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MCQ for training to STEP-1, INTERMEDIATE AND FINAL CONTROL in 2014 2015 years

following sterilization methods

ensures total death of
microorganisms and their spores
during one-time thermal
9. +++When a smear is
processing of an object?
stained by Burry-Gins method a
A) Pasteurization
mucous structure that is tightly
B) Boiling
bound with the cellular wall of
C) Tyndallization
5. +++Antibiotics can be
bacteria and has well-defined outer D) Autoclaving
classified according to various
boundaries can be detected. This
E) principles. According to the action element of a bacteria cell is called:
mechanism cephalosporins relate
A) Episomes
14. +++A lot of
to the following group:
B) Filaments
pyoinflammatory processes in oral
A) Inhibitors of respiratory
C) Capsule
cavity are caused by anaerobes.
2. +++A smear from the
D) Ribosomes
What nutrient medium can be used
tonsillar coating of a patient with
B) Inhibitors of protein synthesis
E) Spore
for control of wound textile
suspected diphtheria was found to C) Inhibitors of cytoplasmic
contamination by anaerobes?
contain blue bacilli with a
membrane synthesis
10. +++A bacterial cell
A) Ploskirev001s
thickening at the poles. What
D) Inhibitors of cell wall synthesis obtains nutrients by different ways. B) Endo
method of smear staining was
E) Inhibitors of oxidative
One of them is the facilitated
C) Kitt-Tarozzi
diffusion that is realized by special D) Sabouraud001s
A) Hins
membrane carrier proteins. What
E) Roux
B) Leffler
6. +++Study of the
are these proteins called?
C) Neisser
antibioticogram of the pure
A) Oxidoreductases
15. +++Bacteriological
D) Gram
salmonella culture revealed
B) Lyases
laboratory has the task to sterilize
E) Burri
multiple antibiotic resistance. What C) Isomerizing enzymes
nutrient mediums containing
factor might have caused this
D) Permeases
substances that convert under the
3. +++Treatment course of
E) Ligases
temperature over 100o? (urea,
bacterial pneumonia included
A) R-plasmids
carbohydrates). What method of
benzylpenicillin sodium salt. What B) Temperate phages
11. +++Production of a
sterilization should be used?
is the mechanism of its
C) Chromosomal mutations
number of drugs requires sterile
A) Tindalization
antimicrobial action?
D) F-plasmids
isotonic solution. Choose the
B) Pasteurization
A) Inhibition of the intracellular
E) Transposons
optimal method of its sterilization: C) Boiling
protein synthesis
A) Boiling
D) Fluid steam sterilization
B) Inhibition of cell wall synthesis
7. +++What method ensures B) Steam under pressure
E) Autoclaving
of the microorganism
reliable sterilization of biological
C) Inhibition of the SH enzyme
fluids (sera, solutions, enzymes,
C) Pasteurization
16. +++A pharmacy
groups of the microorganisms
vitamines etc.) that can001t stand D) Direct flame sterilization
produced a batch of vials with
D) Antagonism with the
high temperatures?
E) Dry heat sterilization
glucose diluent for injections.
paraaminobenzoic acid
A) Tyndallization
What is the best way for their
E) Inhibition of the cholinesterase B) Moist steam under pressure
12. +++Microbiological
C) Flowing steam
analysis of medicinal raw materials A) Autoclave sterilization under 2
D) Flaming
revealed capsular bacteria. What
atmosphere pressure
4. +++In the surgical ward,
E) Dry-heat sterilization
stain method was used to detect the B) X-ray exposure
the dressing material was
C) Autoclave sterilization by
undergoing sterilization in an
8. +++Before a surgical
A) Gram001s
flowing steam (fractional method)
autoclave. Through an oversight of operation, a surgeon treated his
B) Ziehl-Neelsen001s
D) Dry-heat sterilization
a nurse the mode of sterilization
hands with an alcohol-containing
C) Ozheshko001s
E) UV exposure
was changed and the temperature
solution. Which group of drugs
D) Gin001s
in the autoclave reached only
does this solution relate to?
E) Neisser001s
17. +++A patient was
100C instead of the due 120C.
A) Antiseptics
prescribed with an antitumoral
What microorganisms can stay
B) Detergents
13. +++Which of the
antibiotic that inhibits synthesis of
1+++Microscopy of stained
(Ziehl-Neelsen staining) smears
taken from the sputum of a patient
with chronic pulmonary disease
revealed red bacilli. What property
of tuberculous bacillus was shown
A) Capsule formation
B) Sporification
C) Acid resistance
D) Alcohol resistance
E) Alkali resistance

viable under these conditions?

A) Mold and yeast fungi
B) Corynebacteria and
C) Salmonella and klebsiella
D) Staphylococci and streptococci
E) Bacilli and clostridia

C) Surface-active substances
D) Sterilizing solutions
E) Disinfectants

nucleic acids in the cells. What of

the following antibiotics has such a
mechanism of action?
A) Actinomycin
B) Tetracycline
C) Lincomycin
D) Nystatin
E) Erythromycin

C) Thermophilic
D) Anthropophilic
E) Psychrophilic

22. +++A patient was taken

to a hospital with acute food
poisoning caused by home-made
canned mushrooms. The product
analysis revealed some
18. +++ Pathogenic
microorganisms that develop only
microorganisms are characterized in the absence of oxygen. What
by presence of aggression enzymes microorganisms caused the
that determine their virulence.
Select an aggression enzyme:
A) Microaerophiles
A) Hyaluronidase
B) Obligate anaerobes
B) Carbohydrase
C) Obligate aerobes
C) Lyase
D) Facultative anaerobes
D) Transferase
E) Capnophiles
E) Oxidase
23. +++Antibiotics are
19. +++Bacteria may contain classified by sources of production.
not only chromosomal but also
Name an antibiotic of bacterial
nonchromosomal hereditary
elements called plasmids. Presence A) Penicillin
of plasmid genes can show itself
B) Gramicidin
C) Tetracycline
A) Sporogenesis ability
D) Lysozyme
B) Multiple drug resistance
E) Gentamycin
C) Physical factor resistance
D) Mobility
24. +++A consumptive
E) Stain resistance
patient has an open pulmonary
form of disease. Choose what
20. +++Bacteria eventually
sputum staining should be selected
become resistant to antibacterial
for finding out the tubercle
agents. Resistance of gram-positive (Koch001s) bacillus?
bacteria to penicillin antibiotics is A) Method of Gram
caused by:
B) Method of Burry-Gins
A) Active transport of antibiotic
C) Method of Ziel-Neelsen
B) Active synthesis of
D) Method of Neisser
E) Method of RomanowskyC) Protein synthesis
D) Beta-lactamase production
E) Permeability of the cell wall
25. +++Microscopical
examination of a microbial culture
21. +++The causative agents revealed fusiform spore-forming
of intestinal infections can grow at microorganisms that get violetrefrigerator temperatures, which
blue Gram001s stain. What
may cause infection in people.
microorganisms were revealed?
What type of temperature optimum A) Streptococci
do these microorganisms relate to? B) Actinomycete
A) Mesophilic
C) Spirochaete
B) Necrophilic
D) Diplococci

E) Clostridia

E) Reinfection

factor of natural resistance of an

organism. What is it called?
26. +++A specimen stained
30. +++A patient who
A) Interleukin
by Ozheshko method contains rod- suffered form syphilis took a
B) Interferon
like microorganisms stained blue
course of antibiotic therapy and
C) Complement
with round terminal components
fully recovered. Some time later he D) Imanine
stained red. What are these
was infected again with
E) Lysozyme
components called?
Treponema pallidum. What form
A) Cilia
of infection is it?
34. +++The person was
B) Flagella
A) Complication
selling "homemade pork" sausages
C) Spores
B) Secondary infection
on the market. State sanitary
D) Capsules
C) Superinfection
inspector suspected falcification of
E) Mesosomas
D) Reinfection
the sausages.With help of what
E) Recurrence
serological immune reaction can
27. +++Vomiting matters of
food substance be identified?
a patient suspected of having
31. +++Donor skin
A) Precipitation test
cholera were delivered to the
transplantation was performed to a B) Indirect hemagglutination test
bacteriological laboratory. The
patient with extensive burns. On
C) Immunofluorescence test
material was used for preparing a
the 8-th day the graft became
D) Complement- fixation test
"hanging drop" specimen. What
swollen and changed colour; on the E) Agglutination test
type of microscopy will be applied 11-th day graft rejection started.
for identification of the causative
What cells take part in this
35. +++Quite often the cause
agent by its mobility?
of secondary immunodeficiency is
A) Fluorescence microscopy
A) Eosinophils
an infection involvement, when the
B) Phase-contrast microscopy
B) B-lymphocytes
causative agents propagate directly
C) Immune and electron
C) Erythrocytes
in the cells of immune system and
D) Basophils
destroy it. The following diseases
D) Immersion microscopy
E) T-lymphocytes
are characterized by:
E) Electron microscopy
A) Tuberculosis, mycobacteriosis
32. +++After an
B) Infectious mononucleosis,
28. +++A smear of sputum
immunoassay a child was
from the patient with suspected
diagnosed with immunodeficiency C) Poliomyelitis, type A hepatitis
lobar pneumonia was stained with of humoral immunity. What is the D) Dysentery, cholera
the use of the following stains and reason for the primary
E) Q-febris, epidemic typhus
reagents: solution of gentian violet, immunodeficiency development in
Lugol001s solution, 96 alcohol,
the child?
36. +++In a patient with
water magenta. What staining
A) Pathometabolism in
clinical signs of immunodeficiency
method was applied in this case?
mother001s organism
the number and functional activity
A) Romanovsky
B) Immune responsiveness and
of T and B lymphocytes are not
B) Neisser
resistance disorders
changed. Defect with dysfunction
C) Leffler
C) Hereditary abnormality of
of antigen-presentation to the
D) Ziehl-Nielsen
immune system
immunocompetent cells was found
E) Gram
D) Embryonal development
during investigation on the
molecule level. Defect of what
E) Toxic damage of Bcells is the most probable?
29. +++ A patient recovered lymphocytes
A) 0-lymphocytes
from Sonne dysentery and was
B) NK-cells
once more infected with the same
33. +++In order to speed up C) Macrophages, monocytes
causative agent. What is such
healing of a wound of oral mucosa D) Fibroblasts, T-lymphocytes, Binfection form called?
a patient was prescribed a drug that lymphocytes
A) Superinfection
is a thermostable protein occuring E) T-lymphocytes, B-lymphocytes
B) Recidivation
in tears, saliva, mother001s milk as
C) Chronic infection
well as in a new-laid hen001s egg.
37. +++Examination of a
D) Persisting infection
It is known that this protein is a
child who frequently suffers from

