2014

2014,
mars

Namn
Andrea Introini, Karolinska
Institutet
Kajsa Noyan, Karolinska Institutet

Dominic Papquin Prolux,

Karolinska Institutet

Projekttitel
Summa
Role of the immunoregulatory effect of semen in HIV-1 100 000 kr
transmission to the female genital mucosa
Viral suppression assay for HIV-specific CD8+ Tregs
100 000 kr
activity
Innate detection and elimination of HIV-1
100 000 kr

2013

Namn
Projekttitel
Summa
2013, okt Annika Karlsson, Karolinska Institutet Impact of T cell functionality and pathogenesis on HIV 100 000 kr
reservoir size in subjects on long-term ART

Edwin Leeansyah, Karolinska
Exploring the antimicrobial and cytotoxic function of 100 000 kr
Universitetssjukhuset
MAIT cells in HIV-1 infection

Britta Wahren & Eric Sandstrm,
Extraordinr satsning: Optimering av HIVIS DNA vaccin 250 000 kr
Karolinska Institutet
2013,
Robin Lving, Karolinska Institutet
How two broadly neutralizing anti HIV-1 antibodies, 100 000 kr
mars
PG9 and PG16, inactivate the virus

Christopher Sundling, Karolinska
Antibody maturation and diversity elicited by an HIV-1 50 000 kr
Institutet
vaccine candidate

Benjamin King, Lunds Universitet
Inhibition of PKR by non-coding RNA nc886 and effect 100 000 kr
on HIV replication

Arvid Edn, Sahlgrenska Akademin Longitudinell analys av neurologisk skada och viral
50 000 kr
escape i centrala nervsystemet vid HIVinfektion

Bo Heideman, Venhlsan,
Detektion av mukosalt IgA och IgG-svar hos HIV-
50 000 kr
Sdersjukhuset
immuniserade individer

Anna Petrova, Karolinska Institutet Correlation of local immune activation with genital viral 50 000 kr
shedding in HIV infected women

Rada Ellegrd, Linkpings Universitet Initial events of HIV-1 pathogenesis at the cervical and 50 000 kr
colorectal mucosa

Jenny Svrd, Karolinska Institutet
Correlation of serum flagellin with immune activation 100 000 kr
status in HIV patients



rets
mottagare av Linda Morfeldts anslag


Amanda Hggblom, Karolinska
Lngtidsuppfljning av HIV behandling I den svenska 100 000 kr
Universitetssjukhuset
HIV kohorten

2012

Namn
Projekttitel
Summa
2012, okt Klara Hasselrot, Karolinska Institutet Hormonella preventivmedels effekt p
100 000 kr
genitalslemhinna med avseende p motstndskraft
mot HIV

Rose Bosire, Karolinska Institutet
Effect of antiretroviral prophylaxis on maternal
100 000 kr
antibody levels and transfer.



rets
mottagare av Linda Morfeldts anslag


Jenny Stenkvist, Karolinska Institutet Co-infektion med kronisk hepatit C hos HIV-infekterade 100 000 kr
patienter i Sverige

2012,

Robin
Lving, Karolinska Institutet

How
to broadly neutralizing anti HIV-1 antibodies, PG9 100

000 kr
mars
and PG16, inactivate the virus

Annelie Tjernlund, Karolinska
Detailed in situ analysis of SIV-specific CD8T cells in
50 000 kr
Institutet
lymphoid tissue

Johan Winquist, Uppsala Universitet Identifying novel drug resistant inhibitor scaffolds of 100 000 kr
HIV protease by SPR aided fragment screening

