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Safety Data Sheet

According to EC Directive 91/155/EEC


Date of issue:
Supersedes edition of

1.

19.09.2004
22.01.2003

Identification of the substance/preparation and of the company/undertaking


Identification of the product
Catalogue No.:

100944

Product name:

Ethylenedinitrilotetraacetic acid extra pure NF

Use of the substance/preparation


Pharmaceutical production and analysis

Company/undertaking identification

2.

Company:

Merck KGaA * 64271 Darmstadt * Germany * Phone: +49 6151 72-0

Emergency telephone No.:

Please contact the regional Merck representation


in your country.

Composition/information on ingredients
Synonyms
Ethylenediaminetetraacetic acid
CAS-No.:
M:
Formula Hill:

3.

60-00-4
292.25 g/mol
C10H16N2O8

EC-No.:

200-449-4

Hazards identification
Irritating to eyes. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.

4.

First aid measures


After inhalation: fresh air.
After skin contact: wash off with plenty of water. Remove contaminated clothing.
After eye contact: rinse out with plenty of water with the eyelid held wide open. Call in
ophtalmologist.
After swallowing: make victim drink plenty of water, call in physician.

The Safety Data Sheets for catalog items are also available at www.chemdat.info

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Merck Safety Data Sheet


According to EC Directive 91/155/EEC
Catalogue No.:
Product name:

5.

100944
Ethylenedinitrilotetraacetic acid extra pure NF

Fire-fighting measures
Suitable extinguishing media:
Water, CO2, foam, powder.
Special risks:
Combustible. Danger of dust explosion. Development of hazardous combustion gases or vapours possible
in the event of fire. The following may develop in event of fire: nitrogen oxides.
Special protective equipment for fire fighting:
Do not stay in dangerous zone without self-contained breathing apparatus.
Other information:
Contain escaping vapours with water. Prevent fire-fighting water from entering surface water or
groundwater.

6.

Accidental release measures


Person-related precautionary measures:
Avoid substance contact. Avoid generation of dusts; do not inhale dusts. Ensure supply of fresh air
in enclosed rooms.
Environmental-protection measures:
Do not allow to enter sewerage system.
Procedures for cleaning / absorption:
Take up dry. Forward for disposal. Clean up affected area.

7.

Handling and storage


Handling:
No further requirements.

Storage:
Tightly closed. Dry. Storage temperature: no restrictions.

8.

Exposure controls/personal protection


Personal protective equipment:
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Respiratory protection:

required when dusts are generated. Filter P 2 (acc. to DIN 3181) for
solid and liquid particles of harmful substances

Eye protection:

required

The Safety Data Sheets for catalog items are also available at www.chemdat.info

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Merck Safety Data Sheet


According to EC Directive 91/155/EEC
Catalogue No.:
Product name:

100944
Ethylenedinitrilotetraacetic acid extra pure NF

Hand protection:

In full contact:
nitrile rubber
0.11 mm
> 480 Min.

Glove material:
Layer thickness:
Breakthrough time:

In splash contact:
nitrile rubber
0.11 mm
> 480 Min.

Glove material:
Layer thickness:
Breakthrough time:

The protective gloves to be used must comply with the specifications


of EC directive 89/686/EEC and the resultant standard EN374, for
example KCL 740 Dermatril (full contact), 740 Dermatril (splash
contact). The breakthrough times stated above were determined by
KCL in laboratory tests acc. to EN374 with samples of the recommended
glove types.
This recommendation applies only to the product stated in the safety
data sheet and supplied by us as well as to the purpose specified by
us. When dissolving in or mixing with other substances and under
conditions deviating from those stated in EN374 please contact the
supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Industrial hygiene:
Change contaminated clothing. Application of skin- protective barrier cream recommended. Wash hands
after working with substance.

9.

Physical and chemical properties


Form:
Colour:
Odour:

solid
colourless to white
odourless

pH value
(23 C)

at 10 g/l H2O

Melting point
Boiling point
Ignition temperature
Flash point
Explosion limits

220

(slurry)
C

(decomposition)

not applicable

lower

> 200

(DIN 51794)

> 100

c.c. (DIN 51758)

not applicable

upper

Vapour pressure
Density
Bulk density
Solubility in
water
water
Thermal decomposition
log Pow:
Bioconcentration factor

~ 2.5

not applicable
(20 C)

< 0.013

hPa

(20 C)

0.86
~ 600

g/cm3
kg/m3

~ 0.5
~ 2.2

g/l
g/l

> 150

(20 C)
(80 C)

(slurry)

-3.34
19
0.8-1.9

The Safety Data Sheets for catalog items are also available at www.chemdat.info

(calculated)

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Merck Safety Data Sheet


According to EC Directive 91/155/EEC
Catalogue No.:
Product name:

100944
Ethylenedinitrilotetraacetic acid extra pure NF

10. Stability and reactivity


Conditions to be avoided
Heating.

