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Drug Classes
Therapeutic Actions
Hyoscine-N-butylbromide (HNBB) acts by interfering with the transmission of nerv
e impulses by acetylcholine in the parasympathetic nervous system.
Buscopan exerts a spasmolytic action on the smooth muscle of the gastrointestina
l, biliary and urinary tracts. As a quaternary ammonium derivative, hyoscine-Nbutylbromide does not enter the central nervous system. Therefore, anticholinerg
ic side effects at the central nervous system do not occur. Peripheral anticholi
nergic effects result from a ganglion-blocking action within the visceral wall a
s well as from anti- muscarinic activity.
Buscopan Tablets are indicated for the relief of spasm of the genito-urinary tra
ct or gastro- intestinal tract and for the symptomatic relief of Irritable Bowel
Presentation & Administration
Intravenous (IV)
20mg in 1ml (solution)
Dilute required dose to 10ml with normal saline. Inject slowly over 3-5 minutes.
Compatible with the following IV fluids:
Normal saline, 5% glucose glucose and sodium chloride
May be given into the side arm when the above IV fluids are being infused. Store
at room temperature. Protect from light.
IM or SC:
Inject undiluted into a large muscle mass or subcutaneously
Buscopan 10mg (white)
Gastro-Soothe 10mg (white)
Buscopan Tablets should not be administered to patients with myasthenia gravis,
megacolon and narrow angle glaucoma. In addition, they should not be given to pa
tients with a known hypersensitivity to hyoscine-N-butylbromide or any other com
ponent of the product.
Adverse Effects
CNS: dizziness, anaphylactic reactions, anaphylactic shock, increased ICP, disor
ientation, restlessness, irritability, dizziness, drowsiness, headache, confusio
n, hallucination, delirium, impaired memory
CV: hypotension, tachycardia, palpitations, flushing
GI: Dry mouth, constipation, nausea, epigastric distress
DERM: flushing, dyshidrosis
GU: Urinary retention, urinary hesitancy
Resp: dyspnea, bronchial plugging, depressed respiration
EENT: mydriasis, dilated pupils, blurred vision, photopobia, increased intraocul
ar pressure, difficulty of swallowing.
Nursing Considerations
Drug compatibility should be monitored closely in patients requiring adjunctive
Avoid driving & operating machinery after parenteral administration.
Avoid strict heat
Raise side rails as a precaution because some patients become temporarily excite
d or disoriented and some develop amnesia or become drowsy.
Reorient patient, as needed, Tolerance may develop when therapy is prolonged
Atropine-like toxicity may cause dose related adverse reactions. Individual tole
rance varies greatly
Oerdose may cause curare-like effects, such as respiratory paralysis. Keep emerg
ency equipment available.