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Tumor protein p73 [Homo sapiens]

GenBank: AAI17252.1
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LOCUS

AAI17252

636 aa

linear

PRI 26-JUN-

2006
DEFINITION

Tumor protein p73 [Homo sapiens].

ACCESSION

AAI17252

VERSION

AAI17252.1

DBSOURCE

accession BC117251.1

KEYWORDS

MGC.

SOURCE

Homo sapiens (human)

ORGANISM

GI:109658844

Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.

REFERENCE
AUTHORS

(residues 1 to 636)

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,


Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M.,

Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM

Mammalian Gene Collection Program Team

TITLE

Generation and initial analysis of more than 15,000 full-length


human and mouse cDNA sequences

JOURNAL
PUBMED
REFERENCE

Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)


12477932
2

(residues 1 to 636)

CONSRTM

NIH MGC Project

TITLE

Direct Submission

JOURNAL

Submitted (26-MAY-2006) National Institutes of Health, Mammalian


Gene Collection (MGC), Bethesda, MD 20892-2590, USA

REMARK
COMMENT

NIH-MGC Project URL: http://mgc.nci.nih.gov


Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Mike Brownstein, NIMH
cDNA Library Preparation: British Columbia Cancer Research Center
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Genome Sequence Centre,
BC Cancer Agency, Vancouver, BC, Canada
info@bcgsc.bc.ca
Martin Hirst, Thomas Zeng, Ryan Morin, Michelle Moksa, Johnson
Pang, Diana Mah, Jing Wang, Kieth Fichter, Eric Chuah, Allen
Delaney, Rob Kirkpatrick, Agnes Baross, Sarah Barber, Mabel
Brown-John, Steve S. Chand, William Chow, Ryan Babakaiff, Dave
Wong, Corey Matsuo, Jaclyn Beland, Susan Gibson, Luis delRio,

Ruth
Featherstone, Malachi Griffith, Obi Griffith, Ran Guin, Nancy
Liao,
Kim MacDonald,

Mike R. Mayo, Josh Moran, Diana Palmquist, JR

Santos, Duane Smailus, Jeff Stott, Miranda Tsai, George Yang,


Jacquie Schein, Asim Siddiqui,Steven Jones, Rob Holt, Marco
Marra.
Clone distribution: MGC clone distribution information can be
found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCB Plate: 6 Row: F Column: 19.
Method: conceptual translation.
FEATURES
source

Location/Qualifiers
1..636
/organism="Homo sapiens"
/db_xref="taxon:9606"
/clone="MGC:150860 IMAGE:40125802"
/tissue_type="Colon, PCR rescued clones"
/clone_lib="NIH_MGC_294"

/note="Vector: pCR4-TOPO; Clone identification sequence


tag: GCAGCCCT"
Protein

1..636
/product="tumor protein p73"

Region

127..306
/region_name="P53"
/note="P53 DNA-binding domain; cd08367"
/db_xref="CDD:176262"

Site

order(194,197,258,262)
/site_type="other"
/note="zinc binding site [ion binding]"
/db_xref="CDD:176262"

Site

order(195..197,199)
/site_type="other"
/note="dimerization site [polypeptide binding]"
/db_xref="CDD:176262"

Site

order(259,261,268,293,295..297,300)
/site_type="DNA binding"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:176262"

Region

351..386
/region_name="P53_tetramer"
/note="P53 tetramerization motif; pfam07710"
/db_xref="CDD:254376"

Region

487..551
/region_name="SAM_tumor-p73"
/note="SAM domain of tumor-p73 proteins; cd09571"
/db_xref="CDD:188970"

Region

491..550
/region_name="SAM"
/note="Sterile alpha motif; smart00454"
/db_xref="CDD:197735"

CDS

1..636
/gene="TP73"
/gene_synonym="P73"
/coded_by="BC117251.1:111..2021"
/db_xref="GeneID:7161"
/db_xref="HGNC:HGNC:12003"
/db_xref="MIM:601990"

ORIGIN
1 maqstatspd ggttfehlws slepdstyfd lpqssrgnne vvggtdssmd vfhlegmtts

61 vmaqfnllss tmdqmssraa saspytpeha asvpthspya qpsstfdtms papvipsntd


121 ypgphhfevt fqqsstaksa twtyspllkk lycqiaktcp iqikvstppp pgtairampv
181 ykkaehvtdv vkrcpnhelg rdfnegqsap ashlirvegn nlsqyvddpv tgrqsvvvpy
241 eppqvgteft tilynfmcns scvggmnrrp iliiitlemr dgqvlgrrsf egricacpgr
301 drkadedhyr eqqalnessa kngaaskraf kqsppavpal gagvkkrrhg dedtyylqvr
361 grenfeilmk lkeslelmel vpqplvdsyr qqqqllqrps hlqppsygpv lspmnkvhgg
421 mnklpsvnql vgqppphssa atpnlgpvgp gmlnnhghav pangemsssh saqsmvsgsh
481 ctppppyhad pslvsfltgl gcpncieyft sqglqsiyhl qnltiedlga lkipeqyrmt
541 iwrglqdlkq ghdystaqql lrssnaatis iggsgelqrq rvmeavhfrv rhtitipnrg
601 gpgggpdewa dfgfdlpdck arkqpikeef teaeih
//

tumor protein p73 [Rattus norvegicus]


