Beruflich Dokumente
Kultur Dokumente
Medical Imaging
Brett Cowan
Centre for Advanced MRI
University of Auckland
Medical Imaging
Overview
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3. Data Analysis
New statistical analyses of shape, disease classifiers,
and new and improved diagnostic accuracy
Medical Imaging
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Medical Imaging
1995
FLASH
(25seconds)
2005
SSFP
(14seconds)
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2010
Accelerated
(5seconds)
2013
Realtime
(1second)
Medical Imaging
Neurological MRI
T1 weighted
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T2 weighted
Medical Imaging
Tractography
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fMRI
Medical Imaging
in medical imaging, the data are usually grey scale pixel values
they are not demographics (52 years old), blood pressure (155/95),
a genetic sequence (ACAT), they are just numbers representing
grey scale (or colour) in an image
this data is not information in the sense of many other datasets
we must align images into a common reference frame, segment
features of interest, measure distances, thickness, volume and
define shapes or regions of interest
this process is time consuming relative to scan acquisition time (the
acquisition to analysis ratio)
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Medical Imaging
Image Processing
Edge detection
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Non-rigid registration
Feature tracking
CAP Project
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the first two contributing clinical trials were the MESA and DETERMINE
trials
CAP Project
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2. Ownership of data
3. Project infrastructure
CAP Project
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Data
Acquisition
RADIOLOGY
Heart
Modelling
BIOENGINEERING
Patient
Diagnosis
Statistical
Analysis
MEDICINE
BIG DATA
Software
Development
COMPUTER SCIENCE
CAP Project
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CAP Project
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CAP Project
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Individual consent
required
Application to IRB
required
Investigator can
make the decision
Not human
subjects research
Low
High
IRB requirements
CAP Project
the convenience and power of electronic data is also its Achilles heel
the DICOM standard allows for the inclusion of private information,
which is not HIPAA (1996) compliant in many cases.
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Project Infrastructure
CAP Project
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Database
CAP Project
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CAP Project
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Complete mathematical
representation of the left ventricle
CAP Project
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Using image processing (and operator input), the raw images are converted
into a beating mathematical heart in the database. This allows any parameter
to be determined without further analysis.
CAP Project
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Accuracy
Scanrescan variability
Coefficient of variation 3%
Difference (g)
Difference (g)
Postmortem (g)
CAP Project
Segmentation Challenge
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Modal Analysis
CAP Project
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CAP Project
Anterior
Lateral
Septal
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CAP Project
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Normal
Non-Ischaemic HF
CAP Project
Classification of Disease
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CAP Project
Data Analysis
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CAP Project
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Image data
Clinical problem
Database
Statistics
Catalonia
Prospective trials
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Prospective trials
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Specific
High cost
Low cost
Prospective trials
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Prospective trials
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www.regicor.org
Prospective trials
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Cost
Notfundable
Fundable
Benefit
NZSpecificdata
Trialperformedin
NewZealand
Canwedobetterin
thisrange?
Genericdata
Trialperformed
Overseas
Prospective trials
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MESA Investigations
Prospective trials
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Prospective trials
The MESA and Jackson Heart Studies are using software developed in
Auckland to analyse all of their cardiac MRI image data. The data and
results are fully compatible with all of the work already done here.
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Prospective trials
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Prospective trials
Matching
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Fingerprinting
Matching
n =100
n =1000
Prospective trials
OutcomesforNewZealand
datawhichreflectsNZsubgroups
directapplicationofresults
amplificationofsamplesizeby10X
trialcostmetinternationally
prospectivestudydesign
internationalcollaborationand
engagement
developmentoffingerprintingand
matchingtechnologies
NewZealand
Sample(n=100)
Fingerprint
Local(NewZealand)
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20year
outcomes
15year
outcomes
10year
outcomes
NZcohort
followedin
trial
5year
outcomes
Statistical
matching
NZcohortidentifiedin
baselinedata(n=1000)
Global
Summary
Big Data
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Summary
Thank you to -
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Alistair Young
Avan
Michael
Jae Do
Carissa
Lana
Agustn
Ben
Yingmin
Pau
Wenchao
Paul Finn
Randall
John