Beruflich Dokumente
Kultur Dokumente
CS407
Paraic James
18h
Peter Kenny
18h
Introduction
Main Biosynthetic Pathways
Biosynthesis of Carbohydrates (Glucose)
Pyruvate & Acetate Formation
Fatty Acids
Prostaglandins
Shikimate
Amino Acids
Alkaloids
Morphine Biosynthesis
Nucleotides
Pyrrole Pigments
Aromatic Polyketides
Terpenes
Steroids
Mixed Pathways
Plant Sources of Drugs
Flavanoids
Spectroscopic Techniques
Books:
Basic Organic Chemistry Part IV
Tedder, Nechvatal, Murray, Carnduff
Organic Chemistry
I.L.Finar
Natural Products
J.Mann, R.S.Davidson et. al.
Biosynthesis
- Synthesis by Nature
Primary Metabolites
&
Secondary Metabolites
Proteins
Terpenes
Carbohydrates
Steroids
Fatty Acids
Alkaloids
Pharmacognosy
Pharmakon
Greek for
DRUG
gnosis
Greek for
KNOWLEDGE
CO2 + H2O
C6H12O6 + O2
Glucose
C6H12O6
Glucose
O
H3C
COOH
H3C
OH
1. ACETATE
2. SHIKIMATE
3. AMINO ACIDS
H3C
HOOC
OH
OH
OH
Mevalonic Acid
COOH
HO
OH
OH
13
14
18
32
H3C
O
O
H3C
COOH
O
14
C labelled Acetate
CH3
COOH
OH
6-Methylsalicylic Acid
Problems:
Difficult to synthesize labelled precursors
Difficult to get good incorporation of the
label into living organisms
Difficulties arise with dilution of the label
by the unlabelled pool
Usually only a small amount of product and
difficult to establish exact location of the
label