Jan Vesterbacka, Karolinska Institutet Effect of HIV therapy on gut microbiota
100 000 kr



rets
mottagare av Linda Morfeldts anslag

2011

Amanda Hggblom, Karolinska

Universitetssjukhuset

Lngtidsuppfljning av HIV behandling I den svenska

HIV kohorten

100 000 kr

Namn
2011, okt Markus Moll

Summa
50 000 kr

70 000 kr

2011,
mars

2010

Projekttitel
HIV-1 Vpu An inhibitor of innate immunity and a
potential target for novel anti-retroviral drugs
Johanna Brnnstrm
Sent diagnostiserad HIV-1 infektion ett centralt
problem i eran av HAART
Klara Hasselrot
Proteinuttryck i saliv och rektalskljvtska hos HIV-
exponerade icke infekterade MSM
Tove Kaldensj
Assessment of mucosal factors of importance for HIV
susceptibility in the female genital tract


rets
mottagare av Linda Morfeldts anslag
Christina Carlander
Impact of HIV-induced immunosuppression and anti-
retroviral therapy on the development of cervical n
Harold Marcotte, Karolinska Institutet Lactobacillus mediated delivery of antibody
fragments against HIV
Ujjwal Neogi, Karolinska Institutet
Human APOBEC mediated hypermutations induced
drug resistance
Pauline Levinson, Karolinska Institutet Immunological mechanisms of resistance to HIV
acquisition in serodiscordant couples
Mattias Mild, Karolinska Institutet
Underskning av den geografiska spridningen av HIV i
Sverige och stersjomrdet
Marcus Buggert, Karolinska Institutet The early effects of antiviral treatment on CD4+ T cell
reconstitution and immune activation
Marianne Jansson, Karolinska
On the role of microRNA in HIV-Mtb coinfections
Institutet


rets
mottagare av Linda Morfeldts anslag
sa Mellgren, Gteborgs Universitet Studie av HIV-associerade neurokognitiva symptom
Sahlgrenska Akademin

Namn
2010, okt Annelie Tjernlund, Karolinska
Institutet

Markus Moll, Karolinska Institutet

2010,
mars

50 000 kr
70 000 kr

100 000 kr
80 000 kr
80 000 kr
80 000 kr
80 000 kr
80 000 kr
80 000 kr

80 000 kr

Projekttitel
Summa
Detailed in situ analysis of SIV-specific CD8 T cells in
100 000 kr
lymphoid tissue
HIV interference with lipid-specific immunity An
100 000 kr
evolutionarily conserved immune evasion strategy?
Karin Lor, Karolinska Institutet
Defects in human dendritic cell subsets during HIV-1 100 000 kr
infection
Jan Vesterbacka, Karolinska Institutet Effekt av HIV behandling p mikrobiell translokation 50 000 kr
Jarl Wikberg, Uppsala Universitet
Development of proteochemometric based
100 000 kr
technologies for improvement of antiretroviral therapy
in HIV
Agneskog
Eva

Cross-resistance
between etravirine and the first

100
000 kr
generation of NNRTIs by a simple phenotypic assay
Jenny Nilsson
Co-infektion med hepatit B och hepatit C hos HIV-
100 000 kr
infekterade patienter i Sverige
Samir Abdurahman
Immune Activation in HIV patients: The Role of
100 000 kr
Microbial Translocation & HMGB1
Annika Karlsson
Identification of global anti-HIV-specific T cell responses 100 000 kr
Johan Sandberg
NK cell responses and KIR-HLA interactions in the
100 000 kr
Ugandan HIV-1 epidemic
Amanda Hggblom
Lkemedels resistens och behandlingsresultat av HIV 50 000 kr
typ 1

Linda Fogelstrand

Naturliga antikroppar vid HIV- koppling till kad

aterosklerosutveckling?