NCBI Reference Sequence: NP_001102166.1
FASTA Graphics
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LOCUS

NP_001102166

684 aa

linear

ROD 09-FEB-

2014
DEFINITION

tumor protein p73 [Rattus norvegicus].

ACCESSION

NP_001102166 XP_001077013 XP_342993

VERSION

NP_001102166.1

DBSOURCE

REFSEQ: accession NM_001108696.1

KEYWORDS

RefSeq.

SOURCE

Rattus norvegicus (Norway rat)

ORGANISM

GI:157822833

Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Rattus.

REFERENCE
AUTHORS

(residues 1 to 684)

Carmona-Calero EM, Castaneyra-Ruiz L, Gonzalez-Toledo JM, de


Paz-Carmona H, Brage C, Castaneyra-Ruiz A, Rancel-Torres MN,
Gonzalez-Marrero I and Castaneyra-Perdomo A.

TITLE

The expression of p73 in the organum vasculosum of the lamina


terminalis and choroid plexus of spontaneously hypertensive rats

JOURNAL
PUBMED
REMARK

Histol. Histopathol. 28 (7), 925-932 (2013)


23354845
GeneRIF: expression of p73 is weaker in the organum vasculosum of
the lamina terminalis and stronger in the choroid plexus of
hypertensive rats than in control rats

REFERENCE

(residues 1 to 684)

AUTHORS

Mouihate A and Al-Bader MD.

TITLE

Glucocorticoid-induced fetal brain growth restriction is

associated
with p73 gene activation
JOURNAL
PUBMED
REMARK

J. Neurosci. Res. 91 (1), 95-104 (2013)


23086675
GeneRIF: glucocorticoids negative impact on fetal brain

development
likely is due to the modulation of the pro-survival dominant
negative p63 and p73 gene variants
REFERENCE
AUTHORS

(residues 1 to 684)

Klein A, Maldonado C, Vargas LM, Gonzalez M, Robledo F, Perez de

Arce K, Munoz FJ, Hetz C, Alvarez AR and Zanlungo S.


TITLE

Oxidative stress activates the c-Abl/p73 proapoptotic pathway in


Niemann-Pick type C neurons

JOURNAL
PUBMED
REMARK

Neurobiol. Dis. 41 (1), 209-218 (2011)


20883783
GeneRIF: The main upstream stimulus activating the c-Abl/p73
pathway and neuronal apoptosis in Niemann-Pick type C neurons is
oxidative stress.

REFERENCE
AUTHORS

(residues 1 to 684)

Bui T, Sequeira J, Wen TC, Sola A, Higashi Y, Kondoh H and

Genetta
T.
TITLE

ZEB1 links p63 and p73 in a novel neuronal survival pathway

rapidly
induced in response to cortical ischemia
JOURNAL
PUBMED
REMARK

PLoS ONE 4 (2), E4373 (2009)


19194497
GeneRIF: The pro-survival response of neurons, initiated through
the rapid induction of p63, is mediated ultimately by the
transcriptional repression of a pro-apoptotic isoform of p73 by
ZEB1.

REFERENCE
AUTHORS

(residues 1 to 684)

Sayan AE, Sayan BS, Gogvadze V, Dinsdale D, Nyman U, Hansen TM,


Zhivotovsky B, Cohen GM, Knight RA and Melino G.

TITLE

P73 and caspase-cleaved p73 fragments localize to mitochondria

and
augment TRAIL-induced apoptosis
JOURNAL
PUBMED
REMARK

Oncogene 27 (31), 4363-4372 (2008)


18362891
GeneRIF: P73 and caspase-cleaved p73 fragments localize to
mitochondria and augment TRAIL-induced apoptosis

REFERENCE
AUTHORS

(residues 1 to 684)

Hu JF, Ulaner GA, Oruganti H, Ivaturi RD, Balagura KA, Pham J, Vu


TH and Hoffman AR.