infectious diseases revealed that

IgG concentration in blood serum
was 10 times less than normal, IgA
and IgM concentration was also
significantly reduced. Analysis
showed also lack of Blymphocytes and plasmocytes.
What disease are these symptoms
typical for?
A) Bruton001s disease
B) Di George syndrome
C) Louis-Bar syndrome
D) Swiss-type
E) Dysimmunoglobulinemia
38. +++Examination of
patients with periodontitis revealed
the interdependence between the
rate of affection of periodontal
tissues and the amount of
lysozymes in saliva and gingival
liquid. These results can be
obtained during studying the
following protection system of an
A) Humoral immunity
B) Autoresponsiveness
C) Non-specific resistance
D) Tolerance
E) Cellular immunity

E) For immunocorrection
41. +++A pharmaceutical
company received from a
laboratory a delivery order of
diagnostic medications used for
studying antigenic properties of
causative agent. Name these
A) Diagnostic sera
B) Diagnosticums
C) Allergens
D) Immunoglobulins
E) Bacteriophages
42. +++A patient with
clinical presentations of primary
immunodeficiency displays
disturbance of antigen-presenting
function by immunocompetent
cells. What cells may have
structure defect?
A) T-lymphocytes
B) 0-lymphocytes
C) B-lymphocytes
D) Fibroblasts
E) Macrophages, monocytes

should be applied provided that the

level of antigenemia is low?
A) Agglutination test
B) Indirect hemagglutination test
C) Enzyme-linked immunosorbent
D) Latex agglutination test
E) Immunoelectrophoresis
46. +++Seroprophylaxis and
serotherapy of infectious diseases
involves using immune sera. What
type of immunity is thus acquired?
A) Actively acquired natural
B) Passively acquired natural
C) D) Passively acquired artificial
E) Actively acquired artificial

47. +++Bacteritic
preparations are subdivided into
groups according to their purpose
and production principles. What
group do the preparations for
43. +++ Specific prophylaxis initiation of active immunity relate
involved application of a vaccine
containing microorganisms and
A) Vaccines
exotoxin detoxicated by formalin. B) Immune sera
39. +++In our country,
It relates to the following type of
C) Bacteriophages
routine preventive vaccinations
D) Monoclonal antibodies
against poliomyelitis involve using A) Combined
E) Immunoglobulins
live vaccine that is administered
B) Genetically engineered
orally. What immunoglobulins are C) Live
48. +++A laboratory received
responsible for the development of D) Chemical
a material (extract of animal
local post-vaccination immunity in E) Anatoxin
matter) from the region with cases
this case?
of anthrax among animals. What
A) IgE
44. +++Blood serum of a
serological reaction should be used
B) Serum IgA
newborn contains antibodies to
in order to reveal antigenes of
C) IgG
measles virus. What kind of
pathogenic organism in the given
D) IgM
immunity is this indicative of?
E) Secretory IgA
A) Heredoimmunity
A) Indirect hemagglutination
B) Natural active
B) Radio assay
40. +++One of mass
C) Artificial active
C) Complement binding
production drugs is produced by
D) Artificial passive
D) Precipitations in agar
inactivation of bacterial exotoxin
E) Natural passive
E) Thermoprecipitation
by formalin. What is this drug for?
A) For active immunization
45. +++In case of many
49. +++A patient was
B) For passive immunization
infectious diseases patient001s
administered an antibiotic of
C) For toxinemia treatment
blood may contain antigens of
animal origin for the corneal ulcer
D) For serodiagnostic assay
causative agents. What reaction
treatment. What is it called?

A) Chlorophyllipt
B) Imanin
C) Gramicidin
D) Lysozyme
E) Nystatin
50. +++Bacteriological
laboratory examines canned meat
whether it contains botulinum
toxin. For this purpose an extract
of test specimen and antitoxic
antibotulinic serum of A, B, E
types were introducted to a group
of mice under examination; a
control group of mice got the
extract without antibotulinic
serum. What serological reaction
was applied?
A) Opsono-phagocytic
B) Neutralization
C) Complement binding
D) Precipitation
E) Double immune diffusion

D) Agglutinins
E) Precipitins
53. +++Serological
diagnostics of infectious diseases is
based upon specific interaction
with antigenes. Specify the
serological reaction that underlies
adhesion of microorganisms when
they are affected by specific
antibodies in presence of an
A) Complement-binding reaction
B) Hemadsorption reaction
C) Precipitation reaction
D) Agglutination reaction
E) Neutralization reaction

54. +++In order to estimate

toxigenity of diphtheria agents
obtained from patients the cultures
were inoculated on Petri dish with
nutrient agar on either side of a
filter paper strip that was put into
51. +++A patient who came the centre and moistened with
to the doctor because of his
antidiphtheric antitoxic serum.
infertility was administered to
After incubation of inoculations in
make tests for toxoplasmosis and
agar the strip-like areas of medium
chronic gonorrhea. Which reaction turbidity were found between
should be performed to reveal
separate cultures and the strip of
latent toxoplasmosis and chronic
filter paper. What immunological
gonorrhea of the patient?
reaction was conducted?
A) RIHA - Reverse indirect
A) Coomb001s test
hemagglutination assay
B) Precipitation gel reaction
B) (R)CFT- Reiter001s
C) Agglutination reaction
complement fixation test
D) Rings precipitation reaction
C) IFA - Immunofluorescence
E) Opsonization reaction
D) RDHA - Reverse direct
55. +++A patient with
hemagglutination assay
clinical presentations of
E) Immunoblot analysis
immunodeficiency went through
immunological examinations. They
52. +++For serological
revealed significant loss of cells
diagnostics of the whooping cough that form rosettes with erythrocytes
it was made large-scale reaction
of a ram. What conclusion can be
with parapertussis and pertussis
made according to the analysis
diagnosticums. At the bottom of
the test-tubes with diagnosticum of A) Decrease of B-lymphocytes rate
Bordetella parapertussis grain-like B) Insufficiency of effector cells of
sediment formed. What antibodies humoral immunity
have this reaction revealed?
C) Decrease of natural killer cell
A) Antitoxins
B) Bacteriolysins
D) Decrease of T-lymphocytes rate
C) Opsonins
E) Decrease of complement system


dyspnea, hypotension. What type

of allergic reaction is it?
56. +++A female patient
A) Anaphylactic immune reaction
underwent liver transplantation.
B) Cellulotoxic immune reaction
1,5 month after it her condition
C) Aggregate immune reaction
became worse because of reaction D) Stimulating immune reaction
of transplant rejection. What factor E) Cell-mediated immune reaction
of immune system plays the
leading part in this reaction?
60. +++A patient has been
A) Natural killers
diagnosed with acute
B) Interleukin-1
glomerulonephritis that developed
C) T-killers
after he had had streptococcal
D) B-lymphocytes
infection. It is most likely that the
E) T-helpers
affection of basal glomerular
membrane is caused by an allergic
57. +++A child with
reaction of the following type:
suspected tuberculosis was given
A) Immune complex
Mantoux test. After 24 hours the
B) Cytotoxic
site of the allergen injection got
C) Delayed
swollen, hyperemic and painful.
D) Anaphylactic
What are the main components that E) Stimulating
determine such response of the
61. +++A 22-year-old
A) Mononuclear cells, Twoman ate some seafood. 5 Hours
lymphocytes and lymphokines
later the trunk and the distal parts
B) Plasma cells, T-lymphocytes
of limbs covered with small itchy
and lymphokines
papules which were partially fused
C) Macrophages, B-lymphocytes
together. After one day the rash
and monocytes
disappeared spontaneously.
D) Granulocytes, T-lymphocytes
Specify the hypersensitivity
and IgG
mechanism underlying the
E) B-lymphocytes, IgM
A) Immune complex
58. +++ A patient visited a
B) Cellular cytotoxicity
dentist with complaints of redness C) Systemic anaphylaxis
and edema of his mouth mucous
D) Antibody-dependent cellmembrane in a month after dental mediated cytolysis
prosthesis. The patient was
E) Atopy (local anaphylaxis)
diagnosed with allergic stomatitis.
What type of allergic reaction by
62. +++What condition may
Gell and Cumbs underlies this
develop 15-30 minutes after redisease?
administration of the antigen as a
A) Anaphylactic
result of the increased level of
B) Stimulating
antibodies, mainly IgE, that are
C) Delayed type hypersensitivity
adsorbed on the surface of target
D) Immunocomplex
cells, namely tissue basophils
E) Cytotoxic
(mast cells) and blood basophils?
A) Antibody-dependent
59. +++During surgical
manipulations a patient has been
B) Delayed-type hypersensitivity
given novocaine injection for
C) Serum sickness
anesthesia. 10 minutes later the
D) Immune complex
patient developed paleness,

