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Cytogenetic biomarkers

Chromosome Aberrations (CA)

CA CA

Micronuclei (MN)

MN MN

Sister Chromatid Exchanges (SCE)

SCE SCE

Dr.Krishnaja A.P.
15th January 1-2010
Dicentric chromosomes and Acentric fragments

Ring chromosomes

Radiation or radiomimetic chemicals induce….


Chromatid breaks and gaps

Chromatid exchanges

Chemicals induce….
Micronuclei - CBMN assay

MN in binucleate cells

Nucleoplasmic bridge

Nuclear division index (NDI)


Sister Chromatid Exchanges (SCE) - scored in second cycle cells

SCE – chemical method FPG method


Proliferative rate index (PRI)