50 000 kr

2009

Namn
2009, nov Anders Snneborg, Karolinska
Institutet

Bo Hejdeman, Instutitionen
Sdersjukhuset

Piotr Nowak, Karolinska Institutet







2009,
mars

Projekttitel
Summa
Effekt av influensa A(H1N1)v vaccination av HIV-
50 000 kr
infekterade
Immunitet mot nya influensan (H1N1) efter vaccination 50 000 kr
hos mnniskor med HIV-1 infektion
The central role of HMGB1 and bacterial products in 80 000 kr
immune modulation of HIV-1 infection
Marie Borggren, Lunds Universitet Studies on HIV-1 Env glycan evolution and its affect on 80 000 kr
virus sensitivity to inhibitors
Irene Bontell, Karolinska Institutet Resistensutveckling hos HIV-patienter i Stockholm
80 000 kr
1996-2009
Anna Smed-Srensen, Karolinska
THE ROLE OF DENDRITIC CELLS IN HIV-1
80 000 kr
Institutet
TRANSMISSION: implications for HIV-1 pathogenesis
and therapy
Klara Hasselrot, Karolinska Institutet Detektion av funktionella IgA-svar hos HIV-vaccinerade 80 000 kr
individer
Aylin Yilmaz, Gteborgs Universitet Maraviroc koncentrationer i likvor hos HIV-1-
80 000 kr
infekterade individer
Mattias Mild, Karolinska Institutet
Detailed Characterization of the Development of HIV-1 80 000 kr
Drug Resistance
Sarah Palmer, Smittskyddsinstitutet Effects of treatment intensification with raltegravir on 80 000 kr
viral production in plasma and CSF
Agneskog, Karolinska
Eva

Korsresistens
mot etravirin bestmd med enkel

100
000 kr
Universitetssjukhuset
fenotypisk metod
Johanna Brnnstrm, Karolinska
Sent diagnostiserad HIV-1 infektion, ett centralt
100 000 kr
Universitetssjukhuset
problem i eran av HAART

2008

Namn
Projekttitel
Summa
2008, nov Sarah Palmer, Smittskyddsinstitutet Raltegravir substitution for enfuvirtide in patients
70 000 kr
suffering from injection-site reactions

Annika Karlsson, Smittskyddsinstitutet Identification of global anti-HIV-specific CTL Responses 50 000 kr

Markus Moll, Karolinska
HIV-1 interference with lipid-restricted immunity A 50 000 kr
Universitetssjukhuset
novel link between HIV-1 and AIDS-related
opportunistic infections

Karolin Falconer, Karolinska
Antiviral immune responses, HCV kinetics and
50 000 kr
Universitetssjukhuset
assessment of interferon-induced depression in
HCV/HIV-1 coinfection

2008,
juni S usanne Johansson,

Induction
of NK-cell activity against HIV infected cells 50
000 kr
Smittskyddsinstitutet
by antibody treatments

Aylin Yilmaz, Sahlgrenska
Behandlingseffekt i likvor fr antiretrovirala
50 000 kr
Unversitetssjukhuset
lkemedelskombinationer med olika bra CNS-
penetrerande frmga.

Elin Andersson, Gteborgs Universitet Microbicides against HIV-1 and HSV-2
50 000 kr

Jakob Michaelsson, Karolinska
The Role of NK cells in HIV infection
70 000 kr
Universitetssjukhuset

Klara Hasselrot, Karolinska Institutet Mucosal immunity in HIV-exposed uninfected men who 50 000 kr
have sex with men/Partnerstudien

Mattias Forsell, Smittskyddsinstitutet Production and Characterization of recombinant HIV-1 70 000 kr
envelope glycoproteins.

2008,

Johan
Lennerstrand, Uppsala

Improved
management of HIV by studies of novel
000 kr
70

mars

Universitet
Jarl Wikberg, Uppsala Universitet

Taha Hirbod, Karolinska

Universitetssjukhuset

mechanisms of resistance to nucleoside analogs.

Development of proteochemometric models for drug 70 000 kr
resistance predicition in HIV.
Function and regulation of the HIV-1 specific mucosal 70 000 kr
immune response in genital tissue.

2007

2007,
nov

Namn
Signar Mkitalo, Akademiska
sjukhuset Uppsala
Mattias Mild, Smittskyddsinstitutet

Projekttitel
Clinical outcome in patients with low CD4+ T-cell
counts despite effective HAART
Ultra-deep sequence analysis of HIV R5 and X4
subpopulations

Global
Health Emergencies:
Improving DNA-bases Vaccine Strategies to HIV
Freligger kad frakturincidens i samband med ART?