E) Anaphylaxis

66. +++ In the surgical
63. +++A child cut his leg
department of a hospital there was
with a piece of glass while playing an outbreak of hospital infection
and was brought to the clinic for
that showed itself in often
the injection of tetanus toxoid. In
postoperative wound abscesses.
order to prevent the development
Bacteriological examination of pus
of anaphylactic shock the serum
revealed aurococcus. What
was administered by Bezredka
examination shall be conducted to
method. What mechanism
find out the source of this causative
underlies this method of
agent among the department
desensitization of the body?
A) Blocking the mediator synthesis A) Biochemical identification
in the mast cells
B) Estimation of antibiotic
B) Stimulation of the synthesis of susceptibility
antigen- specific IgG
C) Serological identification
C) Binding of IgE receptors to the D) Microscopical examination
mast cells
E) Phagotyping
D) Stimulation of immune
tolerance to the antigen
67. +++A 7 year old child
E) Binding of IgE fixed to the mast often suffers from streprococcic
angina. Doctor suspected
development of rheumatism and
64. +++A patient suffering
administered serological
from periodical attacks caused by examination. The provisional
inhalation of different flavoring
diagnosis will be most probably
substances was diagnosed with
confirmed by presence of
atopic bronchial asthma. IgE level antibodies to the following
was increased. This is typical for
streptococcic antigen:
the following type of reactions:
A) Capsular polysaccharide
A) Autoimmune reactions
B) C-carbohydrate
B) Anaphylactic reactions
C) M-protein
C) Immunocomplex reactions
D) Erythrogenic toxin
D) Delayed-type hypersensitivity
E) O-streptolysin
E) Cytotoxic reactions
68. +++Examination of a
65. +++A 10-year-old child
patient with pustular skin lesions
had the mantoux tuberculin test
allowed to isolate a causative agent
administered. 48 hours later a
that forms in the blood agar
papule up to 8 mm in diameter
roundish yellow middle-sized
appeared on the site of the
colonies surrounded by haemolysis
injection. What type of
zone. Smears from the colonies
hypersensitivity reaction developed contain irregular-shaped clusters of
after the tuberculin injection?
gram-positive cocci. The culture is
A) Type IV hypersensitivity
oxidase- and catalase-positive,
ferments mannitol and synthesizes
B) Atopic reaction
plasmocoagulase. What causative
C) Arthus phenomenon
agent was isolated?
D) Type II hypersensitivity
A) Streptococcus pyogenes
B) Staphylococcus saprophyticus
E) Seroreaction
C) Streptococcus agalactiae
D) Staphylococcus epidermidis
E) Staphylococcus aureus

69. +++Blood of a patient

with presumable sepsis was
inoculated into sugar broth. There
appeared bottom sediment.
Repeated inoculation into blood
agar caused growth of small
transparent round colonies
surrounded by hemolysis zone.
Examination of a smear from the
sediment revealed gram-positive
cocci in form of long chains. What
microorganisms are present in
blood of this patient?
A) Streptococci
B) Tetracocci
C) Staphylococci
D) Sarcina
E) Micrococci

E) Neisseria meningitidis

of genus Staphylococcus. What

morphological pecularities of
72. +++Bacteriological
microbal cell arrangement are
examination of purulent discharges typical for this genus?
from the urethra revealed gramA) They are arranged in pairs
negative bacteria looking like
B) They are arranged in form of a
coffee beans. They were localized chain
in the leukocytes and could
C) They are arranged isolatedly
decompose glucose and maltose to D) They are arranged in form of
acid. These are the causative
bunch of grapes
agents of the following disease:
E) They are arranged in tetrads
A) Soft chancre
B) Syphilis
76. +++It is suspected that
C) Gonorrhoea
the workers of a serum drugs plant
D) Melioidosis
at a regional hemotransfusion
E) Veneral lymphogranulomatosis station are carriers of pathogenic
staphylococcus aureus. In order to
73. +++Bacteriological
detect staphylococcus carriage, the
examination of purulent discharges material from the nasopharynx of
70. +++In a 2-year-old child from urethra revealed some
the workers should be inoculated
with catarrhal presentations and
bacteries that had negative
into the following medium:
skin rash a pediatrician suspected Gram001s stain, resembled of
A) Endo agar
scarlet fever. The child was given coffee corns, decomposed glucose B) Blood agar
intracutaneously a small dose of
and maltose up to acid. They were C) Kessler medium
serum antibody to the streptococcal located in leukocutes. What
D) Meat infusion broth
erythrogenic toxin; on the site of
disease do they cause?
E) Egg-yolk-salt agar
injection the rash disappeared.
A) Gonorrhea
What do the reaction results mean? B) Venereal
77. +++Analysis of sputum
A) The clinical diagnosis was
obtained from a patient with
C) Soft chancre
suspected pneumonia revealed
B) The disease wasn001t caused
D) Syphilis
gram-positive diplococci. They
by haemolytic streptococcus
E) Pseudocholera
were slightly elongated, with the
C) The child has hypersensitivity
pointed opposite ends. What
to the erythrogenic toxin
74. +++Staphylococci were
microorganisms were revealed in
D) The child has very weak
isolated in pure culture from a
the sputum?
immune system
patient with sepsis. These were
A) Staphylococcus aureus
E) The whole serum dose may be staphylococci producing
B) Streptococcus pyogenes
injected intravenously
betalactamase. Such property
C) Neisseria meningitidis
should be taken into account when: D) Streptococcus pneumoniae
71. +++While studying blood A) Choosing optimal conditions
E) Klebsiella pneumoniae
and mucus samples from the
for cultivation
nasopharynx, a bacteriologist took B) Determining biochemical
78. Microscopy of a smear
certain measures to conserve the
obtained from a patient with acute
pathogens in the material.
C) Differentiating specific types of purulent periostitis revealed gramBacterioscopic study revealed the staphylococci
positive bacteria arranged in
presence of gram-negative cocci
D) Choosing an antibiotic for
clusters resembling bunch of
looking like coffee beans and
grapes. What microorganisms is
arranged in pairs or tetrads. Name E) Determining the strain
this morphology typical for?
the pathogen that was isolated by
A) Streptococci
the bacteriologist:
B) Tetracocci
A) Moraxella lacunata
75. +++Bacteriological
C) Candida fungi
B) Staphylococcus aureus
examination for bacteria carrying
D) Sarcina
C) Acinetobacter calcoaceticus
of drugstore workers revealed that E) Staphylococci
D) Neisseria gonorrhoeae
one of the pharmacists had bacteria

79. +++From the purulent

exudate of a patient with
odontogenic phlegmon a pure
culture of Gram + microorganisms
was segregated. This culture was
lecithinously active, coagulated
plasma of a rabbit, decomposed
mannitol under anaerobe
conditions. What microorganism
may have contributed to the origin
of suppurative complication?
A) S.epidermidis
B) S.mutans
C) S.pyogenes
D) S.viridans
E) S.aureus
80. +++A 65-year-old man
has purulent abscess on his neck.
Analyses revealed a culture of
gram-positive cocci with
plasmocoagulase activity. This
culture relates most likely to:
A) Streptococcus pyogenes
B) Staphylococcus saprophyticus
C) Staphylococcus aureus
D) Streptococcus pneumonia
E) Staphylococcus epidermidis
81. +++During examination
of a patient a dentist revealed a lot
of "white spots" - zones of enamel
demineralization. What
microorganisms take part in the
development of this process?
A) Streptococcus salivarius
B) Staphylococcus epidermidis
C) Veilonella parvula
D) Streptococcus mutans
E) Streptococcus pyogenes
82. +++From a patient with
the symptoms of acute meningitis
the spinal fluid was taken. Its
smears contained gram-negative
diplococci within the leukocytes
and outside them. Which
microorganism is the most likely
cause of the disease?
A) Neisseria meningitidis
B) Candida albicans
C) Haemophilus influenzae
D) Escherichia coli
E) Streptococcus pneumoniae

83. +++A female woman has

been clinically diagnosed with
gonorrhea. Which of the following
studies can be used to confirm the
A) Immobilization reaction
B) Disinfection of laboratory
C) Hemagglutination reaction
D) Microscopy of the pathological
E) Bacteriophage test