Substances to be avoided
strong oxidizing agents, strong bases.

Hazardous decomposition products


in the event of fire: See chapter 5.

Further information
dust explosion possible;
unsuitable working materials: copper, copper alloys, nickel.

11. Toxicological information


Acute toxicity
LD50 (oral, rat): 2580 mg/kg.
Specific symptoms in animal studies:
Eye irritation test (rabbit): Irritations (OECD 405).
Skin irritation test (rabbit): No irritation (OECD 404).

Subacute to chronic toxicity


Sensitization:
Sensitization test (guinea pig): negative. (sodium salt)
Noncarcinogenic in animal experiments. (sodium salt)
Bacterial mutagenicity: Salmonella typhimurium: negative.
No teratogenic effect in animal experiments.

Further toxicological information


After inhalation: Irritations of the mucous membranes, coughing, and dyspnoea.
After skin contact: Slight irritations.
After eye contact: Irritations.
After swallowing: gastric pain.
After uptake of large quantities: Damage of: kidneys.
Property which must be anticipated on the basis of structure- effect considerations:
disturbed electrolyte balance.

Further data
Further hazardous properties cannot be excluded.
The product should be handled with the care usual when dealing with chemicals.

The Safety Data Sheets for catalog items are also available at www.chemdat.info

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Merck Safety Data Sheet


According to EC Directive 91/155/EEC
Catalogue No.:
Product name:

100944
Ethylenedinitrilotetraacetic acid extra pure NF

12. Ecological information


Abiotic degradation:
Rapid degradation. (air)
Biologic degradation:
Slightly biodegradable.
Slightly eliminable (DOC reduction <20 %).
BOD5: 0.01 mg/kg
BOD <1 % from TOD /5 d
Biodegradation: 0 % /28 d
COD: 0.85 mg/mg
COD <20 % from TOD /28 d
Behavior in environmental compartments:
Distribution: log p(o/w): -3.34.
No bioaccumulation is to be expected (log P(o/w) <1).
BCF: 19 (calculated).
Ecotoxic effects:
Biological effects: Harmfull effect on aquatic organisms. May cause long-term adverse effects in the
aquatic environment.
Fish toxicity: L.macrochirus LC50: 41 mg/l /96 h (in soft water).
Daphnia toxicity: Daphnia magna EC50: 625 mg/l /24 h (EDTA sodium salt)
Bacterial toxicity: Ps.putida EC50: 28 mg/l /16 h
Maximum permissible toxic concentration:
Ps.putida EC5: 105 mg/l.
Sc.quadricauda IC5: 11 mg/l /8 d (EDTA sodium salt).
E.sulcatum EC5: 36 mg/l /72 h (EDTA sodium salt).
Further ecologic data:
Do not allow to enter waters, waste water, or soil!

13. Disposal considerations


Product:
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as
contact partners.

Packaging:
Merck product packaging must be disposed of in compliance with the country-specific regulations
or must be passed to a packaging return system. Under www.retrologistik.de you will find special
information on the respective national conditions as well as contact partners.

14. Transport information


Not subject to transport regulations.

15. Regulatory information


Labelling according to EC Directives
Symbol:
R-phrases:

Xi

Irritant

36-52/53

S-phrases:

61

Irritating to eyes. Harmful to aquatic organisms,


may cause long-term adverse effects in the aquatic
environment.
Avoid release to the environment. Refer to special
instructions/Safety data sheets.

The Safety Data Sheets for catalog items are also available at www.chemdat.info

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Merck Safety Data Sheet


According to EC Directive 91/155/EEC
Catalogue No.:
Product name:

100944
Ethylenedinitrilotetraacetic acid extra pure NF

Reduced labelling (1999/45/EC,Art.10,4)


Symbol:
R-phrases:

Xi

Irritant

52/53

Harmful to aquatic organisms, may cause long-term


adverse effects in the aquatic environment.

S-phrases:

---

16. Other information


Reason for alteration
General update.

Regional representation:
This information is given on the authorised Safety Data Sheet
for your country.
The information contained herein is based on the present state of our knowledge. It
characterizes the product with regard to the appropriate safety precautions. It does not
represent a guarantee of the properties of the product.

The Safety Data Sheets for catalog items are also available at www.chemdat.info

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