Summa
70 000 kr

70 000 kr

2007,
juni S teven Appelquist, Karolinska
000 kr
70
Institutet

Katarina Gyllensten, Karolinska
70 000 kr
Institutet

Gary Corrigan, Smittskyddsinstitutet Antiretroviral resistance mutations in the HIV-1
50 000 kr
genome result in reduction in reserve transcriptase
fitness

Styrgruppen fr InfCareHIV,
InfCareHIV
854 000 kr
Karolinska Institutet

2007,

Piotr
Nowak, Karolinska Institutet

Immune
activation in HIV-1 infection The central role 70
000 kr
mars
of HMGB1 complexes

Helena Skar, Smittskyddsinstitutet Evolutionary imprint of clinical disease progression in 70 000 kr
HIV-1 phylogenies

Charlotte Hedskog,
Ultra-deep sequencing to monitor previously-
70 000 kr
Smittskyddsinstitutet
undetectible drug-resistance within HIV-1 quasispecies

Taha Hirbod, Karolinska
Function and regulation of the HIV-1 specific mucosal 70 000 kr
Universitetssjukhuset
immune response in genital tissue

2006

Namn
2006, nov Ann Atlas, Karolinska Institutet

Projekttitel
Summa
Immunsystemetsreglering av kynurensyra samt dess 50 000 kr
betydelse fr patofysiologin vid psykos hos HIV-1
infekterade individer

Markus Moll, Karolinska Institutet
The CD1 system New target for HIV-1 immune
70 000 kr
evasion

Aylin Yilmaz, Sahlgrenska
Intrathecal immune markers in HIV-1-infected patients 60 000 kr
Unversitetssjukhuset
on various antiretroviral treatment combinations

Annika Karlsson, Smittskyddsinstitutet Identification of global anti-HIV-specific CTL responses 50 000 kr

Magnus Gissln, Sahlgrenska
NorthHIV-studien
70 000 kr
Universitetssjukhuset

2006,
juni G
ary Corrigan, Smittskyddsinstitutet
000 kr
50

Ann-Sofie sander, Karolinska
Afrikanska frldrar som lever med HIV-infektion i
50 000 kr
Universitetssjukhuset
Sverige

Marianne Jansson, Lunds universitet Studies on early and late HIV-1 variants in relation to 50 000 kr
innate immunity selection forces

Elin Andersson, Gteborgs Universitet Effects on HIV replication in vitro by a novel
70 000 kr
monosulphated cyclitolas a part of the project
Microbicide prophylaxis against transmission of HIV
and genital herpes in Tanzania .

Piotr Nowak, Karolinska Institutet
The role of HMGB- 1 in HIV infection
50 000 kr

Klara Hasselrot, Karolinska Institutet Mucosal immunity in HIV-exposed uninfected men who 50 000 kr
have sex with men/Partnerstudien

Lennart Svensson, Linkpings
Kan Lewis a blockera DC-SIGN medierad spridning av 70 000 kr


2006,
mars

2005

Universitet
sexuellt verfr HIV?
Magnus Gissln, Sahlgrenska
Immunologisk och virologisk effekt av IVIG som tillgg 70 000 kr
Universitetssjukhuset
till antiretroviral terapi mot HIV

Lars-Magnus
Andersson, Sahlgrenska HIV-1

co-receptortropism i CSF och blod longitudinell 35
000 kr
Universitetssjukhuset
studie.
Tobias Bergroth, Karolinska
Resistensutveckling i mindre viruspopulationer mot
70 000 kr
Universitetssjukhuset
lamivudin vid insttning av hiv-behandling samt i
parade blod/CSF prover.
Annika Lindkvist, Karolinska
Analysis of virological parameters in HIV-1 Seropositive, 70 000 kr
Universitetssjukhuset
but virus DNA/RNA-negative subjects.

Namn
2005,
Eric Sandstrm, Sdersjukhuset
november

Magnus Gissln, Sahlgrenska

Universitetssjukhuset
Markus Moll, Karolinska Institutet

Projekttitel
HIVIS 02. Skerhet och immunogenicitet av att
immunisera med MVA med infogade HIV-1 gener fr
env, gag, och pol I individer som tidigare ftt
motsvarande HIV-1 gener i plasmid
NORTHiv-studien

Summa
70 000 kr

70 000 kr

Mechanisms of HIV-1 interference with CD1d-restricted 50 000 kr

T cell-mediated immunity.