E) Immobilization reaction

87. +++ Among junior
children of an orphanage an
outbreak of intestinal infection
with signs of colienteritis was
registered. In order to identify
isolated causative agent it is
necessary to:
A) Study antigenic properties of
the causative agent
B) To study virulence of the
84. +++Gramnegative bincausative agent
shaped diplococcus inside and
C) To determine sensitivity to
outside of leucocytes were detected antibiotics
on bacteriological examination of D) To study biochemical properties
the purulent exudates from the
of the causative agent
cervix of the uterus. Name the
E) To study sensitivity to
causative agent of purulent
inflammation of the cervix of the
88. +++On bacteriological
A) Calymmatobacterium
study of rinsing water of the
patient with food poisoning, the
B) Trichomonas vaginalis
pure bacterial culture was
C) Chlamidia trachomatis
inoculated with the following
D) Neisseria gonorroeae
properties: gram-negative motile
E) Haemophilus vaginalis
bacillus in the Endo environment
grows like achromic colony.
85. +++Bacterioscopy of
Representative of what genus has
nasopharyngeal mucus taken from caused the illness?
a 2,5 year old child with
A) Escherichia
nasopharyngitis revealed gramB) Yersinia
negative diplococci looking like
C) Salmonella
coffee grains. What organs of the
D) Shigella
child are most likely to be affected E) Citrobacter
if these microorganisms penetrate
the blood?
89. +++From the fecal
A) Brain tunics
sample of a patient Shigella sonnei
B) Lymph nodes
were isolated. What additional
C) Cardiac valves
studies are required to identify the
D) Renal glomeruli
source of infection?
E) Urogenital tracts
A) Phage-typing of the isolated
pure culture
86. +++Clinical diagnosis of B) Complement-fixation reaction
a female patient was gonorrhoea.
C) Neutralization reaction
What examination method can be D) Precipitation reaction
applied for confirmation of this
E) Antibiogram
A) Microscopy of pathological
90. +++Retrospective
diagnostics of old bacillary
B) Infection of laboratory animals dysentery required serologic
C) Test with bacteriophage
examination of blood serum in
D) Hemagglutination reaction
order to determine blood titer to

105. +++A 12-year-old boy

has been hospitalized for suspected
food poisoning. The fecal samples
98. +++Stool culture test
were inoculated on the Endo agar,
revealed in a 6-month-old bottlewhich resulted in growth of a large
fed baby the strain of intestinal
number of colorless colonies. What
rod-shaped bacteria of antigen
microorganism is most likely to be
structure 0-111. What diagnosis
EXCLUDED from the list of
can be made?
possible causative agents of the
91. +++A patient was taken
A) Colienteritis
102. +++A 50-year-old
to the hospital with complaints of
B) Gastroenteritis
patient with typhoid fever was
A) Pseudomonas aeruginosa
headache, high temperature,
C) Choleriform disease
treated with Levomycetin, the next B) Salmonella enteritidis
frequent stool, stomach pain with
D) Food poisoning
day his condition became worse,
C) Proteus vulgaris
tenesmus. Doctor made a clinical
95. +++After a
E) Dysentery-like disease
temperature rised to 39,6C. What D) Escherichia coli
diagnosis dysentery and sent the
bacteriological analysis a tableted
caused worthening?
E) Yersinia enterocolitica
material (excrements) to the
medication has been found to be
99. +++On bacteriological
A) The effect of endotoxin agent
bacteriological laboratory for
inapplicable, though its general
examination of the defecation of a B) Irresponsiveness of an agent to
106. +++A patient with
analysis. What diagnostic method microbial contamination was
4-months-old baby with the
the levomycetin
suspected dysentery has been
should the laboratory doctor use to within the norm. The reason for
symptoms of acute bowel infection C) Secondary infection addition
admitted to the infectious diseases
confirm or to disprove the clinical such a conclusion was the presence there were revealed red colonies
D) Allergic reaction
hospital. Which basic method of
of the following microorganisms: spread in the large quantity in the E) Reinfection
laboratory diagnosis must be
A) Bacteriological
A) Micrococci
Endo environment. What
applied in the first place?
B) Bacterioscopic
B) Enterobacteria
microorganism can it be?
103. +++For the purpose of
A) Serological
C) Serological
C) Sarcinae
A) Streptococcus
retrtospective diagnostics of recent B) Bacteriological
D) Allergic
D) Actinomycetes
B) Escherichia
bacterial dysentery it was decided C) Microscopic
E) Biological
E) Mold fungi
C) Staphylococcus
to perform serological examination D) Allergic
D) Shigell
of blood serum in order to
E) Biological
92. +++A patient was
96. +++A patient with
E) Salmonella
determine antibody titer towards
admitted to the infectious
complaints of 3-day-long fever,
Shiga bacilli. What of the
107. +++A 50-year-old
department of a hospital. His
general weakness, loss of appetite
100. +++Bacteriological
following reactions should be
patient has been administered
provisional diagnosis was "acute
came to visit the infectionist. The examination of a patient with food applied?
laevomycetin for the treatment of
gastroenteritis". Inoculation of
doctor suspected enteric fever.
poisoning required inoculation of a A) Bordet-Gengou test
typhoid fever, but on the next day
feces on bismuth-sulfite agar
Which method of laboratory
pure culture of bacteria with the
B) Precipitation
the patient001s condition
induced growth of black colonies
diagnosis is the best to confirm the following properties: gramC) Bacteriolysis
worsened, the temperature rose to
with metallic glitter. What
negative movable bacillus that
D) Passive hemagglutination
39,6C. The deterioration of the
microorganisms should you think A) Detachment of feces culture
grows in the Endo001s medium in E) Hemolysis
patient001s condition can be
B) Detachment of urine culture
form of colourless colonies. A
explained by:
A) Salmonellae
C) Detachment of myeloculture
representative of which species
104. +++During the repeated A) Insensitivity of the pathogen to
B) Brucella
D) Detachment of blood culture
caused this disease?
Widal001s agglutination test it was laevomycetin
C) Shigella
E) Detachment of pure culture
A) Salmonella
noticed that the ratio of antibody
B) Secondary infection
D) Yersinia
B) Iersinia
titers and O-antigens S.typhi in the C) Effects of endotoxins of the
E) Escherichia
97. +++On bacteriological
C) Citrobacter
patient001s serum had increased
causative agent
study of rinsing water of the
D) Esherichia
from 1:100 to 1:400. How would
D) Allergic reaction
93. +++During
patient with food poisoning, the
E) Shigella
you interpret these results?
E) Re-infection
bacteriological analysis of
pure bacterial culture was
A) The patient is a chronic carrier
solutions prepared in a pharmacy
inoculated with the following
101. +++Reaction of passive of typhoid microbs
some red colonies with metallic
properties: gram-negative motile
hemagglutination conducted with B) The patient has typhoid fever
108. +++ While examining a
glitter have grown on Endo agar.
bacillus in the Endo environment
erythrocytic typhoid ViC) The patient was previously
patient an otolaryngologist noticed
What microbes were revealed?
grows like achromic colony.
diagnosticum helped to reveal
vaccinated against typhoid fever
hyperaemia and significantly
A) Streptococci
Representative of what genus has some antibodies in the dilution of D) The patient previously had
edematous tonsils with a grayish
B) Staphylococci
caused the illness?
the patient001s serum at a ratio of typhoid fever
film upon them. Microscopical
C) Escherichia
A) Salmonella
1:80 that exceeds the diagnostic
E) The patient is an acute carrier of examination of this film revealed
D) Shigella
B) Shigella
titer. Such result witnesses of:
typhoid microbes
some gram-positive bacilli placed
E) Salmonella
C) Yersinia
A) Incubation period of typhoid
at an angle with each other. What
the shigells. What reaction should
be applied for this purpose?
A) Bordet-Gengou test
B) Reaction of passive
C) Bacteriolysis reaction
D) Hemolysis reaction
E) Precipitation reaction

94. +++A patient is suspected

to have the typhoid fever. What
method of laboratory diagnostics
would be the most appropriate for
confirmation of this diagnosis in
the first week of disease?
A) Hemoculture identification
B) Coproculture identification
C) Urine culture identification
D) Biliculture identification
E) Myeloculture identification

D) Escherichia
E) Citrobacter

B) Being ill with acute typhoid
C) Reconvalescence of a patient ill
with typhoid fever
D) Being a potential carrier of
typhoid bacilli
E) Typhoid fever recurrence

disease might be suspected?

A) Diphtheria
B) Meningococcal nasopharyngitis
C) Scarlet fever
D) Angina
E) Epidemic parotitis
109. +++From the
nasopharynx of a 5-year-old child
it was excreted a microorganism
which is identical to
Corynebacterium diphtheriae dose
according to morphological and
biochemical signs. Microorganism
does not produce exotoxin. As a
result of what process can this
microorganism become toxigenic?
A) Phage conversion
B) Growing with antitoxic serum
C) Passing through the organism of
the sensitive animals
D) Chromosome mutation
E) Cultivation in the telluric
110. +++Bacterioscopic
examination of a smear from the
pharynx of a diphtheria suspect
revealed bacilli with volutine
granules. What etiotropic drug
should be chosen in this case?
A) Interferon
B) Eubiotic
C) Antidiphtheritic antitoxic serum
D) Bacteriophage
E) Diphtheritic anatoxin
111. +++A diseased child has
a high fever, sore throat, swelling
of submandibular lymph nodes.
Objectively: pharyngeal mucosa is
edematous, moderately hyperemic,
the tonsils are enlarged, covered
with grayish membrane tightly
adhering to the tissues above.
Attempts to remove the membrane
produce the bleeding defects. What
disease are these presentations
typical for?
A) Catarrhal tonsillitis
B) Scarlet fever
C) Measles
D) Meningococcal disease
E) Diphtheria

