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New target for blood cancer treatment discovered

Date: November 10, 2014

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Source: University of York

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Summary: A therapeutic target that could lead to the development of new

treatments for specific blood cancers has been identified by
researchers. Using laboratory models, they found that 'switching off' half
the gene in the Mpl receptor reduced its expression with the result that
the disease did not develop.

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cientists at the University of York have identified a therapeutic target

which could lead to the development of new treatments for specific
blood cancers.

The study, by researchers from the Centre for

Immunology and Infection at York working with
scientists in the Department of Medicine at Stony
Brook University in the USA, could lead to improved
therapies for a group of haematological cancers called
myeloproliferative neoplasms (MPNs).

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in the body is important for good health but, in the majority of MPN patients, a
mutation in a protein called JAK2 causes blood cells to proliferate too quickly.
The team at CII -- a research centre established jointly by the University of York's
Department of Biology and Hull York Medical School -- discovered that the protein
molecule Mpl, which receives chemical signals from outside the cell, is a prerequisite

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molecule Mpl, which receives chemical signals from outside the cell, is a prerequisite
for the development of mutant JAK2 disease.
Using laboratory models, they found that 'switching off' half the gene in the Mpl
receptor reduced its expression with the result that the disease did not develop. The
research is published in the journal Blood.

for the initiation and development of prostate cancer

interact at the molecular level, which could lead to
improved treatments for the ... full story
more related stories

Dr Ian Hitchcock, of CII, said: "This is potentially important medically because it

means we can target Mpl. If you can disrupt its activity you have a completely novel
treatment for the disease. We found that it is unnecessary to get rid of the receptor
entirely, you just need to reduce its expression to have a significant effect on the
development of MPN."
Story Source:
The above story is based on materials provided by University of York. Note: Materials
may be edited for content and length.
Journal Reference:
1. V. Sangkhae, S. L. Etheridge, K. Kaushansky, I. S. Hitchcock. The
thrombopoietin receptor, MPL, is critical for development of a JAK2V617Finduced myeloproliferative neoplasm. Blood, 2014; DOI: 10.1182/blood-201407-587238

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University of York. "New target for blood cancer treatment discovered."

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