HYPOTHALAMIC HORMONES AND

ANTAGONIST AFFECTING GONADAL FUNCTION

Drugs

Action

Therapeutic
uses

ANTERIOR PITUITARY HORMONES AFFECTING GONADAL FUNCTION

GnRH
Synthethic GnRH
: Gonadorelin
GnRH analog :
Leuprolide
Pulsatile
secretion of
GnRH
Increase the
release of FSH &
LH

GnRH Antagonist

Cetrorelix

PIF; Dopamine

Bromocriptine

Pergolide

Inhibit
prolactin
release

Pulsatile dose
Stimulate GnTH
release
Gonadorelin
given IV every
90mins
Used for
hypothalamic
hypogonadism in
both sexes
Steady dose
Inhibit GnTH
release
Leuprolide is
used
Prostatic
carcinoma,
endometriosis

Control
hyperprolactin
emia in
following
conditions :
Amenorrhea to
resume
ovarian
function
Pituitary
adenomas to
suppress
prolactin
release and to
decrease
tumor size

Binds with GnRH

receptors on AP
cells.
Inhibits the
action of GnRH
with subsequent
suppression of
secretion of both
FSH and LH
In vitro
fertilization ;
Given during
follicular
stimulation by
different
regimens
Suppress
endogenous LH
to give it time to
develop good
ova :)
Then given HcG
to induce
ovulation
Treatment of
endometriosis

The pituitary gonadotrophic hormones include ;

o FSH
o LH
o LTH
Preparations and therapeutic indications ;
Preparations :
Therapeutic Indications
Urofollitropin Biological activity similar to FSH
Human FSH extracted from urine of
postmenopausal women
Follitropin
Biological activity similar to FSH
alpha
Synthetic FSH
HMG = FSH
Human menopausal gonadotropin
Rich in LH and FSH activity
Extracted from urine of postmenopausal women
Treat infertility in women who fail to ovulate
despite the presence of potentially functional
ovaries
HcG = LH
Human chorionic gonadotropin
Hormone produced by human placenta
Biological activity similar to LH
Extracted from urine of pregnant women
Pituitary / hypothalamic hypogonadism with
infertility in both sexes
A part of in vitro fertilization programs for
controlled ovarian hyperstimulation. HcG is
injected after priming of ovaries with HMG /
urofollitropin to induce ovulation
To stimulate descent of the testis in male patients
with cryptorchidism in whom no anatomical
obstruction.