112. +++A patient has pure

culture of diphtheria
corynebacteria. What
immunological reaction should be
used in order to determine bacteria
A) Inhibition of hemagglutination
B) Agglutination
C) Complement binding
D) Precipitation in agar
E) Indirect hemagglutination
113. +++When examining a
child the dentist found the deposit
on both tonsils and suspected
atypical form of diphtheria. A
smear was taken, and after the
nutrient media inoculation the
toxicity of the isolated pure culture
was determined. What reaction
was used to determine the
toxigenicity of the isolated strain
of diphtheria bacillus?
A) Agglutination reaction on a
glass slide
B) Complement binding reaction
C) Hemolysis reaction
D) Gel precipitation reaction
E) Ring precipitation reaction
114. +++From pharynx of a
child with suspected diphtheria a
pure culture of microorganisms
was isolated. Their morphological,
tinctorial, cultural and biochemical
properties appeared to be typical
for diphtheria causative agents.
What study should be conducted in
order to drow a conclusion that this
is a pathogenic diphtheria bacillus?
A) Estimation of urease activity
B) Estimation of proteolytic
C) Estimation of cystinous activity
D) Estimation of toxigenic
E) Estimation of ability to
decompose starch
115. +++In order to
determine toxigenicity of
diphtheria bacilli a strip of filter
paper impregnated with antitoxic
diphtherial serum was put on the

dense nutrient medium. There were

also inoculated a microbal culture
under examination and a strain that
is known to be toxigenic. If the
microbal culture under
examination produces exotoxin,
this wil result in formation of:
A) Haemolysis zones
B) Zones of diffuse opacification
C) Zones of lecithovitellinous
D) Precipitin lines
E) Precipitin ring

immunobiological preparation was

A) DTP vaccine
B) Td vaccine
C) Tularinum
D) BCG vaccine
E) Tuberculin

119. +++While registering

the child to the school Mantu001s
test was made to define whether
revaccination was needed test
result is negative. What does this
result of the test mean?
116. +++Inoculum from
A) Absence of antitoxic immunity
pharynx of a patient ill with angina to the tuberculosis
was inoculated into blood-tellurite B) Presence of cell immunity to the
agar. It resulted in growth of grey, tuberculosis
radially striated (in form of
C) Presence of antibodies for
rosettes) colonies 4-5 mm in
tubercle bacillus
diameter. Gram-positive bacilli
D) Absence of cell immunity to the
with clublike thickenings on their tuberculosis
ends placed in form of spread wide E) Absence of antibodies for
apart fingers are visible by
tubercle bacillus
microscope. What microorganisms
are these?
120. +++Study of
A) Diphtheroids
bacteriological sputum specimens
B) Diphtheria corynebacteria
stained by the Ziel-Neelsen method
C) Streptobacilli
revealed some bright-red acidD) Botulism clostridia
resistant bacilli that were found in
E) Streptococci
groups or singularly. When
inoculated onto the nutrient media,
117. +++A 4-year-old child
the signs of their growth show up
presents with general weakness,
on the 10-15 day. These bacteria
sore throat and deglutitive
relate to the following family:
problem. After his examination a
A) Histoplasma dubrosii
doctor suspected diphtheria and
B) Yersinia pseudotuberculosis
sent the material to the
C) Coxiella burnettii
bacteriological laboratory. In order D) Mycobacterium tuberculosis
to determine the diphtheria
E) Klebsiella rhinoscleromatis
causative agent the material should
be inoculated into the following
121. +++Sputum smears of a
differential diagnostic medium:
patient with chronic pulmonary
A) Ploskyrev001s agar
disease were stained by ZiehlB) Endo001s agar
Neelsen method and analyzed in
C) Sabouraud001s agar
the bacteriological laboratory.
D) Blood tellurite agar
Microscopy revealed red bacillus.
E) Levenshtein-Yessen agar
What property of tuberculosis
mycobacteria was found?
A) Alkali resistance
118. +++A 6-year-old child
B) Spore-formation
with suspected active tuberculous C) Alcohol resistance
process underwent the diagnostic
D) Encapsulation
Mantoux test. What
E) Acid resistance

122. +++Microscopic
analysis of tissue sampling from
affected area of mucous membrane
of oral cavity revealed bacillus in
form of accumulations that looked
like a pack of cigarettes. ZiehlNeelsen staining gives them red
colour. What kind of pathogenic
organism was most likely revealed
in tissue sampling?
A) M.leprae
B) A.bovis
C) M.avium
D) A.israilii
E) M.tuberculosis
123. +++A patient with
tuberculosis has been prescribed
some anti-TB preparations. Which
of the following chemotherapeutic
drugs has an effect on the
tuberculosis pathogen?
A) Ftivazide
B) Methisazonum
C) Phthalylsulfathiazole
D) Furacilinum
E) Sulfadimezinum
124. +++For tuberculosis
prevention the newborns got an
injection of a vaccine. What
vaccine was used?
A) Anatoxin
C) Mantoux
D) Oral polio vaccine (Sabin
E) DTaP vaccine
125. +++A 16 y.o. boy from
a countryside entered an
educational establishment.
Scheduled Manteux test revealed
that the boy had negative reaction.
What are the most reasonable
actions in this case?
A) To perform BCG vaccination
B) To perform rapid Price
C) To isolate the boy temporarily
from his mates
D) To repeat the reaction in a

E) To perform serodiagnostics of
126. +++The first grade
pupils were examined in order to
sort out children for tuberculosis
revaccination. What test was
applied for this purpose?
A) Mantoux test
B) Schick test
C) Supracutaneous tularin test
D) Anthraxine test
E) Burnet test

A) Plasma cells, T-lymphocytes

and lymphokines
B) Granulocytes, T-lymphocytes
and IgG
C) Mononuclear cells, Tlymphocytes and lymphokines
D) B-lymphocytes, IgM
E) Macrophages, B-lymphocytes
and monocytes

130. +++A child entering the

school for the first time was given
Mantoux test in order to determine
if there was a need for
127. +++A bacteriological
revaccination. The reaction was
laboratory received sputum sample negative. What is the meaning of
of a patient suffering from
this test result?
tuberculosis. Bacterioscopic
A) Availability of cell-mediated
examination of smears and
immunity to tuberculosis
detection of tuberculosis bacillus
B) No cell-mediated immunity to
can be realized by one of
enrichment methods that involves C) No antibodies to the
processing of sputum only with
tuberculosis bacteria
solution of caustic soda. What is
D) No anti-toxic immunity to
this method called?
A) Homogenization
E) Presence of antibodies to the
B) Filtration
tuberculosis bacteria
C) Flotation
D) Neutralization
E) Inactivation
131. +++SOONOSES +
VIBRIO 6 hours after the initial
128. +++Planned mass
inoculation of water sample into
vaccination of all newborn 5-7 day 1% peptone water, the growth of a
old children against tuberulosis
culture in form of a thin pellicle on
plays an important role in
the medium surface was registered.
tuberculosis prevention. In this
Such cultural properties are typical
case the following vaccine is
for the causative agent of the
following disease:
A) A) Cholera
B) Diphtheria and tetanus anatoxin B) Tuberculosis
C) Pseudotuberculosis
C) Adsorbed diphtheria vaccine
D) Plague
D) Diphteria and tetanus toxoids
E) Dysentery
and pertussis vaccine
132. +++Quite often, the soil
may contain a number of
129. +++A child with
pathogenic microorganisms. The
suspected tuberculosis was given
causative agents of the following
Mantoux test. After 24 hours the
disease may exist in the soil for a
site of the allergen injection got
long time:
swollen, hyperemic and painful.
A) Diphtheria
What are the main components that B) Viral hepatitis
determine such response of the
C) Anthrax
D) Dysentery

E) Pertussis

was referred for a serological assay

(Wright001s reaction) and
Burnet001s skin allergy test. What
was the provisional diagnosis?
A) Leptospirosis
B) Tularemia
C) Rheumatism
D) Anthrax
E) Brucellosis

140. +++ A laboratory
133. +++A patient presents
received a material from a
with fever, chill and cough. From
patient001s wound. Preliminary
his sputum the ovoid Gramdiagnosis is gaseous gangrene.
negative bipolar-stained bacilli
What microbiological method
with a delicate capsule were
should be applied to determine
isolated. What is the most likely
species of causative agent?
A) Plague
B) Allergic
B) Tuberculosis
137. +++It is planned to use C) Bacteriological
C) Toxoplasmosis
the territory of an old cattle burial D) Bacterioscopic
D) Brucellosis
ground (which is not used for more E) Serological
E) Leptospirosis
than 50 years) for building houses.
But ground analysis revealed
141. +++Patient with
134. +++Microscopy of a
presence of the pathogen of the
vomiting, dizziness, sensation of
smear taken from the film that
very dangerous illness. Which of
dubble vision, difficult swallowing
appeared on the peptone water 6
the indicated microorgonisms is
was admitted to the hospital.
hours after seeding and culturing
likely to remain in the ground for
Doctor suspects botulism. What
of a fecal sample in a thermostat
such a long time?
diagnostic methods should be used
revealed mobile gram-negative
A) Francisella tularensis
for diagnosis approving?
bacteria curved in form of a
B) Bacillus anthracis
A) Bacteriological, mycological
comma that didn001t make spores C) Mycobacterium bovis
B) or capsules. What microorganisms D) Yersinia pestis
C) Biological test, bacteriological
were revealed?
E) Brucella abortus
D) Protozoological, microscopical
A) Spirochetes
E) Allergic test, serological
B) Spirilla
138. +++Patient with
C) Vibrios
diarrhoea was admitted to the
142. +++A bacteriological
D) Corynebacteria
infection unit. Gramnegative
laboratory studied the home-made
E) Clostridia
curved rod-like bacteria were
dried fish which had caused a
founded on bacterioscopic
severe food poisoning. Microscopy
135. +++An infectious
examination of faecal masses.
of the culture grown on the Kittdiseases hospital admitted a
What is the most likely disease in Tarozzi medium revealed
veterinarian with assumed
this patient?
microorganisms resembling a
brucellosis. What serologic test can A) Cholera
tennis racket. What is the most
confirm this diagnosis?
B) Intestinal form of plague
likely diagnosis?
A) Ascoli001s precipitation
C) Salmonellosis gastroenteritis
A) Cholera
D) Diphtheria
B) Botulism
B) Wassermann reaction of
E) Typhoid fever
C) Salmonellosis
complement binding
D) Typhoid fever
C) Widal001s agglutination
139. +++There was a record E) Dysentery
of some anthrax cases among
D) Weigl001s agglutination
animals in a countryside. The
143. +++A patient has food
spread of disease can be prevented poisoning. Laboratory analysis
E) Wright001s agglutination
by means of immunization. What
revealed a culture of anaerobic
kind of vaccine should be used?
gram-positive spore-forming
A) STI live vaccine
bacteria. What is the most likely
136. +++Medical
B) Salk vaccine
kind of the isolated causative
examination of a dairymaid
C) Sabin001s vaccine
revealed affection of the
D) BCG vaccine
A) C. perfringens
locomotive system, vision
E) Diphteria and tetanus toxoids
B) Vibrio parahemolyticus
impairment, disorder of the
and pertussis vaccine
C) Proteus vulgaris
nervous and other systems. To
D) Esherichia coli
confirm the diagnosis the patient
E) P. mirabilis