Ali Harandi, Gteborgs Universitet Development of novel CpG DNA-based approaches for 50 000 kr
inhibition of HIV-1 replication in vitro.

2005,
juni Gunilla

Karlsson Hedenstam,

HIV-1
envelope glycoprotein pseudotyping for
000 kr
70
Karolinska Institutet
funcional and neutralization studies

Marie Larsson, Hlsouniversitet
Immunomodulatory effects of HIV-1 on human
70 000 kr
Linkpig
dendritic cells and subesquent T cell activation.

Veronica Svedhem, Karolinska
Expanded evolutionary analyses on the Swedish
35 000 kr
Universitetssjukhuset
transmission chain

Irina Maljkovic, Smittskyddsinstitutet Kinetics of mutation M184V in minor HIV-population 50 000 kr
with treatment failure on lamivudin, abacavir and
didanosin. Del av projekt. Resistensutveckling vid
lkemedelsbehandling.

Eleonor Brandin,
Evolution of HIV-2
30 000 kr
Smittskyddsinstitutet

Bjrn Sdergrd,
Readiness assessments in clinical practice. Predicting 20 000 kr
treatment outcome in HIV patients by the use of
readiness assessments.

2005,

Magnus
Gissln, Sahlgrenska

NORTHiv-studien
000 kr
70
mars
Universitetssjukhuset

Eric Sandstrm, Sdersjukhuset
HIVIS 01
70 000 kr

Johan Sderlund, Karolinska
Immunologiska och genetiska faktorer associerade till 35 000 kr
Universitetssjukhuset
skydd mot HIV-1 infektion hos HIV-1 exponerade
seronegativa mn som har sex med HIV-infekterade
mn.

2004

Namn
2004, nov Ann Atlas, Karolinska Institutet

Babilonia Barqasho, Karolinska

Universitetssjukhuset
Tobias Bergroth, Karolinska
Universitetssjukhuset
Victor Fernandez,

Projekttitel
Summa
Korrelation av IL-7 och IL-7R med CD4+T cells kningen 70 000 kr
under behandling med ART.
Betydelsen av innate immunitet vid primr hiv infektion 70 000 kr
och vid utsttning av behandling.
Resistensutveckling mot lamivudin vid insttning och 70 000 kr
utsttning av hiv-behandling.
Pneumocyctis jiroveci pneumonia: genetic monitoring 54 000 kr

Smittskyddsinstitutet
Ali Harandi, Gteborgs Universitet
Gunilla Karlsson,
Smittskyddsinstitutet

Annelie Tjernlund, Karolinska

Institutet

2004,
juni Johan

Lennerstrand, Karolinska
Universitetssjukhuset

Johan Sandberg, Karolinska
Universitetssjukhuset

2004,
mars

Veronica Svedhem, Karolinska

Universitetssjukhuset

Gran
Bratt, Sdersjukhuset

2003

and rational drug selection.

Development of novel CpG DNA- based approaches for 70 000 kr
inhibition of HIV-1 replication in vitro.
Stimulation of potent antibody and T helper responses 70 000 kr
against HIV-1 using an optimized trimeric envelope
immunogen.
Leukemia inhibitory factor (LIF) en potent endogen 63 000 kr
hmmare av HIV-1.

Improvement
of treatment of HIV by studies of
000 kr
70
mechanism of resistance to NRTIs.
Hepatit C virus dynamics and anti-viral immune
70 000 kr
responses in HCV/HIV-1 co-infected patients treated
with PEG interferon alfa-2a and Ribavirin.
Resistensutveckling vid behandlingssvikt.
70 000 kr
7-rsuppfljning av de 202 patienter som startade
antiretroviral kombinationsbehandling (HAART) vid
Venhlsan under 1996.

000 kr
50

Namn
Projekttitel
2003, nov Nathalie Ylitalo, Karolinska Institutet Long-term evaluation of adverse effects among
uninfected children born to HIV-infected women and
exposed to antiretroviral therapy perinatally.