TITLE

Allelic expression of the putative tumor suppressor gene p73 in


human fetal tissues and tumor specimens

JOURNAL
PUBMED
REFERENCE
AUTHORS
DI,

Biochim. Biophys. Acta 1491 (1-3), 49-56 (2000)


10760569
7

(residues 1 to 684)

Schwartz DI, Lindor NM, Walsh-Vockley C, Roche PC, Mai M, Smith

Liu W and Couch FJ.


TITLE

p73 mutations are not detected in sporadic and hereditary breast


cancer

JOURNAL
PUBMED
REFERENCE

Breast Cancer Res. Treat. 58 (1), 25-29 (1999)


10634515
8

(residues 1 to 684)

AUTHORS

Chi SG, Chang SG, Lee SJ, Lee CH, Kim JI and Park JH.

TITLE

Elevated and biallelic expression of p73 is associated


withprogression of human bladder cancer

JOURNAL
PUBMED
REFERENCE
AUTHORS

Cancer Res. 59 (12), 2791-2793 (1999)


10383132
9

(residues 1 to 684)

Mai M, Qian C, Yokomizo A, Tindall DJ, Bostwick D, Polychronakos

C,
Smith DI and Liu W.
TITLE

Loss of imprinting and allele switching of p73 in renal cell


carcinoma

JOURNAL
PUBMED
REFERENCE
AUTHORS

Oncogene 17 (13), 1739-1741 (1998)


9796703
10 (residues 1 to 684)
Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A,

Minty
A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F and Caput
D.
TITLE

Monoallelically expressed gene related to p53 at 1p36, a region


frequently deleted in neuroblastoma and other human cancers

JOURNAL
PUBMED
COMMENT

Cell 90 (4), 809-819 (1997)


9288759
PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from CH473968.1.
On or before Oct 4, 2007 this sequence version replaced
gi:109475899, gi:109477775.
Publication Note:

This RefSeq record includes a subset of the

publications that are available for this gene. Please see the
Gene
record to access additional publications.
FEATURES
source

Location/Qualifiers
1..684
/organism="Rattus norvegicus"
/db_xref="taxon:10116"

/chromosome="5"
/map="5q36"
Protein

1..684
/product="tumor protein p73"
/note="transformation related protein 73"
/calculated_mol_wt=74448

Region

172..351
/region_name="P53"
/note="P53 DNA-binding domain; cd08367"
/db_xref="CDD:176262"

Site

order(239,242,303,307)
/site_type="other"
/note="zinc binding site [ion binding]"
/db_xref="CDD:176262"

Site

order(240..242,244)
/site_type="other"
/note="dimerization site [polypeptide binding]"
/db_xref="CDD:176262"

Site

order(304,306,313,338,340..342,345)
/site_type="DNA binding"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:176262"

Region

396..431
/region_name="P53_tetramer"
/note="P53 tetramerization motif; pfam07710"
/db_xref="CDD:254376"

Region

534..598
/region_name="SAM_tumor-p73"
/note="SAM domain of tumor-p73 proteins; cd09571"
/db_xref="CDD:188970"

Region

538..598
/region_name="SAM"
/note="Sterile alpha motif; smart00454"
/db_xref="CDD:197735"

CDS

1..684
/gene="Tp73"
/gene_synonym="P73; Trp73"
/coded_by="NM_001108696.1:4..2058"
/db_xref="GeneID:362675"
/db_xref="RGD:1307083"

ORIGIN

1 mssprqlday atalplqatg ppaplpkstd psraqvqprm sngvgemaqs sssssssstf


61 ehlwsslepd styfdlpqps qgnseatgse esnmdvfhlq gmtssvmaqf nllssamdqm
121 gsraapaspy tpehaasapt hspyaqpsst fdtmspapvi psntdypgph hfevtfqqss
181 taksatwtys pllkklycqi aktcpiqikv stppppgtai rampvykkae hvtdivkrcp
241 nhelgrdfne gqsapashli rvegnnlsqy vddpvtgrqs vvvpyeppqv gtefttilyn
301 fmcnsscvgg mnrrpilvii tletrdgqvl grrsfegric acpgrdrkad edhyreqqal
361 nesttkngaa skrafkqspp aipalgtnvk krrhgdedmf ymhvrgrenf eilmkvkesl
421 elmelvpqpl vdsyrqqqqq qllqrpshlq ppsygpvlsp mnkvhggvnk lpsvnqlvgq
481 ppphssaagp nlgsmgsgil nshshsmpan gemngghssq tmvsgshctp pppyhadpsl
541 vsfltglgcp nciecftsqg lqsiyhlqnl tiedlgalki pdqyrmtiwr glqdlkqshd
601 cgqqllrsss naatisiggs gelqrqrvme avhfrvrhti tipnrggagg vtgpdewadf
661 gfdlpdcksr kqpikeefte tesh