144. +++A patient consulted

a dentist about limited mouth
opening (trismus). He has a history
of a stab wound of the lower
extremity. What infection may
cause these symptoms?
A) Tetanus
B) Brucellosis
C) Wound anaerobic infection
D) Whooping cough
E) Tularemia
145. +++Typical
manifestations of food poisoning
caused by C. botulinum are double
vision, abnormal functioning of the
swallowing and breathing. These
symptoms develop as a result of:
A) Exotoxin effects
B) Enterotoxic shock development
C) Enterotoxin effects
D) Pathogen adhesion to the
enterocyte receptors
E) Activation of adenylate cyclase
146. +++The causative agent
of botulism causes severe food
poisoning. Specify the most
characteristic morphological
feature of botulism causative
A) Thick gram-positive bacillus
without spores and flagella
B) Thin mobile bacillus with
central spore
C) Thick gram-positive non-sporeforming bacillus
D) Gram-positive bacillus with
terminal spore
E) Gram-positive bacillus with
subterminal spore
147. +++During a survey of
the sanitary state of an
environment object perfringens
titre was determined. What object
was studied?
A) Soil
B) Indoor pharmacy air
C) Water from an open water
D) Tap water
E) Outdoor air

148. +++A patient diagnosed

with botulism was admitted to the
infectious disease hospital. What
medication should be applied in
the first place?
A) Antitoxic serum
B) Nitrofurans
C) Sulfanilamides
D) Antibiotics
E) Anatoxin

C) Neutralization
D) Complement binding
E) Precipitation

152. +++A patient has severe

catarrhal symptoms. Material
growth on Bordet- Gengou agar
showed mercury-drop-like
colonies. Examination of the blood
smears revealed some small ovoid
gram-positive bacilli sized 1-3
microns. What microorganisms
149. +++ A patient has been were isolated?
suffering from elevated
A) Meningococcus
temperature and attacks of typical B) Mycobacteria
cough for 10 days. Doctor
C) Bordetella
administered inoculation of mucus D) Brucella
from the patient001s nasopharynx E) Corynebacteria
on the agar. What microorganism
is presumed?
153. +++A patient in the oral
A) Pertussis bacillus
surgery department has got
B) Pfeiffer001s bacillus
purulent complication.
C) Listeria
Bacteriological analysis of the
D) Klebsiella
wound material found a culture
E) Staphylococcus
that produces cyan pigment. What
microorganism is the most
150. +++While studying a
probable causative agent?
microslide obtained from the
A) Proteus vulgaris
punctuate of a regional lymph node B) Staphylococcus epidermidis
and stained by RomanovskyC) Bacillus subtilis
Giemsa method a physician
D) Klebsiella pneumoniae
revealed some light-pink thin
E) Pseudomonas aeruginosa
microorganisms with 12-14 regular
spiral coils and pointed ends, up to
154. +++Bacterioscopic
10-13 micrometer long. This might examination of chancre material
be the causative agent of the
revealed some mobile, long,
following disease:
convoluted microorganisms with
A) Relapsing fever
8-12 regular coils. These features
B) Leishmaniasis
are typical for:
C) Leptospirosis
A) Treponema
D) Trypanosomiasis
B) Borrellia
E) Syphilis
C) Vibrios
D) Leptospira
151. +++A patient had been E) Campylobacter
provisionally diagnosed with
syphilis. A laboratory assistant
155. +++During
took the blood serum for an
bacteriological examination of
immunologic test based on the
sputum of a child with choking
detection of antibodies preventing cough and fever there were
the movement of treponemes and
revealed glossy smooth colonies
causing their death. What reaction growing on casein-charcoal agar
was used for the diagnosis?
and reminding of mercury drops.
A) Immobilization
Microscopic examination revealed
B) Agglutination
short Gram-negative bacteria.

What microorganism was secured

from the sputum?
A) Streptococcus pyogenes
B) Haemophylus influenzae
C) Klebsiella pneumoniae
D) Corynebacterium dyphtheriae
E) Bordetella pertussis
156. +++A man was admitted
to the hospital on the 5th day of
disease that manifested itself by
jaundice, muscle aching, chill,
nose bleedings. In course of
laboratory diagnostics a
bacteriologist performed dark-field
microscopy of the patient001s
blood drop. Name a causative
agent of this disease:
A) Leptospira interrogans
B) Borrelia duttonii
C) Calymmatobacterium
D) Bartonella bacilloformis
E) Rickettsia mooseri
157. +++A man died from an
acute infectious disease
accompanied by fever, jaundice,
haemorrhagic rash on the skin and
mucous membranes as well as by
acute renal insufficiency.
Histological examination of renal
tissue (stained by RomanovskyGiemsa method) revealed some
convoluted bacteria looking like C
and S letters. What bacteria were
A) Leptospira
B) Spirilla
C) Treponema
D) Borrelia
E) Campilobacteria
158. +++A patient underwent
Analysis of the biopsy material
enabled doctors to diagnose him
with helicobacteriosis. What
property of the bacteria found in
this patient had to be obligatory
taken into account during their
A) Presence of urease
B) Colonisation of gastral cells

C) Presence of six polar flagella

are they?
D) Absence of spores and capsules A) Candida
E) Microaerophilic ability
B) Diphtheria bacillus
C) Fusobacteria
159. +++Urine examination D) Staphylococci
of a patient with acute cystitis
E) Actinomycetes
revealed leukocytes and a lot of
gram-negative bacilli. Inoculation
163. +++ Slime, blood and
resulted in growth of colonies of
protozoa 30-200 microns long have
mucous nature that formed green
been revealed in a man001s feces.
soluble pigment. What
The body is covered with cilias and
microorganism is the most
has correct oval form with a little
probable cause of the disease?
bit narrowed anterior and wide
A) Salmonella enteritidis
round shaped posterior end. At the
B) Escherihia coli
anterior end a mouth is visible. In
C) Proteus mirabilis
cytoplasm there are two nuclei and
D) Klebsiella pneumoniae
two short vacuoles. What are the
E) Pseudomonas aeruginosa
described features typical for?
A) Intestinal amoeba
B) Dysenteric amoeba
160. +++ Scraps of the
C) Trichomonas
mycelium of a fungus, spores, air D) Lamblia
bubbles and fat drops were
E) Balantidium
discovered on microscopy of the
patient001s hair excluded from the
164. +++A woman delivered
infected areas. For what fungus
a dead child with multiple
disease is this microscopic picture developmental defects. What
protozoan disease might have
A) Sporotrichosis
caused the intrauterine death?
B) Microspory
A) Toxoplasmosis
C) Favus
B) Amebiasis
D) Epidermophytosis
C) Malaria
E) Trichophytosis
D) Leishmaniasis
E) Lambliasis
161. +++Microscopic
examination of a Gram-stained
165. +++In order to establish
scrape from patient001s tongue
the possible contamination of a
revealed oval, round, elongated
medication with fungi, a nutrient
chains of dark-violet gemmating
medium was inoculated, which
cells. What disease can be caused resulted in growth of large creamby this causative agent?
like colonies. What nutrient
A) Staphylococcic infection
medium was used in this case?
B) Actinomycosis
A) Loeffler
C) Diphtheria
B) Lowenstein-Jensen
D) Streptococcic infection
C) Sabouraud
E) Candidosis
D) Roux
E) Finn-2
162. +++Examination of a
child revealed some whitish spots
166. +++A pregnant woman
looking like coagulated milk on the applied to a doctor with complaints
mucous membrane of his cheeks
typical for toxoplasmosis. The
and tongue. Analysis of smears
doctor took a sample of her blood.
revealed gram-positive oval yeast- What serological tests should be
like cells. What causative agents
performed in this case?