Angelo De Milito, Karolinska Institutet Impact of early HAART on memory B cells and specific
anti-HIV humoral immunity during primary HIV
infection.

2003,
juni A
ndreas Boberg,

Utveckling
av vaccine mot drogresistent HIV.
Smittskyddsinstitutet

Sven Britton, Smittskyddsinstitutet Lgkostnadsalternativ fr bestmning och kontroll av
HIV infektion.

Anna-Lena Spetz, Karolinska
From mice to man with the novel therapeutic HIV-1
Universitetssjukhuset
vaccine strategy; apoptotic HIV-1 infected cells.

Annelie Tjernlund, Karolinska
Leukemia inhibitory factor (LIF) en potent endogen
Institutet
hmmare av HIV-1.

2003,

Tobias
Bergroth, Karolinska

Resistensutveckling
mot lamivudin vid insttning och
mars
Universitetssjukhuset
utsttning av HIV behandling.

Ali Harandi, Gteborgs Universitet Immunostimulatory CpG DNA-based strategies for
inducing protective immunity in the female genital
tract mucosa against HIV and HSV-2.

Anna Lindstrm, Karolinska
Reversion av resistensmutationer efter smitta med
Universitetssjukhuset
resistent virus.

Yu Shi, Karolinska
Autologous HIV-2 neutralisation in relation to clinical
Universitetssjukhuset
progression.

Summa
54 000 kr

2002

Namn
Projekttitel
2002, nov Homira Behbahani, Karolinska
Horizontal gene transfer by the uptake of apoptotic
Universitetssjukhuset
HIV-1 infected cells A novel vaccine strategy.

Angelo De Milito, Karolinska Institutet Impact of early HAART on memory B cells and specific
anti-HIV humoral immunity during primary HIV
infection.

Johan Lennerstrand, Karolinska
Improvement of treatment of HIV by studies of
Universitetssjukhuset
mechanisms of resistance to NRTIs

Lilian Walther-Jallow, Karolinska
Ett terapeutiskt HIV vaccin baserat p horisontell

50 000 kr
000 kr
30
50 000 kr
70 000 kr
65 000 kr
(Noaks Ark)
000 kr
70
(Noaks Ark)
70 000 kr
70 000 kr
70 000 kr

Summa
30 000 kr
30 000 kr
70 000 kr
(Noaks Ark)
30 000 kr

Universitetssjukhuset

2002,
juni B
abilonia Barqasho, Karolinska
Universitetssjukhuset

Nico Dantuma, Karolinska Institutet

Lars Eriksson, Smittskyddsinstitutet

Veronica Svedhem, Karolinska

Universitetssjukhuset

Tobias
Bergroth, Karolinska
Universitetssjukhuset
Eleonor Brandin, Karolinska
Universitetssjukhuset
Anna Lindstrm, Karolinska
Universitetssjukhuset

2002,
mars

gentransfer metod.

Betydelsen
av innate immunitet fr immunfrsvaret vid 70
000 kr
primr HIV infektion och vid utsttning av behandling.
Development of a diagnostic phenotypic assay for the 35 000 kr
identification of protease inhibitor resistant HIV-1
strains in AIDS patients.
Utveckling av HIV-1 DNA niver vid behandlings-
35 000 kr
uppehll.
Kliniska aspekter p HIV-1 resistens vid behandling med 70 000 kr
nelfinavir.
(Noaks Ark)

Fitness
of HIV-1 strains resistant to nucleoside reverse 70
000 kr
transcriptase inhibitors.
(Noaks Ark)
Antiretroviral resistance in Swedish HIV-2 patients.
70 000 kr

AZT resistance in pregnant women receiving

61 000 kr
prophylaxis against mother-to-child transmssion of HIV-
1
Linda Morfeldt, Karolinska Institutet HiVBivus En prospektiv kohortstudie kring
300 000 kr
biverkningar av antiretroviral terapi.
Piotr Nowak, Karolinska Institutet
The role of HMGB-1 in HIV infection.
70 000 kr