization.
The destruction by means of “detergent”(that is destructive molecule) molecule of one or
more such cells (ideal case-all 12 cells) will lead to the viroskeleton destruction and as a result, to
the virus destruction.
Apart From the virus, the unusual forms are observed in the population, which differ from
the usual HIV ones with size; these “minimal forms” are 2-3 times less than usual virus. These
small fractions include the main components of the usual virus, except for the complete virus
henom, they appear when the virus propagates itself in unfavorable conditions, partly in the mixed
infection, and it is supposed that they can suppress HIV probation.
In our view, the presence of such small forms with essential defects is caused by the
operation of the same mechanism, as the mechanism of antisense molecule operation [6].

LITERATURE:

1. ABC of AIDS; Edited by Michael W.Adler MD FRCP Professor of Genitourinary Medicine,


Meddlesex Hospital and Medical Journal, 1988.
2. Fundamental Virology; Chief Editors: BERNARD N.FIELDS, M.P. and DAVID M.KNIPE,
Ph.D. by Raven Press Book, Ltd 1986.
3. Fuss N., Eloge de monsieur Leonard Euler, St. Pb., 1783.
4. Erweström G., Verzeichenis der Schriften Leonard Eulers, Lfg 1-2, Lpz., 1910-13 (Jahresbericht der
Deutscher Mathematiker - Vereinigung. Engänzugsband 4, Lfg 1-2).
5. D’arcy Thompson; On Growth and Form; 1917.
6. Harold M.Weintraub; Antisense RNA and DNA, Scientific American, January №1, vol.262,
1990.

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