A) Precipitation test
B) Widal001s test
C) Wassermann test
D) Complement binding assay
E) Neutralization test
167. +++A patient001s
preliminary diagnosis is
toxoplasmosis. What material was
used for diagnostics of this
A) Sputum
B) Feces
C) Urine
D) Blood
E) Duodenal contents

class. What microorganims were

the most probably revealed?
A) Lamblia intestinalis
B) Trypanosoma gambiense
C) Trihomonas vaginaslis
D) Trihomonas hominis
E) Leishmania donovani

171. +++During studying a

medicinal herbal mixture a culture
in form of black fluffy film grew
on the nutrient medium.
Examination of specimen smears
revealed non-septate mycelium
threads with globular thickenings
at the tips. Name these
168. +++After continuous
A) Mucor
treatment with antibiotics a patient B) Aspergill
got symptoms of stomatitis.
C) Ray fungi
Examination of specimens of oral D) Black molds fungus
mucous membrane revealed some E) Candida
oval polymorphous Gram-positive
microorganisms arranged in
172. +++A female patient has
clusters. What microorganism may been treated with antibiotics for a
be the cause of such
long time. Thereafter examination
of smears form vaginal secretion
A) C.albicans
revealed oval cells with wellB) S.aureus
defined nucleus, some cells
C) C.perfringens
gemmate. What preparations can
D) C.pylori
help to confirm the diagnosis
E) S.pyogenes
A) Antiprotozoal
169. +++A patient complains B) Antiviral
of frequent bowel movements and C) Antichlamydial
stool with blood admixtures
D) Antibacterial
("raspberry jelly" stool).
E) Antifungal
Microscopic examination revealed
large mononuclear cells with
173. +++Aetiological factors
absorbed red blood cells. What
for the infectious diseases are often
protozoon is this morphological
microorganisms with various
structure typical for?
ultrastructure. Which of the
A) Giardia lamblia
following microorganism groups
B) Balantidium coli
relates to the eucariots?
C) Campylobacter jejuni
A) Viruses
D) Toxoplasma gondii
B) Prions
E) Entamoeba histolytica
C) Viroids
D) Scotobacteria
170. +++A smear from frothy E) Protozoa
and purulent vaginal discharges of
a 42 y.o. woman was stained by
174. +++A 13 year old child
Romanovsky-Giemsa method. Its complains about poor appetite,
analysis revealed some
pain in the right subcostal area.
microorganisms of flagellates
Microscopical examination of

duodenal contents revealed big

pyriform cells with two nuclei.
What microorganism was
A) Lamblia
B) Amoeba
C) Trichomonad
D) Trypanosoma
E) Toxoplasma
175. +++A duodenal content
smear of a patient with indigestion
contains protosoa 10-18 mcm
large. They have piriform bodies, 4
pairs of filaments, two
symmetrically located nuclei in the
broadened part of body. What kind
of the lowest organisms is it?
A) Balantidium
B) Lamblia
C) Trichomonas
D) Dysentery ameba
E) Intestinal ameba
176. +++ A patient of
surgical department complains
about pain in the small of her back
and in the lower part of her belly;
painful and frequent urination.
Bacteriological examination of
urine revealed gram-negative
oxidase-positive rod-like bacteria
forming greenish mucoid colonies
with specific smell. What causative
agent can it be?
A) Pseudomonas aeruginosa
B) Mycoplasma pneumonie
C) E.coli
D) Proteus mirabilis
E) Str.pyogenes
177. +++As a result of
durative antibiotic therapy a 37year old patient developed
intestinal dysbacteriosis. What type
of drugs should be used in order to
normalize intestinal microflora?
A) Sulfanilamides
B) Autovaccines
C) Bacteriophages
D) Eubiotics

186. +++During the regular

178. +++Bacteriological
inspection of a pharmacy, the
examination of the urine of the
bacteriological analysis of air was
patient with pyelonephritis
performed. The air was found to
revealed microorganisms that
have bacilli, yeast fungi, hemolytic
produced yellow-green pigment
streptococci, micrococci. Which of
and a characteristic odor in meatthe detected microorganisms
peptone agar. What are they
indicate the direct epidemic
A) Proteas
A) Yeast fungi
B) Escherichia
B) Micrococci
C) Pseudomonas
C) Haemolytic streptococci
D) Azotobacter
183. +++During sanitary and D) E) Klebsiella
bacteriological examination of air E) Bacilli
in a drugstore it was revealed that
179. +++A male patient has the air had high concentration of
187. After the sanitary and
been diagnosed with gastric ulcer. sanitary meaningful
bacteriological study of tap water
Bacteriological examination of
microorganisms. What
the following results were
biopsy material from the affected
microorganisms are these?
obtained: the total number of
part of stomach revealed small
A) Staphylococcus aureus and
bacteria in 1,0 ml was 80, coli
colonies of gram-negative, oxide
hemolytic streptococcus
index was 3. How would you
reductase-positive flexibacteria
B) Diphtheritic and tuberculous
interpret the study results?
that grew on the chocolate agar on bacilli
A) Water is of doubtful quality
the fifth day. Which of the
C) Enterococci and Citrobacter
B) Water is contaminated
following microorganisms is the
D) Epidermal staphylococcus and C) Water is safe to be consumed
most likely causative agent?
D) Water is of highly doubtful
A) Mycoplasma hominis
E) Colibacilli and blue pus bacilli quality
B) Helicobacter pylori
E) Water is highly conaminated
C) Campylobacter fetus
184. +++It is known that a
D) Campylobacter jejuni
peroral drug contains over 1 billion 188. +++Sanitary
E) Chlamydia trachomatis
of living microbal cells per 1
bacteriological research on water
millilitre. Nonetheless the drug
by the membrane filter method
180. +++Administration of
was accepted as applicable. What revealed two red colonies on a
doxycycline hydrochloride caused drug group does it relate to?
membrane filter (Endo agar)
an imbalance of the symbiotic
A) Immunostimulants
through which 500 ml of analyzed
intestinal microflora. Specify the
B) Antibiotics
water were passed. Calculate the
kind of imbalance caused by the
C) Sulfanilamides
coli index and coli titer of the
antibiotic therapy:
D) Eubiotics
analyzed water:
A) Sensibilization
E) Vitamins
A) 4 and 250
B) Bacteriosis
B) 500 and 2
C) Dysbacteriosis
185. +++Dysbiosis can be
C) 250 and 4
D) Superimposed infection
treated with drugs that contain
D) 250 and 2
E) Idiosyncrasy
living representatives of normal
E) 2 and 500
microflora as well as their
181. +++Sanitary-biologic
metabolic products. Select the
examination of air in a drugstore
microorganisms that are used for
189. +++ A culture of
revealed a sanitary-indicative
the production of such drugs:
monkey cells (Vero) and a group
microorganism. Name it:
A) Providencia
of mouse sucklings were infected
A) Colon bacillus
B) Yersinia
with an inoculum taken from a
B) Staphylococcus aureus
C) Proteus
child with provisional diagnosis
C) Alpha-haemolytic streptococcus D) Bifidum bacteria
"enterovirus infection". There was
D) Citrobacter
E) Staphylococcus aureus
no cytopathic effect on the cell
E) Fecal enterococcus
culture but mouse sucklings died.
E) Vitamins

182. +++Presence of the

pathogenic microorganisms in the
air can be prognosticated according
to the content of sanitary-indicative
bacteria. Which bacteria indicate
immediate epidemiologic danger?
A) Mold fungi
B) Micrococci
C) Haemolytic streptococci
D) Sarcinae
E) Yeast fungi

What enteric viruses might have

caused disease of this child?
A) Coxsackie A
B) Polioviruses
C) ECHO virus
D) Unclassified enteric viruses 6871
E) Coxsackie B
190. +++A virological
laboratory obtained pathological
material (mucous discharges from
nasal meatuses) taken from a
patient with provisional diagnosis
"influenza". What quick test will
allow to reveal specific viral
antigen in the material under
A) Direct and indirect
immunofluorescence test
B) Direct and indirect fluorescence
C) D) Hemagglutination inhibition
E) Radioimmunoassay

B) Subunit vaccine
C) Interferon
D) Rimantadine
E) Gamma-globulin

B) Vaccine
C) Remantadin
D) Interferon
E) Immunoglobulin

193. +++In the area being the

epicenter of the registered rabies
cases among wild animals a 43year-oldman presented to a clinic
and claimed to have been bitten by
a stray dog. He was given a course
of anti-rabies vaccine. This
preparation relates to the following
type of vaccines:
A) Toxoids
B) Attenuated
C) Synthetic
D) Molecular
E) Inactivated

197. +++Epidemic of
influenza was announced in a
town. Which drug can be
recommended for the nonspecific
prophylaxis of influenza?
A) Anti-influenza immunoglobulin
B) Anti-influenza serum
C) Antibiotics
D) Anti-influenza vaccine
E) Leukocytic interferon

198. +++A female patient

bitten by a stray dog came to a
surgery. Wide lacerated wounds
were localized on the patient001s
194. +++A laboratory
face. What treatment-and
received a sample of water used in prevention aid should be rendered
drug production for sanitary and
in order to prevent rabies?
virological analysis. What group of A) Urgent injection of normal
viruses will indicate faecal
contamination of water and thus
B) Hospitalization, medical
the need for its additional
191. +++A man who was
C) Immunization with the antirabic
bitten by the unknown dog applied A) Orthomyxoviridae
to the surgeon. Wide ragged
B) Flaviviridae
D) Combined antibiotic therapy
woundes were localised on the
C) Picornaviridae
E) Hospitalization, injection of
face. What curative-prophylactic
D) Retroviridae
aid should be given to prevent
E) Herpesviridae
A) Start immunisation with rabies
195. +++Inoculation of
199. +++The contents of
hen001s embryos is the main
vesicles that appeared on the
B) Immediately inject normal
method of detection of influenza
mucous membrane of a patient
gamma globulin
virus. In order to neutralize
with variola was sent to a
C) Immediate injection of
associated bacterial flora in the
virological laboratory. Which of
DPT(Diphtheria, Pertusis, Tetanus) material under examination
the listed changes were revealed
(nasopharyngeal lavage) it is
during the smear microscopy?
D) Hospitalize the patient and keep necessary to add beforehand:
A) Guarnieri bodies
under the doctor001s supervision
A) Leukocytic interferon
B) Syncytium
E) Prescribe combine antibiotic
B) Ant-influenza gamma globulin C) Paschen bodies
C) Eubiotics
D) Babes-Ernst bodies
D) Antibiotics
E) Babes-Negri bodies
192. +++To prevent the
E) Fluorescent serum
seasonal influenza epidemics in the
200. +++A patient with
city hospitals, sanitary epidemic
196. +++A drugstore
clinical signs of encephalitis was
station gave orders to immunize
received a supply of a drug that is delivered to the infectious diseases
health care workers. Which of the widely used for treatment of many hospital. Anamnesis registers a tick
following preparations should be
virus diseases since it is not virus
bite. Hemagglutination-inhibition
used for immunization?
specific. What drug is it?
reaction helped to reveal antibodies
A) Amantadine
A) Metisazone
to the causative agent of tick-borne

encephalitis in the dilution 1:20

which is not diagnostic. What
actions should the doctor take after
he had got such result?
A) To apply more sensitive
B) To examine the same serum
C) To deny diagnosis of tick-borne
D) To repeat the examination with
serum taken 10 days later
E) To repeat examination with
another diagnosticum
201. +++A pregnant woman
was registered in an antenatal
clinic and underwent complex
examination for a number of
infections. Blood serum contained
IgM to the rubella virus. What is
this result indicative of?
A) Of a chronic process
B) Of primary infection
C) The woman is healthy
D) Of exacerbation of a chronic
E) Of recurring infection with
rubella virus

D) DNA-genomic viruses
E) All the complex viruses
203. +++A hospitalized
patient bitten by a rabid animal has
an avulsive wound of shin. What
kind of vaccine must be given to
prevent rabies?
A) Td
C) Anti-rabies vaccine
D) TABte


204. +++ A patient has been
hospitalised with provisional
diagnosis of virus B hepatitis.
Serological reaction based on
complementation of antigen with
antibody chemically bound to
peroxidase or alkaline phosphatase
has been used for disease
diagnostics. What is the name of
the applied serological reaction?
A) Immune-enzyme analysis
B) Bordet-Gengou test
C) Antigen-binding assay
D) Immunofluorescence test
202. +++Material taken from E) Radioimmunoassay technique
a patient with provisional diagnosis
"influenza" was referred to a
205. +++The donor who for a
laboratory. For virological
long time didn001t donate the
examination the hemadsorption
blood was investigated with IFA
reaction was applied. This reaction method. Anti-HBs antibodies were
can be applied for detection of the revealed. What does positive result
following viruses:
of IFA in this case mean?
A) Any viruses
A) Chronic hepatitis E
B) Viruses containing
B) Acute hepatitis C
C) Acute hepatitis B
C) All the simple viruses
D) Chronic hepatitis A

E) Previous hepatitis B

characterized by a predominant
liver affection. Choose from the
206. +++Examination of a
below given list the drugs for the
27-year-old donor who had not
etiotropic therapy of this infection:
donated blood for a long time
A) Sulfanilamides
revealed HBs antibodies detected B) Penicillin
by ELISA method. In this case, the C) Tetracycline
positive ELISA results indicate
D) Fluoroquinolones
that the donor:
E) Acyclovir
A) Had hepatitis B
B) Has chronic hepatitis C
209. +++In order to eliminate
C) Has acute hepatitis C
occupational risks dental workers
D) Has chronic hepatitis B
underwent vaccination. The
E) Has acute hepatitis B
vaccine should protect them from a
viral infection, whose pathogen
207. +++A patient has been may be found in blood of dental
admitted to the infectious diseases patients who had had this infection
department for malaise, fever up to or who are its chronic carriers.
38C, jaundice. A few months ago, What vaccine was used?
the patient underwent blood
A) Genetically engineered HBs
transfusion. The doctor suspected antigen
viral hepatitis B. What are the
B) Live measles vaccine
principal methods of laboratory
C) Inactivated hepatitis A vaccine
diagnosis of hepatitis B?
D) Anti-rabies vaccine
A) Virus isolation in cell culture
E) Subunit influenza vaccine
and its identification by the
cytopathic effects
210. +++Professional dentists
B) Serological and gene
belong to the risk group
concerning professional infection
C) Isolation of the virus in
with viral hepatitis type B. Name
laboratory animals (neutralization an effective method for active
prevention of this disease among
D) Isolation of the virus in chicken the dentists:
A) Introduction of
E) Detection of virions in blood by interferonogenes
electron microscopy
B) Vaccination with recombinant
208. +++It is known that
C) Working with gum gloves on
infectious type B hepatitis is a
D) Introduction of specific
systemic disease caused by the
type B hepatitis virus and
E) Secure sterilization of medical

211. +++A doctor examined
a patient with recurrent aphthous
stomatitis with concominant
candidosis and decided to
eliminate a possibility of HIVinfection. What examination can
help to clear the situation up and
make a provisional diagnosis?
A) Gel precipitation reaction
B) Reaction of hemagglutination
C) Phase-contrast microscopy
D) Reaction of hemagglutination
E) Immune-enzyme analysis
212. +++During surgical
operation a blood transfusion was
made. The blood must be checked
to find antigens of some disease.
What disease is expected to be
A) Virus of hepatitis E
B) Virus of hepatitis B
C) Virus of hepatitis A
D) Enterovirus
E) Adenovirus

target cells of an organism. Which

of the following human
lymphocyte antigens is gp120
complementary bound with?
A) CD 28
B) CD 19
C) CD 8
D) CD 3
E) CD 4
215. +++Examination of a
young man in the AIDS center
produced a positive result of
immune-enzyme assay with HIV
antigens. Patient001s complaints
about state of his health were
absent. What can the positive result
of immune-enzyme assay be
evidence of?
A) Having had AIDS recently
B) Being ill with AIDS
C) HBV persistence
D) Being infected with HBV
E) HIV infection

216. +++The immunoblot

detected gp120 protein in the blood
serum. This protein is typical for
the following disease:
213. +++The immunoblot
A) HIV-infection
detected gp120 protein in the blood B) Syphilis
serum. This protein is typical for
C) Poliomyelitis
the following disease:
D) Virus B hepatitis
A) Tuberculosis
E) Tuberculosis
B) Virus B hepatitis
C) Poliomyelitis
D) Syphilis
E) HIV-infection
214. +++HIV has gp41 and
gp120 on its surface interacts with

10 - D
11 - B
12 - D
13 - D
14 - C
15 - D
16 - C
17 - A
18 - A
19 - B
20 - D
21 - E
22 - B
23 - B
24 - C
25 - E

26 - C
27 - B
28 - E
29 - E
30 - D
31 - E
32 - C
33 - E
34 - A
35 - B
36 - C
37 - A
38 - C
39 - E
40 - A
41 - A
42 - E
43 - A
44 - E
45 - C
46 - D
47 - A
48 - E
49 - D
50 - B

51 - B
52 - D
53 - D
54 - B
55 - D
56 - C
57 - A
58 - C
59 - A
60 - A
61 - E
62 - E
63 - E
64 - B
65 - A
66 - E
67 - E
68 - E
69 - A
70 - A
71 - E
72 - C
73 - A
74 - D
75 - D

76 - E
77 - D
78 - E
79 - E
80 - C
81 - D
82 - A
83 - D
84 - D
85 - A
86 - A
87 - A
88 - C
89 - A
90 - B
91 - A
92 - A
93 - C
94 - A
95 - B
96 - D
97 - A
98 - A
99 - B
100 - A

101 - D
102 - A
103 - D
104 - B
105 - D
106 - B
107 - C
108 - A
109 - A
110 - C
111 - E
112 - D
113 - D
114 - D
115 - D
116 - B
117 - D
118 - E
119 - D
120 - D
121 - E
122 - A
123 - A
124 - B
125 - A

126 - A
127 - A
128 - E
129 - C
130 - B
131 - A
132 - C
133 - A
134 - C
135 - E
136 - E
137 - B
138 - A
139 - A
140 - C
141 - C
142 - B
143 - A
144 - A
145 - A
146 - E
147 - A
148 - A
149 - A
150 - E

151 - A
152 - C
153 - E
154 - A
155 - E
156 - A
157 - A
158 - E
159 - E
160 - C
161 - E
162 - A
163 - E
164 - A
165 - C
166 - D
167 - D
168 - A
169 - E
170 - C
171 - A
172 - E
173 - E
174 - A
175 - B

176 - A
177 - D
178 - C
179 - B
180 - C
181 - B
182 - C
183 - A
184 - D
185 - D
186 - C
187 - C
188 - A
189 - A
190 - A
191 - A
192 - B
193 - B
194 - C
195 - D
196 - D
197 - E
198 - C
199 - C
200 - D

201 - B
202 - B
203 - C
204 - A
205 - E
206 - A
207 - B
208 - E
209 - A
210 - B
211 - E
212 - B
213 - E
214 - E
215 - E
216 - A